BE902528A - 1,24-dihydroxy-delta 22-vitamines d3 et procede pour les preparer. - Google Patents
1,24-dihydroxy-delta 22-vitamines d3 et procede pour les preparer.Info
- Publication number
- BE902528A BE902528A BE0/215091A BE215091A BE902528A BE 902528 A BE902528 A BE 902528A BE 0/215091 A BE0/215091 A BE 0/215091A BE 215091 A BE215091 A BE 215091A BE 902528 A BE902528 A BE 902528A
- Authority
- BE
- Belgium
- Prior art keywords
- bone
- hydrogen atom
- application
- vitamin
- dihydroxy
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940088594 vitamin Drugs 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229930003316 Vitamin D Natural products 0.000 abstract 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 2
- 230000018678 bone mineralization Effects 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 235000019166 vitamin D Nutrition 0.000 abstract 2
- 239000011710 vitamin D Substances 0.000 abstract 2
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 2
- 229940046008 vitamin d Drugs 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000029725 Metabolic bone disease Diseases 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical group [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/615,974 US4588528A (en) | 1984-05-31 | 1984-05-31 | 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE902528A true BE902528A (fr) | 1985-09-16 |
Family
ID=24467528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/215091A BE902528A (fr) | 1984-05-31 | 1985-05-29 | 1,24-dihydroxy-delta 22-vitamines d3 et procede pour les preparer. |
Country Status (9)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5786348A (en) * | 1991-01-08 | 1998-07-28 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5120722A (en) * | 1984-02-08 | 1992-06-09 | Hoffmann-La Roche Inc. | Trihydroxy-cholecacliferol and trihydroxy-ergocalciferol for treating leukemia |
| US4973584A (en) * | 1989-03-09 | 1990-11-27 | Deluca Hector F | Novel 1α-hydroxyvitamin D2 epimer and derivatives |
| WO1991012238A1 (de) * | 1990-02-06 | 1991-08-22 | Schering Aktiengesellschaft Berlin Und Bergkamen | Seitenketten-homologe vitamin-d-derivative, verfahren zu ihrer herstellung, diese derivate enthaltende pharmazeutische präparate sowie deren verwendung als arzneimittel |
| US5030772A (en) * | 1990-02-14 | 1991-07-09 | Deluca Hector F | Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives |
| US5260290A (en) * | 1990-02-14 | 1993-11-09 | Wisconsin Alumni Research Foundation | Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives |
| US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
| DE69229103T2 (de) * | 1991-01-08 | 1999-10-14 | Bone Care International Inc. | Verfahren zur herstellung und verwendung von 1alpha,24-dihydroxy vitamin-d2 |
| AU666529B2 (en) * | 1992-04-24 | 1996-02-15 | Wisconsin Alumni Research Foundation | Method of treating osteoporosis with 1 alpha, 24 (R)-dihydroxy-22 (E)-dehydro-vitamin D3 |
| KR960013798B1 (ko) * | 1992-04-24 | 1996-10-10 | 재단법인 한국전자통신연구소 | 평면 도파로형 공간 스위치 |
| US5247104A (en) * | 1992-11-04 | 1993-09-21 | Wisconsin Alumni Research Foundation | Preparation of 1α, 24-dihydroxyvitamin D analogs |
| TW267161B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1992-11-20 | 1996-01-01 | Hoffmann La Roche | |
| US5422127A (en) * | 1992-12-21 | 1995-06-06 | Bristol-Myers Squibb Company | Nutritional compositions containing vitamin D esters |
| US5716946A (en) * | 1996-02-13 | 1998-02-10 | Wisconsin Alumni Research Foundation | Multiple sclerosis treatment |
| US6136799A (en) * | 1998-04-08 | 2000-10-24 | Abbott Laboratories | Cosolvent formulations |
| US6479474B2 (en) * | 1999-07-08 | 2002-11-12 | Wisconsin Alumni Research Foundation | Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis |
| CA2750659C (en) | 2009-01-27 | 2017-11-21 | Berg Biosystems, Llc | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
| JP5978130B2 (ja) | 2009-08-14 | 2016-08-24 | バーグ エルエルシー | 脱毛症を治療するためのビタミンｄ３およびその類似体 |
| KR20160013201A (ko) | 2013-05-29 | 2016-02-03 | 버그 엘엘씨 | 비타민 d를 이용한 화학요법 유발 탈모증의 예방 또는 완화 |
| PL3328390T3 (pl) * | 2015-07-12 | 2022-03-28 | Cfso Gmbh | Sole lizynowe siarczanu cholekalcyferolu i ich zastosowanie w leczeniu niedoboru witaminy d3 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3786062A (en) * | 1973-02-16 | 1974-01-15 | Wisconsin Alumni Res Found | 22-dehydro-25-hydroxycholecalciferol and process for preparing same |
| US4202829A (en) * | 1978-01-05 | 1980-05-13 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
| US4267117A (en) * | 1978-06-19 | 1981-05-12 | The Upjohn Company | Compounds and process |
| US4206131A (en) * | 1978-06-19 | 1980-06-03 | The Upjohn Company | Compounds and process |
| US4225596A (en) * | 1978-10-13 | 1980-09-30 | Wisconsin Alumni Research Foundation | Method for treating calcium imbalance and improving calcium absorption in mammals |
| US4265822A (en) * | 1979-09-10 | 1981-05-05 | Wisconsin Alumni Research Foundation | Process for preparing 1-hydroxylated vitamin D compounds from 5,6-trans-vitamin D compounds |
| US4313942A (en) * | 1979-10-09 | 1982-02-02 | Wisconsin Alumni Research Foundation | Activated vitamin D rodenticides |
| US4448721A (en) * | 1982-09-20 | 1984-05-15 | Wisconsin Alumni Research Foundation | Hydroxyvitamin D2 compounds and process for preparing same |
-
1984
- 1984-05-31 US US06/615,974 patent/US4588528A/en not_active Expired - Lifetime
-
1985
- 1985-02-28 AU AU40639/85A patent/AU4063985A/en not_active Abandoned
- 1985-02-28 DE DE19853590232 patent/DE3590232C2/de not_active Expired - Lifetime
- 1985-02-28 JP JP60501000A patent/JPS61502257A/ja active Granted
- 1985-02-28 DE DE19853590232 patent/DE3590232T/de active Pending
- 1985-02-28 WO PCT/US1985/000323 patent/WO1985005622A1/en active Application Filing
- 1985-05-22 IE IE128485A patent/IE58286B1/en not_active IP Right Cessation
- 1985-05-29 BE BE0/215091A patent/BE902528A/fr not_active IP Right Cessation
- 1985-05-30 FR FR8508154A patent/FR2565227B1/fr not_active Expired
- 1985-05-31 GB GB08513721A patent/GB2159520B/en not_active Expired
-
1993
- 1993-03-01 JP JP5064683A patent/JPH0662664B2/ja not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5786348A (en) * | 1991-01-08 | 1998-07-28 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61502257A (ja) | 1986-10-09 |
| AU4063985A (en) | 1985-12-31 |
| GB2159520B (en) | 1987-12-16 |
| JPH0662664B2 (ja) | 1994-08-17 |
| IE851284L (en) | 1985-11-30 |
| FR2565227B1 (fr) | 1987-01-16 |
| US4588528A (en) | 1986-05-13 |
| GB2159520A (en) | 1985-12-04 |
| DE3590232C2 (de) | 1992-09-17 |
| JPH0576940B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-10-25 |
| FR2565227A1 (fr) | 1985-12-06 |
| IE58286B1 (en) | 1993-08-25 |
| WO1985005622A1 (en) | 1985-12-19 |
| JPH0692989A (ja) | 1994-04-05 |
| DE3590232T (de) | 1986-06-26 |
| GB8513721D0 (en) | 1985-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: WISCONSIN ALUMNI RESEARCH FOUNDATION Effective date: 20010531 |