FR2113861A1 - - Google Patents

Info

Publication number
FR2113861A1
FR2113861A1 FR7139768A FR7139768A FR2113861A1 FR 2113861 A1 FR2113861 A1 FR 2113861A1 FR 7139768 A FR7139768 A FR 7139768A FR 7139768 A FR7139768 A FR 7139768A FR 2113861 A1 FR2113861 A1 FR 2113861A1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7139768A
Other versions
FR2113861B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2113861A1 publication Critical patent/FR2113861A1/fr
Application granted granted Critical
Publication of FR2113861B1 publication Critical patent/FR2113861B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR7139768A 1970-11-16 1971-11-05 Expired FR2113861B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9007770A 1970-11-16 1970-11-16
US25152272A 1972-05-08 1972-05-08

Publications (2)

Publication Number Publication Date
FR2113861A1 true FR2113861A1 (fr) 1972-06-30
FR2113861B1 FR2113861B1 (fr) 1975-03-14

Family

ID=26781885

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7139768A Expired FR2113861B1 (fr) 1970-11-16 1971-11-05

Country Status (11)

Country Link
US (2) US3707475A (fr)
AT (2) AT324327B (fr)
AU (1) AU465501B2 (fr)
BE (1) BE775028A (fr)
CA (1) CA978960A (fr)
CH (1) CH551416A (fr)
DE (1) DE2155558C2 (fr)
FR (1) FR2113861B1 (fr)
GB (1) GB1347893A (fr)
NL (1) NL170143C (fr)
SE (1) SE401504B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0859771A1 (fr) * 1995-10-31 1998-08-26 Merck & Co., Inc. Pyrroles de pyridyle substitues, compositions contenant de tels composes et mode d'utilisation
WO1999001128A1 (fr) * 1997-07-03 1999-01-14 Neurogen Corporation Certains derives diarylimidazoles; nouvelle classe de ligands specifiques de neuropeptide y (npy)
FR2823747A1 (fr) * 2001-04-24 2002-10-25 Oreal Nouveaux composes de la famille des 3-alkyl-(4,5 diphenyl- imidazol-1-yl) et leur utilisation comme anti-inflammatoires

Families Citing this family (114)

* Cited by examiner, † Cited by third party
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US3940486A (en) * 1971-05-10 1976-02-24 Ciba-Geigy Corporation Imidazole derivatives in the treatment of pain
US3929807A (en) * 1971-05-10 1975-12-30 Ciba Geigy Corp 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles
US4190666A (en) * 1975-08-11 1980-02-26 E. I. Du Pont De Nemours And Company Anti-inflammatory 4,5-diarly-2-(substituted-thio)imidazoles and their corresponding sulfoxides and sulfones
SE428686B (sv) * 1975-08-11 1983-07-18 Du Pont Forfarande for framstellning av antiinflammatoriskt aktiva imidazoler
US4159338A (en) * 1977-02-09 1979-06-26 E. I. Du Pont De Nemours And Company Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones
US4182769A (en) * 1977-02-09 1980-01-08 E. I. Du Pont De Nemours And Company Anti-inflammatory 1-substituted-4,5-diaryl-2-(substituted-thio) imidazoles and their corresponding sulfoxides and sulfones
US4139708A (en) * 1977-05-24 1979-02-13 Sk&F Lab Co. Intermediates and processes useful for preparing medicinal agents imidazolemethylphosphonium salts
US4199592A (en) * 1978-08-29 1980-04-22 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-nitroimidazoles
US4215135A (en) * 1979-06-08 1980-07-29 E. I. Du Pont De Nemours And Company Antiinflammatory 2-substituted-1H-phenanthro[9,10-d]imidazoles
US4314844A (en) * 1979-01-11 1982-02-09 Rohm And Haas Company Herbicidal substituted imidazoles
US4424229A (en) 1979-04-23 1984-01-03 A/S Dumex (Dumex Ltd.) Fluorine containing 2,4,5-triphenylimidazoles
US4246263A (en) 1979-10-15 1981-01-20 Pfizer Inc. Antiinflammatory and immunoregulatory pyrimidines, their method of use and pharmaceutical compositions
DK513580A (da) * 1980-01-07 1981-07-08 Du Pont Fremgangsmaade til fremstilling af 4,5-diaryl-alfa (polyhalogenalkyl)-1h-imidazol-2-methanoler
DK151632C (da) * 1980-04-29 1988-06-27 Hoffmann La Roche Analogifremgangsmaade til fremstilling af 4,5,7,8-tetrahydro-4,4,8,8-tetramethyl-1-h-thiepinooe4,5-daaimidazolderivater
DK193181A (da) * 1980-06-05 1981-12-06 Hoffmann La Roche Fremgangmaade til fremstilling af imidazolderivater
US4348404A (en) * 1980-07-21 1982-09-07 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-α-polyfluoroalkyl-1H-imidazole-2-methanamines
US4372964A (en) * 1980-10-30 1983-02-08 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-1H-imidazole-2-methanols
US4330552A (en) * 1980-11-06 1982-05-18 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-arylthioimidazoles
JPS57150667A (en) * 1981-02-12 1982-09-17 Wellcome Found Antithrombotic
DE3141063A1 (de) * 1981-10-13 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4477463A (en) * 1982-05-10 1984-10-16 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic 1-alkyl-4,5-diaryl-2-fluoroalkyl-1H-pyrroles
US4503065A (en) * 1982-08-03 1985-03-05 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl 1-2-halo imidazoles
US4686231A (en) * 1985-12-12 1987-08-11 Smithkline Beckman Corporation Inhibition of 5-lipoxygenase products
IL83467A0 (en) * 1986-08-15 1988-01-31 Fujisawa Pharmaceutical Co Imidazole derivatives,processes for their preparation and pharmaceutical compositions containing the same
US4780470A (en) * 1986-08-19 1988-10-25 Smithkline Beckman Corporation Inhibition of interleukin-1 by monocytes and/or macrophages
JPH02101065A (ja) * 1988-10-06 1990-04-12 Tanabe Seiyaku Co Ltd イミダゾリン誘導体及びその製法
US5208015A (en) * 1991-07-23 1993-05-04 Bristol-Myers Squibb Company Topical anti-fungal agents having anti-inflammatory activity
ES2053401B1 (es) * 1992-01-13 1995-03-01 Smithkline Beecham Corp Compuestos de imidazol y procedimientos para su prepacion.
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
IL104369A0 (en) * 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
US5656644A (en) * 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
US6008235A (en) * 1992-01-13 1999-12-28 Smithkline Beecham Corporation Pyridyl substituted imidazoles
US5716972A (en) * 1993-01-13 1998-02-10 Smithkline Beecham Corporation Pyridyl substituted imidazoles
US5593992A (en) * 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
US5593991A (en) * 1993-07-16 1997-01-14 Adams; Jerry L. Imidazole compounds, use and process of making
US5670527A (en) * 1993-07-16 1997-09-23 Smithkline Beecham Corporation Pyridyl imidazole compounds and compositions
IL110296A (en) * 1993-07-16 1999-12-31 Smithkline Beecham Corp Imidazole compounds process for their preparation and pharmaceutical compositions containing them
AU7629594A (en) * 1993-07-21 1995-02-20 Smithkline Beecham Corporation Imidazoles for treating cytokine mediated disease
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5620999A (en) * 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US6426360B1 (en) 1994-07-28 2002-07-30 G D Searle & Co. 4,5-substituted imidazolyl compounds for the treatment of inflammation
CA2207404C (fr) * 1994-12-13 2004-06-29 F. Hoffmann-La Roche Ag Derives imidazoles utilises comme inhibiteurs de la proteine kinase, notamment de la tyrosine kinase du recepteur du facteur de croissance de l'epiderme (egf-r)
US6512121B2 (en) 1998-09-14 2003-01-28 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
EP0828718A1 (fr) 1995-06-02 1998-03-18 G.D. SEARLE & CO. Derives heterocyclo-substitues d'acide hydroxamique utilises comme inhibiteurs de la cyclo-oxygenase-2 et de la 5-lipoxygenase
US6515014B2 (en) 1995-06-02 2003-02-04 G. D. Searle & Co. Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US5700826A (en) * 1995-06-07 1997-12-23 Ontogen Corporation 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
US5658903A (en) * 1995-06-07 1997-08-19 Smithkline Beecham Corporation Imidazole compounds, compositions and use
US6369068B1 (en) 1995-06-07 2002-04-09 Smithkline Beecham Corporation Amino substituted pyrimidine containing compounds
US5739143A (en) * 1995-06-07 1998-04-14 Smithkline Beecham Corporation Imidazole compounds and compositions
US6083949A (en) * 1995-10-06 2000-07-04 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
US5717100A (en) * 1995-10-06 1998-02-10 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
ZA9610687B (en) 1995-12-22 1997-09-29 Smithkline Beecham Corp Novel synthesis.
ZA97175B (en) * 1996-01-11 1997-11-04 Smithkline Beecham Corp Novel substituted imidazole compounds.
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
AP9700912A0 (en) 1996-01-11 1997-01-31 Smithkline Beecham Corp Novel cycloalkyl substituted imidazoles
HUP9902460A3 (en) * 1996-01-11 2000-03-28 Smithkline Beecham Corp Novel substituted imidazole compounds, their use, method for their preparation and pharmaceutical compositions containing them
US6235760B1 (en) 1996-03-25 2001-05-22 Smithkline Beecham Corporation Treatment for CNS injuries
JP2000507558A (ja) * 1996-03-25 2000-06-20 スミスクライン・ビーチャム・コーポレイション Ｃｎｓ損傷についての新規な治療
US6677364B2 (en) 1998-04-20 2004-01-13 G.D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
EP0906307B1 (fr) * 1996-06-10 2005-04-27 Merck & Co., Inc. Imidazoles substitues inhibant la cytokine
EP0956018A4 (fr) 1996-08-21 2000-01-12 Smithkline Beecham Corp Composes d'imidazole, compositions les contenant et leur utilisation
WO1998021957A1 (fr) * 1996-11-20 1998-05-28 Merck & Co., Inc. Imidazoles a substitution triaryle, compositions renfermant de tels composes et modes d'utilisation
US5880139A (en) * 1996-11-20 1999-03-09 Merck & Co., Inc. Triaryl substituted imidazoles as glucagon antagonists
WO1998022109A1 (fr) * 1996-11-20 1998-05-28 Merck & Co., Inc. Imidazoles a substitution triaryle en tant qu'antagonistes du glucagon
EP0959885A4 (fr) * 1996-11-20 2002-07-17 Merck & Co Inc Imidazoles a substitution triaryle et leurs procedes d'utilisation
US5929076A (en) * 1997-01-10 1999-07-27 Smithkline Beecham Corporation Cycloalkyl substituted imidazoles
US20030050330A1 (en) * 1997-01-10 2003-03-13 G.D. Searle & Co. 4,5-subtstituted imdazolyl compounds for the treatment of inflammation
CA2293436C (fr) 1997-06-12 2010-10-26 Rhone-Poulenc Rorer Limited Acetals cycliques imidazolyle
AU7966198A (en) 1997-06-13 1998-12-30 Smithkline Beecham Corporation Novel pyrazole and pyrazoline substituted compounds
JP2002505690A (ja) 1997-06-19 2002-02-19 スミスクライン・ビーチャム・コーポレイション 新規なアリールオキシピリミジン置換イミダゾール化合物
KR20010014288A (ko) * 1997-06-30 2001-02-26 오르토-맥네일 파마슈티칼, 인코퍼레이티드 염증성 질환의 치료에 유용한 2-치환된 이미다졸
US6489325B1 (en) 1998-07-01 2002-12-03 Smithkline Beecham Corporation Substituted imidazole compounds
WO1999001452A1 (fr) 1997-07-02 1999-01-14 Smithkline Beecham Corporation Nouveaux imidazoles cycloalkyle-substitues
TW517055B (en) 1997-07-02 2003-01-11 Smithkline Beecham Corp Novel substituted imidazole compounds
US6562832B1 (en) 1997-07-02 2003-05-13 Smithkline Beecham Corporation Substituted imidazole compounds
US7301021B2 (en) * 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
US5840721A (en) * 1997-07-09 1998-11-24 Ontogen Corporation Imidazole derivatives as MDR modulators
AR017219A1 (es) 1997-12-19 2001-08-22 Smithkline Beecham Corp Derivados de imidazol 1,4,5 sustituidos, composiciones que los comprenden, procedimiento para la preparacion de dichos derivados, uso de los derivados parala manufactura de un medicamento
AU757252B2 (en) * 1998-03-25 2003-02-13 Bristol-Myers Squibb Company Imidazolone anorectic agents: I. acyclic derivatives
CN1548436A (zh) 1998-05-22 2004-11-24 ʷ��˿�������ȳ�ķ���޹�˾ 新的2-烷基取代咪唑化合物
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
WO2000010563A1 (fr) 1998-08-20 2000-03-02 Smithkline Beecham Corporation Nouveaux composes de triazole substitues
ATE258055T1 (de) * 1998-11-04 2004-02-15 Smithkline Beecham Corp Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
US6239279B1 (en) 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
US6288089B1 (en) 1998-12-21 2001-09-11 Michael Zawada Use of kinase inhibitors for treating neurodegenerative diseases
US20020147197A1 (en) * 1999-10-08 2002-10-10 Newman Michael J. Methods and compositions for enhancing pharmaceutical treatments
PL355912A1 (en) 1999-11-22 2004-05-31 Smithkline Beecham Plc. Novel compounds
AU1783201A (en) 1999-11-23 2001-06-04 Smithkline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
US6759410B1 (en) * 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
ES2249309T3 (es) 1999-11-23 2006-04-01 Smithkline Beecham Corp Compuestos de 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de csbp/p39 kinasa.
JP2003514899A (ja) 1999-11-23 2003-04-22 スミスクライン・ビーチャム・コーポレイション ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４‐ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物
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JP4524072B2 (ja) 2000-10-23 2010-08-11 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 新規化合物
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US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
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US7041685B2 (en) * 2001-06-08 2006-05-09 Cytovia, Inc. Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
EP1432703A1 (fr) * 2001-09-05 2004-06-30 Smithkline Beecham Plc Derives heterocycles de carboxamide utilises comme inhibiteurs de raf kinase
US7329401B2 (en) * 2002-04-15 2008-02-12 The Regents Of The University Of California Cyclooxygenase-2 selective agents useful as imaging probes and related methods
WO2004005264A2 (fr) * 2002-07-05 2004-01-15 Axxima Pharmaceuticals Ag Composes d'imidazole et proteines cellulaires humaines caseine kinase i alpha, delta et epsilon utilises comme cible lors d'interventions medicales contre des infections par le virus de l'hepatite c
OA12928A (en) * 2002-09-18 2006-10-13 Pfizer Prod Inc Novel imidazole compounds as transforming growth factor (TGF) inhibitors.
US7144876B2 (en) * 2002-12-18 2006-12-05 Cytovia, Inc. 3,5-Disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
PE20061351A1 (es) 2005-03-25 2007-01-14 Glaxo Group Ltd COMPUESTOS 8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA 2,4,8-TRISUSTITUIDOS COMO INHIBIDORES DE LA QUINASA CSBP/RK/p38
KR100694181B1 (ko) * 2005-11-25 2007-03-12 연세대학교 산학협력단 근원세포 또는 근섬유로부터 신경세포 분화를 유도하는화합물, 이를 포함하는 약학적 조성물, 신경세포 분화를유도하는 방법 및 신경세포 분화를 유도하는 화합물을검색하는 스크리닝 방법
KR101408517B1 (ko) 2008-03-21 2014-06-17 노파르티스 아게 신규한 헤테로시클릭 화합물 및 그의 용도
US8865732B2 (en) 2008-03-21 2014-10-21 Novartis Ag Heterocyclic compounds and uses thereof
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
BR112018009906B1 (pt) * 2015-11-18 2022-05-31 Monsanto Technology Llc Método para controle de pragas de inseto, semente tratada, e composição de tratamento
CN109715163B (zh) 2016-09-19 2022-11-22 诺华股份有限公司 包含raf抑制剂和erk抑制剂的治疗组合
CN111057043B (zh) * 2019-11-29 2021-11-02 深圳市贝加电子材料有限公司 咪唑类化合物及其制备方法、应用和含有其的有机可焊保护剂及表面处理方法
US11939298B1 (en) * 2023-10-25 2024-03-26 King Faisal University 5-(4,5-bis(4-bromophenyl)-2-(4-chlorophenyl)-1H-imidazol-1-yl)pentanoic acid as an antimicrobial compound

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7017486A (fr) * 1969-12-15 1971-06-17

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0859771A1 (fr) * 1995-10-31 1998-08-26 Merck & Co., Inc. Pyrroles de pyridyle substitues, compositions contenant de tels composes et mode d'utilisation
EP0859771A4 (fr) * 1995-10-31 2000-03-15 Merck & Co Inc Pyrroles de pyridyle substitues, compositions contenant de tels composes et mode d'utilisation
WO1999001128A1 (fr) * 1997-07-03 1999-01-14 Neurogen Corporation Certains derives diarylimidazoles; nouvelle classe de ligands specifiques de neuropeptide y (npy)
US6121260A (en) * 1997-07-03 2000-09-19 Neurogen Corporation Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives
US6515133B1 (en) 1997-07-03 2003-02-04 Neurogen Corporation Pharmaceutical compositions containing certain diarylimidazole derivatives
FR2823747A1 (fr) * 2001-04-24 2002-10-25 Oreal Nouveaux composes de la famille des 3-alkyl-(4,5 diphenyl- imidazol-1-yl) et leur utilisation comme anti-inflammatoires
WO2002085863A1 (fr) * 2001-04-24 2002-10-31 L'oreal Composes de la famille des 3-alkyl-(4, 5 diphenyl-imidazol-1-yl) et leur utilisation comme apaisants
CN1330637C (zh) * 2001-04-24 2007-08-08 莱雅公司 1－(3－烷基)－4,5－二苯基咪唑族化合物以及其作为镇静剂的应用

Also Published As

Publication number Publication date
GB1347893A (en) 1974-02-27
CA978960A (en) 1975-12-02
CH551416A (fr) 1974-07-15
AT324327B (de) 1975-08-25
AU3474471A (en) 1973-05-03
AU465501B2 (en) 1975-10-02
NL7115493A (fr) 1972-05-18
FR2113861B1 (fr) 1975-03-14
US3772441A (en) 1973-11-13
SE401504B (sv) 1978-05-16
US3707475A (en) 1972-12-26
BE775028A (fr) 1972-05-08
DE2155558A1 (fr) 1972-06-29
DE2155558C2 (de) 1982-08-26
NL170143C (nl) 1982-10-01
AT317201B (de) 1974-08-26
NL170143B (nl) 1982-05-03

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