DE69940969D1 - Detektion von neoplasien durch speichelanalyse - Google Patents

Detektion von neoplasien durch speichelanalyse

Info

Publication number
DE69940969D1
DE69940969D1 DE69940969T DE69940969T DE69940969D1 DE 69940969 D1 DE69940969 D1 DE 69940969D1 DE 69940969 T DE69940969 T DE 69940969T DE 69940969 T DE69940969 T DE 69940969T DE 69940969 D1 DE69940969 D1 DE 69940969D1
Authority
DE
Germany
Prior art keywords
detection
neoplasia
storage analysis
nucleic acids
mutant nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69940969T
Other languages
German (de)
English (en)
Inventor
David Sidransky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Application granted granted Critical
Publication of DE69940969D1 publication Critical patent/DE69940969D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
DE69940969T 1998-03-10 1999-03-10 Detektion von neoplasien durch speichelanalyse Expired - Lifetime DE69940969D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/038,637 US6235470B1 (en) 1993-11-12 1998-03-10 Detection of neoplasia by analysis of saliva
PCT/US1999/005220 WO1999046408A1 (en) 1998-03-10 1999-03-10 Detection of neoplasia by analysis of saliva

Publications (1)

Publication Number Publication Date
DE69940969D1 true DE69940969D1 (de) 2009-07-23

Family

ID=21901047

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69940969T Expired - Lifetime DE69940969D1 (de) 1998-03-10 1999-03-10 Detektion von neoplasien durch speichelanalyse

Country Status (9)

Country Link
US (4) US6235470B1 (enExample)
EP (1) EP1062366B1 (enExample)
JP (2) JP2002505888A (enExample)
AT (1) ATE433498T1 (enExample)
AU (1) AU769035B2 (enExample)
CA (1) CA2323060A1 (enExample)
DE (1) DE69940969D1 (enExample)
NO (1) NO20004504L (enExample)
WO (1) WO1999046408A1 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235470B1 (en) * 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
CA2410120A1 (en) * 1996-08-28 1998-03-05 The Johns Hopkins University School Of Medicine Method for detecting cell proliferative disorders
WO2003072826A1 (en) * 2001-12-14 2003-09-04 Zila, Inc. Stain-directed molecular analysis for cancer prognosis and diagnosis
US7407943B2 (en) * 2001-08-01 2008-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein B expression
US7888324B2 (en) * 2001-08-01 2011-02-15 Genzyme Corporation Antisense modulation of apolipoprotein B expression
US7511131B2 (en) * 2002-11-13 2009-03-31 Genzyme Corporation Antisense modulation of apolipoprotein B expression
US20060009410A1 (en) * 2002-11-13 2006-01-12 Crooke Rosanne M Effects of apolipoprotein B inhibition on gene expression profiles in animals
EP1585974B1 (en) 2003-01-24 2013-02-27 University of Utah Methods of predicting mortality risk by determining telomere length
CA2558649A1 (en) * 2004-03-17 2005-09-29 The Johns Hopkins University Neoplasia diagnostic compositions and methods of use
US20050287558A1 (en) 2004-05-05 2005-12-29 Crooke Rosanne M SNPs of apolipoprotein B and modulation of their expression
HUE026284T2 (en) * 2004-08-10 2016-06-28 Genzyme Corp Oligonucleotides for use in modulating lipoprotein and cholesterol levels in humans
ATE514777T1 (de) 2006-05-05 2011-07-15 Isis Pharmaceuticals Inc Verbindungen und verfahren zur modulation von genexpression
AU2007249805B2 (en) * 2006-05-12 2013-01-10 University Of Miami Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma
RU2559536C2 (ru) * 2007-03-24 2015-08-10 Джензим Корпорейшн Введение антисмысловых олигонуклеотидов, комплементарных человеческому аполипопротеину в
US20090023138A1 (en) * 2007-07-17 2009-01-22 Zila Biotechnology, Inc. Oral cancer markers and their detection
US8012678B2 (en) 2007-07-24 2011-09-06 Wisconsin Alumni Research Foundation Biomarkers for human papilloma virus-associated cancer
CA2748265C (en) 2008-12-22 2018-04-03 University Of Utah Research Foundation Monochrome multiplex quantitative pcr
US9107933B2 (en) 2009-03-16 2015-08-18 Isis Pharmaceuticals, Inc. Compositions and methods of targeting apolipoprotein B for the reduction of apolipoprotein C-III
ITBO20090554A1 (it) * 2009-08-27 2011-02-28 Maria Gabriella Fornaro Metodo per individuare la predisposizione al carcinoma della prostata.
WO2011119934A2 (en) * 2010-03-26 2011-09-29 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal neoplasm
US20140329230A1 (en) 2011-11-15 2014-11-06 University Of Miami Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma
AU2012362210A1 (en) * 2011-12-31 2014-08-21 Telomere Diagnostics, Inc. Saliva-derived measures of telomere abundance and sample collection device
CA2902916C (en) 2013-03-14 2018-08-28 Mayo Foundation For Medical Education And Research Detecting neoplasm
WO2014190138A2 (en) 2013-05-22 2014-11-27 Telomere Diagnostics, Inc. Measures of short telomere abundance
ES2980778T3 (es) 2014-03-31 2024-10-03 Mayo Found Medical Education & Res Detección de neoplasias colorrectales
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
CA2971169A1 (en) 2014-12-30 2016-07-07 Telomere Diagnostics, Inc. Multiplex quantitative pcr
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
CN121204237A (zh) 2015-03-27 2025-12-26 精密科学公司 检测食管疾病
WO2017040627A1 (en) 2015-08-31 2017-03-09 Mayo Foundation For Medical Education And Research Detecting gastric neoplasm
AU2017250663B2 (en) 2016-04-14 2023-06-15 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
CA3054836A1 (en) 2017-02-28 2018-09-07 Mayo Foundation For Medical Education And Research Detecting prostate cancer
WO2019108626A1 (en) 2017-11-30 2019-06-06 Mayo Foundation For Medical Education And Research Detecting breast cancer
TW202015719A (zh) 2018-06-19 2020-05-01 美商尼恩醫療公司 新抗原及其用途
CN114885938A (zh) * 2022-02-25 2022-08-12 厦门迈威生物科技有限公司 一种浆膜腔积液脱落细胞保存液及其生产方法
USD1034632S1 (en) * 2022-05-03 2024-07-09 SimpliSafe, Inc. Display screen with graphical user interface

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
EP0390323B2 (en) 1989-03-29 2012-08-08 Johns Hopkins University Detection of loss of the wild-type p53 gene
US5527676A (en) 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
ES2264239T3 (es) 1990-06-27 2006-12-16 Princeton University Complejo de proteinas p53/p90'.
AU662906B2 (en) 1991-06-26 1995-09-21 F. Hoffmann-La Roche Ag Methods for detection of carcinoma metastases by nucleic acid amplification
WO1993020235A1 (en) 1992-04-01 1993-10-14 The Johns Hopkins University School Of Medicine Methods of detecting mammalian nucleic acids isolated from stool specimen and reagents therefor
CA2134552A1 (en) 1992-04-27 1993-11-11 George D. Sorenson Detection of gene sequences in biological fluids
US5561041A (en) * 1993-11-12 1996-10-01 The Johns Hopkins University School Of Medicine Nucleic acid mutation detection by analysis of sputum
US6235470B1 (en) 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
CH686982A5 (fr) * 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
US5589579A (en) 1994-07-19 1996-12-31 Cytoclonal Pharmaceutics, Inc. Gene sequence and probe for a marker of non-small cell lung carinoma
EP0779935A4 (en) * 1994-08-31 2006-07-19 Univ Johns Hopkins Med DETECTION OF HYPERMUTABLE NUCLEIC ACID SEQUENCES IN THE FABRIC
CA2410120A1 (en) * 1996-08-28 1998-03-05 The Johns Hopkins University School Of Medicine Method for detecting cell proliferative disorders
DE19712332A1 (de) * 1997-03-25 1998-10-01 Boehringer Mannheim Gmbh Verfahren zum Nachweis von Mikrosatelliten-Instabilität zur Tumordiagnostik
CA2285384C (en) * 1997-03-28 2012-10-16 Epitope, Inc. Simultaneous collection of dna and non-nucleic analytes from oral fluids

Also Published As

Publication number Publication date
AU2996999A (en) 1999-09-27
US6235470B1 (en) 2001-05-22
EP1062366B1 (en) 2009-06-10
US20080124729A1 (en) 2008-05-29
JP2004159661A (ja) 2004-06-10
AU2003266475A1 (en) 2004-01-22
US20050009040A1 (en) 2005-01-13
NO20004504L (no) 2000-11-08
AU769035B2 (en) 2004-01-15
WO1999046408A1 (en) 1999-09-16
EP1062366A4 (en) 2002-05-08
EP1062366A1 (en) 2000-12-27
US7279312B2 (en) 2007-10-09
US7601521B2 (en) 2009-10-13
ATE433498T1 (de) 2009-06-15
JP2002505888A (ja) 2002-02-26
US20020197608A1 (en) 2002-12-26
HK1033765A1 (en) 2001-09-21
NO20004504D0 (no) 2000-09-08
CA2323060A1 (en) 1999-09-16

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