AU769035B2 - Detection of neoplasia by analysis of saliva - Google Patents

Detection of neoplasia by analysis of saliva Download PDF

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Publication number
AU769035B2
AU769035B2 AU29969/99A AU2996999A AU769035B2 AU 769035 B2 AU769035 B2 AU 769035B2 AU 29969/99 A AU29969/99 A AU 29969/99A AU 2996999 A AU2996999 A AU 2996999A AU 769035 B2 AU769035 B2 AU 769035B2
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Australia
Prior art keywords
seq
nucleic acid
linear
base pairs
length
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Expired
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AU29969/99A
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English (en)
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AU2996999A (en
Inventor
David Sidransky
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Johns Hopkins University
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Johns Hopkins University
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Publication of AU2996999A publication Critical patent/AU2996999A/en
Priority to AU2003266475A priority Critical patent/AU2003266475B2/en
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Publication of AU769035B2 publication Critical patent/AU769035B2/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82Translation products from oncogenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • A61B10/0051Devices for taking samples of body liquids for taking saliva or sputum samples
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AU29969/99A 1998-03-10 1999-03-10 Detection of neoplasia by analysis of saliva Expired AU769035B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003266475A AU2003266475B2 (en) 1998-03-10 2003-12-04 Detection of neoplasia by analysis of saliva

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/038,637 US6235470B1 (en) 1993-11-12 1998-03-10 Detection of neoplasia by analysis of saliva
US09/038637 1998-03-10
PCT/US1999/005220 WO1999046408A1 (en) 1998-03-10 1999-03-10 Detection of neoplasia by analysis of saliva

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2003266475A Division AU2003266475B2 (en) 1998-03-10 2003-12-04 Detection of neoplasia by analysis of saliva

Publications (2)

Publication Number Publication Date
AU2996999A AU2996999A (en) 1999-09-27
AU769035B2 true AU769035B2 (en) 2004-01-15

Family

ID=21901047

Family Applications (1)

Application Number Title Priority Date Filing Date
AU29969/99A Expired AU769035B2 (en) 1998-03-10 1999-03-10 Detection of neoplasia by analysis of saliva

Country Status (9)

Country Link
US (4) US6235470B1 (enExample)
EP (1) EP1062366B1 (enExample)
JP (2) JP2002505888A (enExample)
AT (1) ATE433498T1 (enExample)
AU (1) AU769035B2 (enExample)
CA (1) CA2323060A1 (enExample)
DE (1) DE69940969D1 (enExample)
NO (1) NO20004504L (enExample)
WO (1) WO1999046408A1 (enExample)

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US6235470B1 (en) * 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
US6291163B1 (en) * 1996-08-28 2001-09-18 The Johns Hopkins University School Of Medicine Method for detecting cell proliferative disorders
WO2003057918A1 (en) * 2001-12-14 2003-07-17 Zila, Inc Light-directed molecular analysis for cancer prognosis and diagnosis
US7888324B2 (en) * 2001-08-01 2011-02-15 Genzyme Corporation Antisense modulation of apolipoprotein B expression
US7407943B2 (en) * 2001-08-01 2008-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein B expression
US20060009410A1 (en) * 2002-11-13 2006-01-12 Crooke Rosanne M Effects of apolipoprotein B inhibition on gene expression profiles in animals
US7511131B2 (en) * 2002-11-13 2009-03-31 Genzyme Corporation Antisense modulation of apolipoprotein B expression
JP5686493B2 (ja) 2003-01-24 2015-03-18 ユニバーシティ・オブ・ユタUniversity Of Utah テロメアの長さを決定することによって死亡の危険性を予測する方法
EP1730160A4 (en) * 2004-03-17 2008-04-09 Univ Johns Hopkins Neoplasia diagnostic compositions and methods of use
US20050287558A1 (en) 2004-05-05 2005-12-29 Crooke Rosanne M SNPs of apolipoprotein B and modulation of their expression
DK2997980T3 (en) * 2004-08-10 2018-03-26 Kastle Therapeutics Llc PROCEDURES FOR MODULATING LIPROPROTEIN AND CHOLESTEROL LEVELS
JP5731115B2 (ja) 2006-05-05 2015-06-10 アイシス ファーマシューティカルズ, インコーポレーテッド 遺伝子発現を調節するための化合物および方法
AU2007249805B2 (en) * 2006-05-12 2013-01-10 University Of Miami Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma
KR20090128494A (ko) * 2007-03-24 2009-12-15 겐자임 코포레이션 인간 아포리포프로틴 b에 상보적인 안티센스 올리고뉴클레오타이드 투여
US20090023138A1 (en) * 2007-07-17 2009-01-22 Zila Biotechnology, Inc. Oral cancer markers and their detection
US8012678B2 (en) * 2007-07-24 2011-09-06 Wisconsin Alumni Research Foundation Biomarkers for human papilloma virus-associated cancer
CN102439171B (zh) 2008-12-22 2017-07-14 犹他大学研究基金会 单色多重定量pcr
EP2408796B1 (en) 2009-03-16 2020-04-22 Ionis Pharmaceuticals, Inc. Targeting Apolipoprotein B for the reduction of Apolipoprotein C-III
ITBO20090554A1 (it) * 2009-08-27 2011-02-28 Maria Gabriella Fornaro Metodo per individuare la predisposizione al carcinoma della prostata.
ES2633111T3 (es) * 2010-03-26 2017-09-19 Hongzhi Zou Métodos y materiales para detectar neoplasia colorrectal
JP6174035B2 (ja) 2011-11-15 2017-08-02 ユニヴァーシティ・オヴ・マイアミ ヒトパピローマウイルスを検出し頭頸部扁平上皮癌を予後予測する方法
TW201343919A (zh) * 2011-12-31 2013-11-01 Telome Health Inc 唾液衍生之端粒豐度計量及樣本收集裝置
US9506116B2 (en) 2013-03-14 2016-11-29 Mayo Foundation For Medical Education And Research Detecting neoplasm
HK1220737A1 (zh) 2013-05-22 2017-05-12 Telomere Diagnostics, Inc. 短端粒丰度的量度
WO2015153284A1 (en) 2014-03-31 2015-10-08 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
CA2971169A1 (en) 2014-12-30 2016-07-07 Telomere Diagnostics, Inc. Multiplex quantitative pcr
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
CN107532124B (zh) 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
CN108138235B (zh) 2015-08-31 2022-04-15 梅约医药教育及研究基金会 检测胃肿瘤
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
AU2017250663B2 (en) 2016-04-14 2023-06-15 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia
KR102747156B1 (ko) 2017-02-28 2024-12-26 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 전립선 암의 검출
CA3084584A1 (en) 2017-11-30 2019-06-06 Mayo Foundation For Medical Education And Research Detecting breast cancer
TW202015719A (zh) 2018-06-19 2020-05-01 美商尼恩醫療公司 新抗原及其用途
CN114885938A (zh) * 2022-02-25 2022-08-12 厦门迈威生物科技有限公司 一种浆膜腔积液脱落细胞保存液及其生产方法
USD1034632S1 (en) * 2022-05-03 2024-07-09 SimpliSafe, Inc. Display screen with graphical user interface

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996006951A1 (en) * 1994-08-31 1996-03-07 The Johns Hopkins University School Of Medicine Detection of hypermutable nucleic acid sequence in tissue
US5561041A (en) * 1993-11-12 1996-10-01 The Johns Hopkins University School Of Medicine Nucleic acid mutation detection by analysis of sputum
WO1998008980A1 (en) * 1996-08-28 1998-03-05 The Johns Hopkins University School Of Medicine Method for detecting cell proliferative disorders

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US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5527676A (en) 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
DE69032864T3 (de) 1989-03-29 2013-01-31 The Johns Hopkins University Nachweis des Ausfalls des Wildtyps des p53-Gens
WO1992000311A1 (en) 1990-06-27 1992-01-09 Princeton University Probes for detecting mutant p53
AU662906B2 (en) 1991-06-26 1995-09-21 F. Hoffmann-La Roche Ag Methods for detection of carcinoma metastases by nucleic acid amplification
ATE253645T1 (de) 1992-04-01 2003-11-15 Univ Johns Hopkins Med Verfahren zur bestimmung von säugetier nukleinsäuren aus stuhlproben und dafür benötigte reagenzien
JP2001507921A (ja) 1992-04-27 2001-06-19 トラスティーズ オブ ダートマス カレッジ 生物学的液体中の遺伝子配列の検出
US6235470B1 (en) * 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
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US5589579A (en) 1994-07-19 1996-12-31 Cytoclonal Pharmaceutics, Inc. Gene sequence and probe for a marker of non-small cell lung carinoma
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Patent Citations (3)

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US5561041A (en) * 1993-11-12 1996-10-01 The Johns Hopkins University School Of Medicine Nucleic acid mutation detection by analysis of sputum
WO1996006951A1 (en) * 1994-08-31 1996-03-07 The Johns Hopkins University School Of Medicine Detection of hypermutable nucleic acid sequence in tissue
WO1998008980A1 (en) * 1996-08-28 1998-03-05 The Johns Hopkins University School Of Medicine Method for detecting cell proliferative disorders

Also Published As

Publication number Publication date
US6235470B1 (en) 2001-05-22
ATE433498T1 (de) 2009-06-15
US7279312B2 (en) 2007-10-09
HK1033765A1 (en) 2001-09-21
AU2003266475A1 (en) 2004-01-22
US20020197608A1 (en) 2002-12-26
US20080124729A1 (en) 2008-05-29
EP1062366A1 (en) 2000-12-27
NO20004504L (no) 2000-11-08
AU2996999A (en) 1999-09-27
US20050009040A1 (en) 2005-01-13
CA2323060A1 (en) 1999-09-16
EP1062366A4 (en) 2002-05-08
EP1062366B1 (en) 2009-06-10
WO1999046408A1 (en) 1999-09-16
JP2004159661A (ja) 2004-06-10
DE69940969D1 (de) 2009-07-23
US7601521B2 (en) 2009-10-13
NO20004504D0 (no) 2000-09-08
JP2002505888A (ja) 2002-02-26

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