BE900899A - Nouveaux composes du cepheme et leurs procedes de preparation. - Google Patents

Nouveaux composes du cepheme et leurs procedes de preparation.

Info

Publication number
BE900899A
BE900899A BE0/213889A BE213889A BE900899A BE 900899 A BE900899 A BE 900899A BE 0/213889 A BE0/213889 A BE 0/213889A BE 213889 A BE213889 A BE 213889A BE 900899 A BE900899 A BE 900899A
Authority
BE
Belgium
Prior art keywords
compounds
cepheme
novel
processes
preparation
Prior art date
Application number
BE0/213889A
Other languages
English (en)
Inventor
T Takaya
Z Tozuka
N Yasuda
K Kawabata
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of BE900899A publication Critical patent/BE900899A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Les nouveaux composés du céphem et leurs sels pharmaceutiquement acceptables ont la formule (I) dans laquelle R1 est un amino ou un amino protégé, R2 est un aryle qui peut avoir un ou plusieurs substituants appropriés, un groupe hétérocyclique qui peut avoir un ou plusieurs substituants appropriés, un cyano, un hydrogène ou un tri(alkyle inférieur)silyle, R3 est un carboxy ou un carboxy protégé, et A est -CH=CH- ou C=C-, Les composés de l'invention sont particulièrement utiles contre un certain nombre de microorganismes.
BE0/213889A 1983-10-31 1984-10-25 Nouveaux composes du cepheme et leurs procedes de preparation. BE900899A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838329030A GB8329030D0 (en) 1983-10-31 1983-10-31 Cephem compounds

Publications (1)

Publication Number Publication Date
BE900899A true BE900899A (fr) 1985-04-25

Family

ID=10550996

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/213889A BE900899A (fr) 1983-10-31 1984-10-25 Nouveaux composes du cepheme et leurs procedes de preparation.

Country Status (10)

Country Link
US (1) US4622318A (fr)
EP (1) EP0145906B1 (fr)
JP (2) JPH064642B2 (fr)
BE (1) BE900899A (fr)
CH (1) CH664571A5 (fr)
DE (1) DE3485569D1 (fr)
DK (1) DK499784A (fr)
FR (1) FR2554110B1 (fr)
GB (2) GB8329030D0 (fr)
IT (1) IT1177097B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2550200B1 (fr) * 1983-08-01 1988-04-08 Fujisawa Pharmaceutical Co Procede de preparation de composes de cephem a activite antimicrobienne et nouveaux produits ainsi obtenus
US4880797A (en) * 1986-03-20 1989-11-14 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives and antibacterial agents
US6906187B2 (en) * 2003-02-27 2005-06-14 Miat S.P.A. Manufacture of cefalosporins and intermediates
US20130065874A1 (en) 2011-09-09 2013-03-14 Cubist Pharmaceuticals, Inc. Methods for treating intrapulmonary infections
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US20140274997A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Cephalosporin pharmaceutical compositions
CA2906151A1 (fr) 2013-03-15 2014-09-18 Merck Sharp & Dohme Corp. Compositions antibiotiques de ceftolozane
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
WO2015035376A2 (fr) 2013-09-09 2015-03-12 Calixa Therapeutics, Inc. Traitement d'infections au moyen de ceftolozane/tazobactam chez des sujets ayant une fonction rénale altérée
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5729474B2 (fr) * 1974-01-14 1982-06-23
CH605997A5 (fr) * 1974-08-30 1978-10-13 Ciba Geigy Ag
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
GB2045233B (en) * 1979-03-23 1983-05-11 Erba Farmitalia Unsaturated 3-heterocyclylthiomethyl-7a-methoxy-7-acylamido-3-cephem-4-carboxylic acid derivatives
US4409215A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
ZA806977B (en) * 1979-11-19 1981-10-28 Fujisawa Pharmaceutical Co 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4349672A (en) * 1979-11-29 1982-09-14 Hoffmann-La Roche Inc. Cephalosporin derivatives
FR2476087A1 (fr) * 1980-02-18 1981-08-21 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
ZA813787B (en) * 1980-06-18 1982-07-28 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
US4443444A (en) * 1980-08-11 1984-04-17 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds

Also Published As

Publication number Publication date
JPH064642B2 (ja) 1994-01-19
EP0145906B1 (fr) 1992-03-11
IT8423392A1 (it) 1986-04-30
EP0145906A2 (fr) 1985-06-26
GB8426338D0 (en) 1984-11-21
CH664571A5 (de) 1988-03-15
GB2148890B (en) 1987-10-28
JPH0539292A (ja) 1993-02-19
IT1177097B (it) 1987-08-26
IT8423392A0 (it) 1984-10-30
DE3485569D1 (de) 1992-04-16
FR2554110B1 (fr) 1988-12-02
US4622318A (en) 1986-11-11
GB2148890A (en) 1985-06-05
FR2554110A1 (fr) 1985-05-03
GB8329030D0 (en) 1983-11-30
DK499784A (da) 1985-05-01
JPS60109590A (ja) 1985-06-15
DK499784D0 (da) 1984-10-18
EP0145906A3 (en) 1986-03-12

Similar Documents

Publication Publication Date Title
BE900899A (fr) Nouveaux composes du cepheme et leurs procedes de preparation.
Cooper et al. Siderophore electrochemistry: relation to intracellular iron release mechanism.
ES8401016A1 (es) Un metodo para la preparacion de un peptido inhibidor de la renina.
BE1003279A5 (fr) Nouveaux composes pharmacologiquement actifs, leurs procedes de preparation et les compositions en contenant.
FR2454270A1 (fr) Application fongicide de derives benzamidiques
NZ335013A (en) Compositions comprising cytosine derivatives for the treatment of cancer
BE901224A (fr) Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation.
ZA847550B (en) Anticonvulsant sulfamate derivatives
ES8403439A1 (es) Procedimiento para preparar derivados de amidas.
ES8608526A1 (es) Un procedimiento para preparar nuevos compuestos de cefem
AU570920B2 (en) 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines
KR970704710A (ko) 트리아졸 화합물 및 도파민 D₃리간드로서의 그의 용도(Triazole Compounds and Their Use as Dopamine-D₃-Ligands)
AU4453596A (en) Nitrogen mustard prodrugs with novel lipophilic protecting groups, and processes for their production
ES8504211A1 (es) Procedimiento para la preparacion de derivados de oligoglucosido
US4340728A (en) Nucleoside derivatives and process for preparing same
JPS57167978A (en) N-heterocyclylmethylamide derivative, manufacture and agricultural composition containing same
KR850002964A (ko) 심장병 치료제의 제조방법
US4528397A (en) Aminocarboxylic acid derivatives
HUP0203422A2 (hu) Foszfodiészteráz VII inhibitor hatású imidazolszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
KR850006421A (ko) 새로운 세팔로스포린 유도체의 제조방법
TNSN99218A1 (fr) Nouveaux composes azabicycliques a substitution heteroaryl- ethyl/benzisoxazole, leur procede de production et composition pharmaceutique les contenant.
FR2362845A1 (fr) Nouveaux derives de o-(3-amino-2-hydroxy-propyl)-amidoxime, procede pour leur preparation et compositions pharmaceutiques les contenant
RU94030470A (ru) Производные 1-(арилалкиламиноалкил)имидазола, способ их получения, фармацевтическая композиция и способ лечения
HUP0003155A2 (hu) Eljárás COX-2 inhibitorként alkalmazható 2-aril-3-aril-5-halogénpiridin-származékok előállítására
FI850505A0 (fi) Foerfarande foer framstaellning av pyrrolidonderivat.

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: FUJISAWA PHARMACEUTICAL CO. LTD

Effective date: 19951031