AU772851B2 - Therapeutic and diagnostic domain 1 beta2GPI polypeptides and methods of using same - Google Patents

Therapeutic and diagnostic domain 1 beta2GPI polypeptides and methods of using same Download PDF

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Publication number
AU772851B2
AU772851B2 AU43395/99A AU4339599A AU772851B2 AU 772851 B2 AU772851 B2 AU 772851B2 AU 43395/99 A AU43395/99 A AU 43395/99A AU 4339599 A AU4339599 A AU 4339599A AU 772851 B2 AU772851 B2 AU 772851B2
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AU
Australia
Prior art keywords
polypeptide
gpi
domain
antibody
conjugate
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Ceased
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AU43395/99A
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English (en)
Other versions
AU4339599A (en
Inventor
Gilbert M. Iverson
David S Jones
Matthew D Linnik
David M. Marquis
Edward J. Victoria
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La Jolla Pharmaceutical Co
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La Jolla Pharmaceutical Co
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Application filed by La Jolla Pharmaceutical Co filed Critical La Jolla Pharmaceutical Co
Publication of AU4339599A publication Critical patent/AU4339599A/en
Priority to AU2004201699A priority Critical patent/AU2004201699A1/en
Application granted granted Critical
Publication of AU772851B2 publication Critical patent/AU772851B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU43395/99A 1998-06-09 1999-06-09 Therapeutic and diagnostic domain 1 beta2GPI polypeptides and methods of using same Ceased AU772851B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2004201699A AU2004201699A1 (en) 1998-06-09 2004-04-19 Therapeutic and diagnostic domain 1 Beta2GPI polypeptides and methods of using same

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US8865698P 1998-06-09 1998-06-09
US60/088656 1998-06-09
US10308898P 1998-10-05 1998-10-05
US60/103088 1998-10-05
US09/328,199 US6858210B1 (en) 1998-06-09 1999-06-08 Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
US09/328199 1999-06-08
PCT/US1999/013194 WO1999064595A1 (en) 1998-06-09 1999-06-09 THERAPEUTIC AND DIAGNOSTIC DOMAIN 1 β2GPI POLYPEPTIDES AND METHODS OF USING SAME

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2004201699A Division AU2004201699A1 (en) 1998-06-09 2004-04-19 Therapeutic and diagnostic domain 1 Beta2GPI polypeptides and methods of using same

Publications (2)

Publication Number Publication Date
AU4339599A AU4339599A (en) 1999-12-30
AU772851B2 true AU772851B2 (en) 2004-05-06

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AU43395/99A Ceased AU772851B2 (en) 1998-06-09 1999-06-09 Therapeutic and diagnostic domain 1 beta2GPI polypeptides and methods of using same

Country Status (12)

Country Link
US (2) US6858210B1 (enExample)
EP (1) EP1092027B1 (enExample)
JP (1) JP2002517245A (enExample)
KR (1) KR20010052713A (enExample)
CN (1) CN1310759A (enExample)
AT (1) ATE346922T1 (enExample)
AU (1) AU772851B2 (enExample)
CA (1) CA2329942A1 (enExample)
DE (1) DE69934228T2 (enExample)
ES (1) ES2275348T3 (enExample)
PT (1) PT1092027E (enExample)
WO (1) WO1999064595A1 (enExample)

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US6858210B1 (en) 1998-06-09 2005-02-22 La Jolla Pharmaceutical Co. Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
US6399578B1 (en) 1998-12-09 2002-06-04 La Jolla Pharmaceutical Company Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same
US6458953B1 (en) * 1998-12-09 2002-10-01 La Jolla Pharmaceutical Company Valency platform molecules comprising carbamate linkages
WO2000075105A1 (en) * 1999-06-08 2000-12-14 La Jolla Pharmaceutical Company Valency platform molecules comprising aminooxy groups
CZ2002343A3 (cs) * 1999-07-29 2002-08-14 Epix Medical, Inc. Cílená multimerní zobrazovací činidla s multilokální vazebnou schopností
CN1399562A (zh) * 1999-11-28 2003-02-26 拉卓拉药物公司 基于抗体亲和力来治疗狼疮的方法及使用这种方法的筛选方法和组合物
AU2001268228A1 (en) * 2000-06-08 2001-12-17 La Jolla Pharmaceutical Company Multivalent platform molecules comprising high molecular weight polyethylene oxide
EP1360207B1 (en) * 2000-12-13 2011-06-22 Bac Ip B.V. Protein arrays of camelid heavy-chain immunoglobulin variable domains
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
US20030114405A1 (en) * 2001-08-13 2003-06-19 Linnik Matthew D. Methods of treating systemic lupus erythematosus in individuals having significantly impaired renal function
JP4800614B2 (ja) 2002-07-19 2011-10-26 ザ ジェネラル ホスピタル コーポレイション オキシム結合体、およびそれらの形成および使用のための方法
AU2003303524A1 (en) * 2002-12-27 2004-07-29 La Jolla Pharmaceutical Company Methods of improving health-related quality of life in individuals with systemic lupus erythematosus
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US20040258683A1 (en) * 2003-03-30 2004-12-23 Linnik Matthew D. Methods of treating and monitoring systemic lupus erythematosus in individuals
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WO2006113720A2 (en) 2005-04-18 2006-10-26 Bio-Rad Laboratories, Inc. Solid phase immobilization of phospholipids and cofactor proteins via covalent attachment
US20100021379A1 (en) * 2006-06-29 2010-01-28 The Regents Of The University Of California Chemical Antibodies for Immunotherapy and Imaging
US20080015145A1 (en) 2006-07-11 2008-01-17 Maria Gyongyossy-Issa Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
EP2384440B1 (en) * 2009-01-02 2015-08-12 Flysun Development Co. Ltd Synthetic peptides, methods and kits for diagnosing autoimmune diseases
WO2011163568A1 (en) 2010-06-24 2011-12-29 University Of Kansas Conjugates comprising an n-oxime bond and associated methods
CN105273080A (zh) * 2014-07-14 2016-01-27 于珮 一种还原型β2-糖蛋白Ⅰ的制备方法
US10098960B2 (en) 2015-04-03 2018-10-16 Ucl Business Plc Polymer conjugate
TWI572617B (zh) * 2016-01-20 2017-03-01 國立陽明大學 重組β－醣蛋白胜肽及其於抗腫瘤之應用
CN105801694A (zh) * 2016-05-03 2016-07-27 上海科新生物技术股份有限公司 一种抗心磷脂/β2糖蛋白I复合物的嵌合抗体
US11661447B2 (en) * 2017-08-03 2023-05-30 The Cleveland Clinic Foundation Human β2-glycoprotein I expression
EP4308602A1 (en) * 2021-03-18 2024-01-24 Université de Genève Peptides and use thereof for diagnosing and treating antiphospholipid syndrome
CN115894270B (zh) * 2022-10-10 2024-09-06 深圳市迪克曼生物科技有限公司 一种神经酰胺及其制备方法和应用

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Also Published As

Publication number Publication date
DE69934228T2 (de) 2007-10-04
CN1310759A (zh) 2001-08-29
WO1999064595A9 (en) 2000-09-08
ES2275348T3 (es) 2007-06-01
ATE346922T1 (de) 2006-12-15
PT1092027E (pt) 2007-02-28
DE69934228D1 (de) 2007-01-11
KR20010052713A (ko) 2001-06-25
US6858210B1 (en) 2005-02-22
EP1092027A1 (en) 2001-04-18
US20050004351A1 (en) 2005-01-06
WO1999064595A1 (en) 1999-12-16
CA2329942A1 (en) 1999-12-16
JP2002517245A (ja) 2002-06-18
AU4339599A (en) 1999-12-30
EP1092027B1 (en) 2006-11-29

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