BE861849A - Nouveaux derives de la piperazine, leur procede de preparation et leur utilisation - Google Patents

Nouveaux derives de la piperazine, leur procede de preparation et leur utilisation

Info

Publication number
BE861849A
BE861849A BE183452A BE861849A BE861849A BE 861849 A BE861849 A BE 861849A BE 183452 A BE183452 A BE 183452A BE 861849 A BE861849 A BE 861849A BE 861849 A BE861849 A BE 861849A
Authority
BE
Belgium
Prior art keywords
piperazine
preparation process
new derivatives
derivatives
new
Prior art date
Application number
BE183452A
Other languages
English (en)
French (fr)
Inventor
Karoly Fefoldi
Jozsef Apjok
Mihaly Bartok
Jozsef Czombos
Arpad Molnar
Ferenc Noteisz
Egon Karpati
Laszlo Szporny
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of BE861849A publication Critical patent/BE861849A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE183452A 1976-12-15 1977-12-14 Nouveaux derives de la piperazine, leur procede de preparation et leur utilisation BE861849A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU76RI605A HU174215B (hu) 1976-12-15 1976-12-15 Sposob poluchenija novykh proizvodnykh piperazina i kislotnykh additivnykh i chetvjortichnykh solej

Publications (1)

Publication Number Publication Date
BE861849A true BE861849A (fr) 1978-03-31

Family

ID=11001009

Family Applications (1)

Application Number Title Priority Date Filing Date
BE183452A BE861849A (fr) 1976-12-15 1977-12-14 Nouveaux derives de la piperazine, leur procede de preparation et leur utilisation

Country Status (21)

Country Link
US (2) US4140790A (xx)
JP (2) JPS6026114B2 (xx)
AT (1) AT359507B (xx)
BE (1) BE861849A (xx)
CA (1) CA1080219A (xx)
CH (1) CH632750A5 (xx)
DE (1) DE2755707A1 (xx)
ES (1) ES465061A1 (xx)
FI (1) FI65427C (xx)
FR (1) FR2374322A1 (xx)
GB (1) GB1580227A (xx)
HU (1) HU174215B (xx)
IL (1) IL53552A (xx)
IN (1) IN146474B (xx)
NL (1) NL7713827A (xx)
NO (1) NO147306C (xx)
PT (1) PT67403B (xx)
SE (1) SE430159B (xx)
SU (1) SU694071A3 (xx)
YU (1) YU293677A (xx)
ZA (1) ZA777398B (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1060168C (zh) * 1994-05-06 2001-01-03 中国人民解放军军事医学科学院毒物药物研究所 新的呫吨衍生物，其制备方法及含它们的药物组合物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU174215B (hu) * 1976-12-15 1979-11-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh proizvodnykh piperazina i kislotnykh additivnykh i chetvjortichnykh solej
US4703120A (en) * 1986-04-28 1987-10-27 Ortho Pharmaceutical Corporation Furo(3,4-d)pyrimidine-2,4-dione derivatives and intermediates thereof
PL371486A1 (en) 2002-02-01 2005-06-13 Astrazeneca Ab Quinazoline compounds
CA2521330A1 (en) * 2003-04-08 2004-10-21 Neuromed Technologies, Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US20080207738A1 (en) * 2007-02-28 2008-08-28 Cancure Laboratories, Llc Drug combinations to treat drug resistant tumors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3481930A (en) * 1966-11-21 1969-12-02 American Home Prod Xanthene and thioxanthene-9 ureas and propionamides
US3502662A (en) * 1968-03-18 1970-03-24 American Home Prod N-(9-xanthenyl or thioxanthenyl)-3-amino or iodo-propionamides and 4-(9-xanthenyl or thioxanthenyl)-thiosemicarbazones
FR2201084B1 (xx) * 1972-09-29 1975-10-31 Bouchara Emile
US3953449A (en) * 1973-05-09 1976-04-27 Synthelabo 2-(4-M-CF3 or -SCF3 phenylpiperazino)-ethyl benzoates
HU174215B (hu) * 1976-12-15 1979-11-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh proizvodnykh piperazina i kislotnykh additivnykh i chetvjortichnykh solej

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1060168C (zh) * 1994-05-06 2001-01-03 中国人民解放军军事医学科学院毒物药物研究所 新的呫吨衍生物，其制备方法及含它们的药物组合物

Also Published As

Publication number Publication date
DE2755707A1 (de) 1978-06-29
NO774294L (no) 1978-06-16
IL53552A (en) 1981-07-31
SE430159B (sv) 1983-10-24
JPS5377073A (en) 1978-07-08
PT67403A (en) 1978-01-01
NL7713827A (nl) 1978-06-19
FR2374322A1 (fr) 1978-07-13
NO147306C (no) 1983-03-16
YU293677A (en) 1982-08-31
GB1580227A (en) 1980-11-26
PT67403B (en) 1979-05-21
AT359507B (de) 1980-11-10
SE7713906L (sv) 1978-06-16
IN146474B (xx) 1979-06-16
FI773743A (fi) 1978-06-16
ATA867677A (de) 1980-04-15
FI65427B (fi) 1984-01-31
ZA777398B (en) 1978-10-25
US4140790A (en) 1979-02-20
IL53552A0 (en) 1978-03-10
CH632750A5 (de) 1982-10-29
ES465061A1 (es) 1979-01-01
JPS6026114B2 (ja) 1985-06-21
US4250310A (en) 1981-02-10
HU174215B (hu) 1979-11-28
NO147306B (no) 1982-12-06
JPS5377080A (en) 1978-07-08
FI65427C (fi) 1984-05-10
SU694071A3 (ru) 1979-10-25
FR2374322B1 (xx) 1981-11-27
CA1080219A (en) 1980-06-24

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: RICHTER GEDEON VEGYESZETI GYAR RT

Effective date: 19861231