US3940486A
(en)
*
|
1971-05-10 |
1976-02-24 |
Ciba-Geigy Corporation |
Imidazole derivatives in the treatment of pain
|
US3929807A
(en)
*
|
1971-05-10 |
1975-12-30 |
Ciba Geigy Corp |
2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles
|
SE428686B
(sv)
*
|
1975-08-11 |
1983-07-18 |
Du Pont |
Forfarande for framstellning av antiinflammatoriskt aktiva imidazoler
|
US4190666A
(en)
*
|
1975-08-11 |
1980-02-26 |
E. I. Du Pont De Nemours And Company |
Anti-inflammatory 4,5-diarly-2-(substituted-thio)imidazoles and their corresponding sulfoxides and sulfones
|
US4159338A
(en)
*
|
1977-02-09 |
1979-06-26 |
E. I. Du Pont De Nemours And Company |
Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones
|
US4182769A
(en)
*
|
1977-02-09 |
1980-01-08 |
E. I. Du Pont De Nemours And Company |
Anti-inflammatory 1-substituted-4,5-diaryl-2-(substituted-thio) imidazoles and their corresponding sulfoxides and sulfones
|
US4139708A
(en)
*
|
1977-05-24 |
1979-02-13 |
Sk&F Lab Co. |
Intermediates and processes useful for preparing medicinal agents imidazolemethylphosphonium salts
|
US4199592A
(en)
*
|
1978-08-29 |
1980-04-22 |
E. I. Du Pont De Nemours And Company |
Antiinflammatory 4,5-diaryl-2-nitroimidazoles
|
US4215135A
(en)
*
|
1979-06-08 |
1980-07-29 |
E. I. Du Pont De Nemours And Company |
Antiinflammatory 2-substituted-1H-phenanthro[9,10-d]imidazoles
|
US4314844A
(en)
*
|
1979-01-11 |
1982-02-09 |
Rohm And Haas Company |
Herbicidal substituted imidazoles
|
US4424229A
(en)
|
1979-04-23 |
1984-01-03 |
A/S Dumex (Dumex Ltd.) |
Fluorine containing 2,4,5-triphenylimidazoles
|
US4246263A
(en)
|
1979-10-15 |
1981-01-20 |
Pfizer Inc. |
Antiinflammatory and immunoregulatory pyrimidines, their method of use and pharmaceutical compositions
|
DK513580A
(da)
*
|
1980-01-07 |
1981-07-08 |
Du Pont |
Fremgangsmaade til fremstilling af 4,5-diaryl-alfa (polyhalogenalkyl)-1h-imidazol-2-methanoler
|
US4348404A
(en)
*
|
1980-07-21 |
1982-09-07 |
E. I. Du Pont De Nemours And Company |
Antiinflammatory 4,5-diaryl-α-polyfluoroalkyl-1H-imidazole-2-methanamines
|
US4372964A
(en)
*
|
1980-10-30 |
1983-02-08 |
E. I. Du Pont De Nemours And Company |
Antiinflammatory 4,5-diaryl-1H-imidazole-2-methanols
|
US4330552A
(en)
*
|
1980-11-06 |
1982-05-18 |
E. I. Du Pont De Nemours And Company |
Antiinflammatory 4,5-diaryl-2-arylthioimidazoles
|
JPS57150667A
(en)
*
|
1981-02-12 |
1982-09-17 |
Wellcome Found |
Antithrombotic
|
DE3141063A1
(de)
*
|
1981-10-13 |
1983-04-28 |
Schering Ag, 1000 Berlin Und 4619 Bergkamen |
Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
|
US4477463A
(en)
*
|
1982-05-10 |
1984-10-16 |
E. I. Du Pont De Nemours And Company |
Antiinflammatory and/or analgesic 1-alkyl-4,5-diaryl-2-fluoroalkyl-1H-pyrroles
|
US4503065A
(en)
*
|
1982-08-03 |
1985-03-05 |
E. I. Du Pont De Nemours And Company |
Antiinflammatory 4,5-diaryl 1-2-halo imidazoles
|
US4686231A
(en)
*
|
1985-12-12 |
1987-08-11 |
Smithkline Beckman Corporation |
Inhibition of 5-lipoxygenase products
|
IL83467A0
(en)
*
|
1986-08-15 |
1988-01-31 |
Fujisawa Pharmaceutical Co |
Imidazole derivatives,processes for their preparation and pharmaceutical compositions containing the same
|
US4780470A
(en)
*
|
1986-08-19 |
1988-10-25 |
Smithkline Beckman Corporation |
Inhibition of interleukin-1 by monocytes and/or macrophages
|
JPH02101065A
(ja)
*
|
1988-10-06 |
1990-04-12 |
Tanabe Seiyaku Co Ltd |
イミダゾリン誘導体及びその製法
|
US5208015A
(en)
*
|
1991-07-23 |
1993-05-04 |
Bristol-Myers Squibb Company |
Topical anti-fungal agents having anti-inflammatory activity
|
US5916891A
(en)
*
|
1992-01-13 |
1999-06-29 |
Smithkline Beecham Corporation |
Pyrimidinyl imidazoles
|
US6008235A
(en)
*
|
1992-01-13 |
1999-12-28 |
Smithkline Beecham Corporation |
Pyridyl substituted imidazoles
|
IL104369A0
(en)
*
|
1992-01-13 |
1993-05-13 |
Smithkline Beecham Corp |
Novel compounds and compositions
|
US5656644A
(en)
*
|
1994-07-20 |
1997-08-12 |
Smithkline Beecham Corporation |
Pyridyl imidazoles
|
ES2053401B1
(es)
*
|
1992-01-13 |
1995-03-01 |
Smithkline Beecham Corp |
Compuestos de imidazol y procedimientos para su prepacion.
|
US5716972A
(en)
*
|
1993-01-13 |
1998-02-10 |
Smithkline Beecham Corporation |
Pyridyl substituted imidazoles
|
US5593991A
(en)
*
|
1993-07-16 |
1997-01-14 |
Adams; Jerry L. |
Imidazole compounds, use and process of making
|
IL110296A
(en)
*
|
1993-07-16 |
1999-12-31 |
Smithkline Beecham Corp |
Imidazole compounds process for their preparation and pharmaceutical compositions containing them
|
US5670527A
(en)
*
|
1993-07-16 |
1997-09-23 |
Smithkline Beecham Corporation |
Pyridyl imidazole compounds and compositions
|
US5593992A
(en)
*
|
1993-07-16 |
1997-01-14 |
Smithkline Beecham Corporation |
Compounds
|
ZA945363B
(en)
*
|
1993-07-21 |
1995-03-14 |
Smithkline Beecham Corp |
Novel compounds
|
US5922751A
(en)
*
|
1994-06-24 |
1999-07-13 |
Euro-Celtique, S.A. |
Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
|
US5620999A
(en)
*
|
1994-07-28 |
1997-04-15 |
Weier; Richard M. |
Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
|
US6426360B1
(en)
|
1994-07-28 |
2002-07-30 |
G D Searle & Co. |
4,5-substituted imidazolyl compounds for the treatment of inflammation
|
CA2207404C
(fr)
*
|
1994-12-13 |
2004-06-29 |
F. Hoffmann-La Roche Ag |
Derives imidazoles utilises comme inhibiteurs de la proteine kinase, notamment de la tyrosine kinase du recepteur du facteur de croissance de l'epiderme (egf-r)
|
US6515014B2
(en)
|
1995-06-02 |
2003-02-04 |
G. D. Searle & Co. |
Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
|
WO1996038418A1
(fr)
|
1995-06-02 |
1996-12-05 |
G.D. Searle & Co. |
Derives heterocyclo-substitues d'acide hydroxamique utilises comme inhibiteurs de la cyclo-oxygenase-2 et de la 5-lipoxygenase
|
US6512121B2
(en)
|
1998-09-14 |
2003-01-28 |
G.D. Searle & Co. |
Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
|
US6369068B1
(en)
|
1995-06-07 |
2002-04-09 |
Smithkline Beecham Corporation |
Amino substituted pyrimidine containing compounds
|
US5739143A
(en)
*
|
1995-06-07 |
1998-04-14 |
Smithkline Beecham Corporation |
Imidazole compounds and compositions
|
US5658903A
(en)
|
1995-06-07 |
1997-08-19 |
Smithkline Beecham Corporation |
Imidazole compounds, compositions and use
|
US5700826A
(en)
*
|
1995-06-07 |
1997-12-23 |
Ontogen Corporation |
1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
|
US5717100A
(en)
*
|
1995-10-06 |
1998-02-10 |
Merck & Co., Inc. |
Substituted imidazoles having anti-cancer and cytokine inhibitory activity
|
US6083949A
(en)
*
|
1995-10-06 |
2000-07-04 |
Merck & Co., Inc. |
Substituted imidazoles having anti-cancer and cytokine inhibitory activity
|
WO1997016442A1
(fr)
*
|
1995-10-31 |
1997-05-09 |
Merck & Co., Inc. |
Pyrroles de pyridyle substitues, compositions contenant de tels composes et mode d'utilisation
|
ZA9610687B
(en)
|
1995-12-22 |
1997-09-29 |
Smithkline Beecham Corp |
Novel synthesis.
|
US5756499A
(en)
*
|
1996-01-11 |
1998-05-26 |
Smithkline Beecham Corporation |
Substituted imidazole compounds
|
US6046208A
(en)
*
|
1996-01-11 |
2000-04-04 |
Smithkline Beecham Corporation |
Substituted imidazole compounds
|
ZA97175B
(en)
*
|
1996-01-11 |
1997-11-04 |
Smithkline Beecham Corp |
Novel substituted imidazole compounds.
|
AP9700912A0
(en)
|
1996-01-11 |
1997-01-31 |
Smithkline Beecham Corp |
Novel cycloalkyl substituted imidazoles
|
JP2000507545A
(ja)
*
|
1996-03-25 |
2000-06-20 |
スミスクライン・ビーチャム・コーポレイション |
Cns損傷についての新規な治療
|
JP2000507558A
(ja)
*
|
1996-03-25 |
2000-06-20 |
スミスクライン・ビーチャム・コーポレイション |
Cns損傷についての新規な治療
|
US6677364B2
(en)
|
1998-04-20 |
2004-01-13 |
G.D. Searle & Co. |
Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
|
DE69733135T2
(de)
*
|
1996-06-10 |
2006-03-02 |
Merck & Co., Inc. |
Substituierte imidazole mit cytokinin-inhibirender wirkung
|
WO1998007425A1
(fr)
|
1996-08-21 |
1998-02-26 |
Smithkline Beecham Corporation |
Composes d'imidazole, compositions les contenant et leur utilisation
|
JP2001504489A
(ja)
*
|
1996-11-20 |
2001-04-03 |
メルク エンド カンパニー インコーポレーテッド |
トリアリール置換イミダゾール及び使用方法
|
US5880139A
(en)
*
|
1996-11-20 |
1999-03-09 |
Merck & Co., Inc. |
Triaryl substituted imidazoles as glucagon antagonists
|
EP0948257A4
(fr)
*
|
1996-11-20 |
1999-12-29 |
Merck & Co Inc |
Imidazoles a substitution triaryle, compositions renfermant de tels composes et modes d'utilisation
|
JP2000514088A
(ja)
*
|
1996-11-20 |
2000-10-24 |
メルク エンド カンパニー インコーポレーテッド |
グルカゴンアンタゴニストとしてのトリアリール置換イミダゾール
|
US5929076A
(en)
*
|
1997-01-10 |
1999-07-27 |
Smithkline Beecham Corporation |
Cycloalkyl substituted imidazoles
|
US20030050330A1
(en)
*
|
1997-01-10 |
2003-03-13 |
G.D. Searle & Co. |
4,5-subtstituted imdazolyl compounds for the treatment of inflammation
|
JP4380803B2
(ja)
|
1997-06-12 |
2009-12-09 |
アベンテイス・フアルマ・リミテツド |
イミダゾリル−環式アセタール
|
CA2294057A1
(fr)
|
1997-06-13 |
1998-12-17 |
Smithkline Beecham Corporation |
Nouveaux composes de pyrazole et de pyrazoline substitues
|
EP0994870A4
(fr)
|
1997-06-19 |
2002-10-23 |
Smithkline Beecham |
Nouveaux composes imidazole a substitution d'aryloxypymiridine
|
US6040320A
(en)
*
|
1997-06-30 |
2000-03-21 |
Ortho-Mcneil Pharmaceutical, Inc. |
2-substituted imidazoles useful in the treatment of inflammatory diseases
|
CA2295762A1
(fr)
|
1997-07-02 |
1999-01-14 |
Ravi Shanker Garigipati |
Nouveaux imidazoles cycloalkyle-substitues
|
US7301021B2
(en)
*
|
1997-07-02 |
2007-11-27 |
Smithkline Beecham Corporation |
Substituted imidazole compounds
|
US6489325B1
(en)
|
1998-07-01 |
2002-12-03 |
Smithkline Beecham Corporation |
Substituted imidazole compounds
|
TW517055B
(en)
|
1997-07-02 |
2003-01-11 |
Smithkline Beecham Corp |
Novel substituted imidazole compounds
|
US6562832B1
(en)
|
1997-07-02 |
2003-05-13 |
Smithkline Beecham Corporation |
Substituted imidazole compounds
|
WO1999001128A1
(fr)
*
|
1997-07-03 |
1999-01-14 |
Neurogen Corporation |
Certains derives diarylimidazoles; nouvelle classe de ligands specifiques de neuropeptide y (npy)
|
US5840721A
(en)
*
|
1997-07-09 |
1998-11-24 |
Ontogen Corporation |
Imidazole derivatives as MDR modulators
|
AR017219A1
(es)
|
1997-12-19 |
2001-08-22 |
Smithkline Beecham Corp |
Derivados de imidazol 1,4,5 sustituidos, composiciones que los comprenden, procedimiento para la preparacion de dichos derivados, uso de los derivados parala manufactura de un medicamento
|
EP1066279A4
(fr)
*
|
1998-03-25 |
2004-09-08 |
Bristol Myers Squibb Co |
Agents anorexigenes a base d'imidazolones: derives phenyles ii
|
AU760527C
(en)
|
1998-05-22 |
2004-05-06 |
Smithkline Beecham Corporation |
Novel 2-alkyl substituted imidazole compounds
|
US6858617B2
(en)
|
1998-05-26 |
2005-02-22 |
Smithkline Beecham Corporation |
Substituted imidazole compounds
|
CA2341370A1
(fr)
|
1998-08-20 |
2000-03-02 |
Smithkline Beecham Corporation |
Nouveaux composes de triazole substitues
|
ATE258055T1
(de)
|
1998-11-04 |
2004-02-15 |
Smithkline Beecham Corp |
Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
|
US6239279B1
(en)
|
1998-12-16 |
2001-05-29 |
Smithkline Beecham Corporation |
Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
|
US6288089B1
(en)
|
1998-12-21 |
2001-09-11 |
Michael Zawada |
Use of kinase inhibitors for treating neurodegenerative diseases
|
US20020147197A1
(en)
*
|
1999-10-08 |
2002-10-10 |
Newman Michael J. |
Methods and compositions for enhancing pharmaceutical treatments
|
DE60015594T2
(de)
|
1999-11-22 |
2005-10-27 |
Smithkline Beecham P.L.C., Brentford |
Imidazolderivate und deren verwendung als raf kinase inhibitoren
|
US6759410B1
(en)
*
|
1999-11-23 |
2004-07-06 |
Smithline Beecham Corporation |
3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
|
US7053098B1
(en)
|
1999-11-23 |
2006-05-30 |
Smithkline Beecham Corporation |
3,4-Dihydro-(1H) quinazolin-2-one compounds as CSBP/P38 kinase inhibitors
|
EP1235814B1
(fr)
|
1999-11-23 |
2004-11-03 |
Smithkline Beecham Corporation |
COMPOSES DE 3,4-DIHYDRO-(1H)QUINAZOLINE-2-ONE UTILISES COMME INHIBITEURS DE LA KINASE CSBP/p38
|
WO2001038313A1
(fr)
|
1999-11-23 |
2001-05-31 |
Smithkline Beecham Corporation |
Composes de 3,4-dihydro-(1h)quinazolin-2-one comme inhibiteurs de csbp/p38 kinase
|
AU2001234128B2
(en)
*
|
2000-02-22 |
2004-11-11 |
Banyu Pharmaceutical Co., Ltd. |
Novel imidazoline compounds
|
US7235551B2
(en)
|
2000-03-02 |
2007-06-26 |
Smithkline Beecham Corporation |
1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
|
EP2404603A1
(fr)
|
2000-10-23 |
2012-01-11 |
Glaxosmithkline LLC |
Nouveaux composés 8H-pyrido[2,3-d]pyrimidin-7-one trisubstituté pour le traitement des maladies faisant intervenir les kinases CSBP/p38.
|
JP4217480B2
(ja)
*
|
2000-11-20 |
2009-02-04 |
スミスクライン・ビーチャム・コーポレイション |
新規化合物
|
US20030105144A1
(en)
|
2001-04-17 |
2003-06-05 |
Ping Gao |
Stabilized oral pharmaceutical composition
|
FR2823747B1
(fr)
*
|
2001-04-24 |
2003-05-23 |
Oreal |
Nouveaux composes de la famille des 3-alkyl-(4,5 diphenyl- imidazol-1-yl) et leur utilisation comme anti-inflammatoires
|
US6627309B2
(en)
*
|
2001-05-08 |
2003-09-30 |
3M Innovative Properties Company |
Adhesive detackification
|
GB0112348D0
(en)
*
|
2001-05-19 |
2001-07-11 |
Smithkline Beecham Plc |
Compounds
|
AU2002313633B2
(en)
*
|
2001-06-08 |
2007-03-01 |
Cytovia, Inc. |
Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs
|
US20040192689A1
(en)
*
|
2001-09-05 |
2004-09-30 |
Dean David Kenneth |
Heterocycle-carboxamide derivatives as raf kinase inhibitors
|
US7329401B2
(en)
*
|
2002-04-15 |
2008-02-12 |
The Regents Of The University Of California |
Cyclooxygenase-2 selective agents useful as imaging probes and related methods
|
EP1532118A2
(fr)
*
|
2002-07-05 |
2005-05-25 |
Axxima Pharmaceuticals Aktiengesellschaft |
Composes d'imidazole pour le traitement des infections par le virus de l'hepatite c
|
ES2325687T3
(es)
*
|
2002-09-18 |
2009-09-14 |
Pfizer Products Inc. |
Compuestos de imidazol novedosos como inhibidores del factor de crecimiento transformante (tgf).
|
EP1581213A4
(fr)
*
|
2002-12-18 |
2008-11-19 |
Cytovia Inc |
3,5-disubstitues- 1,2,4 -oxadiazoles et analogues servant d'activateurs des caspases et de promoteurs de l'apoptose, et leur utilisation
|
PE20100737A1
(es)
|
2005-03-25 |
2010-11-27 |
Glaxo Group Ltd |
Nuevos compuestos
|
KR100694181B1
(ko)
*
|
2005-11-25 |
2007-03-12 |
연세대학교 산학협력단 |
근원세포 또는 근섬유로부터 신경세포 분화를 유도하는화합물, 이를 포함하는 약학적 조성물, 신경세포 분화를유도하는 방법 및 신경세포 분화를 유도하는 화합물을검색하는 스크리닝 방법
|
EP2274300A2
(fr)
*
|
2008-03-21 |
2011-01-19 |
Novartis AG |
Nouveaux composés hétérocycliques et leurs utilisations
|
US8865732B2
(en)
|
2008-03-21 |
2014-10-21 |
Novartis Ag |
Heterocyclic compounds and uses thereof
|
US9242969B2
(en)
|
2013-03-14 |
2016-01-26 |
Novartis Ag |
Biaryl amide compounds as kinase inhibitors
|
UY36294A
(es)
|
2014-09-12 |
2016-04-29 |
Novartis Ag |
Compuestos y composiciones como inhibidores de quinasa
|
MX2018005549A
(es)
*
|
2015-11-18 |
2018-11-09 |
Monsanto Technology Llc |
Composiciones y metodos insecticidas.
|
CN109715163B
(zh)
|
2016-09-19 |
2022-11-22 |
诺华股份有限公司 |
包含raf抑制剂和erk抑制剂的治疗组合
|
ES2952265T3
(es)
|
2017-05-02 |
2023-10-30 |
Novartis Ag |
Terapia combinada que comprende un inhibidor de Raf y trametinib
|
CN111057043B
(zh)
*
|
2019-11-29 |
2021-11-02 |
深圳市贝加电子材料有限公司 |
咪唑类化合物及其制备方法、应用和含有其的有机可焊保护剂及表面处理方法
|
US11939298B1
(en)
*
|
2023-10-25 |
2024-03-26 |
King Faisal University |
5-(4,5-bis(4-bromophenyl)-2-(4-chlorophenyl)-1H-imidazol-1-yl)pentanoic acid as an antimicrobial compound
|