AU766235B2 - IL-8 receptor antagonists - Google Patents
IL-8 receptor antagonists Download PDFInfo
- Publication number
- AU766235B2 AU766235B2 AU56161/00A AU5616100A AU766235B2 AU 766235 B2 AU766235 B2 AU 766235B2 AU 56161/00 A AU56161/00 A AU 56161/00A AU 5616100 A AU5616100 A AU 5616100A AU 766235 B2 AU766235 B2 AU 766235B2
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- optionally substituted
- heteroaryl
- alkenyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 108010038415 interleukin-8 receptors Proteins 0.000 title description 6
- 229940044551 receptor antagonist Drugs 0.000 title description 2
- 239000002464 receptor antagonist Substances 0.000 title description 2
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- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
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- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- ZWZVWGITAAIFPS-UHFFFAOYSA-N thiophosgene Chemical compound ClC(Cl)=S ZWZVWGITAAIFPS-UHFFFAOYSA-N 0.000 description 1
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- 230000000699 topical effect Effects 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14002499P | 1999-06-16 | 1999-06-16 | |
| US60/140024 | 1999-06-16 | ||
| PCT/US2000/016506 WO2000076501A1 (en) | 1999-06-16 | 2000-06-15 | Il-8 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU5616100A AU5616100A (en) | 2001-01-02 |
| AU766235B2 true AU766235B2 (en) | 2003-10-09 |
Family
ID=22489379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU56161/00A Ceased AU766235B2 (en) | 1999-06-16 | 2000-06-15 | IL-8 receptor antagonists |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1185265A4 (no) |
| JP (1) | JP2003501463A (no) |
| KR (1) | KR20020015347A (no) |
| CN (1) | CN1356899A (no) |
| AR (1) | AR024350A1 (no) |
| AU (1) | AU766235B2 (no) |
| BR (1) | BR0011122A (no) |
| CA (1) | CA2377386A1 (no) |
| CO (1) | CO5190696A1 (no) |
| CZ (1) | CZ20014472A3 (no) |
| HU (1) | HUP0201582A3 (no) |
| IL (1) | IL145762A0 (no) |
| MX (1) | MXPA01013005A (no) |
| NO (1) | NO20016052D0 (no) |
| NZ (1) | NZ514696A (no) |
| PL (1) | PL352213A1 (no) |
| TR (1) | TR200103638T2 (no) |
| WO (1) | WO2000076501A1 (no) |
| ZA (1) | ZA200109480B (no) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE422203T1 (de) | 2002-10-09 | 2009-02-15 | Schering Corp | Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden |
| DE10334309A1 (de) * | 2003-07-28 | 2005-03-03 | Aventis Pharma Deutschland Gmbh | Substituierte Thiazol-Benzoisothiazoldioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
| US7094794B2 (en) | 2003-07-28 | 2006-08-22 | Sanofi-Aventis Deutschland Gmbh | Substituted thiazole-benzoisothiazole dioxide derivatives, process for their preparation and their use |
| US7442709B2 (en) | 2003-08-21 | 2008-10-28 | Osi Pharmaceuticals, Inc. | N3-substituted imidazopyridine c-Kit inhibitors |
| AU2004268949A1 (en) | 2003-08-21 | 2005-03-10 | Osi Pharmaceuticals, Inc. | N-substituted benzimidazolyl C-kit inhibitors |
| AP2006003553A0 (en) | 2003-08-21 | 2006-04-30 | Osi Pharm Inc | N-substituted pyrazolyl-amidyl-benzimidazolyl C- kit inhibitors. |
| MXPA06007076A (es) | 2003-12-19 | 2006-08-31 | Pharmacopeia Drug Discovery | Tiadiazoles como ligandos del receptor cxc y cc-quimiocina. |
| JP2008517930A (ja) | 2004-10-21 | 2008-05-29 | トランス テック ファーマ，インコーポレイテッド | ＧａｌＲ１のアゴニストとしてのビススルホンアミド化合物、組成物、及び使用法 |
| US7419995B2 (en) | 2004-12-01 | 2008-09-02 | Osi Pharmaceuticals, Inc. | N-substituted benzimidazoyl c-Kit inhibitors and combinatorial benzimidazole library |
| BR112012003462A2 (pt) | 2009-08-24 | 2016-02-23 | Ascepion Pharmaceuticals Inc | "composto, composição farmacêutica, e, método para tratar um paciente tendo uma condição mediada pela proteína quinase." |
| EP2377850A1 (en) | 2010-03-30 | 2011-10-19 | Pharmeste S.r.l. | TRPV1 vanilloid receptor antagonists with a bicyclic portion |
| CN102060780B (zh) * | 2010-12-27 | 2014-11-05 | 雅本化学股份有限公司 | 2-(n-取代)-氨基苯并咪唑衍生物的制备方法 |
| CN111116502A (zh) * | 2018-10-30 | 2020-05-08 | 中国石油化工股份有限公司 | 一步法合成苯骈三氮唑的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA921120B (en) * | 1991-02-19 | 1993-01-27 | Smithkline Beecham Corp | Cytokine inhibitors |
| EP0991406A4 (en) * | 1997-01-23 | 2000-12-13 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
-
2000
- 2000-06-13 CO CO00043846A patent/CO5190696A1/es not_active Application Discontinuation
- 2000-06-14 AR ARP000102922A patent/AR024350A1/es not_active Application Discontinuation
- 2000-06-15 BR BR0011122-8A patent/BR0011122A/pt not_active IP Right Cessation
- 2000-06-15 KR KR1020017016144A patent/KR20020015347A/ko not_active Application Discontinuation
- 2000-06-15 CA CA002377386A patent/CA2377386A1/en not_active Abandoned
- 2000-06-15 AU AU56161/00A patent/AU766235B2/en not_active Ceased
- 2000-06-15 IL IL14576200A patent/IL145762A0/xx unknown
- 2000-06-15 EP EP00941455A patent/EP1185265A4/en not_active Withdrawn
- 2000-06-15 WO PCT/US2000/016506 patent/WO2000076501A1/en not_active Application Discontinuation
- 2000-06-15 CN CN00809090A patent/CN1356899A/zh active Pending
- 2000-06-15 NZ NZ514696A patent/NZ514696A/xx unknown
- 2000-06-15 CZ CZ20014472A patent/CZ20014472A3/cs unknown
- 2000-06-15 JP JP2001502834A patent/JP2003501463A/ja not_active Withdrawn
- 2000-06-15 TR TR2001/03638T patent/TR200103638T2/xx unknown
- 2000-06-15 HU HU0201582A patent/HUP0201582A3/hu unknown
- 2000-06-15 MX MXPA01013005A patent/MXPA01013005A/es unknown
- 2000-06-15 PL PL00352213A patent/PL352213A1/xx not_active Application Discontinuation
- 2000-11-16 ZA ZA200109480A patent/ZA200109480B/en unknown
-
2001
- 2001-12-11 NO NO20016052A patent/NO20016052D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2377386A1 (en) | 2000-12-21 |
| HUP0201582A2 (hu) | 2002-12-28 |
| TR200103638T2 (tr) | 2002-04-22 |
| KR20020015347A (ko) | 2002-02-27 |
| CN1356899A (zh) | 2002-07-03 |
| WO2000076501A1 (en) | 2000-12-21 |
| MXPA01013005A (es) | 2002-07-02 |
| IL145762A0 (en) | 2002-07-25 |
| JP2003501463A (ja) | 2003-01-14 |
| HUP0201582A3 (en) | 2003-02-28 |
| NO20016052L (no) | 2001-12-11 |
| AU5616100A (en) | 2001-01-02 |
| EP1185265A1 (en) | 2002-03-13 |
| BR0011122A (pt) | 2002-02-26 |
| NO20016052D0 (no) | 2001-12-11 |
| CO5190696A1 (es) | 2002-08-29 |
| CZ20014472A3 (cs) | 2002-06-12 |
| ZA200109480B (en) | 2002-11-18 |
| PL352213A1 (en) | 2003-08-11 |
| EP1185265A4 (en) | 2004-02-04 |
| AR024350A1 (es) | 2002-10-02 |
| NZ514696A (en) | 2004-03-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |