BG100747A - Производни на индола като 5-нт долу 1 агонисти - Google Patents

Производни на индола като 5-нт долу 1 агонисти

Info

Publication number
BG100747A
BG100747A BG100747A BG10074796A BG100747A BG 100747 A BG100747 A BG 100747A BG 100747 A BG100747 A BG 100747A BG 10074796 A BG10074796 A BG 10074796A BG 100747 A BG100747 A BG 100747A
Authority
BG
Bulgaria
Prior art keywords
group
agonists
indole derivatives
optionally substituted
cycloalkyl
Prior art date
Application number
BG100747A
Other languages
English (en)
Inventor
Robert Glen
Christopher Foster
David Selwood
Graeme Martin
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Publication of BG100747A publication Critical patent/BG100747A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Съединенията са приложими в лечението на клиничнисъстояния, за които се изисква 5-нт1 подобен рецепторен агонист. Те имат формула, в която r и r1 саводород или с1-4 алкил или са свързани така, че образуват пръстен, а е алкил циклоалкилна група, n е цяло число със стойност от 0 до 3, w е евентуално заместен 5или 6-членен хетероциклен пръстен или евентуално заместена арилна, хетероарилна, арилокси или тиофеноксигрупа или w е групата -sо2nr6r7, -nнс(о)r6r7 или -с(о)nнr6r7.
BG100747A 1994-01-26 1996-07-25 Производни на индола като 5-нт долу 1 агонисти BG100747A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9401436A GB9401436D0 (en) 1994-01-26 1994-01-26 Therapeutic heterocyclic compounds
PCT/GB1995/000142 WO1995020588A1 (en) 1994-01-26 1995-01-25 Indole derivatives as 5-ht1 agonists

Publications (1)

Publication Number Publication Date
BG100747A true BG100747A (bg) 1997-03-31

Family

ID=10749321

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100747A BG100747A (bg) 1994-01-26 1996-07-25 Производни на индола като 5-нт долу 1 агонисти

Country Status (26)

Country Link
US (3) US5744466A (bg)
EP (1) EP0741725A1 (bg)
JP (1) JPH09512248A (bg)
CN (1) CN1143960A (bg)
AP (1) AP632A (bg)
AU (2) AU689195B2 (bg)
BG (1) BG100747A (bg)
BR (1) BR9506581A (bg)
CA (1) CA2181475A1 (bg)
CZ (1) CZ216996A3 (bg)
EE (1) EE9600095A (bg)
FI (1) FI962969A0 (bg)
GB (1) GB9401436D0 (bg)
HU (1) HUT76288A (bg)
IL (1) IL112443A (bg)
MX (1) MX9602979A (bg)
NO (1) NO963117L (bg)
NZ (1) NZ278644A (bg)
OA (1) OA10307A (bg)
PL (1) PL315666A1 (bg)
SG (1) SG44926A1 (bg)
SK (1) SK96796A3 (bg)
TW (1) TW377344B (bg)
WO (1) WO1995020588A1 (bg)
YU (1) YU4795A (bg)
ZA (1) ZA95601B (bg)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376463B1 (en) * 1992-04-07 2002-04-23 Emory University Modified factor VIII
GB9515060D0 (en) * 1995-07-22 1995-09-20 Wellcome Found Therapeutic heterocyclic compounds
GB9515305D0 (en) * 1995-07-26 1995-09-20 Wellcome Found Therapeutic heterocyclic compounds
GB9516143D0 (en) * 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
GB9516145D0 (en) * 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
US6909005B1 (en) 1995-08-07 2005-06-21 Astrazeneca Uk Limited One post synthesis of 2-oxazolidinone derivatives
AU2104097A (en) * 1996-03-13 1997-10-01 Glaxo Group Limited Medicaments comprising 5ht1-like receptor agonists with an increased absorption
US5654431A (en) * 1996-05-30 1997-08-05 Meng; Qingchang 5-alkoxy tryptamine derivatives
US6355672B1 (en) * 1998-08-07 2002-03-12 Takeda Chemical Industries, Ltd. Benzothiepin derivatives, process for the preparation of the same and uses thereof
BR0015401A (pt) * 1999-11-08 2002-07-02 Wyeth Corp [(indol-3-il)-cicloalquil]-3-azetidinas substituìdas para o tratamento de distúrbios do sistema nervoso central
US6245799B1 (en) 1999-11-08 2001-06-12 American Home Products Corp [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
CA2403806A1 (en) * 2000-03-23 2002-09-20 Bayer Aktiengesellschaft Indoles for treating diseases that can be treated using thyroid hormones
US6462234B2 (en) * 2000-09-18 2002-10-08 Pharmacia & Upjohn Company Process to prepare (2S)-2-(dipropylamino)-6-ethoxy-2, 3-dihydro-1H-indene-5-carboxamide
JP2004517851A (ja) 2000-12-27 2004-06-17 バイエル アクチェンゲゼルシャフト 甲状腺受容体のリガンドとしてのインドール誘導体
CA2610655A1 (en) * 2005-06-03 2006-12-14 Abbott Laboratories Cyclobutyl amine derivatives
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
CA2655604C (en) 2006-06-23 2016-08-09 Abbott Laboratories Cyclopropyl amine derivatives
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
US9580431B2 (en) 2013-03-13 2017-02-28 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
TWI750728B (zh) * 2019-07-11 2021-12-21 大陸商蘇州亞盛藥業有限公司 2-吲哚啉螺環酮類化合物的製備方法及其中間體

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
IL92096A0 (en) * 1988-10-25 1990-07-12 Abbott Lab Carboxylic nucleoside analogs
US4988703A (en) * 1989-05-22 1991-01-29 Abbott Laboratories Carbocyclic nucleoside analogs with antiviral activity
SI9111010B (sl) * 1990-06-07 2005-02-28 Astrazeneca Ab 3,5-disubstituirani indolni derivati kot "5-HT1-podobni" receptorski agonisti
WO1994002477A1 (en) * 1992-07-24 1994-02-03 Merck Sharp & Dohme Limited Imidazole, triazole and tetrazole derivatives

Also Published As

Publication number Publication date
ZA95601B (en) 1996-07-25
WO1995020588A1 (en) 1995-08-03
FI962969A (fi) 1996-07-25
CN1143960A (zh) 1997-02-26
SG44926A1 (en) 1997-12-19
IL112443A (en) 1998-12-27
JPH09512248A (ja) 1997-12-09
IL112443A0 (en) 1995-03-30
GB9401436D0 (en) 1994-03-23
EE9600095A (et) 1996-12-16
US5744466A (en) 1998-04-28
BR9506581A (pt) 1997-09-23
CA2181475A1 (en) 1995-08-03
PL315666A1 (en) 1996-11-25
SK96796A3 (en) 1997-06-04
NO963117L (no) 1996-09-23
NO963117D0 (no) 1996-07-25
TW377344B (en) 1999-12-21
AP9600834A0 (en) 1996-07-31
FI962969A0 (fi) 1996-07-25
AU689195B2 (en) 1998-03-26
EP0741725A1 (en) 1996-11-13
MX9602979A (es) 1998-01-31
AU1462095A (en) 1995-08-15
HUT76288A (en) 1997-07-28
AP632A (en) 1998-03-30
YU4795A (sh) 1998-12-23
NZ278644A (en) 1998-02-26
US6103752A (en) 2000-08-15
OA10307A (en) 1997-10-07
AU6348998A (en) 1998-06-18
CZ216996A3 (en) 1997-06-11
HU9602035D0 (en) 1996-09-30
US5922748A (en) 1999-07-13

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