BE2010C019I2 - - Google Patents
Download PDFInfo
- Publication number
- BE2010C019I2 BE2010C019I2 BE2010C019C BE2010C019C BE2010C019I2 BE 2010C019 I2 BE2010C019 I2 BE 2010C019I2 BE 2010C019 C BE2010C019 C BE 2010C019C BE 2010C019 C BE2010C019 C BE 2010C019C BE 2010C019 I2 BE2010C019 I2 BE 2010C019I2
- Authority
- BE
- Belgium
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compression Of Band Width Or Redundancy In Fax (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0013810.7A GB0013810D0 (en) | 2000-06-06 | 2000-06-06 | Biological products |
PCT/GB2001/002477 WO2001094585A1 (en) | 2000-06-06 | 2001-06-05 | Antibody molecules having specificity for human tumor necrosis factor alpha, and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BE2010C019I2 true BE2010C019I2 (hr) | 2020-08-20 |
Family
ID=9893121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE2010C019C BE2010C019I2 (hr) | 2000-06-06 | 2010-04-13 |
Country Status (43)
Families Citing this family (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0013810D0 (en) * | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
CA2817619A1 (en) | 2001-06-08 | 2002-12-08 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
US20060073141A1 (en) * | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
GB0129105D0 (en) * | 2001-12-05 | 2002-01-23 | Celltech R&D Ltd | Expression control using variable intergenic sequences |
DE60336214D1 (de) * | 2002-03-20 | 2011-04-14 | Ucb Pharma Sa | Methoden zur analyse von antikörperdisulfidisomere |
US20040009172A1 (en) * | 2002-04-26 | 2004-01-15 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
DK1507556T3 (en) | 2002-05-02 | 2016-09-12 | Wyeth Holdings Llc | Calicheamicin derivative-carrier conjugates |
GB0210121D0 (en) * | 2002-05-02 | 2002-06-12 | Celltech R&D Ltd | Biological products |
ATE518885T1 (de) * | 2002-05-28 | 2011-08-15 | Ucb Pharma Sa | Peg-positionsisomer von einem antikorper gegen tnfalpha (cdp870) |
US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
EP2371859A3 (en) * | 2002-07-19 | 2011-12-28 | Abbott Biotechnology Ltd | Treatment of TNF alpha related disorders |
US20040091490A1 (en) * | 2002-08-28 | 2004-05-13 | Robert Johnson | Stable pH optimized formulation of a modified antibody |
WO2004019860A2 (en) * | 2002-08-28 | 2004-03-11 | Pharmacia Corporation | Formulations of modified antibodies and methods of making the same |
US20040105858A1 (en) * | 2002-08-29 | 2004-06-03 | Kim Joanne Young Hee Kwak | Diagnosis and treatment of infertility |
MY150740A (en) | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
AU2003277828B2 (en) | 2002-10-29 | 2009-06-04 | Anaphore, Inc. | Trimeric binding proteins for trimeric cytokines |
US7101978B2 (en) | 2003-01-08 | 2006-09-05 | Applied Molecular Evolution | TNF-α binding molecules |
US7575893B2 (en) * | 2003-01-23 | 2009-08-18 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
GB0303337D0 (en) * | 2003-02-13 | 2003-03-19 | Celltech R&D Ltd | Biological products |
WO2004074345A2 (en) * | 2003-02-19 | 2004-09-02 | Pharmacia Corporation | Carbonate esters of polyethylene glycol activated by means of oxalate esters |
WO2004098578A2 (en) * | 2003-05-12 | 2004-11-18 | Altana Pharma Ag | Composition comprising a pde4 inhibitor and a tnf-alfa antagonist selected from infliximab, adalimumab, cdp870 and cdp517 |
DK1639011T3 (da) * | 2003-06-30 | 2009-02-16 | Domantis Ltd | Pegylerede enkelt-domæne antistoffer (dAb) |
WO2005014649A2 (en) * | 2003-08-08 | 2005-02-17 | Pharmacia Corporation | Method for the preparation of molecules having antibody activity |
WO2005017174A2 (en) * | 2003-08-13 | 2005-02-24 | Sandoz Ag | Process for the purification of recombinant polypeptides |
DE602004004796T2 (de) * | 2003-08-13 | 2007-12-06 | Sandoz Ag | Expressionsvektoren, transformierte wirtszellen und fermentationsverfahren zur herstellung rekombinanter polypeptide |
GB0319601D0 (en) | 2003-08-20 | 2003-09-24 | Sandoz Ag | Production process |
KR100570422B1 (ko) * | 2003-10-16 | 2006-04-11 | 한미약품 주식회사 | 대장균 분비서열을 이용하여 항체 단편을 분비·생산하는 발현벡터 및 이를 이용하여 항체 단편을 대량 생산하는 방법 |
CN100393748C (zh) * | 2003-11-06 | 2008-06-11 | 上海中信国健药业有限公司 | 全人源肿瘤坏死因子抗体,其制备方法以及药物组合物 |
KR100772800B1 (ko) * | 2003-11-17 | 2007-11-01 | 주식회사유한양행 | 인간 종양괴사인자 α를 인식하는 단일클론항체의가변영역 및 이를 코딩하는 유전자 |
US7435799B2 (en) | 2004-01-08 | 2008-10-14 | Applied Molecular Evolution | TNF-α binding molecules |
CN100427504C (zh) * | 2004-06-02 | 2008-10-22 | 北京天广实生物技术有限公司 | TNFα高亲和力嵌合抗体及其用途 |
JP2008504356A (ja) * | 2004-06-30 | 2008-02-14 | ドマンティス リミテッド | 炎症性疾患を治療するための組成物及び方法 |
GB0425972D0 (en) * | 2004-11-25 | 2004-12-29 | Celltech R&D Ltd | Biological products |
WO2006062776A2 (en) * | 2004-11-29 | 2006-06-15 | The Regents Of The University Of California | Hydroxyapatite-binding peptides for bone growth and inhibition |
ES2359567T3 (es) * | 2004-12-29 | 2011-05-24 | Yuhan Corporation | Anticuerpo humanizado específico para el factor de necrosis tumoral-alfa. |
AU2006246721B2 (en) | 2005-05-16 | 2012-12-13 | Abbvie Biotechnology Ltd | Use of TNF inhibitor for treatment of erosive polyarthritis |
EP1888644A1 (en) * | 2005-06-01 | 2008-02-20 | Micromet AG | Anti-il2 antibodies |
KR101457223B1 (ko) | 2005-06-07 | 2014-11-04 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | TNFα를 억제하는 안정적이고 가용성인 항체 |
GB0520169D0 (en) | 2005-10-04 | 2005-11-09 | Celltech R&D Ltd | Biological products |
CA2648582C (en) | 2006-04-07 | 2016-12-06 | Nektar Therapeutics Al, Corporation | Conjugates of an anti-tnf-alpha antibody |
US9399061B2 (en) | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
US9605064B2 (en) | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
US9624295B2 (en) | 2006-04-10 | 2017-04-18 | Abbvie Biotechnology Ltd. | Uses and compositions for treatment of psoriatic arthritis |
US20080131374A1 (en) * | 2006-04-19 | 2008-06-05 | Medich John R | Uses and compositions for treatment of rheumatoid arthritis |
AU2007269714A1 (en) | 2006-07-03 | 2008-01-10 | Charles David Adair | Composition for modulating the expression of cell adhesion molecules |
EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
US10888521B2 (en) * | 2007-03-02 | 2021-01-12 | Farnam Companies, Inc. | Sustained release compositions using wax-like materials |
WO2008153997A1 (en) * | 2007-06-07 | 2008-12-18 | Brookwood Pharmaceuticals, Inc. | Reduced-mass, long-acting dosage forms |
WO2008154543A2 (en) | 2007-06-11 | 2008-12-18 | Abbott Biotechnology Ltd. | Methods for treating juvenile idiopathic arthritis |
WO2009026274A1 (en) * | 2007-08-22 | 2009-02-26 | Medarex, Inc. | Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions |
BRPI0907485A2 (pt) * | 2008-02-05 | 2015-08-04 | Delenex Therapeutics Ag | Polipeptídeos de ligação a antígeno contra degeneração de cartilagem |
CN102083859B (zh) * | 2008-05-07 | 2014-09-17 | 阿哥斯医疗公司 | 人源化抗人干扰素-α抗体 |
KR102007492B1 (ko) | 2008-06-25 | 2019-08-05 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | 보편적 항체 프레임워크를 사용한 래빗 항체의 인간화 |
PT2307457T (pt) * | 2008-06-25 | 2018-10-16 | Esbatech Alcon Biomed Res Unit | Anticorpos estáveis e solúveis que inibem o tnf |
EP3216803B1 (en) | 2008-06-25 | 2020-03-11 | Novartis Ag | Stable and soluble antibodies inhibiting vegf |
HUE056007T2 (hu) | 2008-06-25 | 2022-01-28 | Novartis Ag | Nyúl ellenanyagok humanizálása univerzális ellenanyagváz alkalmazásával |
CN101684156B (zh) * | 2008-09-27 | 2011-12-28 | 苏州工业园区晨健抗体组药物开发有限公司 | 人TNFα单克隆抗体、其PEG化纳米颗粒及其应用 |
US20110165063A1 (en) * | 2009-01-29 | 2011-07-07 | Abbott Laboratories | Il-1 binding proteins |
JP2012516153A (ja) * | 2009-01-29 | 2012-07-19 | アボット・ラボラトリーズ | Il−1結合タンパク質 |
HUE051430T2 (hu) | 2009-07-10 | 2021-03-01 | Ablynx Nv | Eljárás variábilis domének elõállítására |
JP6132551B2 (ja) | 2009-09-24 | 2017-05-24 | ユセベ ファルマ ソシエテ アノニム | シャペロン活性を保持するプロテアーゼ欠損DegP並びにノックアウトTsp及びptr遺伝子を持つ、組換えタンパク質発現のための細菌株 |
MX2012003198A (es) | 2009-10-23 | 2012-06-12 | Millennium Pharm Inc | Moleculas de anticuerpo anti-gcc y composiciones y metodos relacionados. |
GB201000587D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
GB201000588D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
GB201000591D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
GB201000590D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
GB201001791D0 (en) | 2010-02-03 | 2010-03-24 | Ucb Pharma Sa | Process for obtaining antibodies |
US9616120B2 (en) | 2010-03-04 | 2017-04-11 | Vet Therapeutics, Inc. | Monoclonal antibodies directed to CD20 |
WO2011109662A1 (en) | 2010-03-04 | 2011-09-09 | Vet Therapeutics, Inc. | Monoclonal antibodies directed to cd52 |
AU2011237679B2 (en) | 2010-04-07 | 2014-11-06 | Abbvie Inc. | TNF-alpha binding proteins |
GB201012603D0 (en) * | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Protein purification |
GB201012599D0 (en) | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Process for purifying proteins |
GB201012784D0 (en) * | 2010-07-29 | 2010-09-15 | Ucb Pharma Sa | Method |
TWI538918B (zh) | 2010-10-20 | 2016-06-21 | 財團法人工業技術研究院 | 人源化之單株抗體、其核苷酸序列與其用途 |
AR083495A1 (es) | 2010-10-22 | 2013-02-27 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles |
JP6175428B2 (ja) | 2011-06-01 | 2017-08-02 | イントレクソン・アクトバイオテイクス・エヌブイIntrexon Actobiotics NV | 細菌のポリシストロン性発現系 |
EP2546267A1 (en) | 2011-07-13 | 2013-01-16 | UCB Pharma S.A. | Bacterial host strain expressing recombinant DsbC |
KR102023786B1 (ko) | 2011-07-13 | 2019-09-20 | 유씨비 파마, 에스.에이. | 재조합 dsbc를 발현하는 세균 숙주 균주 |
HUE038336T2 (hu) | 2011-09-23 | 2018-10-29 | Intrexon Actobiotics Nv | Módosított gram-pozitív baktériumok és alkalmazásaik |
ES2676707T3 (es) | 2011-09-23 | 2018-07-24 | Intrexon Actobiotics Nv | Bacterias gram positivas modificadas y usos de las mismas |
WO2013087913A1 (en) | 2011-12-16 | 2013-06-20 | Synthon Biopharmaceuticals B.V. | Compounds and methods for treating inflammatory diseases |
US9156915B2 (en) | 2012-04-26 | 2015-10-13 | Thomas Jefferson University | Anti-GCC antibody molecules |
GB201208367D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Biological product |
KR20200143502A (ko) | 2012-08-13 | 2020-12-23 | 제넨테크, 인크. | 항-jagged 항체 및 사용 방법 |
JP2017518737A (ja) | 2014-04-21 | 2017-07-13 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | SYK標的治療薬のための抗pSYK抗体分子及びその使用 |
EP3220961B1 (en) | 2014-10-22 | 2023-07-05 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
US9616109B2 (en) | 2014-10-22 | 2017-04-11 | Extend Biosciences, Inc. | Insulin vitamin D conjugates |
US10626143B2 (en) | 2014-12-22 | 2020-04-21 | Ucb Biopharma Sprl | Method of protein manufacture |
EP3341021A4 (en) * | 2015-08-27 | 2019-03-13 | Celldex Therapeutics, Inc. | ANTI-ALK ANTIBODIES AND METHOD OF USE THEREOF |
GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
DK3402499T3 (da) | 2016-01-14 | 2021-09-27 | Intrexon Actobiotics Nv | Sammensætninger og fremgangsmåder til behandlingen af type 1 diabetes |
RU2680011C2 (ru) * | 2016-04-29 | 2019-02-14 | Закрытое Акционерное Общество "Биокад" | Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы |
US20180126000A1 (en) | 2016-06-02 | 2018-05-10 | Abbvie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
KR20200095477A (ko) | 2017-12-01 | 2020-08-10 | 애브비 인코포레이티드 | 글루코코르티코이드 수용체 작용제 및 이의 면역접합체 |
AU2020215795A1 (en) | 2019-01-31 | 2021-07-29 | Numab Therapeutics AG | Multispecific antibodies having specificity for TNFA and IL-17A, antibodies targeting IL-17A, and methods of use thereof |
KR102323342B1 (ko) * | 2019-04-26 | 2021-11-08 | 주식회사 와이바이오로직스 | IL-17A 및 TNF-α에 특이적으로 결합하는 이중표적 항체 |
CN111909268B (zh) * | 2019-05-07 | 2022-04-19 | 北京天成新脉生物技术有限公司 | 低免疫原性低ADCC/CDC功能抗TNF-α人源化单克隆抗体TCX060及其应用 |
TW202237638A (zh) | 2020-12-09 | 2022-10-01 | 日商武田藥品工業股份有限公司 | 烏苷酸環化酶c(gcc)抗原結合劑之組成物及其使用方法 |
TW202237639A (zh) | 2020-12-09 | 2022-10-01 | 日商武田藥品工業股份有限公司 | 鳥苷酸環化酶c(gcc)抗原結合劑之組成物及其使用方法 |
WO2022172085A2 (en) | 2021-02-15 | 2022-08-18 | Takeda Pharmaceutical Company Limited | Cell therapy compositions and methods for modulating tgf-b signaling |
EP4393937A1 (en) | 2021-08-26 | 2024-07-03 | Duality Biologics (Suzhou) Co., Ltd. | Steroid compound and conjugate thereof |
CA3232722A1 (en) | 2021-09-24 | 2023-03-30 | Kiavash MIRZADEH | Dna constructs and host cells for expressing recombinant protein |
SE545694C2 (en) * | 2021-09-24 | 2023-12-05 | Xbrane Biopharma Ab | Dna construct comprising nucleotide sequences encoding amino acid sequences of certolizumab and pelb signal peptides |
SE545714C2 (en) * | 2021-09-24 | 2023-12-19 | Xbrane Biopharma Ab | Dna contructs for producing a pelb signal peptide |
WO2023154799A1 (en) | 2022-02-14 | 2023-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Combination immunotherapy for treating cancer |
WO2024180518A1 (en) * | 2023-03-01 | 2024-09-06 | Lupin Limited | Process for manufacturing antibody fragment protein |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
DK336987D0 (da) | 1987-07-01 | 1987-07-01 | Novo Industri As | Immobiliseringsmetode |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
GB8719042D0 (en) | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
US5030570A (en) | 1988-06-30 | 1991-07-09 | The Eunice Kennedy Shriver Center For Mental Retardation | DNA encoding and method of expressing human monoamine oxidase type A |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
PT92900A (pt) * | 1989-01-24 | 1990-07-31 | Sistema de vectores de expressao para a producao de anticorpos monoclonais quimericos | |
GB8907617D0 (en) | 1989-04-05 | 1989-05-17 | Celltech Ltd | Drug delivery system |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
GB9109645D0 (en) * | 1991-05-03 | 1991-06-26 | Celltech Ltd | Recombinant antibodies |
US5919452A (en) | 1991-03-18 | 1999-07-06 | New York University | Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies |
GB9112536D0 (en) | 1991-06-11 | 1991-07-31 | Celltech Ltd | Chemical compounds |
GB9120467D0 (en) | 1991-09-26 | 1991-11-06 | Celltech Ltd | Anti-hmfg antibodies and process for their production |
NO309690B1 (no) | 1995-01-23 | 2001-03-12 | Western Atlas Int Inc | Detonasjonsanordning av type eksploderende brotråd for bruk med et perforeringsverktöy i en brönn |
EP0871641A4 (en) | 1995-04-20 | 2001-09-26 | Kennedy Inst Of Rheumatology | MULTIPLE ADMINISTRATION OF ANTI-TNF ANTIBODIES |
NZ512006A (en) | 1996-02-09 | 2005-05-27 | Abbott Biotech Ltd | Medical treatment with human TNF-alpha antibodies |
US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
GB9625640D0 (en) * | 1996-12-10 | 1997-01-29 | Celltech Therapeutics Ltd | Biological products |
AU9262598A (en) * | 1997-08-18 | 1999-03-08 | Innogenetics N.V. | Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders |
GB9720054D0 (en) * | 1997-09-19 | 1997-11-19 | Celltech Therapeutics Ltd | Biological products |
JP4078032B2 (ja) | 1998-03-12 | 2008-04-23 | ネクター セラピューティックス エイエル,コーポレイション | 近位の反応性基を持つポリ(エチレングリコール)誘導体 |
GB9812545D0 (en) * | 1998-06-10 | 1998-08-05 | Celltech Therapeutics Ltd | Biological products |
GB0013810D0 (en) | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
-
2000
- 2000-06-06 GB GBGB0013810.7A patent/GB0013810D0/en not_active Ceased
-
2001
- 2001-06-05 EP EP16154916.7A patent/EP3059314B1/en not_active Expired - Lifetime
- 2001-06-05 OA OA1200200368A patent/OA12282A/en unknown
- 2001-06-05 EP EP01934209A patent/EP1287140B1/en not_active Expired - Lifetime
- 2001-06-05 SI SI200130960T patent/SI1287140T1/sl unknown
- 2001-06-05 LT LTEP10010795.2T patent/LT2308975T/lt unknown
- 2001-06-05 ES ES200250012A patent/ES2230975B2/es not_active Expired - Lifetime
- 2001-06-05 EP EP09176251A patent/EP2230308B1/en not_active Expired - Lifetime
- 2001-06-05 DK DK16154916.7T patent/DK3059314T3/en active
- 2001-06-05 DE DE10192353T patent/DE10192353T1/de not_active Withdrawn
- 2001-06-05 JP JP2002502126A patent/JP4064812B2/ja not_active Expired - Lifetime
- 2001-06-05 PT PT16154916T patent/PT3059314T/pt unknown
- 2001-06-05 CN CNB018016294A patent/CN1289671C/zh not_active Expired - Lifetime
- 2001-06-05 DE DE60140738T patent/DE60140738D1/de not_active Expired - Lifetime
- 2001-06-05 EP EP10010795.2A patent/EP2308975B1/en not_active Expired - Lifetime
- 2001-06-05 CZ CZ20020837A patent/CZ300737B6/cs not_active IP Right Cessation
- 2001-06-05 HU HUP1600483A patent/HU230669B1/hu unknown
- 2001-06-05 ES ES01934209T patent/ES2337763T3/es not_active Expired - Lifetime
- 2001-06-05 AP APAP/P/2002/002690A patent/AP2092A/en active
- 2001-06-05 MX MXPA01013440A patent/MXPA01013440A/es active IP Right Grant
- 2001-06-05 NZ NZ516596A patent/NZ516596A/en not_active IP Right Cessation
- 2001-06-05 PL PL399351A patent/PL218516B1/pl unknown
- 2001-06-05 SK SK315-2002A patent/SK288343B6/sk not_active IP Right Cessation
- 2001-06-05 RU RU2002105922/13A patent/RU2303604C2/ru active Protection Beyond IP Right Term
- 2001-06-05 AU AU60511/01A patent/AU783756B2/en active Active
- 2001-06-05 BR BR0106682-0A patent/BR0106682A/pt not_active IP Right Cessation
- 2001-06-05 CA CA2707766A patent/CA2707766C/en not_active Expired - Lifetime
- 2001-06-05 DE DE122010000027C patent/DE122010000027I1/de active Pending
- 2001-06-05 DK DK10010795.2T patent/DK2308975T3/da active
- 2001-06-05 MY MYPI20012634A patent/MY136603A/en unknown
- 2001-06-05 CA CA2380298A patent/CA2380298C/en not_active Expired - Lifetime
- 2001-06-05 SI SI200131056A patent/SI2308975T1/sl unknown
- 2001-06-05 ES ES10010795.2T patent/ES2600080T3/es not_active Expired - Lifetime
- 2001-06-05 DK DK09176251.8T patent/DK2230308T3/da active
- 2001-06-05 PL PL353960A patent/PL212738B1/pl unknown
- 2001-06-05 WO PCT/GB2001/002477 patent/WO2001094585A1/en active Application Filing
- 2001-06-05 HU HU1600016A patent/HU230553B1/hu unknown
- 2001-06-05 SI SI200131020T patent/SI2230308T1/sl unknown
- 2001-06-05 HU HU0202346A patent/HU230561B1/hu active Protection Beyond IP Right Term
- 2001-06-05 PT PT01934209T patent/PT1287140E/pt unknown
- 2001-06-05 BR BRPI0106682A patent/BRPI0106682B8/pt not_active IP Right Cessation
- 2001-06-05 GB GB0128386A patent/GB2366800B/en not_active Expired - Lifetime
- 2001-06-05 KR KR1020027001131A patent/KR20020047097A/ko active Search and Examination
- 2001-06-05 ES ES09176251T patent/ES2403217T3/es not_active Expired - Lifetime
- 2001-06-05 DK DK01934209.6T patent/DK1287140T3/da active
- 2001-06-05 PT PT100107952T patent/PT2308975T/pt unknown
- 2001-06-05 ES ES16154916T patent/ES2707714T3/es not_active Expired - Lifetime
- 2001-06-05 IL IL14799201A patent/IL147992A0/xx unknown
- 2001-06-05 AT AT01934209T patent/ATE451460T1/de active
- 2001-06-05 TR TR2019/00227T patent/TR201900227T4/tr unknown
- 2001-06-05 PT PT91762518T patent/PT2230308E/pt unknown
- 2001-06-06 AR ARP010102689A patent/AR033978A1/es active IP Right Grant
- 2001-06-06 US US09/875,221 patent/US7012135B2/en not_active Expired - Lifetime
- 2001-06-06 TW TW090113707A patent/TWI316088B/zh active
- 2001-06-06 PE PE2001000529A patent/PE20020292A1/es active IP Right Grant
- 2001-06-06 TW TW096150671A patent/TWI353358B/zh not_active IP Right Cessation
- 2001-09-10 US US09/949,559 patent/US7186820B2/en not_active Expired - Lifetime
-
2002
- 2002-01-03 IS IS6217A patent/IS2808B/is unknown
- 2002-01-04 BG BG106278A patent/BG66072B1/bg unknown
- 2002-01-04 ZA ZA200200097A patent/ZA200200097B/xx unknown
- 2002-02-04 IL IL147992A patent/IL147992A/en active IP Right Grant
- 2002-02-04 NO NO20020554A patent/NO334808B1/no not_active IP Right Cessation
- 2002-02-06 EC EC2002004210A patent/ECSP024210A/es unknown
-
2003
- 2003-05-22 HK HK03103635.2A patent/HK1051385A1/xx not_active IP Right Cessation
-
2006
- 2006-03-13 US US11/374,231 patent/US7402662B2/en not_active Expired - Lifetime
- 2006-10-19 JP JP2006285205A patent/JP4476989B2/ja not_active Expired - Lifetime
-
2008
- 2008-06-18 US US12/141,667 patent/US7977464B2/en not_active Expired - Fee Related
- 2008-11-03 IL IL195085A patent/IL195085A0/en unknown
-
2009
- 2009-01-09 JP JP2009003953A patent/JP5185143B2/ja not_active Expired - Lifetime
-
2010
- 2010-03-09 CY CY20101100219T patent/CY1109889T1/el unknown
- 2010-03-15 FR FR10C0015C patent/FR10C0015I2/fr active Active
- 2010-03-29 LU LU91674C patent/LU91674I2/fr unknown
- 2010-04-13 BE BE2010C019C patent/BE2010C019I2/fr unknown
- 2010-05-13 CY CY2010011C patent/CY2010011I1/el unknown
-
2011
- 2011-03-22 HK HK11102887.9A patent/HK1148776A1/xx not_active IP Right Cessation
- 2011-11-18 IS IS8986A patent/IS3016B/is unknown
-
2013
- 2013-04-23 CY CY20131100333T patent/CY1114143T1/el unknown
- 2013-10-01 NO NO20131316A patent/NO339282B1/no not_active IP Right Cessation
-
2014
- 2014-10-23 NO NO2014026C patent/NO2014026I2/no unknown
-
2016
- 2016-04-26 NO NO20160694A patent/NO341218B1/no not_active IP Right Cessation
- 2016-11-10 CY CY20161101159T patent/CY1118220T1/el unknown
-
2017
- 2017-04-06 HU HUS1700013C patent/HUS1700013I1/hu unknown
-
2019
- 2019-01-24 CY CY20191100095T patent/CY1121173T1/el unknown
- 2019-04-19 CY CY2019018C patent/CY2019018I2/el unknown
- 2019-04-24 NL NL300982C patent/NL300982I9/nl unknown