EP0948257A4 - Imidazoles a substitution triaryle, compositions renfermant de tels composes et modes d'utilisation - Google Patents
Imidazoles a substitution triaryle, compositions renfermant de tels composes et modes d'utilisationInfo
- Publication number
- EP0948257A4 EP0948257A4 EP97948342A EP97948342A EP0948257A4 EP 0948257 A4 EP0948257 A4 EP 0948257A4 EP 97948342 A EP97948342 A EP 97948342A EP 97948342 A EP97948342 A EP 97948342A EP 0948257 A4 EP0948257 A4 EP 0948257A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compounds
- methods
- compositions containing
- substituted imidazoles
- triaryl substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3146796P | 1996-11-20 | 1996-11-20 | |
US31467P | 1996-11-20 | ||
GBGB9702823.7A GB9702823D0 (en) | 1997-02-12 | 1997-02-12 | Triayl substituted imidazoles, compositions containing such compounds and methods of use |
GB9702823 | 1997-02-12 | ||
PCT/US1997/021019 WO1998021957A1 (fr) | 1996-11-20 | 1997-11-17 | Imidazoles a substitution triaryle, compositions renfermant de tels composes et modes d'utilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0948257A1 EP0948257A1 (fr) | 1999-10-13 |
EP0948257A4 true EP0948257A4 (fr) | 1999-12-29 |
Family
ID=26310972
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97948342A Withdrawn EP0948257A4 (fr) | 1996-11-20 | 1997-11-17 | Imidazoles a substitution triaryle, compositions renfermant de tels composes et modes d'utilisation |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0948257A4 (fr) |
JP (1) | JP2001504490A (fr) |
AU (1) | AU728760B2 (fr) |
CA (1) | CA2271963A1 (fr) |
WO (1) | WO1998021957A1 (fr) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6613942B1 (en) | 1997-07-01 | 2003-09-02 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
DE69821132T2 (de) | 1997-10-27 | 2004-10-21 | Takeda Chemical Industries Ltd | 1,3-thiazole als adenosine a3 rezeptor antagonisten zur behandlung von asthma, allergien und diabetes |
WO2000019824A1 (fr) | 1998-10-07 | 2000-04-13 | Smithkline Beecham Corporation | Nouveau traitement pour la gestion des accidents vasculaires cerebraux |
US6503949B1 (en) | 1999-05-17 | 2003-01-07 | Noro Nordisk A/S | Glucagon antagonists/inverse agonists |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
DK1248604T4 (da) | 2000-01-21 | 2012-05-21 | Novartis Ag | Kombinationer indeholdende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler |
GB0007405D0 (en) * | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
US6562807B2 (en) | 2000-06-23 | 2003-05-13 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
EP1345890A1 (fr) | 2000-11-17 | 2003-09-24 | Novo Nordisk A/S | Agonistes de glucagon/antagonistes inverses |
US6821960B2 (en) | 2000-11-17 | 2004-11-23 | Noyo Nordisk Pharmaceuticals, Inc. | Glucagon antagonists/inverse agonists |
US6706744B2 (en) | 2000-11-17 | 2004-03-16 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
DE122010000047I1 (de) | 2001-06-26 | 2011-05-05 | Amgen Fremont Inc | Antikörper gegen opgl |
EP1414443B1 (fr) * | 2001-08-01 | 2006-11-15 | Merck & Co., Inc. | Derives de la benzimidazo 4,5-f|isoquinolinone |
US6762318B2 (en) | 2001-12-03 | 2004-07-13 | Novo Nordisk A/S | Glucagon antagonists |
US6881746B2 (en) | 2001-12-03 | 2005-04-19 | Novo Nordick A/S | Glucagon antagonists/inverse agonists |
WO2003097031A1 (fr) * | 2002-05-22 | 2003-11-27 | Sanwa Kagaku Kenkyusho Co., Ltd. | Medicament contre l'obesite a base de methylidene hydrazide |
CN100471871C (zh) | 2002-09-06 | 2009-03-25 | 安姆根有限公司 | 治疗性人抗-il-1r1单克隆抗体 |
US7196106B2 (en) | 2002-11-05 | 2007-03-27 | Merck & Co., Inc | Cyanothiophene derivatives, compositions containing such compounds and methods of use |
WO2004063192A1 (fr) * | 2003-01-10 | 2004-07-29 | Pharmacopeia Drug Discovery, Inc. | Derives de d'imidazolyl pyrimidine utilises comme modulateurs du recepteur de il-8 |
WO2004069158A2 (fr) | 2003-01-27 | 2004-08-19 | Merck & Co., Inc. | Pyrazoles substitues, compositions contenant de tels composes et procedes d'utilisation |
CA2522476A1 (fr) * | 2003-04-18 | 2004-11-04 | Merck & Co., Inc. | Thiazoles, oxazoles et imidazoles a substitution biaryle utilises comme bloqueurs du canal sodique |
AU2004312001B2 (en) | 2003-12-19 | 2009-08-27 | Merck & Co., Inc. | Cyclic guanidines, compositions containing such compounds and methods of use |
MY143599A (en) | 2004-06-04 | 2011-06-15 | Merck Sharp & Dohme | Pyrazole derivatives, compositions containing such compounds and methods of use |
ATE449604T1 (de) | 2004-07-07 | 2009-12-15 | Merck & Co Inc | Pyrazolamid-derivate, diese verbindungen enthaltende zusammensetzungen und anwendungsverfahren |
EP1773330B1 (fr) * | 2004-07-22 | 2010-05-26 | Merck Sharp & Dohme Corp. | Pyrazoles substitues, compositions contenant de tels composes et leurs methodes d'utilisation |
JP2008533200A (ja) | 2005-03-21 | 2008-08-21 | メルク エンド カムパニー インコーポレーテッド | 置換アリールおよびヘテロアリール誘導体、かかる化合物を含有する組成物および使用法 |
US7803951B2 (en) | 2005-03-30 | 2010-09-28 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
WO2007015999A2 (fr) | 2005-07-26 | 2007-02-08 | Merck & Co., Inc. | Procede de synthese d'un pyrazole substitue |
MY159522A (en) | 2005-09-14 | 2017-01-13 | Takeda Pharmaceuticals Co | Administration of dipeptidyl peptidase inhibitors |
TW200745031A (en) | 2005-10-13 | 2007-12-16 | Merck & Co Inc | Acyl indoles, compositions containing such compounds and methods of use |
EP2001472A2 (fr) | 2006-03-23 | 2008-12-17 | Merck and Co., Inc. | Composes antagonistes du recepteur du glucagon, compositions contenant de tels composes et procedes d'utilisation |
WO2007136577A2 (fr) | 2006-05-16 | 2007-11-29 | Merck & Co., Inc. | Composés antagonistes du récepteur du glucagon, compositions contenant ces composés, et procédés d'utilisation |
US20080090834A1 (en) * | 2006-07-06 | 2008-04-17 | Pfizer Inc | Selective azole pde10a inhibitor compounds |
TW200821284A (en) | 2006-10-03 | 2008-05-16 | Merck & Co Inc | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
WO2011041293A1 (fr) | 2009-09-30 | 2011-04-07 | Takeda Pharmaceutical Company Limited | Dérivés pyrazolo [1, 5a] pyrimidines comme inhibiteurs de kinase 1 régulatrice de signal d'apoptose |
RS53176B (en) | 2010-02-03 | 2014-06-30 | Takeda Pharmaceutical Company Limited | KINASE INHIBITORS 1 REGULATING SIGNALS IN APOPTOSIS |
WO2013096093A1 (fr) * | 2011-12-21 | 2013-06-27 | Merck Sharp & Dohme Corp. | Composés en tant qu'inhibiteurs de dgat-1 |
US9649294B2 (en) | 2013-11-04 | 2017-05-16 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
WO2020035482A1 (fr) | 2018-08-13 | 2020-02-20 | Iltoo Pharma | Combinaison d'interleukine 2 et d'un inhibiteur de l'interleukine 1, conjugués et utilisations thérapeutiques de celle-ci |
WO2023222565A1 (fr) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Procédés d'évaluation de l'épuisement de cellules souches hématopoïétiques induites par une inflammation chronique |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3772441A (en) * | 1970-11-16 | 1973-11-13 | Pfizer | Anti-inflammatory imidazoles |
US3929807A (en) * | 1971-05-10 | 1975-12-30 | Ciba Geigy Corp | 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles |
WO1993014081A1 (fr) * | 1992-01-13 | 1993-07-22 | Smithkline Beecham Corporation | Derives imidazole et leur utilisation comme inhibiteurs de cytokine |
WO1995003297A1 (fr) * | 1993-07-21 | 1995-02-02 | Smithkline Beecham Corporation | Imidazoles actives contre les maladies transmises par la cytokine |
WO1996018626A1 (fr) * | 1994-12-13 | 1996-06-20 | F. Hoffmann-La Roche Ag | Derives imidazoles utilises comme inhibiteurs de la proteine kinase, notamment de la tyrosine kinase du recepteur du facteur de croissance de l'epiderme (egf-r) |
-
1997
- 1997-11-17 CA CA002271963A patent/CA2271963A1/fr not_active Abandoned
- 1997-11-17 EP EP97948342A patent/EP0948257A4/fr not_active Withdrawn
- 1997-11-17 JP JP52379798A patent/JP2001504490A/ja active Pending
- 1997-11-17 AU AU54427/98A patent/AU728760B2/en not_active Ceased
- 1997-11-17 WO PCT/US1997/021019 patent/WO1998021957A1/fr not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3772441A (en) * | 1970-11-16 | 1973-11-13 | Pfizer | Anti-inflammatory imidazoles |
US3929807A (en) * | 1971-05-10 | 1975-12-30 | Ciba Geigy Corp | 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles |
WO1993014081A1 (fr) * | 1992-01-13 | 1993-07-22 | Smithkline Beecham Corporation | Derives imidazole et leur utilisation comme inhibiteurs de cytokine |
WO1995003297A1 (fr) * | 1993-07-21 | 1995-02-02 | Smithkline Beecham Corporation | Imidazoles actives contre les maladies transmises par la cytokine |
WO1996018626A1 (fr) * | 1994-12-13 | 1996-06-20 | F. Hoffmann-La Roche Ag | Derives imidazoles utilises comme inhibiteurs de la proteine kinase, notamment de la tyrosine kinase du recepteur du facteur de croissance de l'epiderme (egf-r) |
Non-Patent Citations (1)
Title |
---|
See also references of WO9821957A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1998021957A1 (fr) | 1998-05-28 |
EP0948257A1 (fr) | 1999-10-13 |
JP2001504490A (ja) | 2001-04-03 |
CA2271963A1 (fr) | 1998-05-28 |
AU728760B2 (en) | 2001-01-18 |
AU5442798A (en) | 1998-06-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0948257A4 (fr) | Imidazoles a substitution triaryle, compositions renfermant de tels composes et modes d'utilisation | |
EP0956018A4 (fr) | Composes d'imidazole, compositions les contenant et leur utilisation | |
IL125716A0 (en) | Triaryl compounds and their use as antiinflamatory | |
EP0959885A4 (fr) | Imidazoles a substitution triaryle et leurs procedes d'utilisation | |
EP0859771A4 (fr) | Pyrroles de pyridyle substitues, compositions contenant de tels composes et mode d'utilisation | |
EP0871444A4 (fr) | Pyrroles d'aryle substitues en position 2 et 5, compositions contenant de tels composes et leurs modes d'utilisation | |
PL319684A1 (en) | Novel metaloprotease inhibitors, method of obtaining them and pharmaceutic compositions containing such inhibitors | |
HUP9902460A3 (en) | Novel substituted imidazole compounds, their use, method for their preparation and pharmaceutical compositions containing them | |
PL331259A1 (en) | Synthetic polysaccharides, method of obtaining them and pharmaceutic compositions containing such compounds | |
AU7529096A (en) | Substituted aryl pyrroles, compositions containing such compounds and methods of use | |
PL328691A1 (en) | Novel taxoides, method of obtaining them and pharmaceutic compositions containing such compounds | |
PL327833A1 (en) | Diosegnin containing compositions | |
HK1021186A1 (en) | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment | |
AU7961498A (en) | 9a-azalides, compositions containing such compounds and methods of treatment | |
AU1841195A (en) | 1-beta -methyl-carbapenem, compositions containing same and methods of use | |
AU7986098A (en) | 9a-aza-3-ketolides, compositions containing such compounds and methods of treatment | |
GB9814269D0 (en) | 9a-Aza-3-ketolides, compositions containing such compounds and methods of treatment | |
GB2308812B (en) | Antiseptic compositions | |
PL319070A1 (en) | Derivatives of 1,25-dihydroxy-16,22,23-trisdehyrochoecalcifero, method of obtaining them and compositions containing such derivatives | |
GB9702823D0 (en) | Triayl substituted imidazoles, compositions containing such compounds and methods of use | |
EP1021445A4 (fr) | Compositions antibacteriennes de carbapenem, preparations les contenant et methodes de traitement | |
PL320294A1 (en) | Derivatives of 6-methoxy-1h-benzotriazolo-5-carboxylamide, methods of obtaining them and pharmaceutic compositions containing such derivatives | |
AU8147598A (en) | 8a-azalides, compositions containing such compounds and methods of treatment | |
AU5341098A (en) | Fulgimide compounds, use of them, and compositions containing the same | |
GB9607254D0 (en) | 2-Substituted aryl pyrroles, compositions containing such compounds and methods of use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19990621 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19991112 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Effective date: 20030924 |