BE775028A - Imidazoles anti-inflammatoires - Google Patents

Imidazoles anti-inflammatoires

Info

Publication number
BE775028A
BE775028A BE775028A BE775028A BE775028A BE 775028 A BE775028 A BE 775028A BE 775028 A BE775028 A BE 775028A BE 775028 A BE775028 A BE 775028A BE 775028 A BE775028 A BE 775028A
Authority
BE
Belgium
Prior art keywords
imidazoles
inflammatory
inflammatory imidazoles
Prior art date
Application number
BE775028A
Other languages
English (en)
French (fr)
Inventor
J G Lombardino
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BE775028A publication Critical patent/BE775028A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE775028A 1970-11-16 1971-11-08 Imidazoles anti-inflammatoires BE775028A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9007770A 1970-11-16 1970-11-16
US25152272A 1972-05-08 1972-05-08

Publications (1)

Publication Number Publication Date
BE775028A true BE775028A (fr) 1972-05-08

Family

ID=26781885

Family Applications (1)

Application Number Title Priority Date Filing Date
BE775028A BE775028A (fr) 1970-11-16 1971-11-08 Imidazoles anti-inflammatoires

Country Status (11)

Country Link
US (2) US3707475A (de)
AT (2) AT324327B (de)
AU (1) AU465501B2 (de)
BE (1) BE775028A (de)
CA (1) CA978960A (de)
CH (1) CH551416A (de)
DE (1) DE2155558C2 (de)
FR (1) FR2113861B1 (de)
GB (1) GB1347893A (de)
NL (1) NL170143C (de)
SE (1) SE401504B (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382945A (en) 1980-04-29 1983-05-10 Hoffmann-La Roche Inc. Tetrahydrothiepino[4,5-d]imidazole derivatives, composition and method of use
US4582844A (en) * 1980-06-05 1986-04-15 Hoffmann-La Roche Inc. Antithrombotic 4,5 di-t-butyl-imidazole derivatives

Families Citing this family (116)

* Cited by examiner, † Cited by third party
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US3940486A (en) * 1971-05-10 1976-02-24 Ciba-Geigy Corporation Imidazole derivatives in the treatment of pain
US3929807A (en) * 1971-05-10 1975-12-30 Ciba Geigy Corp 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles
SE428686B (sv) * 1975-08-11 1983-07-18 Du Pont Forfarande for framstellning av antiinflammatoriskt aktiva imidazoler
US4190666A (en) * 1975-08-11 1980-02-26 E. I. Du Pont De Nemours And Company Anti-inflammatory 4,5-diarly-2-(substituted-thio)imidazoles and their corresponding sulfoxides and sulfones
US4182769A (en) * 1977-02-09 1980-01-08 E. I. Du Pont De Nemours And Company Anti-inflammatory 1-substituted-4,5-diaryl-2-(substituted-thio) imidazoles and their corresponding sulfoxides and sulfones
US4159338A (en) * 1977-02-09 1979-06-26 E. I. Du Pont De Nemours And Company Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones
US4139708A (en) * 1977-05-24 1979-02-13 Sk&F Lab Co. Intermediates and processes useful for preparing medicinal agents imidazolemethylphosphonium salts
US4199592A (en) * 1978-08-29 1980-04-22 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-nitroimidazoles
US4215135A (en) * 1979-06-08 1980-07-29 E. I. Du Pont De Nemours And Company Antiinflammatory 2-substituted-1H-phenanthro[9,10-d]imidazoles
US4314844A (en) * 1979-01-11 1982-02-09 Rohm And Haas Company Herbicidal substituted imidazoles
US4424229A (en) 1979-04-23 1984-01-03 A/S Dumex (Dumex Ltd.) Fluorine containing 2,4,5-triphenylimidazoles
US4246263A (en) 1979-10-15 1981-01-20 Pfizer Inc. Antiinflammatory and immunoregulatory pyrimidines, their method of use and pharmaceutical compositions
DK513580A (da) * 1980-01-07 1981-07-08 Du Pont Fremgangsmaade til fremstilling af 4,5-diaryl-alfa (polyhalogenalkyl)-1h-imidazol-2-methanoler
US4348404A (en) * 1980-07-21 1982-09-07 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-α-polyfluoroalkyl-1H-imidazole-2-methanamines
US4372964A (en) * 1980-10-30 1983-02-08 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-1H-imidazole-2-methanols
US4330552A (en) * 1980-11-06 1982-05-18 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-arylthioimidazoles
JPS57150667A (en) * 1981-02-12 1982-09-17 Wellcome Found Antithrombotic
DE3141063A1 (de) * 1981-10-13 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4477463A (en) * 1982-05-10 1984-10-16 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic 1-alkyl-4,5-diaryl-2-fluoroalkyl-1H-pyrroles
US4503065A (en) * 1982-08-03 1985-03-05 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl 1-2-halo imidazoles
US4686231A (en) * 1985-12-12 1987-08-11 Smithkline Beckman Corporation Inhibition of 5-lipoxygenase products
IL83467A0 (en) * 1986-08-15 1988-01-31 Fujisawa Pharmaceutical Co Imidazole derivatives,processes for their preparation and pharmaceutical compositions containing the same
US4780470A (en) * 1986-08-19 1988-10-25 Smithkline Beckman Corporation Inhibition of interleukin-1 by monocytes and/or macrophages
JPH02101065A (ja) * 1988-10-06 1990-04-12 Tanabe Seiyaku Co Ltd イミダゾリン誘導体及びその製法
US5208015A (en) * 1991-07-23 1993-05-04 Bristol-Myers Squibb Company Topical anti-fungal agents having anti-inflammatory activity
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
ES2053401B1 (es) * 1992-01-13 1995-03-01 Smithkline Beecham Corp Compuestos de imidazol y procedimientos para su prepacion.
US5656644A (en) * 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
IL104369A0 (en) * 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
US6008235A (en) * 1992-01-13 1999-12-28 Smithkline Beecham Corporation Pyridyl substituted imidazoles
US5716972A (en) * 1993-01-13 1998-02-10 Smithkline Beecham Corporation Pyridyl substituted imidazoles
US5593992A (en) * 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
US5670527A (en) * 1993-07-16 1997-09-23 Smithkline Beecham Corporation Pyridyl imidazole compounds and compositions
US5593991A (en) * 1993-07-16 1997-01-14 Adams; Jerry L. Imidazole compounds, use and process of making
IL110296A (en) * 1993-07-16 1999-12-31 Smithkline Beecham Corp Imidazole compounds process for their preparation and pharmaceutical compositions containing them
ZA945363B (en) * 1993-07-21 1995-03-14 Smithkline Beecham Corp Novel compounds
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US6426360B1 (en) 1994-07-28 2002-07-30 G D Searle & Co. 4,5-substituted imidazolyl compounds for the treatment of inflammation
US5620999A (en) * 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
CN1145623C (zh) * 1994-12-13 2004-04-14 霍夫曼-拉罗奇有限公司 咪唑衍生物
WO1996038418A1 (en) 1995-06-02 1996-12-05 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US6515014B2 (en) 1995-06-02 2003-02-04 G. D. Searle & Co. Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US6512121B2 (en) 1998-09-14 2003-01-28 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US5700826A (en) * 1995-06-07 1997-12-23 Ontogen Corporation 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
US5739143A (en) * 1995-06-07 1998-04-14 Smithkline Beecham Corporation Imidazole compounds and compositions
US6369068B1 (en) 1995-06-07 2002-04-09 Smithkline Beecham Corporation Amino substituted pyrimidine containing compounds
IL118544A (en) 1995-06-07 2001-08-08 Smithkline Beecham Corp History of imidazole, the process for their preparation and the pharmaceutical preparations containing them
US6083949A (en) * 1995-10-06 2000-07-04 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
US5717100A (en) * 1995-10-06 1998-02-10 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
JPH11514651A (ja) * 1995-10-31 1999-12-14 メルク エンド カンパニー インコーポレーテッド 置換ピリジルピロール、前記化合物を含む組成物及び使用方法
ZA9610687B (en) * 1995-12-22 1997-09-29 Smithkline Beecham Corp Novel synthesis.
ZA97175B (en) * 1996-01-11 1997-11-04 Smithkline Beecham Corp Novel substituted imidazole compounds.
AU715900B2 (en) * 1996-01-11 2000-02-10 Smithkline Beecham Corporation Novel substituted imidazole compounds
AP9700912A0 (en) 1996-01-11 1997-01-31 Smithkline Beecham Corp Novel cycloalkyl substituted imidazoles
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
US6096739A (en) * 1996-03-25 2000-08-01 Smithkline Beecham Corporation Treatment for CNS injuries
US6235760B1 (en) 1996-03-25 2001-05-22 Smithkline Beecham Corporation Treatment for CNS injuries
US6677364B2 (en) 1998-04-20 2004-01-13 G.D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
JP3418624B2 (ja) * 1996-06-10 2003-06-23 メルク エンド カンパニー インコーポレーテッド サイトカイン阻害活性を有する置換イミダゾール類
WO1998007425A1 (en) 1996-08-21 1998-02-26 Smithkline Beecham Corporation Imidazole compounds, compositions and use
US5880139A (en) * 1996-11-20 1999-03-09 Merck & Co., Inc. Triaryl substituted imidazoles as glucagon antagonists
AU728760B2 (en) * 1996-11-20 2001-01-18 Merck & Co., Inc. Triaryl substituted imidazoles, compositions containing such compounds and methods of use
CA2271941A1 (en) * 1996-11-20 1998-05-28 Merck & Co., Inc. Triaryl substituted imidazoles and methods of use
WO1998022109A1 (en) * 1996-11-20 1998-05-28 Merck & Co., Inc. Triaryl substituted imidazoles as glucagon antagonists
US5929076A (en) * 1997-01-10 1999-07-27 Smithkline Beecham Corporation Cycloalkyl substituted imidazoles
US20030050330A1 (en) * 1997-01-10 2003-03-13 G.D. Searle & Co. 4,5-subtstituted imdazolyl compounds for the treatment of inflammation
CZ9904452A3 (cs) 1997-06-12 2002-02-13 Rhone-Poulenc Rorer Limited Cyklické acetaly imidazolylu, způsob jejich přípravy, jejich pouľití a farmaceutický prostředek, který je obsahuje
AU7966198A (en) 1997-06-13 1998-12-30 Smithkline Beecham Corporation Novel pyrazole and pyrazoline substituted compounds
US6610695B1 (en) 1997-06-19 2003-08-26 Smithkline Beecham Corporation Aryloxy substituted pyrimidine imidazole compounds
KR20010014288A (ko) * 1997-06-30 2001-02-26 오르토-맥네일 파마슈티칼, 인코퍼레이티드 염증성 질환의 치료에 유용한 2-치환된 이미다졸
US7301021B2 (en) * 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
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AU8381098A (en) 1997-07-02 1999-01-25 Smithkline Beecham Corporation Novel cycloalkyl substituted imidazoles
US6562832B1 (en) 1997-07-02 2003-05-13 Smithkline Beecham Corporation Substituted imidazole compounds
US6489325B1 (en) 1998-07-01 2002-12-03 Smithkline Beecham Corporation Substituted imidazole compounds
HUP0003934A3 (en) * 1997-07-03 2002-01-28 Pfizer A part of diaryl imidazole derivatives, pharmaceutical composit
US5840721A (en) * 1997-07-09 1998-11-24 Ontogen Corporation Imidazole derivatives as MDR modulators
AR017219A1 (es) 1997-12-19 2001-08-22 Smithkline Beecham Corp Derivados de imidazol 1,4,5 sustituidos, composiciones que los comprenden, procedimiento para la preparacion de dichos derivados, uso de los derivados parala manufactura de un medicamento
WO1999048873A1 (en) * 1998-03-25 1999-09-30 Bristol-Myers Squibb Company Imidazolone anorectic agents: i. acyclic derivatives
JP2002516322A (ja) 1998-05-22 2002-06-04 スミスクライン・ビーチャム・コーポレイション 新規２−アルキル置換イミダゾール化合物
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
EP1112070B1 (de) 1998-08-20 2004-05-12 Smithkline Beecham Corporation Neue substituierte triazolverbindungen
DE69914357T2 (de) 1998-11-04 2004-11-11 Smithkline Beecham Corp. Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
US6239279B1 (en) 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
US6288089B1 (en) 1998-12-21 2001-09-11 Michael Zawada Use of kinase inhibitors for treating neurodegenerative diseases
US20020147197A1 (en) * 1999-10-08 2002-10-10 Newman Michael J. Methods and compositions for enhancing pharmaceutical treatments
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ES2241675T3 (es) 1999-11-23 2005-11-01 Smithkline Beecham Corporation Compuestos de 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de cspb/p38 quinasa.
WO2001038312A1 (en) 1999-11-23 2001-05-31 Smithkline Beecham Corporation 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/p38 KINASE INHIBITORS
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FR2823747B1 (fr) * 2001-04-24 2003-05-23 Oreal Nouveaux composes de la famille des 3-alkyl-(4,5 diphenyl- imidazol-1-yl) et leur utilisation comme anti-inflammatoires
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US7329401B2 (en) * 2002-04-15 2008-02-12 The Regents Of The University Of California Cyclooxygenase-2 selective agents useful as imaging probes and related methods
AU2003249977A1 (en) * 2002-07-05 2004-01-23 Axxima Pharmaceuticals Ag Imidazole compounds for the treatment of hepatitis c virus infections
EA200500378A1 (ru) * 2002-09-18 2005-08-25 Пфайзер Продактс Инк. Новые соединения имидазола в качестве ингибиторов трансформирующего фактора роста (tgf)
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KR100694181B1 (ko) * 2005-11-25 2007-03-12 연세대학교 산학협력단 근원세포 또는 근섬유로부터 신경세포 분화를 유도하는화합물, 이를 포함하는 약학적 조성물, 신경세포 분화를유도하는 방법 및 신경세포 분화를 유도하는 화합물을검색하는 스크리닝 방법
US8865732B2 (en) 2008-03-21 2014-10-21 Novartis Ag Heterocyclic compounds and uses thereof
KR101408517B1 (ko) * 2008-03-21 2014-06-17 노파르티스 아게 신규한 헤테로시클릭 화합물 및 그의 용도
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
CN108349953B (zh) * 2015-11-18 2022-06-17 孟山都技术公司 杀虫组合物和方法
AU2017329090B9 (en) 2016-09-19 2019-09-05 Novartis Ag Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor
JP7309614B2 (ja) 2017-05-02 2023-07-18 ノバルティス アーゲー 組み合わせ療法
CN111057043B (zh) * 2019-11-29 2021-11-02 深圳市贝加电子材料有限公司 咪唑类化合物及其制备方法、应用和含有其的有机可焊保护剂及表面处理方法
US11939298B1 (en) * 2023-10-25 2024-03-26 King Faisal University 5-(4,5-bis(4-bromophenyl)-2-(4-chlorophenyl)-1H-imidazol-1-yl)pentanoic acid as an antimicrobial compound

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7017486A (de) * 1969-12-15 1971-06-17

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382945A (en) 1980-04-29 1983-05-10 Hoffmann-La Roche Inc. Tetrahydrothiepino[4,5-d]imidazole derivatives, composition and method of use
US4493841A (en) * 1980-04-29 1985-01-15 Hoffmann-La Roche Inc. Blood-platelet aggregation inhibiting 4,5,7,8-tetrahydro-4,4,8,8-tetramethyl-2-thienyl-1H-thiepino[4,5-d]imidazole derivatives
US4582844A (en) * 1980-06-05 1986-04-15 Hoffmann-La Roche Inc. Antithrombotic 4,5 di-t-butyl-imidazole derivatives

Also Published As

Publication number Publication date
DE2155558A1 (de) 1972-06-29
FR2113861B1 (de) 1975-03-14
GB1347893A (en) 1974-02-27
CH551416A (fr) 1974-07-15
SE401504B (sv) 1978-05-16
NL7115493A (de) 1972-05-18
NL170143B (nl) 1982-05-03
CA978960A (en) 1975-12-02
US3707475A (en) 1972-12-26
US3772441A (en) 1973-11-13
NL170143C (nl) 1982-10-01
AU3474471A (en) 1973-05-03
FR2113861A1 (de) 1972-06-30
DE2155558C2 (de) 1982-08-26
AT324327B (de) 1975-08-25
AU465501B2 (en) 1975-10-02
AT317201B (de) 1974-08-26

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: PFIZER INC.

Effective date: 19871130