BE628212A - - Google Patents
Info
- Publication number
- BE628212A BE628212A BE628212DA BE628212A BE 628212 A BE628212 A BE 628212A BE 628212D A BE628212D A BE 628212DA BE 628212 A BE628212 A BE 628212A
- Authority
- BE
- Belgium
- Prior art keywords
- cells
- virus
- bhk
- culture
- foot
- Prior art date
Links
- 210000004027 cells Anatomy 0.000 claims description 92
- 241000700605 Viruses Species 0.000 claims description 49
- 239000002609 media Substances 0.000 claims description 20
- 210000002966 Serum Anatomy 0.000 claims description 10
- 229960005486 vaccines Drugs 0.000 claims description 9
- 241000710198 Foot-and-mouth disease virus Species 0.000 claims description 8
- 210000003734 Kidney Anatomy 0.000 claims description 8
- 241001505332 Polyomavirus sp. Species 0.000 claims description 8
- 235000015097 nutrients Nutrition 0.000 claims description 8
- 239000000725 suspension Substances 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 7
- 239000010452 phosphate Substances 0.000 claims description 7
- 210000000630 fibrocyte Anatomy 0.000 claims description 6
- 239000001963 growth media Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 241000283690 Bos taurus Species 0.000 claims description 5
- 241000699673 Mesocricetus auratus Species 0.000 claims description 5
- 229940029983 VITAMINS Drugs 0.000 claims description 5
- 229940021016 Vitamin IV solution additives Drugs 0.000 claims description 5
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 238000004113 cell culture Methods 0.000 claims description 5
- 235000013343 vitamin Nutrition 0.000 claims description 5
- 239000011782 vitamin Substances 0.000 claims description 5
- 229930003231 vitamins Natural products 0.000 claims description 5
- 241000699800 Cricetinae Species 0.000 claims description 3
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 claims description 2
- 239000012531 culture fluid Substances 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 241000272184 Falconiformes Species 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000010410 layer Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 241000711404 Avian avulavirus 1 Species 0.000 description 3
- 241000712469 Fowl plague virus Species 0.000 description 3
- 206010044325 Trachoma Diseases 0.000 description 3
- 241000390203 Trachoma Species 0.000 description 3
- 210000003292 kidney cell Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- UCSJYZPVAKXKNQ-HZYVHMACSA-N 1-[(1S,2R,3R,4S,5R,6R)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 208000009889 Herpes Simplex Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000700584 Simplexvirus Species 0.000 description 2
- 241000282898 Sus scrofa Species 0.000 description 2
- 238000005273 aeration Methods 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000002458 infectious Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000000717 retained Effects 0.000 description 2
- 239000012588 trypsin Substances 0.000 description 2
- 230000003612 virological Effects 0.000 description 2
- 229940064005 Antibiotic throat preparations Drugs 0.000 description 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 description 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 description 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 description 1
- 210000000481 Breast Anatomy 0.000 description 1
- 101700027702 CYSD1 Proteins 0.000 description 1
- 210000003837 Chick Embryo Anatomy 0.000 description 1
- 241000725619 Dengue virus Species 0.000 description 1
- 241001492218 Foot-and-mouth disease virus - type SAT 2 Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 description 1
- 208000006572 Human Influenza Diseases 0.000 description 1
- 206010022000 Influenza Diseases 0.000 description 1
- 241000712431 Influenza A virus Species 0.000 description 1
- 102000004407 Lactalbumin Human genes 0.000 description 1
- 108090000942 Lactalbumin Proteins 0.000 description 1
- 229940049954 Penicillin Drugs 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 101710043164 Segment-4 Proteins 0.000 description 1
- 229960005322 Streptomycin Drugs 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 101700038759 VP1 Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001058 adult Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000038129 antigens Human genes 0.000 description 1
- 108091007172 antigens Proteins 0.000 description 1
- 229960000626 benzylpenicillin Drugs 0.000 description 1
- 230000003115 biocidal Effects 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000000875 corresponding Effects 0.000 description 1
- 230000000120 cytopathologic Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 229910001651 emery Inorganic materials 0.000 description 1
- 230000029578 entry into host Effects 0.000 description 1
- 230000003328 fibroblastic Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 101700005460 hemA Proteins 0.000 description 1
- 239000000185 hemagglutinin Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 200000000003 influenza A Diseases 0.000 description 1
- 229940079866 intestinal antibiotics Drugs 0.000 description 1
- 238000011031 large scale production Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- ZDFDJJJGIRGMBE-AFARJNEBSA-N nystatin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)OC1OC1/C=C/C=C/C=C/C=C/CC/C=C/C=C/C(C)C(O)C(C)C(C)OC(=O)CC(O)CC(O)CC(O)CCC(O)C(O)CC(=O)CC(O)C(C(O)=O)C(O)C1 ZDFDJJJGIRGMBE-AFARJNEBSA-N 0.000 description 1
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N p-acetaminophenol Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000000644 propagated Effects 0.000 description 1
- 239000005297 pyrex Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000000405 serological Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000004114 suspension culture Methods 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
- C12N2770/32161—Methods of inactivation or attenuation
- C12N2770/32164—Methods of inactivation or attenuation by serial passage
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE628212A true BE628212A (pt) |
Family
ID=198197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE628212D BE628212A (pt) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE628212A (pt) |
-
0
- BE BE628212D patent/BE628212A/fr unknown
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