ATE433498T1 - Detektion von neoplasien durch speichelanalyse - Google Patents
Detektion von neoplasien durch speichelanalyseInfo
- Publication number
- ATE433498T1 ATE433498T1 AT99911289T AT99911289T ATE433498T1 AT E433498 T1 ATE433498 T1 AT E433498T1 AT 99911289 T AT99911289 T AT 99911289T AT 99911289 T AT99911289 T AT 99911289T AT E433498 T1 ATE433498 T1 AT E433498T1
- Authority
- AT
- Austria
- Prior art keywords
- detection
- neoplasia
- saliva analysis
- nucleic acids
- mutant nucleic
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title abstract 2
- 230000009826 neoplastic cell growth Effects 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 210000003296 saliva Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/038,637 US6235470B1 (en) | 1993-11-12 | 1998-03-10 | Detection of neoplasia by analysis of saliva |
| PCT/US1999/005220 WO1999046408A1 (en) | 1998-03-10 | 1999-03-10 | Detection of neoplasia by analysis of saliva |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE433498T1 true ATE433498T1 (de) | 2009-06-15 |
Family
ID=21901047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99911289T ATE433498T1 (de) | 1998-03-10 | 1999-03-10 | Detektion von neoplasien durch speichelanalyse |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6235470B1 (de) |
| EP (1) | EP1062366B1 (de) |
| JP (2) | JP2002505888A (de) |
| AT (1) | ATE433498T1 (de) |
| AU (1) | AU769035B2 (de) |
| CA (1) | CA2323060A1 (de) |
| DE (1) | DE69940969D1 (de) |
| NO (1) | NO20004504L (de) |
| WO (1) | WO1999046408A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6235470B1 (en) * | 1993-11-12 | 2001-05-22 | The Johns Hopkins University School Of Medicine | Detection of neoplasia by analysis of saliva |
| US6291163B1 (en) * | 1996-08-28 | 2001-09-18 | The Johns Hopkins University School Of Medicine | Method for detecting cell proliferative disorders |
| US7407943B2 (en) * | 2001-08-01 | 2008-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein B expression |
| US7888324B2 (en) * | 2001-08-01 | 2011-02-15 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
| AU2002347835A1 (en) * | 2001-12-14 | 2003-07-24 | Zila Biotechnology, Inc. | Light-directed molecular analysis for cancer prognosis and diagnosis |
| US20060009410A1 (en) * | 2002-11-13 | 2006-01-12 | Crooke Rosanne M | Effects of apolipoprotein B inhibition on gene expression profiles in animals |
| US7511131B2 (en) * | 2002-11-13 | 2009-03-31 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
| EP3351919A1 (de) | 2003-01-24 | 2018-07-25 | University of Utah | Verfahren zur vorhersage des sterblichkeitsrisikos mittels bestimmung der telomerlänge |
| US20090023134A1 (en) * | 2004-03-17 | 2009-01-22 | The Johns Hopkins University | Neoplasia diagnostic compositions and methods of use |
| US20050287558A1 (en) * | 2004-05-05 | 2005-12-29 | Crooke Rosanne M | SNPs of apolipoprotein B and modulation of their expression |
| US20090326040A1 (en) * | 2004-08-10 | 2009-12-31 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein b expression |
| JP5825754B2 (ja) | 2006-05-05 | 2015-12-02 | アイシス ファーマシューティカルズ， インコーポレーテッド | Ａｐｏｂの発現を調節するための化合物および方法 |
| US8088591B2 (en) * | 2006-05-12 | 2012-01-03 | University Of Miami | Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma |
| CN103480002A (zh) * | 2007-03-24 | 2014-01-01 | 基酶有限公司 | 施用与人载脂蛋白 b互补的反义寡核苷酸 |
| US20090023138A1 (en) * | 2007-07-17 | 2009-01-22 | Zila Biotechnology, Inc. | Oral cancer markers and their detection |
| WO2009015294A1 (en) | 2007-07-24 | 2009-01-29 | Wisconsin Alumni Research Foundation | Biomarkers for human papillomavirus-associated cancers |
| CN102439171B (zh) | 2008-12-22 | 2017-07-14 | 犹他大学研究基金会 | 单色多重定量pcr |
| EP2408796B1 (de) | 2009-03-16 | 2020-04-22 | Ionis Pharmaceuticals, Inc. | Targeting Apolipoprotein B für die Reduktion von Apolipoprotein C-III |
| ITBO20090554A1 (it) * | 2009-08-27 | 2011-02-28 | Maria Gabriella Fornaro | Metodo per individuare la predisposizione al carcinoma della prostata. |
| ES2633111T3 (es) * | 2010-03-26 | 2017-09-19 | Hongzhi Zou | Métodos y materiales para detectar neoplasia colorrectal |
| EP2780714B1 (de) | 2011-11-15 | 2017-08-16 | University Of Miami | Methoden für den nachweis von humanem papillomavirus und zur prognose von kopf-hals-plattenepithelkarzinom |
| AU2012362210A1 (en) * | 2011-12-31 | 2014-08-21 | Telomere Diagnostics, Inc. | Saliva-derived measures of telomere abundance and sample collection device |
| EP4234721A3 (de) | 2013-03-14 | 2023-10-18 | Mayo Foundation for Medical Education and Research | Detektion von neoplasma |
| MX2015015891A (es) | 2013-05-22 | 2016-06-02 | Telomere Diagnostics Inc | Mediciones de abundancia de telomeros cortos. |
| US11078539B2 (en) | 2014-03-31 | 2021-08-03 | Mayo Foundation For Medical Education And Research | Detecting colorectal neoplasm |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| BR112017014116A2 (pt) | 2014-12-30 | 2018-03-06 | Telomere Diagnostics Inc | pcr quantitativo multiplex |
| US10030272B2 (en) | 2015-02-27 | 2018-07-24 | Mayo Foundation For Medical Education And Research | Detecting gastrointestinal neoplasms |
| EP3274440A4 (de) | 2015-03-27 | 2019-03-06 | Exact Sciences Corporation | Nachweis von erkrankungen der speiseröhre |
| KR102892240B1 (ko) | 2015-08-31 | 2025-11-27 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 위 신생물 검출 방법 |
| CN109153993B (zh) | 2016-04-14 | 2023-02-17 | 梅约医学教育与研究基金会 | 检测胰腺高度异型增生 |
| US10370726B2 (en) | 2016-04-14 | 2019-08-06 | Mayo Foundation For Medical Education And Research | Detecting colorectal neoplasia |
| AU2018229294B2 (en) | 2017-02-28 | 2024-06-13 | Exact Sciences Corporation | Detecting prostate cancer |
| CN111655869B (zh) | 2017-11-30 | 2024-06-28 | 梅约医学教育与研究基金会 | 检测乳腺癌 |
| TW202015719A (zh) | 2018-06-19 | 2020-05-01 | 美商尼恩醫療公司 | 新抗原及其用途 |
| CN114885938A (zh) * | 2022-02-25 | 2022-08-12 | 厦门迈威生物科技有限公司 | 一种浆膜腔积液脱落细胞保存液及其生产方法 |
| USD1034632S1 (en) * | 2022-05-03 | 2024-07-09 | SimpliSafe, Inc. | Display screen with graphical user interface |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| EP0390323B2 (de) | 1989-03-29 | 2012-08-08 | Johns Hopkins University | Nachweis des Ausfalls des Wildtyps des p53-Gens |
| US5527676A (en) | 1989-03-29 | 1996-06-18 | The Johns Hopkins University | Detection of loss of the wild-type P53 gene and kits therefor |
| DE69132771T2 (de) | 1990-06-27 | 2002-08-01 | Princeton University, Princeton | Sonden für die detektion der p53 mutante |
| AU662906B2 (en) | 1991-06-26 | 1995-09-21 | F. Hoffmann-La Roche Ag | Methods for detection of carcinoma metastases by nucleic acid amplification |
| EP0672181B1 (de) | 1992-04-01 | 2003-11-05 | The Johns Hopkins University School Of Medicine | Verfahren zur bestimmung von säugetier nukleinsäuren aus stuhlproben und dafür benötigte reagenzien |
| WO1993022456A1 (en) | 1992-04-27 | 1993-11-11 | Trustees Of Dartmouth College | Detection of gene sequences in biological fluids |
| US6235470B1 (en) * | 1993-11-12 | 2001-05-22 | The Johns Hopkins University School Of Medicine | Detection of neoplasia by analysis of saliva |
| US5561041A (en) | 1993-11-12 | 1996-10-01 | The Johns Hopkins University School Of Medicine | Nucleic acid mutation detection by analysis of sputum |
| CH686982A5 (fr) * | 1993-12-16 | 1996-08-15 | Maurice Stroun | Méthode pour le diagnostic de cancers. |
| US5589579A (en) | 1994-07-19 | 1996-12-31 | Cytoclonal Pharmaceutics, Inc. | Gene sequence and probe for a marker of non-small cell lung carinoma |
| BR9508666B1 (pt) * | 1994-08-31 | 2010-12-14 | mÉtodos para detectar distérbio proliferativo celular e cÂncer de um àrgço, bem como kit. | |
| US6291163B1 (en) * | 1996-08-28 | 2001-09-18 | The Johns Hopkins University School Of Medicine | Method for detecting cell proliferative disorders |
| DE19712332A1 (de) * | 1997-03-25 | 1998-10-01 | Boehringer Mannheim Gmbh | Verfahren zum Nachweis von Mikrosatelliten-Instabilität zur Tumordiagnostik |
| AU6589698A (en) * | 1997-03-28 | 1998-10-22 | Epitope, Inc. | Simultaneous collection of dna and non-nucleic analytes from oral fluids |
-
1998
- 1998-03-10 US US09/038,637 patent/US6235470B1/en not_active Expired - Lifetime
-
1999
- 1999-03-10 DE DE69940969T patent/DE69940969D1/de not_active Expired - Lifetime
- 1999-03-10 AU AU29969/99A patent/AU769035B2/en not_active Expired
- 1999-03-10 AT AT99911289T patent/ATE433498T1/de not_active IP Right Cessation
- 1999-03-10 CA CA002323060A patent/CA2323060A1/en not_active Abandoned
- 1999-03-10 JP JP2000535774A patent/JP2002505888A/ja active Pending
- 1999-03-10 WO PCT/US1999/005220 patent/WO1999046408A1/en not_active Ceased
- 1999-03-10 EP EP99911289A patent/EP1062366B1/de not_active Expired - Lifetime
-
2000
- 2000-09-08 NO NO20004504A patent/NO20004504L/no unknown
-
2001
- 2001-05-22 US US09/863,806 patent/US20020197608A1/en not_active Abandoned
-
2004
- 2004-01-05 JP JP2004000679A patent/JP2004159661A/ja active Pending
- 2004-01-09 US US10/754,478 patent/US7279312B2/en not_active Expired - Fee Related
-
2007
- 2007-10-08 US US11/868,683 patent/US7601521B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7279312B2 (en) | 2007-10-09 |
| CA2323060A1 (en) | 1999-09-16 |
| EP1062366B1 (de) | 2009-06-10 |
| EP1062366A1 (de) | 2000-12-27 |
| US7601521B2 (en) | 2009-10-13 |
| AU769035B2 (en) | 2004-01-15 |
| US6235470B1 (en) | 2001-05-22 |
| EP1062366A4 (de) | 2002-05-08 |
| WO1999046408A1 (en) | 1999-09-16 |
| US20080124729A1 (en) | 2008-05-29 |
| NO20004504L (no) | 2000-11-08 |
| NO20004504D0 (no) | 2000-09-08 |
| JP2004159661A (ja) | 2004-06-10 |
| DE69940969D1 (de) | 2009-07-23 |
| US20020197608A1 (en) | 2002-12-26 |
| HK1033765A1 (en) | 2001-09-21 |
| JP2002505888A (ja) | 2002-02-26 |
| AU2996999A (en) | 1999-09-27 |
| AU2003266475A1 (en) | 2004-01-22 |
| US20050009040A1 (en) | 2005-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |