BE893943A - 26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxycholecalciferol et derives de ce compose - Google Patents

26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxycholecalciferol et derives de ce compose

Info

Publication number
BE893943A
BE893943A BE0/208679A BE208679A BE893943A BE 893943 A BE893943 A BE 893943A BE 0/208679 A BE0/208679 A BE 0/208679A BE 208679 A BE208679 A BE 208679A BE 893943 A BE893943 A BE 893943A
Authority
BE
Belgium
Prior art keywords
dihydroxycholecalciferol
1alpha
hexafluoro
derivatives
compound
Prior art date
Application number
BE0/208679A
Other languages
English (en)
French (fr)
Inventor
H F De Luca
Y Tanaka
N Ikekawa
Y Kobayashi
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of BE893943A publication Critical patent/BE893943A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BE0/208679A 1981-07-27 1982-07-26 26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxycholecalciferol et derives de ce compose BE893943A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/286,790 US4358406A (en) 1981-07-27 1981-07-27 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same

Publications (1)

Publication Number Publication Date
BE893943A true BE893943A (fr) 1982-11-16

Family

ID=23100174

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/208679A BE893943A (fr) 1981-07-27 1982-07-26 26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxycholecalciferol et derives de ce compose

Country Status (14)

Country Link
US (1) US4358406A (https=)
JP (1) JPS58501176A (https=)
AU (2) AU552210B2 (https=)
BE (1) BE893943A (https=)
CH (2) CH655307A5 (https=)
DE (2) DE3250034C2 (https=)
DK (2) DK162282C (https=)
FR (1) FR2510566B1 (https=)
GB (2) GB2102806B (https=)
IE (2) IE54370B1 (https=)
IL (5) IL76090A (https=)
IT (1) IT1157309B (https=)
NL (1) NL8220265A (https=)
WO (1) WO1983000335A1 (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634692A (en) * 1981-08-28 1987-01-06 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol
US4411833A (en) * 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US4448726A (en) * 1983-05-11 1984-05-15 Wisconsin Alumni Research Foundation Ring A- and triene-modified vitamin D compounds
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
ZA859138B (en) * 1984-12-19 1986-08-27 Hoffmann La Roche Cholecalciferol derivatives
EP0205025A1 (en) * 1985-05-27 1986-12-17 Sumitomo Pharmaceuticals Company, Limited Fluorine derivatives of vitamin D3 and cell differentiation-inducing agents containing the same as an active ingredient
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
JPH0764804B2 (ja) * 1986-04-25 1995-07-12 住友製薬株式会社 活性型ビタミンｄ３のフッ素誘導体
CA1314872C (en) 1986-04-25 1993-03-23 Toshio Nishizawa Fluorine derivatives of vitamin d _and process for producing the same
US4853378A (en) * 1986-10-20 1989-08-01 Sumitomo Chemical Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
WO1990009179A1 (en) * 1989-02-16 1990-08-23 University Of Georgia Research Foundation, Inc. Treatment of tibial dyschondroplasia
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
FI934891L (fi) * 1991-05-06 1993-12-03 Procter & Gamble Kombinerade kalcium- och vitamin d-supplement
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
WO1994008958A1 (fr) * 1992-10-16 1994-04-28 Chugai Seiyaku Kabushiki Kaisha Derive de la vitamine d et procede pour sa production
US5571802A (en) * 1993-02-19 1996-11-05 Wisconsin Alumni Research Foundation Method of treating post menopausal osteoporosis with hexafluro-vitamin D
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
KR20010043558A (ko) * 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
US6080879A (en) * 1998-05-19 2000-06-27 Tetrionics, Inc. Hexafluoro-vitamin synthesis and crystallization method, solvent and product
WO2009086436A1 (en) * 2007-12-28 2009-07-09 Wisconsin Alumni Research Foundation (20s)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin d analogs
EA201691980A1 (ru) 2009-01-27 2017-07-31 БЕРГ ЭлЭлСи Способы уменьшения побочных эффектов, связанных с химиотерапией
CN102655869B (zh) 2009-08-14 2016-08-10 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
HRP20230747T1 (hr) * 2011-09-08 2024-01-05 Sage Therapeutics, Inc. Neuroaktivni steroidi, pripravci i njihova uporaba
WO2014194133A1 (en) 2013-05-29 2014-12-04 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
ES2536256B2 (es) * 2013-11-20 2016-02-01 Universidade De Santiago De Compostela Análogos de vitamina d con interés farmacéutico
PL3319611T3 (pl) 2015-07-06 2021-07-12 Sage Therapeutics, Inc. Oksysterole i sposoby ich stosowania
EP3436022B1 (en) 2016-04-01 2022-03-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
PT3519422T (pt) 2016-09-30 2022-12-05 Sage Therapeutics Inc Oxisteróis substituídos em c7 e métodos como moduladores nmda
CA3041088C (en) 2016-10-18 2024-05-21 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
CN111960938B (zh) * 2020-08-20 2022-06-17 甘肃皓天医药科技有限责任公司 用于制备氟骨化醇的中间体的制备方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL45897A (en) * 1974-10-22 1978-12-17 Yeda Res & Dev Process for the preparation of 1 hydroxy-provitamin d3
US4199518A (en) * 1978-03-30 1980-04-22 Diamond Shamrock Corporation 1α,3β-Dihydroxy-steroid-5-enes from 1α,2α-epoxy-steroid-4,6-dien-3-ones
PH16989A (en) * 1978-11-07 1984-05-04 Res Inst Medicine Chem Process for the preparation of 1-hydroxylated vitamin d compounds
US4226788A (en) * 1979-03-28 1980-10-07 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol

Also Published As

Publication number Publication date
IL66351A0 (en) 1982-11-30
DK162282C (da) 1992-03-16
AU8760582A (en) 1983-03-17
IT1157309B (it) 1987-02-11
JPS58501176A (ja) 1983-07-21
DE3250034C2 (https=) 1991-02-28
IL76090A0 (en) 1985-12-31
IE54369B1 (en) 1989-09-13
CH656134A5 (de) 1986-06-13
GB2118556B (en) 1985-02-27
NL8220265A (nl) 1983-06-01
DK554084A (da) 1984-11-22
FR2510566A1 (fr) 1983-02-04
US4358406A (en) 1982-11-09
IE54370B1 (en) 1989-09-13
CH655307A5 (de) 1986-04-15
DK165695B (da) 1993-01-04
AU586267B2 (en) 1989-07-06
IL66351A (en) 1987-12-31
IL76091A0 (en) 1985-12-31
FR2510566B1 (fr) 1985-06-28
GB2102806B (en) 1985-02-27
AU6056086A (en) 1986-12-18
IL76091A (en) 1987-12-31
DK554084D0 (da) 1984-11-22
JPH0348903B2 (https=) 1991-07-25
DK165695C (da) 1993-06-07
WO1983000335A1 (en) 1983-02-03
DK137083A (da) 1983-03-25
DK137083D0 (da) 1983-03-25
DK162282B (da) 1991-10-07
IL76090A (en) 1987-12-31
IT8222574A0 (it) 1982-07-26
GB2102806A (en) 1983-02-09
DE3248900C2 (https=) 1990-12-13
DE3248900T1 (de) 1983-07-07
IE891226L (en) 1983-01-27
IE821797L (en) 1983-01-27
GB8311517D0 (en) 1983-06-02
GB2118556A (en) 1983-11-02
AU552210B2 (en) 1986-05-22

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: WISCONSIN ALUMNI RESEARCH FOUNDATION

Effective date: 20010731