BE775028A - Imidazoles anti-inflammatoires - Google Patents

Imidazoles anti-inflammatoires

Info

Publication number
BE775028A
BE775028A BE775028A BE775028A BE775028A BE 775028 A BE775028 A BE 775028A BE 775028 A BE775028 A BE 775028A BE 775028 A BE775028 A BE 775028A BE 775028 A BE775028 A BE 775028A
Authority
BE
Belgium
Prior art keywords
imidazoles
inflammatory
inflammatory imidazoles
Prior art date
Application number
BE775028A
Other languages
English (en)
Inventor
J G Lombardino
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BE775028A publication Critical patent/BE775028A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE775028A 1970-11-16 1971-11-08 Imidazoles anti-inflammatoires BE775028A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9007770A 1970-11-16 1970-11-16
US25152272A 1972-05-08 1972-05-08

Publications (1)

Publication Number Publication Date
BE775028A true BE775028A (fr) 1972-05-08

Family

ID=26781885

Family Applications (1)

Application Number Title Priority Date Filing Date
BE775028A BE775028A (fr) 1970-11-16 1971-11-08 Imidazoles anti-inflammatoires

Country Status (11)

Country Link
US (2) US3707475A (fr)
AT (2) AT317201B (fr)
AU (1) AU465501B2 (fr)
BE (1) BE775028A (fr)
CA (1) CA978960A (fr)
CH (1) CH551416A (fr)
DE (1) DE2155558C2 (fr)
FR (1) FR2113861B1 (fr)
GB (1) GB1347893A (fr)
NL (1) NL170143C (fr)
SE (1) SE401504B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382945A (en) 1980-04-29 1983-05-10 Hoffmann-La Roche Inc. Tetrahydrothiepino[4,5-d]imidazole derivatives, composition and method of use
US4582844A (en) * 1980-06-05 1986-04-15 Hoffmann-La Roche Inc. Antithrombotic 4,5 di-t-butyl-imidazole derivatives

Families Citing this family (116)

* Cited by examiner, † Cited by third party
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US3940486A (en) * 1971-05-10 1976-02-24 Ciba-Geigy Corporation Imidazole derivatives in the treatment of pain
US3929807A (en) * 1971-05-10 1975-12-30 Ciba Geigy Corp 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles
SE428686B (sv) * 1975-08-11 1983-07-18 Du Pont Forfarande for framstellning av antiinflammatoriskt aktiva imidazoler
US4190666A (en) * 1975-08-11 1980-02-26 E. I. Du Pont De Nemours And Company Anti-inflammatory 4,5-diarly-2-(substituted-thio)imidazoles and their corresponding sulfoxides and sulfones
US4159338A (en) * 1977-02-09 1979-06-26 E. I. Du Pont De Nemours And Company Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones
US4182769A (en) * 1977-02-09 1980-01-08 E. I. Du Pont De Nemours And Company Anti-inflammatory 1-substituted-4,5-diaryl-2-(substituted-thio) imidazoles and their corresponding sulfoxides and sulfones
US4139708A (en) * 1977-05-24 1979-02-13 Sk&F Lab Co. Intermediates and processes useful for preparing medicinal agents imidazolemethylphosphonium salts
US4199592A (en) * 1978-08-29 1980-04-22 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-nitroimidazoles
US4215135A (en) * 1979-06-08 1980-07-29 E. I. Du Pont De Nemours And Company Antiinflammatory 2-substituted-1H-phenanthro[9,10-d]imidazoles
US4314844A (en) * 1979-01-11 1982-02-09 Rohm And Haas Company Herbicidal substituted imidazoles
US4424229A (en) 1979-04-23 1984-01-03 A/S Dumex (Dumex Ltd.) Fluorine containing 2,4,5-triphenylimidazoles
US4246263A (en) 1979-10-15 1981-01-20 Pfizer Inc. Antiinflammatory and immunoregulatory pyrimidines, their method of use and pharmaceutical compositions
DK513580A (da) * 1980-01-07 1981-07-08 Du Pont Fremgangsmaade til fremstilling af 4,5-diaryl-alfa (polyhalogenalkyl)-1h-imidazol-2-methanoler
US4348404A (en) * 1980-07-21 1982-09-07 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-α-polyfluoroalkyl-1H-imidazole-2-methanamines
US4372964A (en) * 1980-10-30 1983-02-08 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-1H-imidazole-2-methanols
US4330552A (en) * 1980-11-06 1982-05-18 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-arylthioimidazoles
JPS57150667A (en) * 1981-02-12 1982-09-17 Wellcome Found Antithrombotic
DE3141063A1 (de) * 1981-10-13 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4477463A (en) * 1982-05-10 1984-10-16 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic 1-alkyl-4,5-diaryl-2-fluoroalkyl-1H-pyrroles
US4503065A (en) * 1982-08-03 1985-03-05 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl 1-2-halo imidazoles
US4686231A (en) * 1985-12-12 1987-08-11 Smithkline Beckman Corporation Inhibition of 5-lipoxygenase products
IL83467A0 (en) * 1986-08-15 1988-01-31 Fujisawa Pharmaceutical Co Imidazole derivatives,processes for their preparation and pharmaceutical compositions containing the same
US4780470A (en) * 1986-08-19 1988-10-25 Smithkline Beckman Corporation Inhibition of interleukin-1 by monocytes and/or macrophages
JPH02101065A (ja) * 1988-10-06 1990-04-12 Tanabe Seiyaku Co Ltd イミダゾリン誘導体及びその製法
US5208015A (en) * 1991-07-23 1993-05-04 Bristol-Myers Squibb Company Topical anti-fungal agents having anti-inflammatory activity
US5916891A (en) * 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
US6008235A (en) * 1992-01-13 1999-12-28 Smithkline Beecham Corporation Pyridyl substituted imidazoles
IL104369A0 (en) * 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
US5656644A (en) * 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
ES2053401B1 (es) * 1992-01-13 1995-03-01 Smithkline Beecham Corp Compuestos de imidazol y procedimientos para su prepacion.
US5716972A (en) * 1993-01-13 1998-02-10 Smithkline Beecham Corporation Pyridyl substituted imidazoles
US5593991A (en) * 1993-07-16 1997-01-14 Adams; Jerry L. Imidazole compounds, use and process of making
IL110296A (en) * 1993-07-16 1999-12-31 Smithkline Beecham Corp Imidazole compounds process for their preparation and pharmaceutical compositions containing them
US5670527A (en) * 1993-07-16 1997-09-23 Smithkline Beecham Corporation Pyridyl imidazole compounds and compositions
US5593992A (en) * 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
ZA945363B (en) * 1993-07-21 1995-03-14 Smithkline Beecham Corp Novel compounds
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5620999A (en) * 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US6426360B1 (en) 1994-07-28 2002-07-30 G D Searle & Co. 4,5-substituted imidazolyl compounds for the treatment of inflammation
CA2207404C (fr) * 1994-12-13 2004-06-29 F. Hoffmann-La Roche Ag Derives imidazoles utilises comme inhibiteurs de la proteine kinase, notamment de la tyrosine kinase du recepteur du facteur de croissance de l'epiderme (egf-r)
US6515014B2 (en) 1995-06-02 2003-02-04 G. D. Searle & Co. Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
WO1996038418A1 (fr) 1995-06-02 1996-12-05 G.D. Searle & Co. Derives heterocyclo-substitues d'acide hydroxamique utilises comme inhibiteurs de la cyclo-oxygenase-2 et de la 5-lipoxygenase
US6512121B2 (en) 1998-09-14 2003-01-28 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US6369068B1 (en) 1995-06-07 2002-04-09 Smithkline Beecham Corporation Amino substituted pyrimidine containing compounds
US5739143A (en) * 1995-06-07 1998-04-14 Smithkline Beecham Corporation Imidazole compounds and compositions
US5658903A (en) 1995-06-07 1997-08-19 Smithkline Beecham Corporation Imidazole compounds, compositions and use
US5700826A (en) * 1995-06-07 1997-12-23 Ontogen Corporation 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
US5717100A (en) * 1995-10-06 1998-02-10 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
US6083949A (en) * 1995-10-06 2000-07-04 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
WO1997016442A1 (fr) * 1995-10-31 1997-05-09 Merck & Co., Inc. Pyrroles de pyridyle substitues, compositions contenant de tels composes et mode d'utilisation
ZA9610687B (en) 1995-12-22 1997-09-29 Smithkline Beecham Corp Novel synthesis.
US5756499A (en) * 1996-01-11 1998-05-26 Smithkline Beecham Corporation Substituted imidazole compounds
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
ZA97175B (en) * 1996-01-11 1997-11-04 Smithkline Beecham Corp Novel substituted imidazole compounds.
AP9700912A0 (en) 1996-01-11 1997-01-31 Smithkline Beecham Corp Novel cycloalkyl substituted imidazoles
JP2000507545A (ja) * 1996-03-25 2000-06-20 スミスクライン・ビーチャム・コーポレイション Ｃｎｓ損傷についての新規な治療
JP2000507558A (ja) * 1996-03-25 2000-06-20 スミスクライン・ビーチャム・コーポレイション Ｃｎｓ損傷についての新規な治療
US6677364B2 (en) 1998-04-20 2004-01-13 G.D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
DE69733135T2 (de) * 1996-06-10 2006-03-02 Merck & Co., Inc. Substituierte imidazole mit cytokinin-inhibirender wirkung
WO1998007425A1 (fr) 1996-08-21 1998-02-26 Smithkline Beecham Corporation Composes d'imidazole, compositions les contenant et leur utilisation
JP2001504489A (ja) * 1996-11-20 2001-04-03 メルク エンド カンパニー インコーポレーテッド トリアリール置換イミダゾール及び使用方法
US5880139A (en) * 1996-11-20 1999-03-09 Merck & Co., Inc. Triaryl substituted imidazoles as glucagon antagonists
EP0948257A4 (fr) * 1996-11-20 1999-12-29 Merck & Co Inc Imidazoles a substitution triaryle, compositions renfermant de tels composes et modes d'utilisation
JP2000514088A (ja) * 1996-11-20 2000-10-24 メルク エンド カンパニー インコーポレーテッド グルカゴンアンタゴニストとしてのトリアリール置換イミダゾール
US5929076A (en) * 1997-01-10 1999-07-27 Smithkline Beecham Corporation Cycloalkyl substituted imidazoles
US20030050330A1 (en) * 1997-01-10 2003-03-13 G.D. Searle & Co. 4,5-subtstituted imdazolyl compounds for the treatment of inflammation
JP4380803B2 (ja) 1997-06-12 2009-12-09 アベンテイス・フアルマ・リミテツド イミダゾリル−環式アセタール
CA2294057A1 (fr) 1997-06-13 1998-12-17 Smithkline Beecham Corporation Nouveaux composes de pyrazole et de pyrazoline substitues
EP0994870A4 (fr) 1997-06-19 2002-10-23 Smithkline Beecham Nouveaux composes imidazole a substitution d'aryloxypymiridine
US6040320A (en) * 1997-06-30 2000-03-21 Ortho-Mcneil Pharmaceutical, Inc. 2-substituted imidazoles useful in the treatment of inflammatory diseases
CA2295762A1 (fr) 1997-07-02 1999-01-14 Ravi Shanker Garigipati Nouveaux imidazoles cycloalkyle-substitues
US7301021B2 (en) * 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
US6489325B1 (en) 1998-07-01 2002-12-03 Smithkline Beecham Corporation Substituted imidazole compounds
TW517055B (en) 1997-07-02 2003-01-11 Smithkline Beecham Corp Novel substituted imidazole compounds
US6562832B1 (en) 1997-07-02 2003-05-13 Smithkline Beecham Corporation Substituted imidazole compounds
WO1999001128A1 (fr) * 1997-07-03 1999-01-14 Neurogen Corporation Certains derives diarylimidazoles; nouvelle classe de ligands specifiques de neuropeptide y (npy)
US5840721A (en) * 1997-07-09 1998-11-24 Ontogen Corporation Imidazole derivatives as MDR modulators
AR017219A1 (es) 1997-12-19 2001-08-22 Smithkline Beecham Corp Derivados de imidazol 1,4,5 sustituidos, composiciones que los comprenden, procedimiento para la preparacion de dichos derivados, uso de los derivados parala manufactura de un medicamento
EP1066279A4 (fr) * 1998-03-25 2004-09-08 Bristol Myers Squibb Co Agents anorexigenes a base d'imidazolones: derives phenyles ii
AU760527C (en) 1998-05-22 2004-05-06 Smithkline Beecham Corporation Novel 2-alkyl substituted imidazole compounds
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
CA2341370A1 (fr) 1998-08-20 2000-03-02 Smithkline Beecham Corporation Nouveaux composes de triazole substitues
ATE258055T1 (de) 1998-11-04 2004-02-15 Smithkline Beecham Corp Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
US6239279B1 (en) 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
US6288089B1 (en) 1998-12-21 2001-09-11 Michael Zawada Use of kinase inhibitors for treating neurodegenerative diseases
US20020147197A1 (en) * 1999-10-08 2002-10-10 Newman Michael J. Methods and compositions for enhancing pharmaceutical treatments
DE60015594T2 (de) 1999-11-22 2005-10-27 Smithkline Beecham P.L.C., Brentford Imidazolderivate und deren verwendung als raf kinase inhibitoren
US6759410B1 (en) * 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
US7053098B1 (en) 1999-11-23 2006-05-30 Smithkline Beecham Corporation 3,4-Dihydro-(1H) quinazolin-2-one compounds as CSBP/P38 kinase inhibitors
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JP4217480B2 (ja) * 2000-11-20 2009-02-04 スミスクライン・ビーチャム・コーポレイション 新規化合物
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FR2823747B1 (fr) * 2001-04-24 2003-05-23 Oreal Nouveaux composes de la famille des 3-alkyl-(4,5 diphenyl- imidazol-1-yl) et leur utilisation comme anti-inflammatoires
US6627309B2 (en) * 2001-05-08 2003-09-30 3M Innovative Properties Company Adhesive detackification
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US20040192689A1 (en) * 2001-09-05 2004-09-30 Dean David Kenneth Heterocycle-carboxamide derivatives as raf kinase inhibitors
US7329401B2 (en) * 2002-04-15 2008-02-12 The Regents Of The University Of California Cyclooxygenase-2 selective agents useful as imaging probes and related methods
EP1532118A2 (fr) * 2002-07-05 2005-05-25 Axxima Pharmaceuticals Aktiengesellschaft Composes d'imidazole pour le traitement des infections par le virus de l'hepatite c
ES2325687T3 (es) * 2002-09-18 2009-09-14 Pfizer Products Inc. Compuestos de imidazol novedosos como inhibidores del factor de crecimiento transformante (tgf).
EP1581213A4 (fr) * 2002-12-18 2008-11-19 Cytovia Inc 3,5-disubstitues- 1,2,4 -oxadiazoles et analogues servant d'activateurs des caspases et de promoteurs de l'apoptose, et leur utilisation
PE20100737A1 (es) 2005-03-25 2010-11-27 Glaxo Group Ltd Nuevos compuestos
KR100694181B1 (ko) * 2005-11-25 2007-03-12 연세대학교 산학협력단 근원세포 또는 근섬유로부터 신경세포 분화를 유도하는화합물, 이를 포함하는 약학적 조성물, 신경세포 분화를유도하는 방법 및 신경세포 분화를 유도하는 화합물을검색하는 스크리닝 방법
EP2274300A2 (fr) * 2008-03-21 2011-01-19 Novartis AG Nouveaux composés hétérocycliques et leurs utilisations
US8865732B2 (en) 2008-03-21 2014-10-21 Novartis Ag Heterocyclic compounds and uses thereof
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
MX2018005549A (es) * 2015-11-18 2018-11-09 Monsanto Technology Llc Composiciones y metodos insecticidas.
CN109715163B (zh) 2016-09-19 2022-11-22 诺华股份有限公司 包含raf抑制剂和erk抑制剂的治疗组合
ES2952265T3 (es) 2017-05-02 2023-10-30 Novartis Ag Terapia combinada que comprende un inhibidor de Raf y trametinib
CN111057043B (zh) * 2019-11-29 2021-11-02 深圳市贝加电子材料有限公司 咪唑类化合物及其制备方法、应用和含有其的有机可焊保护剂及表面处理方法
US11939298B1 (en) * 2023-10-25 2024-03-26 King Faisal University 5-(4,5-bis(4-bromophenyl)-2-(4-chlorophenyl)-1H-imidazol-1-yl)pentanoic acid as an antimicrobial compound

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7017486A (fr) * 1969-12-15 1971-06-17

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382945A (en) 1980-04-29 1983-05-10 Hoffmann-La Roche Inc. Tetrahydrothiepino[4,5-d]imidazole derivatives, composition and method of use
US4493841A (en) * 1980-04-29 1985-01-15 Hoffmann-La Roche Inc. Blood-platelet aggregation inhibiting 4,5,7,8-tetrahydro-4,4,8,8-tetramethyl-2-thienyl-1H-thiepino[4,5-d]imidazole derivatives
US4582844A (en) * 1980-06-05 1986-04-15 Hoffmann-La Roche Inc. Antithrombotic 4,5 di-t-butyl-imidazole derivatives

Also Published As

Publication number Publication date
US3772441A (en) 1973-11-13
CH551416A (fr) 1974-07-15
DE2155558C2 (de) 1982-08-26
FR2113861A1 (fr) 1972-06-30
AT317201B (de) 1974-08-26
AT324327B (de) 1975-08-25
NL7115493A (fr) 1972-05-18
CA978960A (en) 1975-12-02
NL170143B (nl) 1982-05-03
AU3474471A (en) 1973-05-03
NL170143C (nl) 1982-10-01
DE2155558A1 (fr) 1972-06-29
US3707475A (en) 1972-12-26
SE401504B (sv) 1978-05-16
GB1347893A (en) 1974-02-27
FR2113861B1 (fr) 1975-03-14
AU465501B2 (en) 1975-10-02

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: PFIZER INC.

Effective date: 19871130