BE567850A - - Google Patents
Info
- Publication number
- BE567850A BE567850A BE567850DA BE567850A BE 567850 A BE567850 A BE 567850A BE 567850D A BE567850D A BE 567850DA BE 567850 A BE567850 A BE 567850A
- Authority
- BE
- Belgium
- Prior art keywords
- antibiotic
- exchange resin
- ion exchange
- resin
- fermentation
- Prior art date
Links
- 239000011347 resin Substances 0.000 claims description 55
- 229920005989 resin Polymers 0.000 claims description 55
- 238000000855 fermentation Methods 0.000 claims description 48
- 230000004151 fermentation Effects 0.000 claims description 48
- 230000003115 biocidal Effects 0.000 claims description 46
- 239000003456 ion exchange resin Substances 0.000 claims description 25
- 229920003303 ion-exchange polymer Polymers 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 21
- 239000003242 anti bacterial agent Substances 0.000 claims description 20
- YJQPYGGHQPGBLI-KGSXXDOSSA-N Cathomycin Chemical compound O1C(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@@H](O)[C@@H]1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-KGSXXDOSSA-N 0.000 claims description 13
- 229960002950 Novobiocin Drugs 0.000 claims description 12
- 230000002378 acidificating Effects 0.000 claims description 8
- 238000000926 separation method Methods 0.000 claims description 8
- 239000003729 cation exchange resin Substances 0.000 claims description 5
- 238000003306 harvesting Methods 0.000 claims description 5
- 229960004927 neomycin Drugs 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 4
- 238000007792 addition Methods 0.000 claims description 3
- 239000003957 anion exchange resin Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 230000000717 retained Effects 0.000 claims description 2
- 229920001098 polystyrene-block-poly(ethylene/propylene) Polymers 0.000 description 37
- 235000010633 broth Nutrition 0.000 description 34
- 229940064005 Antibiotic throat preparations Drugs 0.000 description 16
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 description 16
- 229940042052 Antibiotics for systemic use Drugs 0.000 description 16
- 229940042786 Antitubercular Antibiotics Drugs 0.000 description 16
- 229940093922 Gynecological Antibiotics Drugs 0.000 description 16
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 description 16
- 229940079866 intestinal antibiotics Drugs 0.000 description 16
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 description 16
- 239000000243 solution Substances 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- UCSJYZPVAKXKNQ-HZYVHMACSA-N 1-[(1S,2R,3R,4S,5R,6R)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 5
- 229920001429 Chelating resin Polymers 0.000 description 4
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 238000010828 elution Methods 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000002955 isolation Methods 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 229920001888 polyacrylic acid Polymers 0.000 description 4
- UIPBKZGYQDPIPY-UHFFFAOYSA-N EULICIN Chemical compound NC(N)=NCCCCCCCCC(O)C(CCCN)NC(=O)CCCCCCCCN=C(N)N UIPBKZGYQDPIPY-UHFFFAOYSA-N 0.000 description 3
- 229940049954 Penicillin Drugs 0.000 description 3
- 229960005322 Streptomycin Drugs 0.000 description 3
- 229960000626 benzylpenicillin Drugs 0.000 description 3
- 238000011081 inoculation Methods 0.000 description 3
- -1 neomycin Chemical compound 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 240000005020 Acaciella glauca Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 235000003499 redwood Nutrition 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- CHRJZRDFSQHIFI-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;styrene Chemical compound C=CC1=CC=CC=C1.C=CC1=CC=CC=C1C=C CHRJZRDFSQHIFI-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N AI2O3 Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- 229940056360 Penicillin G Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 230000002421 anti-septic Effects 0.000 description 1
- 230000001174 ascending Effects 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 229940023913 cation exchange resins Drugs 0.000 description 1
- 230000005591 charge neutralization Effects 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000000875 corresponding Effects 0.000 description 1
- 239000012045 crude solution Substances 0.000 description 1
- 230000005712 crystallization Effects 0.000 description 1
- 230000000593 degrading Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- MYRTYDVEIRVNKP-UHFFFAOYSA-N divinylbenzene Substances C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000002255 enzymatic Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001264 neutralization Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 150000002829 nitrogen Chemical class 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 230000000737 periodic Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920003053 polystyrene-divinylbenzene Polymers 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000001954 sterilising Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE567850A true BE567850A (de) |
Family
ID=187420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE567850D BE567850A (de) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE567850A (de) |
-
0
- BE BE567850D patent/BE567850A/fr unknown
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