AU779619B2 - Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues - Google Patents

Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues Download PDF

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Publication number
AU779619B2
AU779619B2 AU50974/00A AU5097400A AU779619B2 AU 779619 B2 AU779619 B2 AU 779619B2 AU 50974/00 A AU50974/00 A AU 50974/00A AU 5097400 A AU5097400 A AU 5097400A AU 779619 B2 AU779619 B2 AU 779619B2
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AU
Australia
Prior art keywords
nucleic acid
pdx
cell
subject
pancreatic
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
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AU50974/00A
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English (en)
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AU5097400A (en
Inventor
Sarah Ferber
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Individual
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Publication of AU5097400A publication Critical patent/AU5097400A/en
Application granted granted Critical
Publication of AU779619B2 publication Critical patent/AU779619B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU50974/00A 1999-06-01 2000-06-01 Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues Expired AU779619B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US13714399P 1999-06-01 1999-06-01
US60/137143 1999-06-01
US19853200P 2000-04-19 2000-04-19
US60/198532 2000-04-19
US09/584216 2000-05-31
US09/584,216 US6774120B1 (en) 1999-06-01 2000-05-31 Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
PCT/IB2000/000824 WO2000072885A2 (en) 1999-06-01 2000-06-01 Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues

Publications (2)

Publication Number Publication Date
AU5097400A AU5097400A (en) 2000-12-18
AU779619B2 true AU779619B2 (en) 2005-02-03

Family

ID=27384964

Family Applications (1)

Application Number Title Priority Date Filing Date
AU50974/00A Expired AU779619B2 (en) 1999-06-01 2000-06-01 Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues

Country Status (8)

Country Link
US (3) US6774120B1 (enExample)
EP (1) EP1180143B1 (enExample)
JP (2) JP2003500457A (enExample)
AT (1) ATE361977T1 (enExample)
AU (1) AU779619B2 (enExample)
CA (1) CA2371995C (enExample)
DE (1) DE60034781T2 (enExample)
WO (1) WO2000072885A2 (enExample)

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US8778899B2 (en) 1999-06-01 2014-07-15 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US6774120B1 (en) 1999-06-01 2004-08-10 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US7567870B1 (en) * 2000-07-31 2009-07-28 Institute For Systems Biology Multiparameter analysis for predictive medicine
CA2442177A1 (en) 2001-03-29 2002-10-10 Ixion Biotechnology, Inc. Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway
US7343247B2 (en) * 2001-07-30 2008-03-11 The Institute For Systems Biology Methods of classifying drug responsiveness using multiparameter analysis
WO2003033697A1 (en) * 2001-10-18 2003-04-24 Ixion Biotechnology, Inc. Conversion of liver stem and progenitor cells to pancreatic functional cells
CA2468335C (en) 2001-12-07 2014-07-08 Geron Corporation Chondrocyte precursors derived from human embryonic stem cells
JP4666567B2 (ja) 2001-12-07 2011-04-06 ジェロン・コーポレーション ヒト胚幹細胞由来の膵島細胞
JP2003189875A (ja) * 2001-12-28 2003-07-08 Japan Science & Technology Corp 膵β細胞関連転写因子の遺伝子導入によるインスリン産生細胞の形成誘導
GB0206357D0 (en) * 2002-03-18 2002-05-01 Univ Bath Cells
JP4136434B2 (ja) * 2002-04-17 2008-08-20 進 清野 インスリン産生細胞の誘導
GB0300208D0 (en) * 2003-01-06 2003-02-05 Oxford Biomedica Ltd Insulin producing cells
EP1617888B1 (en) 2003-04-23 2019-06-12 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
AU2004236573B2 (en) * 2003-05-12 2009-10-22 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
WO2005083059A1 (en) * 2004-02-23 2005-09-09 University Of Florida Compositions and methods for making insulin-producing cells
WO2006014425A1 (en) 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
WO2006010531A1 (en) * 2004-07-28 2006-02-02 F. Hoffmann-La Roche Ag Prohormone convertase i as target/marker for beta cell failure
AU2006203990B2 (en) * 2005-01-07 2011-08-11 Wake Forest University Health Sciences Regeneration of pancreatic islets by amniotic fluid stem cell therapy
JP2007061096A (ja) * 2005-08-31 2007-03-15 Lifescan Inc 細胞分化を促進する方法
JP2007063225A (ja) 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
CN103989710B (zh) 2005-12-21 2019-11-15 鲁汶大学 分离的肝脏干细胞
WO2007104034A2 (en) 2006-03-08 2007-09-13 Takeda San Diego, Inc. Glucokinase activators
ES2656675T3 (es) 2006-03-30 2018-02-28 Valeritas, Inc. Dispositivo de suministro de fluidos de múltiples cartuchos
EP2049518B1 (en) 2006-05-31 2011-08-31 Takeda San Diego, Inc. Indazole and isoindole derivatives as glucokinase activating agents.
WO2007149182A2 (en) 2006-06-19 2007-12-27 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
WO2008079787A2 (en) 2006-12-20 2008-07-03 Takeda San Diego, Inc. Glucokinase activators
WO2008116107A2 (en) 2007-03-21 2008-09-25 Takeda San Diego, Inc. Piperazine derivatives as glucokinase activators
CN102154210A (zh) * 2010-12-28 2011-08-17 沈达青 一种胰岛素基因修饰的肝干细胞制法及其应用和制剂
BR112015031253B1 (pt) 2013-06-13 2021-09-28 Orgenesis Ltd. Método para produção de uma população de células transdiferenciada
ES2759228T3 (es) 2013-07-05 2020-05-08 Univ Catholique Louvain Medio acondicionado de células madre de hígado de adultos y su uso en el tratamiento de trastornos del hígado
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
SG11201911256UA (en) 2017-05-08 2020-01-30 Orgenesis Ltd Transdifferentiated cell populations and methods of use thereof

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US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4980286A (en) * 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US4737323A (en) * 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
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US4837028A (en) * 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4873316A (en) * 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US4992417A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogues
US5703055A (en) * 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5328470A (en) * 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5427940A (en) * 1991-06-03 1995-06-27 Board Of Regents, The University Of Texas System Engineered cells producing insulin in response to glucose
ATE200625T1 (de) 1992-10-09 2001-05-15 Advanced Tissue Sciences Inc Leberreservezellen
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WO1995005463A1 (en) 1993-08-16 1995-02-23 Research Development Foundation A novel homeobox factor which stimulates insulin expression in pancreatic islet cells
US5858973A (en) 1994-02-23 1999-01-12 The General Hospital Corporation Transcription factor and uses therefor
US5849989A (en) 1994-10-07 1998-12-15 Ontogeny, Inc. Insulin promoter factor, and uses related thereto
JP2000501290A (ja) * 1995-11-30 2000-02-08 リサーチ ディベロップメント ファンデーション ソマトスタチン及びインシュリン生成を刺激する化合物のスクリーニング・アッセイ
AU724745B2 (en) * 1996-06-24 2000-09-28 Vivorx Pharmaceuticals, Inc. Methods for the isolation and proliferation of insulin-secreting cells
EP0996736A1 (en) * 1997-08-11 2000-05-03 Chiron Corporation Methods for genetically modifying t cells
US6242666B1 (en) * 1998-12-16 2001-06-05 The Scripps Research Institute Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells
US6774120B1 (en) 1999-06-01 2004-08-10 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US6759039B2 (en) * 2000-06-30 2004-07-06 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
WO2003033697A1 (en) 2001-10-18 2003-04-24 Ixion Biotechnology, Inc. Conversion of liver stem and progenitor cells to pancreatic functional cells
JP4136434B2 (ja) * 2002-04-17 2008-08-20 進 清野 インスリン産生細胞の誘導
AU2004236573B2 (en) 2003-05-12 2009-10-22 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues

Also Published As

Publication number Publication date
AU5097400A (en) 2000-12-18
WO2000072885A2 (en) 2000-12-07
JP2003500457A (ja) 2003-01-07
US8119405B2 (en) 2012-02-21
JP2011057716A (ja) 2011-03-24
US20120329710A1 (en) 2012-12-27
ATE361977T1 (de) 2007-06-15
US20040213769A1 (en) 2004-10-28
CA2371995A1 (en) 2000-12-07
WO2000072885A3 (en) 2001-05-10
EP1180143A2 (en) 2002-02-20
WO2000072885A9 (en) 2001-03-01
EP1180143B1 (en) 2007-05-09
CA2371995C (en) 2014-01-21
DE60034781D1 (de) 2007-06-21
DE60034781T2 (de) 2008-01-17
US6774120B1 (en) 2004-08-10

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase
TH Corrigenda

Free format text: IN VOL 15, NO 12, PAGE(S) 2367-2373 UNDER THE HEADING APPLICATIONS LAPSED, REFUSED OR WITHDRAWN PLEASE DELETE ALL REFERENCE TO APPLICATION NO. 49232/00, 50972/00, 50974/00 AND 52363/00

MK14 Patent ceased section 143(a) (annual fees not paid) or expired