AU779653B2 - Methods for encoding and sorting in vitro translated proteins - Google Patents
Methods for encoding and sorting in vitro translated proteinsInfo
- Publication number
- AU779653B2 AU779653B2 AU69387/00A AU6938700A AU779653B2 AU 779653 B2 AU779653 B2 AU 779653B2 AU 69387/00 A AU69387/00 A AU 69387/00A AU 6938700 A AU6938700 A AU 6938700A AU 779653 B2 AU779653 B2 AU 779653B2
- Authority
- AU
- Australia
- Prior art keywords
- protein
- encoding
- nucleic acid
- molecule
- encoded
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/13—Labelling of peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15126199P | 1999-08-27 | 1999-08-27 | |
| US60/151261 | 1999-08-27 | ||
| PCT/US2000/023414 WO2001016352A1 (en) | 1999-08-27 | 2000-08-25 | Methods for encoding and sorting in vitro translated proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU6938700A AU6938700A (en) | 2001-03-26 |
| AU779653B2 true AU779653B2 (en) | 2005-02-03 |
Family
ID=22537976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU69387/00A Expired AU779653B2 (en) | 1999-08-27 | 2000-08-25 | Methods for encoding and sorting in vitro translated proteins |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6436665B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1212452B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4803933B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU779653B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2382545C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001016352A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1068356B8 (en) * | 1998-04-03 | 2007-01-03 | Adnexus Therapeutics, Inc. | Addressable protein arrays |
| DE19923966C2 (de) * | 1999-05-25 | 2003-04-24 | Phylos Inc | Erkennungssystem zur Auftrennung von Probenbestandteilen, seine Herstellung und Verwendung |
| CA2377468C (en) * | 1999-07-27 | 2010-04-20 | Phylos, Inc. | Peptide acceptor ligation methods |
| CA2382545C (en) * | 1999-08-27 | 2013-08-13 | Phylos, Inc. | Methods for encoding and sorting in vitro translated proteins |
| DE19959857C1 (de) * | 1999-12-10 | 2001-06-28 | Aventis Res & Tech Gmbh & Co | Testsystem zum Nachweis von Analyten sowie ein Verfahren zur Herstellung und Verwendung |
| PT1423400E (pt) * | 2001-03-19 | 2006-12-29 | Harvard College | Evolução de nova função molecular |
| EP1419274A4 (en) * | 2001-07-31 | 2006-02-08 | Phylos Inc | MODULAR CONSTRUCTION OF NUCLEIC ACID PROTEIN FUSION MULTIMERS |
| US7125669B2 (en) * | 2001-11-27 | 2006-10-24 | Compound Therapeutics, Inc. | Solid-phase immobilization of proteins and peptides |
| WO2004016767A2 (en) | 2002-08-19 | 2004-02-26 | The President And Fellows Of Harvard College | Evolving new molecular function |
| WO2004024084A2 (en) * | 2002-09-12 | 2004-03-25 | Massachusetts Institute Of Technology | Rb pahtway and chromatin remodeling genes that antagonize let-60 ras signaling |
| US20050019806A1 (en) * | 2003-06-30 | 2005-01-27 | Horvitz H. Robert | Nucleic acids and polypeptides required for cell survival in the absence of Rb |
| WO2005074417A2 (en) * | 2003-09-03 | 2005-08-18 | Salk Institute For Biological Studies | Multiple antigen detection assays and reagents |
| US8299210B2 (en) * | 2003-11-20 | 2012-10-30 | Sanofi Pasteur | Methods for purifying pertussis toxin and peptides useful therefor |
| AU2005220746A1 (en) | 2004-03-05 | 2005-09-22 | Medical College Of Ohio | Methods and compositions for assessing nucleic acids and alleles |
| WO2005106036A2 (en) | 2004-04-12 | 2005-11-10 | Medical College Of Ohio | Methods and compositions for assaying analytes |
| US20050260652A1 (en) * | 2004-04-15 | 2005-11-24 | The General Hospital Corporation | Compositions and methods that modulate RNA interference |
| US7635563B2 (en) * | 2004-06-30 | 2009-12-22 | Massachusetts Institute Of Technology | High throughput methods relating to microRNA expression analysis |
| EP1951890A4 (en) | 2005-11-16 | 2009-06-24 | Ambrx Inc | PROCESSES AND COMPOSITIONS WITH NON-NATURAL AMINO ACIDS |
| US7749957B2 (en) | 2006-04-06 | 2010-07-06 | E.I. Du Pont De Nemours And Company | Clay-binding peptides and methods of use |
| US7951559B2 (en) * | 2007-07-25 | 2011-05-31 | E.I. Du Pont De Nemours And Company | Recombinant peptide production using a cross-linkable solubility tag |
| US7829311B2 (en) | 2007-07-25 | 2010-11-09 | E.I. Du Pont De Nemours And Company | Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate |
| US7678883B2 (en) * | 2007-07-25 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Solubility tags for the expression and purification of bioactive peptides |
| US7794963B2 (en) | 2007-11-02 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins |
| US8420081B2 (en) | 2007-11-30 | 2013-04-16 | Abbvie, Inc. | Antibody formulations and methods of making same |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| EP3062106B1 (en) | 2008-04-16 | 2020-11-11 | The Johns Hopkins University | Method for determining androgen receptor variants in prostate cancer |
| KR20110036638A (ko) | 2008-07-25 | 2011-04-07 | 리차드 더블유. 와그너 | 단백질 스크리닝 방법 |
| US8287845B2 (en) * | 2008-12-18 | 2012-10-16 | E I Du Pont De Nemours And Company | Hair-binding peptides |
| US20100158837A1 (en) | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Iron oxide-binding peptides |
| US20100158846A1 (en) * | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Hair-binding peptides |
| US20100158822A1 (en) * | 2008-12-18 | 2010-06-24 | E .I. Du Pont De Nemours And Company | Peptides that bind to silica-coated particles |
| SG173627A1 (en) | 2009-02-13 | 2011-09-29 | Chem Inc X | Methods of creating and screening dna-encoded libraries |
| CN102596155A (zh) * | 2009-03-30 | 2012-07-18 | 庄臣消费者有限公司 | 用于递送美容试剂的基于肽的系统 |
| WO2010114638A1 (en) | 2009-03-30 | 2010-10-07 | E. I. Du Pont De Nemours And Company | Peptide-based tooth whitening reagents |
| US9989533B2 (en) | 2009-05-28 | 2018-06-05 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Anti-TNF induced apoptosis (ATIA) diagnostic markers and therapies |
| MX2012009318A (es) | 2010-02-10 | 2012-09-07 | Novartis Ag | Metodos y compuestos para el crecimiento muscular. |
| EP2655413B1 (en) * | 2010-12-23 | 2019-01-16 | F.Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| DE102010056289A1 (de) | 2010-12-24 | 2012-06-28 | Geneart Ag | Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken |
| WO2012112685A2 (en) | 2011-02-15 | 2012-08-23 | The Johns Hopkins University | Compositions and methods for diagnosing ovarian cancer |
| EP3798236B1 (en) | 2011-03-15 | 2022-08-10 | X-Body, Inc. | Antibody screening methods |
| SG10201900183VA (en) | 2011-04-28 | 2019-05-30 | Univ Leland Stanford Junior | Identification of polynucleotides associated with a sample |
| DK2748357T3 (en) | 2011-09-07 | 2018-07-16 | X Chem Inc | Methods for labeling DNA-encoded libraries |
| CN107353342B (zh) | 2011-12-05 | 2021-08-10 | X 博迪生物科学公司 | PDGF受体β结合多肽 |
| KR102146721B1 (ko) | 2012-07-13 | 2020-08-21 | 엑스-켐, 인크. | 폴리머라제에 의해 판독가능하지 않은 코딩 올리고뉴클레오티드 연결을 갖는 dna-코딩된 라이브러리 |
| US10487363B2 (en) | 2013-01-23 | 2019-11-26 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Compositions and methods for detecting neoplasia |
| CA2904170A1 (en) | 2013-03-14 | 2014-09-25 | University Of Maryland, Baltimore | Androgen receptor down-regulating agents and uses thereof |
| US20140327460A1 (en) * | 2013-05-03 | 2014-11-06 | Second Sight Medical Products, Inc. | Test Apparatus and Method for Determining Long Term Reliability of an Implantable Device |
| CA3210220A1 (en) | 2013-05-10 | 2014-11-13 | Johns Hopkins University | Compositions for ovarian cancer assessment having improved specificity |
| US10370651B2 (en) | 2013-06-28 | 2019-08-06 | X-Body, Inc. | Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes |
| AU2014321251B2 (en) | 2013-09-23 | 2020-04-16 | X-Body, Inc. | Methods and compositions for generation of binding agents against cell surface antigens |
| WO2015179404A1 (en) | 2014-05-19 | 2015-11-26 | The Johns Hopkins University | Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer |
| WO2016033114A1 (en) | 2014-08-25 | 2016-03-03 | The Johns Hopkins University | Methods and compositions related to prostate cancer therapeutics |
| JP6478392B2 (ja) * | 2014-12-26 | 2019-03-06 | 国立研究開発法人産業技術総合研究所 | 核酸リンカー |
| EP3386594B1 (en) | 2015-12-11 | 2023-05-03 | The General Hospital Corporation | Combination of a platelet-derived growth factor receptor alpha inhibitor and a histone lysine demethylase inhibitor for treating drug-tolerant glioblastoma |
| US12130290B2 (en) | 2016-11-29 | 2024-10-29 | Trustees Of Tufts College | Compositions and methods for diagnosing breast cancer |
| EP3669004A1 (en) | 2017-08-16 | 2020-06-24 | Medimmune, LLC | Compositions and methods for treatment of atopic dermatitis and treatment selection |
| US11988663B2 (en) | 2018-12-18 | 2024-05-21 | The University Of Memphis Research Foundation | Compositions and methods for the detection and molecular profiling of membrane bound vesicles |
| WO2022197933A1 (en) | 2021-03-18 | 2022-09-22 | The Broad Institute, Inc. | Compositions and methods for characterizing lymphoma and related conditions |
| WO2023122723A1 (en) | 2021-12-23 | 2023-06-29 | The Broad Institute, Inc. | Panels and methods for diagnosing and treating lung cancer |
| WO2025106804A1 (en) | 2023-11-16 | 2025-05-22 | Massachusetts Institute Of Technology | Compositions and methods for characterizing hepatocyte stress |
| WO2025217069A1 (en) | 2024-04-08 | 2025-10-16 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for treating cardiotoxicity |
| WO2026096383A1 (en) | 2024-10-28 | 2026-05-07 | The Broad Institute, Inc. | Compositions and methods for inducing phagocytosis |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| JP2547149B2 (ja) * | 1992-03-05 | 1996-10-23 | 三洋化成工業株式会社 | 免疫測定法及び免疫測定用試薬キット |
| GB2284208A (en) * | 1993-11-25 | 1995-05-31 | Pna Diagnostics As | Nucleic acid analogues with a chelating functionality for metal ions |
| US5695934A (en) * | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
| IL131016A (en) * | 1997-01-21 | 2004-12-15 | Gen Hospital Corp | Selection of proteins using RNA-protein blends |
| US6261804B1 (en) * | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| JPH10253632A (ja) * | 1997-03-10 | 1998-09-25 | Nissui Pharm Co Ltd | 分析方法、キット及び装置 |
| EP1068356B8 (en) * | 1998-04-03 | 2007-01-03 | Adnexus Therapeutics, Inc. | Addressable protein arrays |
| EP1073730A1 (en) * | 1998-04-17 | 2001-02-07 | Whitehead For Biomedical Research | Use of a ribozyme to join nucleic acids and peptides |
| US5965352A (en) * | 1998-05-08 | 1999-10-12 | Rosetta Inpharmatics, Inc. | Methods for identifying pathways of drug action |
| DK1105360T3 (da) * | 1998-08-17 | 2009-11-02 | Bristol Myers Squibb Co | Identifikation af forbindelse-protein-interaktioner ved anvendelse af biblioteker af protein-nukleinsyrefusionsmolekyler |
| CA2382545C (en) * | 1999-08-27 | 2013-08-13 | Phylos, Inc. | Methods for encoding and sorting in vitro translated proteins |
-
2000
- 2000-08-25 CA CA2382545A patent/CA2382545C/en not_active Expired - Lifetime
- 2000-08-25 EP EP00957818.8A patent/EP1212452B1/en not_active Expired - Lifetime
- 2000-08-25 AU AU69387/00A patent/AU779653B2/en not_active Expired
- 2000-08-25 US US09/648,040 patent/US6436665B1/en not_active Expired - Lifetime
- 2000-08-25 WO PCT/US2000/023414 patent/WO2001016352A1/en not_active Ceased
- 2000-08-25 JP JP2001520897A patent/JP4803933B2/ja not_active Expired - Lifetime
-
2002
- 2002-08-13 US US10/217,914 patent/US7892785B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20030013160A1 (en) | 2003-01-16 |
| EP1212452B1 (en) | 2013-07-17 |
| CA2382545A1 (en) | 2001-03-08 |
| EP1212452A1 (en) | 2002-06-12 |
| EP1212452A4 (en) | 2003-09-24 |
| US6436665B1 (en) | 2002-08-20 |
| JP4803933B2 (ja) | 2011-10-26 |
| CA2382545C (en) | 2013-08-13 |
| WO2001016352A1 (en) | 2001-03-08 |
| US7892785B2 (en) | 2011-02-22 |
| AU6938700A (en) | 2001-03-26 |
| JP2003508761A (ja) | 2003-03-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: COMPOUND THERAPEUTICS, INC. Free format text: THE FORMER OWNER WAS: PHYLOS, INC. |
|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |