NO982417L - Vektorer og fremgangsmÕter for genoverf°ring til celler - Google Patents
Vektorer og fremgangsmÕter for genoverf°ring til cellerInfo
- Publication number
- NO982417L NO982417L NO982417A NO982417A NO982417L NO 982417 L NO982417 L NO 982417L NO 982417 A NO982417 A NO 982417A NO 982417 A NO982417 A NO 982417A NO 982417 L NO982417 L NO 982417L
- Authority
- NO
- Norway
- Prior art keywords
- coat protein
- cells
- vector
- methods
- chimeric
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
- C12N2810/405—Vectors comprising RGD peptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
Det er beskrevet et chimerisk adenovirus kappeprotein som er forskjellig fra vild-type kapperprotein ved introduksjon av en nonnativ aminosyresekvens. Ht slikt chimerisk adenovirus kappeprotein har evnen til å lede innførsel i cellene til en vektor omfattende kappeproteinet som er mer effektivt enn innførsel i cellene til en vektor som er identisk med unntagelse av at den omfatter et vild-type adenovirus kappeprotein isteden for chimerisk adenovirus kappeprotein. Det crumeriske kappeproteinet er fortrinnsvis et fiber, hekson eller pentonprotein. Det er videre beskrevet en adenoviral vektor som omfatter chimerisk adenovirus kappeprotein samt fremgangsmåte for konstruering og andvendelse av en slik vektor.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/563,368 US5965541A (en) | 1995-11-28 | 1995-11-28 | Vectors and methods for gene transfer to cells |
US08/700,846 US5962311A (en) | 1994-09-08 | 1996-08-21 | Short-shafted adenoviral fiber and its use |
US08/701,124 US5846782A (en) | 1995-11-28 | 1996-08-21 | Targeting adenovirus with use of constrained peptide motifs |
PCT/US1996/019150 WO1997020051A2 (en) | 1995-11-28 | 1996-11-27 | Vectors and methods for gene transfer to cells |
Publications (2)
Publication Number | Publication Date |
---|---|
NO982417D0 NO982417D0 (no) | 1998-05-27 |
NO982417L true NO982417L (no) | 1998-07-06 |
Family
ID=27415918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO982417A NO982417L (no) | 1995-11-28 | 1998-05-27 | Vektorer og fremgangsmÕter for genoverf°ring til celler |
Country Status (17)
Country | Link |
---|---|
EP (3) | EP0863987B1 (no) |
JP (1) | JP3420586B2 (no) |
AT (1) | ATE382694T1 (no) |
AU (1) | AU724189B2 (no) |
BG (1) | BG102554A (no) |
BR (1) | BR9612685A (no) |
CA (1) | CA2236912C (no) |
CZ (1) | CZ162398A3 (no) |
EA (1) | EA199800475A1 (no) |
EE (1) | EE9800160A (no) |
IL (1) | IL124654A0 (no) |
IS (1) | IS4754A (no) |
NO (1) | NO982417L (no) |
NZ (1) | NZ323834A (no) |
PL (1) | PL327038A1 (no) |
SK (1) | SK72298A3 (no) |
WO (1) | WO1997020051A2 (no) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6465253B1 (en) | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
US5962311A (en) * | 1994-09-08 | 1999-10-05 | Genvec, Inc. | Short-shafted adenoviral fiber and its use |
US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
FR2761689B1 (fr) * | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
CA2307842C (en) | 1997-10-31 | 2010-10-19 | The Board Of Regents Of The University Of Oklahoma | Hyaluronan synthase gene and uses thereof |
JP2002508967A (ja) * | 1998-01-16 | 2002-03-26 | ジェンザイム・コーポレイション | 修飾カプシド蛋白を有するアデノウイルスベクター |
US20030017138A1 (en) * | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
JP2002523105A (ja) | 1998-08-27 | 2002-07-30 | アバンテイス・フアルマ・エス・アー | 異種遺伝子の運搬用の標的化アデノウイルスベクター |
EP1020529B1 (en) * | 1998-11-20 | 2005-06-01 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
IL133032A (en) * | 1998-11-20 | 2007-06-03 | Introgene Bv | Adenoviral gene delivery vectors provided with a tissue tropism for smooth muscle cells and /or endothelial cells |
JP4683727B2 (ja) * | 1999-03-04 | 2011-05-18 | クルーセル ホランド ベスローテン フェンノートシャップ | 線維芽細胞様またはマクロファージ様細胞の形質導入のための手段と方法 |
AU763733B2 (en) * | 1999-07-06 | 2003-07-31 | Got-A-Gene Ab | Recombinant adenovirus |
US6955808B2 (en) * | 1999-09-24 | 2005-10-18 | Uab Research Foundation | Capsid-modified recombinant adenovirus and methods of use |
EP1276888A2 (en) * | 2000-04-26 | 2003-01-22 | Crucell Holland B.V. | Adenovirus vectors with knobless fibers, and their uses |
AU6368901A (en) * | 2000-05-31 | 2001-12-11 | Univ Saskatchewan | Modified bovine adenovirus having altered tropism |
US6579522B1 (en) * | 2000-06-27 | 2003-06-17 | Genvec, Inc. | Replication deficient adenoviral TNF vector |
GB0017720D0 (en) * | 2000-07-19 | 2000-09-06 | Got A Gene Ab | Modified virus |
US6573092B1 (en) | 2000-10-10 | 2003-06-03 | Genvec, Inc. | Method of preparing a eukaryotic viral vector |
US20030086903A1 (en) | 2001-11-02 | 2003-05-08 | Genvec, Inc. | Therapeutic regimen for treating cancer |
US20040166091A1 (en) | 2003-02-24 | 2004-08-26 | Genvec, Inc. | Materials and methods for treating disorders of the ear |
US7611868B2 (en) | 2003-05-14 | 2009-11-03 | Instituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Recombinant modified adenovirus fiber protein |
EP1687032B1 (en) | 2003-11-14 | 2010-02-24 | Genvec, Inc. | Pharmaceutical composition for treating unresectable, locally advanced pancreatic cancer (lapc). |
JP2007228802A (ja) * | 2004-03-31 | 2007-09-13 | Dnavec Research Inc | 標的細胞への遺伝子の導入方法 |
JP2007532656A (ja) | 2004-04-12 | 2007-11-15 | アメリカ合衆国 | アデノウイルスベクターを用いて免疫応答を誘導するための方法 |
WO2006033679A2 (en) | 2004-05-25 | 2006-03-30 | Chimeracore, Inc. | Self-assembling nanoparticle drug delivery system |
WO2007027860A2 (en) | 2005-08-31 | 2007-03-08 | Genvec, Inc. | Adenoviral vector-based malaria vaccines |
BRPI0618441B8 (pt) | 2005-11-10 | 2021-07-27 | Genvec Inc | vetor adenoviral |
EP2018156B1 (en) | 2006-04-07 | 2010-03-17 | Chimeros, Inc. | Compositions and methods for treating b- cell malignancies |
WO2010120874A2 (en) | 2009-04-14 | 2010-10-21 | Chimeros, Inc. | Chimeric therapeutics, compositions, and methods for using same |
US20120219583A1 (en) | 2009-10-16 | 2012-08-30 | Los Alamos National Security, Llc | Nucleic acid sequences encoding expandable hiv mosaic proteins |
WO2011057248A2 (en) | 2009-11-09 | 2011-05-12 | Genvec, Inc. | Simian adenovirus and methods of use |
WO2011057254A2 (en) | 2009-11-09 | 2011-05-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Simian adenoviral vector-based vaccines |
WO2012021730A2 (en) | 2010-08-11 | 2012-02-16 | Genvec, Inc. | Respiratory syncytial virus (rsv) vaccine |
WO2012083297A2 (en) | 2010-12-17 | 2012-06-21 | Genvec, Inc. | Adenoviral vectors with modified hexon regions |
US8920813B2 (en) | 2010-12-20 | 2014-12-30 | Genvec, Inc. | Adenoviral vector-based dengue fever vaccine |
CA2847888A1 (en) | 2011-09-09 | 2013-03-14 | Biomed Realty, L.P. | Methods and compositions for controlling assembly of viral proteins |
WO2013154744A1 (en) * | 2012-04-13 | 2013-10-17 | Cornell University | Development of a highly efficient second generation nicotine-conjugate vaccine to treat nicotine addiction |
EP2855669B1 (en) | 2012-05-29 | 2018-10-10 | GenVec, Inc. | Modified serotype 28 adenoviral vectors |
AU2013296218B2 (en) | 2012-08-03 | 2019-07-18 | Cedars-Sinai Medical Center | Isolating traffic-enhancing mutants of drug delivery protein |
SG11201507393TA (en) | 2013-03-14 | 2015-10-29 | Salk Inst For Biological Studi | Oncolytic adenovirus compositions |
TWI710635B (zh) | 2014-10-09 | 2020-11-21 | 美商珍維克公司 | 編碼人類無調同源物-1(hath1)之腺病毒載體 |
KR102471633B1 (ko) | 2016-02-23 | 2022-11-25 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
EP3390428B1 (en) | 2016-02-23 | 2019-09-25 | Salk Institute for Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
WO2018064523A1 (en) | 2016-09-30 | 2018-04-05 | Genvec, Inc. | Adenovectors for delivery of therapeutic genetic material into t cells |
JP2019536468A (ja) | 2016-12-12 | 2019-12-19 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腫瘍を標的にする合成アデノウイルスおよびその使用 |
JP2023506768A (ja) | 2019-12-12 | 2023-02-20 | ティン セラピューティックス エルエルシー | 聴覚損失の予防及び治療のための組成物及び方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9223084D0 (en) * | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
US5543328A (en) * | 1993-08-13 | 1996-08-06 | Genetic Therapy, Inc. | Adenoviruses having modified fiber proteins |
US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
-
1996
- 1996-11-27 NZ NZ323834A patent/NZ323834A/xx unknown
- 1996-11-27 AT AT96940927T patent/ATE382694T1/de not_active IP Right Cessation
- 1996-11-27 CA CA002236912A patent/CA2236912C/en not_active Expired - Fee Related
- 1996-11-27 BR BR9612685A patent/BR9612685A/pt not_active Application Discontinuation
- 1996-11-27 EP EP96940927A patent/EP0863987B1/en not_active Expired - Lifetime
- 1996-11-27 WO PCT/US1996/019150 patent/WO1997020051A2/en active IP Right Grant
- 1996-11-27 SK SK722-98A patent/SK72298A3/sk unknown
- 1996-11-27 EE EE9800160A patent/EE9800160A/xx unknown
- 1996-11-27 IL IL12465496A patent/IL124654A0/xx unknown
- 1996-11-27 PL PL96327038A patent/PL327038A1/xx unknown
- 1996-11-27 EA EA199800475A patent/EA199800475A1/ru unknown
- 1996-11-27 AU AU10868/97A patent/AU724189B2/en not_active Ceased
- 1996-11-27 EP EP05021223A patent/EP1616961A1/en not_active Withdrawn
- 1996-11-27 EP EP04028530A patent/EP1518933A1/en not_active Withdrawn
- 1996-11-27 JP JP52072097A patent/JP3420586B2/ja not_active Expired - Fee Related
- 1996-11-27 CZ CZ981623A patent/CZ162398A3/cs unknown
-
1998
- 1998-05-25 IS IS4754A patent/IS4754A/is unknown
- 1998-05-27 NO NO982417A patent/NO982417L/no not_active Application Discontinuation
- 1998-06-18 BG BG102554A patent/BG102554A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU724189B2 (en) | 2000-09-14 |
NZ323834A (en) | 2000-01-28 |
MX9804203A (es) | 1998-10-31 |
WO1997020051A2 (en) | 1997-06-05 |
SK72298A3 (en) | 1998-12-02 |
EP1518933A1 (en) | 2005-03-30 |
PL327038A1 (en) | 1998-11-09 |
EA199800475A1 (ru) | 1998-12-24 |
CA2236912C (en) | 2006-04-25 |
WO1997020051A3 (en) | 1997-08-28 |
EP0863987A2 (en) | 1998-09-16 |
IS4754A (is) | 1998-05-25 |
AU1086897A (en) | 1997-06-19 |
BR9612685A (pt) | 1999-07-20 |
EP0863987B1 (en) | 2008-01-02 |
JPH11501219A (ja) | 1999-02-02 |
EE9800160A (et) | 1998-12-15 |
NO982417D0 (no) | 1998-05-27 |
IL124654A0 (en) | 1998-12-06 |
CZ162398A3 (cs) | 1998-10-14 |
JP3420586B2 (ja) | 2003-06-23 |
ATE382694T1 (de) | 2008-01-15 |
CA2236912A1 (en) | 1997-06-05 |
BG102554A (en) | 1999-04-30 |
EP1616961A1 (en) | 2006-01-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO982417D0 (no) | Vektorer og fremgangsmÕter for genoverf°ring til celler | |
ATE382695T1 (de) | Targeting von adenoviren mit hilfe von konformationsbeschränkten peptidmotiven | |
ATE213022T1 (de) | Adenovirale vektoren für die gentherapie | |
DE69637545D1 (de) | Chimärisches , adenovirales faserprotein und verfahren zu dessen verwendung | |
EP0866721A4 (en) | ADENOVIRAL TARGET VECTORS | |
SG165153A1 (en) | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use | |
ATE336587T1 (de) | Adenoviren-vektor systeme und zelllinien | |
DE69535103D1 (de) | Rekombinanter adenovirus welcher eine chimäre penton-base aufweist | |
ATE342350T1 (de) | Modifizierte adenoviren welche ein faserersatzprotein enthalten | |
DK0632129T3 (da) | Rekombinante foamy-virusvektorer til medicinsk og diagnostisk anvendelse, og fremgangsmåder til at præparere rekombinante foamy-virusvektorer | |
CA2252493A1 (en) | .beta.-galactoside - .alpha. 2,6-sialyltransferase gene | |
WO2000009693A3 (en) | Identification of the gene causing the mouse scurfy phenotype and its human ortholog | |
WO2002086098A3 (en) | A lac operator-repressor system | |
DK0843731T3 (da) | Adenovirusvektorer til genterapi | |
MX9706290A (es) | Secuencias amplificadoras, vectores que portan estas secuencias y sus utilizaciones en composiciones para la expresion de secuencias nucleotidicas en celulas transfectadas, aplicaciones terapeuticas y vacunales. | |
NO951315D0 (no) | Ökt produksjon av utsondrede proteiner fra rekombinante eukaryote-celler | |
EP0723014A3 (en) | cDNA of DOCK180 gene and DOCK180 protein | |
CA2237059A1 (en) | Targeted adenovirus vectors | |
TH19876A (th) | จีนที่ประมวลรหัสและวิธีสำหรับแสดงลักษณะเอนไซม์ชนิดใหม่ | |
IT1276724B1 (it) | Vettore plasmidico di espressione per cellule di mammifero |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |