BE898968A - Composes du platine (ii) et leur preparation - Google Patents
Composes du platine (ii) et leur preparationInfo
- Publication number
- BE898968A BE898968A BE0/212426A BE212426A BE898968A BE 898968 A BE898968 A BE 898968A BE 0/212426 A BE0/212426 A BE 0/212426A BE 212426 A BE212426 A BE 212426A BE 898968 A BE898968 A BE 898968A
- Authority
- BE
- Belgium
- Prior art keywords
- platinum
- preparation
- ptl2i2
- coordinated
- amine
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 title 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 229910052697 platinum Inorganic materials 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'invention concerne un procédé de préparation d'un oligomère possédant la formule empirique (PtL2Ix), dans laquelle x représente un nombre entier inférieur, égal à 2 ou à plus de 2, et chaque symbole L est identique et représente l'amine, une monoamine primaire ou secondaire ou une amine du type pyridine, coordinée au platine par l'intermédiaire de l'azote aminé, ou le diméthylformamide coordiné au platine par l'intermédiaire de l'atome d'oxygène, caractérisé en ce que l'on fait réagir un composé répondant a la formule cis-(PtL2I2) en présence d'un excés molaire d'un acide aqueux ne réagissant par sur le platine, en mélange à un solvant poue ledit (PtL2I2), inerte, miscible à l'eau, de facon à former l'oligomère précité.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/468,619 US4533502A (en) | 1983-02-22 | 1983-02-22 | Platinum (II) compounds and their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
BE898968A true BE898968A (fr) | 1984-08-21 |
Family
ID=23860544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/212426A BE898968A (fr) | 1983-02-22 | 1984-02-21 | Composes du platine (ii) et leur preparation |
Country Status (13)
Country | Link |
---|---|
US (1) | US4533502A (fr) |
JP (3) | JPS59231096A (fr) |
BE (1) | BE898968A (fr) |
CH (1) | CH659075A5 (fr) |
DE (1) | DE3406161A1 (fr) |
DK (1) | DK83184A (fr) |
ES (2) | ES529896A0 (fr) |
FR (1) | FR2541284B1 (fr) |
GB (1) | GB2137198B (fr) |
GR (1) | GR81655B (fr) |
IE (1) | IE56937B1 (fr) |
IT (1) | IT1180435B (fr) |
SE (1) | SE8400865L (fr) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5749928A (en) * | 1984-12-04 | 1998-05-12 | Platinum Plus, Inc. | Method for reducing emissions from or increasing the utilizable energy of fuel for powering internal combustion engines |
US4665210A (en) * | 1984-12-17 | 1987-05-12 | American Cyanamid Company | Platinum complexes of aliphatic tricarboxylic acids |
US4871729A (en) * | 1986-07-25 | 1989-10-03 | University Of Vermont And State Agricultural College | Bisplatinum complexes as chemotherapeutic agents |
US5770591A (en) * | 1986-07-25 | 1998-06-23 | The University Of Vermont And State Agricultural College | Bis-platinum complexes as chemotherapeutic agents |
US5107007A (en) * | 1989-09-01 | 1992-04-21 | The University Of Vermont And State Agricultural College | Bis-platinum complexes as chemotherapeutic agents |
US4797393A (en) * | 1986-07-25 | 1989-01-10 | University Of Vermont And State Agricultural College | Bis-platinum complexes as chemotherapeutic agents |
US5266083A (en) * | 1988-12-28 | 1993-11-30 | Platinum Plus, Inc. | Method for reducing pollution emissions from a diesel engine |
CA1340871C (fr) * | 1988-12-28 | 2000-01-04 | Robert W. Epperly | Methode pour reduire les emissions provenant de moteurs a combustion interne ou pour augmenter l'energie utilisable d'un carburant pour l'alimentation de ces moteurs |
JPH02275891A (ja) * | 1988-12-29 | 1990-11-09 | Tsumura & Co | 新規な複核白金錯体および該錯体を有効成分とする抗腫瘍剤 |
DE3938710A1 (de) * | 1989-11-17 | 1991-05-23 | Schering Ag | Komplexverbindungen mit oligomerem bis polymerem charakter |
KR940010295B1 (ko) * | 1991-07-05 | 1994-10-22 | 한국과학기술연구원 | 신규 항암성 백금 착화합물 유도체 및 그 제조방법 |
US5409915A (en) * | 1993-09-14 | 1995-04-25 | The University Of Vermont And State Agricultural College | Bis-platinum (IV) complexes as chemotherapeutic agents |
GB9502799D0 (en) | 1995-02-14 | 1995-04-05 | Johnson Matthey Plc | Improvements in platinum complexes |
JP3862758B2 (ja) * | 1996-03-11 | 2006-12-27 | 喜徳 喜谷 | 二核白金錯体、その調製方法及びその錯体を含有する医薬組成物 |
BR0009780B1 (pt) | 1999-04-13 | 2013-09-24 | processo para preparar um complexo de cisplatina | |
GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
US6894049B1 (en) | 2000-10-04 | 2005-05-17 | Anormed, Inc. | Platinum complexes as antitumor agents |
WO2004006859A2 (fr) | 2002-07-16 | 2004-01-22 | Sonus Pharmaceuticals, Inc. | Composes de platine |
WO2005090372A2 (fr) * | 2004-03-15 | 2005-09-29 | Sonus Pharmaceuticals, Inc. | Composes anticancereux a base de carboxylate de platine |
CN1314394C (zh) * | 2004-11-22 | 2007-05-09 | 张金超 | 含有双核铂配合物的药物组合物及其抗肿瘤应用 |
US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US8168661B2 (en) * | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US8178564B2 (en) * | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
US20100260832A1 (en) * | 2007-06-27 | 2010-10-14 | Poniard Pharmaceuticals, Inc. | Combination therapy for ovarian cancer |
TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
EP2178893A4 (fr) * | 2007-07-16 | 2012-09-19 | Poniard Pharmaceuticals Inc | Formulations orales pour du picoplatine |
JP2011511071A (ja) * | 2008-02-08 | 2011-04-07 | ポニアード ファーマシューティカルズ, インコーポレイテッド | 肺癌を治療するためのピコプラチンおよびアムルビシン |
CN101318980B (zh) * | 2008-07-22 | 2011-04-27 | 河北大学 | 含有双核铂配合物、制备方法及应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3904662A (en) * | 1972-02-07 | 1975-09-09 | Zoecon Corp | 2,4-dienoic acids, esters and derivatives |
GB1432562A (en) * | 1972-04-10 | 1976-04-22 | Rustenburg Platinum Mines Ltd | Platinum co-ordination compounds |
GB1432563A (en) * | 1972-04-10 | 1976-04-22 | Rustenburg Platinum Mines Ltd | Platinum- co-ordination compounds |
CH605550A5 (fr) * | 1972-06-08 | 1978-09-29 | Research Corp | |
GB1578323A (en) * | 1976-02-26 | 1980-11-05 | Rustenburg Platinum Mines Ltd | Compositions containing platinum |
GB1585103A (en) * | 1976-04-06 | 1981-02-25 | Rustenburg Platinum Mines Ltd | Pharmaceutical compositions containing platinum compounds |
US4182724A (en) * | 1976-04-06 | 1980-01-08 | Rustenburg Platinum Mines Limited | Compositions containing platinum |
US4115418A (en) * | 1976-09-02 | 1978-09-19 | Government Of The United States Of America | 1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity |
JPS5829957B2 (ja) * | 1977-09-12 | 1983-06-25 | 喜徳 喜谷 | 新規な白金錯体 |
DE2845371A1 (de) * | 1977-10-19 | 1979-04-26 | Johnson Matthey Co Ltd | Platinkomplexverbindung, pharmazeutische stoffzusammensetzung mit einer solchen verbindung und deren anwendung |
SE447902B (sv) * | 1977-10-19 | 1986-12-22 | Johnson Matthey Co Ltd | Cis-koordinationsforening av platina och komposition innehallande foreningen |
SE447385B (sv) * | 1977-10-19 | 1986-11-10 | Johnson Matthey Co Ltd | Cis-koordinationsforeningar av platina |
SE7903361L (sv) * | 1978-04-20 | 1979-10-21 | Johnson Matthey Co Ltd | Kompositioner innehallande platina |
ZA805101B (en) * | 1979-08-23 | 1981-08-26 | Johnson Matthey Co Ltd | Compositions containing platinium |
-
1983
- 1983-02-22 US US06/468,619 patent/US4533502A/en not_active Expired - Fee Related
-
1984
- 1984-02-17 CH CH774/84A patent/CH659075A5/fr not_active IP Right Cessation
- 1984-02-17 SE SE8400865A patent/SE8400865L/ not_active Application Discontinuation
- 1984-02-20 GR GR73844A patent/GR81655B/el unknown
- 1984-02-20 GB GB08404380A patent/GB2137198B/en not_active Expired
- 1984-02-20 FR FR8402533A patent/FR2541284B1/fr not_active Expired
- 1984-02-21 DE DE3406161A patent/DE3406161A1/de not_active Withdrawn
- 1984-02-21 DK DK83184A patent/DK83184A/da not_active Application Discontinuation
- 1984-02-21 BE BE0/212426A patent/BE898968A/fr not_active IP Right Cessation
- 1984-02-21 ES ES529896A patent/ES529896A0/es active Granted
- 1984-02-21 IE IE400/84A patent/IE56937B1/en not_active IP Right Cessation
- 1984-02-22 JP JP59033334A patent/JPS59231096A/ja active Pending
- 1984-02-22 IT IT12443/84A patent/IT1180435B/it active
-
1985
- 1985-06-12 ES ES544095A patent/ES8604070A1/es not_active Expired
-
1992
- 1992-05-01 JP JP4112028A patent/JPH05271265A/ja active Pending
- 1992-05-01 JP JP4112027A patent/JPH05170781A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ES544095A0 (es) | 1986-01-16 |
JPH05271265A (ja) | 1993-10-19 |
GB2137198B (en) | 1987-08-12 |
GB2137198A (en) | 1984-10-03 |
US4533502A (en) | 1985-08-06 |
GB8404380D0 (en) | 1984-03-28 |
DK83184D0 (da) | 1984-02-21 |
CH659075A5 (fr) | 1986-12-31 |
IT8412443A1 (it) | 1985-08-22 |
FR2541284B1 (fr) | 1988-11-04 |
ES8602025A1 (es) | 1985-11-01 |
IE56937B1 (en) | 1992-02-12 |
IT8412443A0 (it) | 1984-02-22 |
DK83184A (da) | 1984-08-23 |
SE8400865D0 (sv) | 1984-02-17 |
IE840400L (en) | 1984-08-22 |
JPH05170781A (ja) | 1993-07-09 |
SE8400865L (sv) | 1984-08-23 |
DE3406161A1 (de) | 1984-08-23 |
ES529896A0 (es) | 1985-11-01 |
JPS59231096A (ja) | 1984-12-25 |
IT1180435B (it) | 1987-09-23 |
ES8604070A1 (es) | 1986-01-16 |
FR2541284A1 (fr) | 1984-08-24 |
GR81655B (fr) | 1984-12-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: ROCHON FERNANDE D. Effective date: 19930228 Owner name: KONG PI-CHANG Effective date: 19930228 |