AU779653B2 - Methods for encoding and sorting in vitro translated proteins - Google Patents

Methods for encoding and sorting in vitro translated proteins

Info

Publication number
AU779653B2
AU779653B2 AU69387/00A AU6938700A AU779653B2 AU 779653 B2 AU779653 B2 AU 779653B2 AU 69387/00 A AU69387/00 A AU 69387/00A AU 6938700 A AU6938700 A AU 6938700A AU 779653 B2 AU779653 B2 AU 779653B2
Authority
AU
Australia
Prior art keywords
protein
encoding
nucleic acid
molecule
encoded
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU69387/00A
Other languages
English (en)
Other versions
AU6938700A (en
Inventor
Robert G. Kuimelis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Compound Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Compound Therapeutics Inc filed Critical Compound Therapeutics Inc
Publication of AU6938700A publication Critical patent/AU6938700A/en
Assigned to COMPOUND THERAPEUTICS, INC. reassignment COMPOUND THERAPEUTICS, INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: PHYLOS, INC.
Application granted granted Critical
Publication of AU779653B2 publication Critical patent/AU779653B2/en
Assigned to ADNEXUS THERAPEUTICS, INC. reassignment ADNEXUS THERAPEUTICS, INC. Request to Amend Deed and Register Assignors: COMPOUND THERAPEUTICS, INC.
Assigned to BRISTOL-MYERS SQUIBB COMPANY reassignment BRISTOL-MYERS SQUIBB COMPANY Alteration of Name(s) in Register under S187 Assignors: ADNEXUS THERAPEUTICS, INC.
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU69387/00A 1999-08-27 2000-08-25 Methods for encoding and sorting in vitro translated proteins Expired AU779653B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15126199P 1999-08-27 1999-08-27
US60/151261 1999-08-27
PCT/US2000/023414 WO2001016352A1 (en) 1999-08-27 2000-08-25 Methods for encoding and sorting in vitro translated proteins

Publications (2)

Publication Number Publication Date
AU6938700A AU6938700A (en) 2001-03-26
AU779653B2 true AU779653B2 (en) 2005-02-03

Family

ID=22537976

Family Applications (1)

Application Number Title Priority Date Filing Date
AU69387/00A Expired AU779653B2 (en) 1999-08-27 2000-08-25 Methods for encoding and sorting in vitro translated proteins

Country Status (6)

Country Link
US (2) US6436665B1 (cg-RX-API-DMAC7.html)
EP (1) EP1212452B1 (cg-RX-API-DMAC7.html)
JP (1) JP4803933B2 (cg-RX-API-DMAC7.html)
AU (1) AU779653B2 (cg-RX-API-DMAC7.html)
CA (1) CA2382545C (cg-RX-API-DMAC7.html)
WO (1) WO2001016352A1 (cg-RX-API-DMAC7.html)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1068356B8 (en) * 1998-04-03 2007-01-03 Adnexus Therapeutics, Inc. Addressable protein arrays
DE19923966C2 (de) * 1999-05-25 2003-04-24 Phylos Inc Erkennungssystem zur Auftrennung von Probenbestandteilen, seine Herstellung und Verwendung
CA2377468C (en) * 1999-07-27 2010-04-20 Phylos, Inc. Peptide acceptor ligation methods
CA2382545C (en) * 1999-08-27 2013-08-13 Phylos, Inc. Methods for encoding and sorting in vitro translated proteins
DE19959857C1 (de) * 1999-12-10 2001-06-28 Aventis Res & Tech Gmbh & Co Testsystem zum Nachweis von Analyten sowie ein Verfahren zur Herstellung und Verwendung
PT1423400E (pt) * 2001-03-19 2006-12-29 Harvard College Evolução de nova função molecular
EP1419274A4 (en) * 2001-07-31 2006-02-08 Phylos Inc MODULAR CONSTRUCTION OF NUCLEIC ACID PROTEIN FUSION MULTIMERS
US7125669B2 (en) * 2001-11-27 2006-10-24 Compound Therapeutics, Inc. Solid-phase immobilization of proteins and peptides
WO2004016767A2 (en) 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
WO2004024084A2 (en) * 2002-09-12 2004-03-25 Massachusetts Institute Of Technology Rb pahtway and chromatin remodeling genes that antagonize let-60 ras signaling
US20050019806A1 (en) * 2003-06-30 2005-01-27 Horvitz H. Robert Nucleic acids and polypeptides required for cell survival in the absence of Rb
WO2005074417A2 (en) * 2003-09-03 2005-08-18 Salk Institute For Biological Studies Multiple antigen detection assays and reagents
US8299210B2 (en) * 2003-11-20 2012-10-30 Sanofi Pasteur Methods for purifying pertussis toxin and peptides useful therefor
AU2005220746A1 (en) 2004-03-05 2005-09-22 Medical College Of Ohio Methods and compositions for assessing nucleic acids and alleles
WO2005106036A2 (en) 2004-04-12 2005-11-10 Medical College Of Ohio Methods and compositions for assaying analytes
US20050260652A1 (en) * 2004-04-15 2005-11-24 The General Hospital Corporation Compositions and methods that modulate RNA interference
US7635563B2 (en) * 2004-06-30 2009-12-22 Massachusetts Institute Of Technology High throughput methods relating to microRNA expression analysis
EP1951890A4 (en) 2005-11-16 2009-06-24 Ambrx Inc PROCESSES AND COMPOSITIONS WITH NON-NATURAL AMINO ACIDS
US7749957B2 (en) 2006-04-06 2010-07-06 E.I. Du Pont De Nemours And Company Clay-binding peptides and methods of use
US7951559B2 (en) * 2007-07-25 2011-05-31 E.I. Du Pont De Nemours And Company Recombinant peptide production using a cross-linkable solubility tag
US7829311B2 (en) 2007-07-25 2010-11-09 E.I. Du Pont De Nemours And Company Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate
US7678883B2 (en) * 2007-07-25 2010-03-16 E.I. Du Pont De Nemours And Company Solubility tags for the expression and purification of bioactive peptides
US7794963B2 (en) 2007-11-02 2010-09-14 E.I. Du Pont De Nemours And Company Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins
US8420081B2 (en) 2007-11-30 2013-04-16 Abbvie, Inc. Antibody formulations and methods of making same
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
EP3062106B1 (en) 2008-04-16 2020-11-11 The Johns Hopkins University Method for determining androgen receptor variants in prostate cancer
KR20110036638A (ko) 2008-07-25 2011-04-07 리차드 더블유. 와그너 단백질 스크리닝 방법
US8287845B2 (en) * 2008-12-18 2012-10-16 E I Du Pont De Nemours And Company Hair-binding peptides
US20100158837A1 (en) 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Iron oxide-binding peptides
US20100158846A1 (en) * 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Hair-binding peptides
US20100158822A1 (en) * 2008-12-18 2010-06-24 E .I. Du Pont De Nemours And Company Peptides that bind to silica-coated particles
SG173627A1 (en) 2009-02-13 2011-09-29 Chem Inc X Methods of creating and screening dna-encoded libraries
CN102596155A (zh) * 2009-03-30 2012-07-18 庄臣消费者有限公司 用于递送美容试剂的基于肽的系统
WO2010114638A1 (en) 2009-03-30 2010-10-07 E. I. Du Pont De Nemours And Company Peptide-based tooth whitening reagents
US9989533B2 (en) 2009-05-28 2018-06-05 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Anti-TNF induced apoptosis (ATIA) diagnostic markers and therapies
MX2012009318A (es) 2010-02-10 2012-09-07 Novartis Ag Metodos y compuestos para el crecimiento muscular.
EP2655413B1 (en) * 2010-12-23 2019-01-16 F.Hoffmann-La Roche Ag Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
WO2012112685A2 (en) 2011-02-15 2012-08-23 The Johns Hopkins University Compositions and methods for diagnosing ovarian cancer
EP3798236B1 (en) 2011-03-15 2022-08-10 X-Body, Inc. Antibody screening methods
SG10201900183VA (en) 2011-04-28 2019-05-30 Univ Leland Stanford Junior Identification of polynucleotides associated with a sample
DK2748357T3 (en) 2011-09-07 2018-07-16 X Chem Inc Methods for labeling DNA-encoded libraries
CN107353342B (zh) 2011-12-05 2021-08-10 X 博迪生物科学公司 PDGF受体β结合多肽
KR102146721B1 (ko) 2012-07-13 2020-08-21 엑스-켐, 인크. 폴리머라제에 의해 판독가능하지 않은 코딩 올리고뉴클레오티드 연결을 갖는 dna-코딩된 라이브러리
US10487363B2 (en) 2013-01-23 2019-11-26 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Compositions and methods for detecting neoplasia
CA2904170A1 (en) 2013-03-14 2014-09-25 University Of Maryland, Baltimore Androgen receptor down-regulating agents and uses thereof
US20140327460A1 (en) * 2013-05-03 2014-11-06 Second Sight Medical Products, Inc. Test Apparatus and Method for Determining Long Term Reliability of an Implantable Device
CA3210220A1 (en) 2013-05-10 2014-11-13 Johns Hopkins University Compositions for ovarian cancer assessment having improved specificity
US10370651B2 (en) 2013-06-28 2019-08-06 X-Body, Inc. Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes
AU2014321251B2 (en) 2013-09-23 2020-04-16 X-Body, Inc. Methods and compositions for generation of binding agents against cell surface antigens
WO2015179404A1 (en) 2014-05-19 2015-11-26 The Johns Hopkins University Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer
WO2016033114A1 (en) 2014-08-25 2016-03-03 The Johns Hopkins University Methods and compositions related to prostate cancer therapeutics
JP6478392B2 (ja) * 2014-12-26 2019-03-06 国立研究開発法人産業技術総合研究所 核酸リンカー
EP3386594B1 (en) 2015-12-11 2023-05-03 The General Hospital Corporation Combination of a platelet-derived growth factor receptor alpha inhibitor and a histone lysine demethylase inhibitor for treating drug-tolerant glioblastoma
US12130290B2 (en) 2016-11-29 2024-10-29 Trustees Of Tufts College Compositions and methods for diagnosing breast cancer
EP3669004A1 (en) 2017-08-16 2020-06-24 Medimmune, LLC Compositions and methods for treatment of atopic dermatitis and treatment selection
US11988663B2 (en) 2018-12-18 2024-05-21 The University Of Memphis Research Foundation Compositions and methods for the detection and molecular profiling of membrane bound vesicles
WO2022197933A1 (en) 2021-03-18 2022-09-22 The Broad Institute, Inc. Compositions and methods for characterizing lymphoma and related conditions
WO2023122723A1 (en) 2021-12-23 2023-06-29 The Broad Institute, Inc. Panels and methods for diagnosing and treating lung cancer
WO2025106804A1 (en) 2023-11-16 2025-05-22 Massachusetts Institute Of Technology Compositions and methods for characterizing hepatocyte stress
WO2025217069A1 (en) 2024-04-08 2025-10-16 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for treating cardiotoxicity
WO2026096383A1 (en) 2024-10-28 2026-05-07 The Broad Institute, Inc. Compositions and methods for inducing phagocytosis

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
JP2547149B2 (ja) * 1992-03-05 1996-10-23 三洋化成工業株式会社 免疫測定法及び免疫測定用試薬キット
GB2284208A (en) * 1993-11-25 1995-05-31 Pna Diagnostics As Nucleic acid analogues with a chelating functionality for metal ions
US5695934A (en) * 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
IL131016A (en) * 1997-01-21 2004-12-15 Gen Hospital Corp Selection of proteins using RNA-protein blends
US6261804B1 (en) * 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
JPH10253632A (ja) * 1997-03-10 1998-09-25 Nissui Pharm Co Ltd 分析方法、キット及び装置
EP1068356B8 (en) * 1998-04-03 2007-01-03 Adnexus Therapeutics, Inc. Addressable protein arrays
EP1073730A1 (en) * 1998-04-17 2001-02-07 Whitehead For Biomedical Research Use of a ribozyme to join nucleic acids and peptides
US5965352A (en) * 1998-05-08 1999-10-12 Rosetta Inpharmatics, Inc. Methods for identifying pathways of drug action
DK1105360T3 (da) * 1998-08-17 2009-11-02 Bristol Myers Squibb Co Identifikation af forbindelse-protein-interaktioner ved anvendelse af biblioteker af protein-nukleinsyrefusionsmolekyler
CA2382545C (en) * 1999-08-27 2013-08-13 Phylos, Inc. Methods for encoding and sorting in vitro translated proteins

Also Published As

Publication number Publication date
US20030013160A1 (en) 2003-01-16
EP1212452B1 (en) 2013-07-17
CA2382545A1 (en) 2001-03-08
EP1212452A1 (en) 2002-06-12
EP1212452A4 (en) 2003-09-24
US6436665B1 (en) 2002-08-20
JP4803933B2 (ja) 2011-10-26
CA2382545C (en) 2013-08-13
WO2001016352A1 (en) 2001-03-08
US7892785B2 (en) 2011-02-22
AU6938700A (en) 2001-03-26
JP2003508761A (ja) 2003-03-04

Similar Documents

Publication Publication Date Title
EP1212452B1 (en) Methods for encoding and sorting in vitro translated proteins
JP2003508761A5 (cg-RX-API-DMAC7.html)
EP1068356B1 (en) Addressable protein arrays
CA2350417C (en) Dna-protein fusions and uses thereof
AU757955B2 (en) Identification of compound-protein interactions using libraries of protein-nucleic acid fusion molecules
RU2238326C2 (ru) Способ продуцирования библиотеки белков (варианты), способ отбора нужного белка и нуклеиновой кислоты
US6716973B2 (en) Use of a ribozyme to join nucleic acids and peptides
US7125669B2 (en) Solid-phase immobilization of proteins and peptides
WO1999054458A1 (en) Use of a ribozyme to join nucleic acids and peptides
WO2003062417A1 (fr) Produit de ligation arn-adn, et utilisation correspondante
JPWO2005024018A1 (ja) 核酸構築物およびその製造方法
JPWO2005001086A1 (ja) 固定化mRNA−ピューロマイシン連結体及びその用途

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: COMPOUND THERAPEUTICS, INC.

Free format text: THE FORMER OWNER WAS: PHYLOS, INC.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired