ATE361977T1 - In vitro verfahren zur induzierung der regulierten pankreatische-hormon produktion in nicht-pankreatischen inselngeweben, damit verbundene pharmazeutische zusammenseztzungen - Google Patents

In vitro verfahren zur induzierung der regulierten pankreatische-hormon produktion in nicht-pankreatischen inselngeweben, damit verbundene pharmazeutische zusammenseztzungen

Info

Publication number
ATE361977T1
ATE361977T1 AT00935435T AT00935435T ATE361977T1 AT E361977 T1 ATE361977 T1 AT E361977T1 AT 00935435 T AT00935435 T AT 00935435T AT 00935435 T AT00935435 T AT 00935435T AT E361977 T1 ATE361977 T1 AT E361977T1
Authority
AT
Austria
Prior art keywords
pancreatic
pharmaceutical compositions
tissues
vitro method
hormone production
Prior art date
Application number
AT00935435T
Other languages
German (de)
English (en)
Inventor
Sarah Ferber
Original Assignee
Sarah Ferber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarah Ferber filed Critical Sarah Ferber
Application granted granted Critical
Publication of ATE361977T1 publication Critical patent/ATE361977T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT00935435T 1999-06-01 2000-06-01 In vitro verfahren zur induzierung der regulierten pankreatische-hormon produktion in nicht-pankreatischen inselngeweben, damit verbundene pharmazeutische zusammenseztzungen ATE361977T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13714399P 1999-06-01 1999-06-01
US19853200P 2000-04-19 2000-04-19
US09/584,216 US6774120B1 (en) 1999-06-01 2000-05-31 Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues

Publications (1)

Publication Number Publication Date
ATE361977T1 true ATE361977T1 (de) 2007-06-15

Family

ID=27384964

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00935435T ATE361977T1 (de) 1999-06-01 2000-06-01 In vitro verfahren zur induzierung der regulierten pankreatische-hormon produktion in nicht-pankreatischen inselngeweben, damit verbundene pharmazeutische zusammenseztzungen

Country Status (8)

Country Link
US (3) US6774120B1 (enExample)
EP (1) EP1180143B1 (enExample)
JP (2) JP2003500457A (enExample)
AT (1) ATE361977T1 (enExample)
AU (1) AU779619B2 (enExample)
CA (1) CA2371995C (enExample)
DE (1) DE60034781T2 (enExample)
WO (1) WO2000072885A2 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8778899B2 (en) 1999-06-01 2014-07-15 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US6774120B1 (en) 1999-06-01 2004-08-10 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US7567870B1 (en) 2000-07-31 2009-07-28 Institute For Systems Biology Multiparameter analysis for predictive medicine
US7202080B2 (en) 2001-03-29 2007-04-10 Ixion Biotechnology, Inc. Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway
US7343247B2 (en) * 2001-07-30 2008-03-11 The Institute For Systems Biology Methods of classifying drug responsiveness using multiparameter analysis
JP2005506074A (ja) * 2001-10-18 2005-03-03 イクシオン・バイオテクノロジー・インコーポレーテッド 肝臓の幹細胞および前駆細胞の膵臓機能細胞への転換
CN1599793A (zh) 2001-12-07 2005-03-23 杰龙公司 人胚胎干细胞衍生的软骨细胞前体
CA2692325C (en) 2001-12-07 2015-10-20 Geron Corporation Islet cells from human embryonic stem cells
JP2003189875A (ja) * 2001-12-28 2003-07-08 Japan Science & Technology Corp 膵β細胞関連転写因子の遺伝子導入によるインスリン産生細胞の形成誘導
GB0206357D0 (en) * 2002-03-18 2002-05-01 Univ Bath Cells
JP4136434B2 (ja) * 2002-04-17 2008-08-20 進 清野 インスリン産生細胞の誘導
GB0300208D0 (en) * 2003-01-06 2003-02-05 Oxford Biomedica Ltd Insulin producing cells
CA2820537C (en) 2003-04-23 2015-10-20 Valeritas, Inc. Hydraulically actuated pump for fluid administration
JP2006525994A (ja) * 2003-05-12 2006-11-16 サラ ファーバー， 非膵島組織における調節された膵ホルモンの産生を誘導する方法
US20080267928A1 (en) * 2004-02-23 2008-10-30 Lijun Yang Compositions and Methods for Making Insulin-Producing Cells
WO2006014425A1 (en) 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
WO2006010531A1 (en) * 2004-07-28 2006-02-02 F. Hoffmann-La Roche Ag Prohormone convertase i as target/marker for beta cell failure
EP1833494B1 (en) * 2005-01-07 2016-05-18 Wake Forest University Health Sciences Regeneration of pancreatic islets by amniotic fluid stem cell therapy
JP2007061096A (ja) * 2005-08-31 2007-03-15 Lifescan Inc 細胞分化を促進する方法
JP2007063225A (ja) 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
JP5250423B2 (ja) 2005-12-21 2013-07-31 ユニヴァルシテ カソリック デ ルーバン 単離肝幹細胞
JP5302012B2 (ja) 2006-03-08 2013-10-02 タケダ カリフォルニア インコーポレイテッド グルコキナーゼ活性剤
RU2438719C2 (ru) 2006-03-30 2012-01-10 ВАЛЕРИТАС Инк. Многокартриджное устройство для введения жидкости
JP5386350B2 (ja) 2006-05-31 2014-01-15 タケダ カリフォルニア インコーポレイテッド グルコキナーゼ活性剤としての、インダゾールおよびイソインドール誘導体
US8415153B2 (en) 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
WO2008079787A2 (en) 2006-12-20 2008-07-03 Takeda San Diego, Inc. Glucokinase activators
US8173645B2 (en) 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
CN102154210A (zh) * 2010-12-28 2011-08-17 沈达青 一种胰岛素基因修饰的肝干细胞制法及其应用和制剂
WO2014207578A2 (en) 2013-06-13 2014-12-31 Orgenesis Ltd. Cell populations, methods of transdifferention and methods of use thereof
EP3016665B1 (en) 2013-07-05 2019-09-18 Université Catholique de Louvain Conditioned medium from human adult liver stem cells and its use in the treatment of liver disorders
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
EP3635106A4 (en) 2017-05-08 2021-01-06 Orgenesis Ltd. POPULATIONS OF TRANSDIFFERENTIATED CELLS AND THEIR METHODS OF USE

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
DE122007000007I2 (de) 1986-04-09 2010-12-30 Genzyme Corp Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US4992417A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogues
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5427940A (en) 1991-06-03 1995-06-27 Board Of Regents, The University Of Texas System Engineered cells producing insulin in response to glucose
ES2157225T3 (es) 1992-10-09 2001-08-16 Advanced Tissue Sciences Inc Celulas hepaticas de reserva.
US5424286A (en) * 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
CA2169631C (en) 1993-08-16 2005-01-11 Marc R. Montminy A novel homeobox factor which stimulates insulin expression in pancreatic islet cells
US5858973A (en) 1994-02-23 1999-01-12 The General Hospital Corporation Transcription factor and uses therefor
US5849989A (en) 1994-10-07 1998-12-15 Ontogeny, Inc. Insulin promoter factor, and uses related thereto
DE69635998D1 (de) 1995-11-30 2006-05-18 Res Dev Foundation Nachweisverfahren für verbindungen, welche die somatostatin- und insulinproduktion stimulieren
AU724745B2 (en) * 1996-06-24 2000-09-28 Vivorx Pharmaceuticals, Inc. Methods for the isolation and proliferation of insulin-secreting cells
AU8777898A (en) 1997-08-11 1999-03-01 Chiron Corporation Methods for genetically modifying t cells
US6242666B1 (en) * 1998-12-16 2001-06-05 The Scripps Research Institute Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells
US6774120B1 (en) 1999-06-01 2004-08-10 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US6759039B2 (en) * 2000-06-30 2004-07-06 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
JP2005506074A (ja) 2001-10-18 2005-03-03 イクシオン・バイオテクノロジー・インコーポレーテッド 肝臓の幹細胞および前駆細胞の膵臓機能細胞への転換
JP4136434B2 (ja) 2002-04-17 2008-08-20 進 清野 インスリン産生細胞の誘導
JP2006525994A (ja) 2003-05-12 2006-11-16 サラ ファーバー， 非膵島組織における調節された膵ホルモンの産生を誘導する方法

Also Published As

Publication number Publication date
AU779619B2 (en) 2005-02-03
WO2000072885A2 (en) 2000-12-07
EP1180143B1 (en) 2007-05-09
CA2371995A1 (en) 2000-12-07
US6774120B1 (en) 2004-08-10
DE60034781D1 (de) 2007-06-21
US20040213769A1 (en) 2004-10-28
CA2371995C (en) 2014-01-21
EP1180143A2 (en) 2002-02-20
DE60034781T2 (de) 2008-01-17
US8119405B2 (en) 2012-02-21
US20120329710A1 (en) 2012-12-27
WO2000072885A9 (en) 2001-03-01
JP2003500457A (ja) 2003-01-07
WO2000072885A3 (en) 2001-05-10
JP2011057716A (ja) 2011-03-24
AU5097400A (en) 2000-12-18

Similar Documents

Publication Publication Date Title
ATE361977T1 (de) In vitro verfahren zur induzierung der regulierten pankreatische-hormon produktion in nicht-pankreatischen inselngeweben, damit verbundene pharmazeutische zusammenseztzungen
DE602005018043D1 (de) Liposomale formulierungen mit dihydrosphingomyelin und verfahren zu ihrer verwendung
ATE290351T1 (de) BIOAKTIVER ABBAUBARER VERBUNDSTOFF FÜR ßTISSUE ENGINEERINGß
DE69533551D1 (de) Camptothecin arzneimittelkombinationen mit verringerten nebenwirkungen
AU2003205315A1 (en) Methods and kits for delivering pharmaceutical agents into the coronary vascular adventitia
BRPI0410467A (pt) composições e métodos para tratamento de sìndrome respiratória aguda severa (sars)
MY147393A (en) Administration of dipeptidyl peptidase inhibitors
GB2352395A (en) Paroxetine methanesulfonate
MY124214A (en) Compositions for promoting crowth
PT1011632E (pt) Composicao farmaceutica para o tratamento de dismenorreia e parto prematuro
MXPA02009275A (es) Metodo para preparar dispersiones de alta presion/alto esfuerzo cortante que contienen ingredientes fisiologicamente activos.
SG144712A1 (en) Nordihydroguaiartic derivaties for use in treatment of tumors
EA200001129A2 (ru) Способ получения 4-карбоксиамино-2-замещенного-1,2,3,4-тетрагидрохинолина
DE60021381D1 (de) Chinonverbindungen zur behandlung von krankheiten
AU4258101A (en) Combination therapies with vascular damaging activity
DE60025905D1 (de) In vitro methode zur synchronisation von oozytenreifung
IL182505A0 (en) Purified phospholipid-non-steroidal, anti-inflammatory drug associated compositions and method for preparing and using same
AR030140A1 (es) Composiciones derivadas de la 2-piridinamina y metodos relacionados
DE60332721D1 (de) Verfahren und zusammensetzung zur erhöhung der absorption und der bioverfügbarkeit von hydrophoben wirkstoffen im magen-darmtrakt
DK1549329T3 (da) Ekstrakt med antitumoraktivitet og anti-giftaktivitet
DE60226313D1 (de) Verwendung von sesquiterpene enthaltenden zusammenstellungen zur behandlung von krebs
ATE350064T1 (de) Pharmazeutische zusammensetzungen von rapamycines
BR0212834A (pt) Formulações e uso das mesmas
HU0103686D0 (en) Pharmaceutical composition for preventing or treating diseases associated with an excess in il-12 production
ATE259659T1 (de) Zusammensetzung die mindestens ein stickstoffmonoxid-synthase inhibitor und mindestens ein phospholipase a2 inhibitor enthält zur herstellung eines medikamentes

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties