BE827354A - Nouveaux derives benzamidiques de pyrrolidine et piperidine, leur procede de preparation et medicament les contenant - Google Patents

Nouveaux derives benzamidiques de pyrrolidine et piperidine, leur procede de preparation et medicament les contenant

Info

Publication number
BE827354A
BE827354A BE154920A BE154920A BE827354A BE 827354 A BE827354 A BE 827354A BE 154920 A BE154920 A BE 154920A BE 154920 A BE154920 A BE 154920A BE 827354 A BE827354 A BE 827354A
Authority
BE
Belgium
Prior art keywords
pyrrolidine
piperidine
preparation process
product containing
medicinal product
Prior art date
Application number
BE154920A
Other languages
English (en)
French (fr)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BE827354A publication Critical patent/BE827354A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BE154920A 1974-04-01 1975-03-28 Nouveaux derives benzamidiques de pyrrolidine et piperidine, leur procede de preparation et medicament les contenant BE827354A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US457099A US3900481A (en) 1974-04-01 1974-04-01 Derivatives of pyrrolidine and piperidine

Publications (1)

Publication Number Publication Date
BE827354A true BE827354A (fr) 1975-09-29

Family

ID=23815433

Family Applications (1)

Application Number Title Priority Date Filing Date
BE154920A BE827354A (fr) 1974-04-01 1975-03-28 Nouveaux derives benzamidiques de pyrrolidine et piperidine, leur procede de preparation et medicament les contenant

Country Status (22)

Country Link
US (1) US3900481A (xx)
JP (2) JPS5827268B2 (xx)
AR (1) AR210990A1 (xx)
BE (1) BE827354A (xx)
CA (1) CA1054602A (xx)
CH (1) CH618425A5 (xx)
CS (1) CS209846B2 (xx)
DE (1) DE2513916C2 (xx)
DK (1) DK158980C (xx)
ES (1) ES435870A1 (xx)
FR (1) FR2265366B1 (xx)
GB (1) GB1508015A (xx)
HU (1) HU169762B (xx)
IE (1) IE41224B1 (xx)
IL (1) IL46967A (xx)
NL (1) NL186633C (xx)
NO (1) NO144262C (xx)
OA (1) OA04912A (xx)
PL (1) PL95576B1 (xx)
SE (1) SE391336B (xx)
SU (1) SU668599A3 (xx)
ZA (1) ZA751040B (xx)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1520584A (en) * 1975-04-02 1978-08-09 Yamanouchi Pharma Co Ltd 2 - alkoxy - 5 substituted benzamide derivatives and their use in pharmaceutical compositions
US4197243A (en) * 1975-04-02 1980-04-08 Yamanouchi Pharmaceutical Co., Ltd. N-1-Benzyl-3-pyrrolidinyl-4-dimethylamino benzamide derivatives
US4093734A (en) * 1975-11-03 1978-06-06 Boehringer Ingelheim Gmbh Amino-benzoic acid amides
US4097481A (en) * 1976-11-08 1978-06-27 Riker Laboratories, Inc. Tertiary amide derivatives of pyrrolidine and piperidine
US4071524A (en) * 1976-11-08 1978-01-31 Riker Laboratories, Inc. Derivatives of urea
ZA801565B (en) * 1979-03-19 1981-05-27 Riker Laboratories Inc Process for the preparation of 2,5-bis(2,2,2-trifluoroethoxy)-n-(2-piperidylmethyl)benzamide
US4684733A (en) * 1979-03-19 1987-08-04 Riker Laboratories, Inc. Process for the preparation of intermediates of derivatives of pyrrolidine and piperidine
US4642384A (en) * 1979-03-19 1987-02-10 Riker Laboratories, Inc. Process for the preparation of derivatives of pyrrolidine and piperidine
GB2097000B (en) * 1979-03-19 1983-11-30 Riker Laboratories Inc Process for the preparation of 1,4-bis(2,2,2-trifluoroethoxy) benzene
US4617396A (en) * 1979-03-19 1986-10-14 Riker Laboratories, Inc. Process for the preparation of derivatives of piperidine
US4390716A (en) * 1981-06-08 1983-06-28 Riker Laboratories, Inc. Phenolic derivative
US4452983A (en) * 1981-06-08 1984-06-05 Riker Laboratories, Inc. Phenolic derivative
US4339587A (en) * 1981-06-08 1982-07-13 Riker Laboratories, Inc. 5-Benzyloxy or 5-hydroxy-2-(2,2,2-trifluoroethoxy)-N-(2-pyridylmethyl)benzamide
JPS5970666A (ja) * 1982-10-15 1984-04-21 Kyowa Hakko Kogyo Co Ltd １，４−ジヒドロピリジン誘導体
US4599434A (en) * 1983-11-15 1986-07-08 Riker Laboratories, Inc. Cyclopentanone derivatives
US4656285A (en) * 1983-11-15 1987-04-07 Riker Laboratories, Inc. Compound 2-acetamidomethyl-6-methoxy-pyridine
US4555573A (en) * 1983-11-15 1985-11-26 Riker Laboratories, Inc. Certain 6-benzamidomethyl-2(1H)-pyridone derivatives
US4497954A (en) * 1983-11-15 1985-02-05 Riker Laboratories, Inc. Cyclopentanone derivatives
US4496734A (en) * 1983-11-15 1985-01-29 Riker Laboratories, Inc. Metabolite
US5336622A (en) * 1986-04-25 1994-08-09 Abbott Laboratories Tracers for use in flecainide fluorescence polarization immunoassay
NZ219913A (en) * 1986-04-25 1990-08-28 Riker Laboratories Inc Various flecainide derivatives and antibodies raised thereto
EP0242847B1 (en) * 1986-04-25 1993-06-02 Abbott Laboratories Tracers for use in flecainide fluorescence polarization immunoassay
US4952574A (en) * 1988-09-26 1990-08-28 Riker Laboratories, Inc. Antiarrhythmic substituted N-(2-piperidylmethyl)benzamides
US4938966A (en) * 1988-11-30 1990-07-03 Riker Laboratories, Inc. Controlled release flecainide acetate formulation
US5254569A (en) * 1991-01-14 1993-10-19 The Du Pont Merck Pharmaceutical Company (Amidomethyl)nitrogen heterocyclic analgesics
IL121288A (en) * 1997-07-11 2000-10-31 Finetech Ltd Process and a novel intermediate for the preparation of flecainide
ITMI20011772A1 (it) * 2001-08-10 2003-02-10 A M S A Anonima Materie Sint E Processo per la preparazione della 2,5-bis-(2,2,2-trifluoroetossi)-n-(2-piperidilmetil)-benzamide(flecainide)
EP1500651A1 (en) * 2003-07-25 2005-01-26 Bayer CropScience S.A. N-[2-(2-Pyridinyl)ethyl]benzamide compounds and their use as fungicides
US7196197B2 (en) * 2003-09-17 2007-03-27 Apotex Pharmachem Inc. Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof
EP1918280A1 (en) * 2006-11-06 2008-05-07 "Joint Stock Company Grindeks" Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamide and salts thereof
EP2101819B1 (en) 2006-11-20 2013-01-09 President and Fellows of Harvard College Methods, compositions, and kits for treating pain and pruritis
JP4946482B2 (ja) 2007-02-08 2012-06-06 船井電機株式会社 緩衝用梱包材及びｔｖ受像機の緩衝用梱包材
CA3027255C (en) 2009-07-10 2022-06-21 The General Hospital Corporation Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
JP6833811B2 (ja) 2015-08-03 2021-02-24 プレジデント アンド フェローズ オブ ハーバード カレッジ 荷電イオンチャネル遮断薬及び使用方法
US11377422B2 (en) 2019-03-11 2022-07-05 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10828287B2 (en) 2019-03-11 2020-11-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
AU2020237474A1 (en) 2019-03-11 2021-09-30 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CA3129089A1 (en) 2019-03-11 2020-09-17 Bridget Mccarthy Cole Ester substituted ion channel blockers and methods for use
KR20220123381A (ko) 2019-11-06 2022-09-06 녹시온 테라퓨틱스 인코포레이티드 하전된 이온 채널 차단제 및 사용 방법
US10933055B1 (en) 2019-11-06 2021-03-02 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
EP4118070A4 (en) 2020-03-11 2024-04-10 Nocion Therapeutics, Inc. CHARGED ION CHANNEL BLOCKERS AND METHODS OF USE
WO2024132080A1 (en) 2022-12-22 2024-06-27 Colonis Pharma Ltd Liquid pharmaceutical composition containing flecainide and process for the preparaton thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6209M (xx) * 1967-04-03 1968-07-29
US3719687A (en) * 1970-07-22 1973-03-06 Riker Laboratories Inc N-(2-dialkylaminoalkylene)amides of 1,1-dihydroperfluoroalkoxy-substituted aryl acids and salts thereof
US3655728A (en) * 1970-07-22 1972-04-11 Riker Laboratories Inc N-(2 - dialkylaminoalkylene)-esters of fluoroalkoxy-substituted aryl carboxylic acid and salts thereof

Also Published As

Publication number Publication date
FR2265366A1 (xx) 1975-10-24
US3900481A (en) 1975-08-19
NO144262C (no) 1981-07-29
NL186633C (nl) 1991-01-16
IE41224L (en) 1975-10-01
DE2513916A1 (de) 1975-10-09
DK158980B (da) 1990-08-13
JPS5827268B2 (ja) 1983-06-08
DE2513916C2 (de) 1982-12-23
JPS5858347B2 (ja) 1983-12-24
CA1054602A (en) 1979-05-15
IL46967A0 (en) 1975-05-22
IE41224B1 (en) 1979-11-21
DK158980C (da) 1991-01-07
JPS50137975A (xx) 1975-11-01
CS209846B2 (en) 1981-12-31
NL7503389A (nl) 1975-10-03
CH618425A5 (xx) 1980-07-31
HU169762B (xx) 1977-02-28
SE7503262L (xx) 1975-10-02
FR2265366B1 (xx) 1980-01-11
OA04912A (fr) 1980-10-31
AU7957875A (en) 1976-09-30
NL186633B (nl) 1990-08-16
AR210990A1 (es) 1977-10-14
ZA751040B (en) 1976-01-28
DK119675A (xx) 1975-10-02
IL46967A (en) 1978-09-29
PL95576B1 (pl) 1977-10-31
NO144262B (no) 1981-04-21
SE391336B (sv) 1977-02-14
JPS5865268A (ja) 1983-04-18
GB1508015A (en) 1978-04-19
NO750976L (xx) 1975-10-02
SU668599A3 (ru) 1979-06-15
ES435870A1 (es) 1976-12-16

Similar Documents

Publication Publication Date Title
BE827354A (fr) Nouveaux derives benzamidiques de pyrrolidine et piperidine, leur procede de preparation et medicament les contenant
FR2293928A1 (fr) Nouveaux derives d'acide 3-amino-indazolecarboxylique, leur procede de preparation et medicament les contenant
BE860726A (fr) Nouveaux aryl-acylamides n-(2-aminocy-cloaliphatiques), leur procede de preparation et medicament les contenant
FR2274294A1 (fr) Nouveaux amides d'acides carboxyliques, leur procede de preparation et medicament les contenant
BE827777A (fr) Nouveaux amides d'acides carboxyliques, leur procede de preparation et medicament les contenant
BE826900A (fr) Nouveaux derives 1-(4-phenoxy-phenyl)-1,3,5 triaziniques, leur triaziniques procede de preparation et medicament les contenant
BE829052A (fr) Nouvelles phenylguanidines substituees, leur procede de preparation et medicament les contenant
FR2273546A1 (fr) Nouveaux derives de cephalosporine, leur procede de preparation et medicament les contenant
BE855713Q (fr) Nouveaux derives de 4-aminoquinoleine, leur procede de preparation et medicament les contenant
FR2307543A1 (fr) Nouveaux amides peptidiques, leur procede de preparation et medicament les contenant
FR2287916A1 (fr) Nouveaux derives dipeptidiques, leur procede de preparation et medicament les contenant
BE829417A (fr) Nouveaux pyrimidinols, leur procede de preparation et medicament les contenant
FR2292471A1 (fr) Nouveaux antibiotiques du type b-lactame, leur procede de preparation et medicament les contenant
BE825458A (fr) Nouveaux derives de piperidine, leur procede de preparation et compositions pharmaceutiques les contenant
FR2290897A1 (fr) Nouveaux derives d'aminopropanol, leur procede de preparation et des medicaments les contenant
FR2292477A1 (fr) Derives de 1-amidoalkyl-4-sulfonyl-piperazine, leur procede d'obtention et medicaments contenant lesdits derives
BE831421A (fr) Nouvelles phenylisothiourees substituees, leur procede de preparation et medicament les contenant
FR2290211A1 (fr) Nouveaux 1,1-bioxydes de 4-hydroxy-2h-naphto (2,1-e)-1,2-thiazine-3-carboxamides, leur procede de preparation et medicaments les renfermant
BE825245A (fr) Nouvelles 2-amino-6-dialkylaminodihydropyridines leur procede de preparation et medicament les contenant
BE836022A (fr) Nouveaux antibiotiques du type beta-lactame, leur procede de preparation et medicament les contenant
FR2291753A1 (fr) Nouveau derive de 5,7-dihydroxy-tetrahydroisoquinoleine, son procede de preparation et medicament le contenant
BE805210A (fr) Nouveaux amides d'acides imidazoiylacetiques, leur procede de preparation et medicaments les contenant
FR2292472A1 (fr) Nouveaux derives d'isoindole utiles en tant que medicaments, et leur procede de preparation
FR2292474A1 (fr) Nouveaux diaryloxy-imidazolyl-o,n-acetals, leur procede de preparation et medicament les contenant
FR2274288A1 (fr) Nouveaux composes arylsulfonylcarbamoyl-1,3-dicarbonyliques, leur procede de preparation et medicament les contenant

Legal Events

Date Code Title Description
CCPA Application for a supplementary protection certificate

Free format text: 093C0124

RE20 Patent expired

Owner name: RIKER LABORATORIES INC.

Effective date: 19950328

CCPV Grant of a supplementary protection certificate

Free format text: 093C0124, EXPIRES 19970625