AU765642B2 - Growth hormone secretagogues - Google Patents

Growth hormone secretagogues Download PDF

Info

Publication number
AU765642B2
AU765642B2 AU34968/00A AU3496800A AU765642B2 AU 765642 B2 AU765642 B2 AU 765642B2 AU 34968/00 A AU34968/00 A AU 34968/00A AU 3496800 A AU3496800 A AU 3496800A AU 765642 B2 AU765642 B2 AU 765642B2
Authority
AU
Australia
Prior art keywords
mmol
preparation
product
compound
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU34968/00A
Other languages
English (en)
Other versions
AU3496800A (en
Inventor
Jeffrey Alan Dodge
Charles Willis Lugar Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of AU3496800A publication Critical patent/AU3496800A/en
Application granted granted Critical
Publication of AU765642B2 publication Critical patent/AU765642B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU34968/00A 1999-02-19 2000-02-18 Growth hormone secretagogues Ceased AU765642B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12081399P 1999-02-19 1999-02-19
US60/120813 1999-02-19
PCT/US2000/004274 WO2000049037A1 (en) 1999-02-19 2000-02-18 Growth hormone secretagogues

Publications (2)

Publication Number Publication Date
AU3496800A AU3496800A (en) 2000-09-04
AU765642B2 true AU765642B2 (en) 2003-09-25

Family

ID=22392709

Family Applications (1)

Application Number Title Priority Date Filing Date
AU34968/00A Ceased AU765642B2 (en) 1999-02-19 2000-02-18 Growth hormone secretagogues

Country Status (13)

Country Link
EP (1) EP1153034B1 (enExample)
JP (1) JP2002539089A (enExample)
CN (1) CN1179972C (enExample)
AR (1) AR023369A1 (enExample)
AT (1) ATE375996T1 (enExample)
AU (1) AU765642B2 (enExample)
BR (1) BR0008321A (enExample)
CA (1) CA2362303A1 (enExample)
CO (1) CO5160260A1 (enExample)
DE (1) DE60036785D1 (enExample)
IL (1) IL144350A0 (enExample)
PE (1) PE20001468A1 (enExample)
WO (1) WO2000049037A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6639076B1 (en) 1998-08-18 2003-10-28 Eli Lilly And Company Growth hormone secretagogues
US6828331B1 (en) 1999-02-19 2004-12-07 Eli Lilly And Company Growth hormone secretagogues
EP1289526A4 (en) 2000-05-30 2005-03-16 Merck & Co Inc MELANOCORTIN RECEPTOR AGONISTS
US6756385B2 (en) * 2000-07-31 2004-06-29 Pfizer Inc. Imidazole derivatives
GT200100147A (es) * 2000-07-31 2002-06-25 Derivados de imidazol
AU2001294532A1 (en) * 2000-10-13 2002-04-29 Eli Lilly And Company Resolution process for preparation of substantially pure (r) and (s) enantiomersof 2-(4-nitroimidazolyl)-4-methoxyphenylpropionic acid and salts thereof
CA2431515C (en) * 2001-01-23 2008-01-22 Gador S.A. Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition, and use thereof
US7125840B2 (en) 2001-10-09 2006-10-24 Eli Lilly And Company Substituted dipeptides as growth hormone secretagogues
AU2003220441A1 (en) 2002-04-09 2003-10-27 Eli Lilly And Company Dipeptidic growth hormone secretagogues
AP2379A (en) * 2004-03-23 2012-03-08 Pfizer Prod Inc Imidazole compounds for the treatment of neurodegenerative disorders.
EP1940802A2 (en) 2005-09-22 2008-07-09 Pfizer Products Inc. Imidazole compounds for the treatment of neurological disorders
ES3055762T3 (en) 2019-08-09 2026-02-16 Pfizer Solid state forms of (s)-2-(((s)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-n-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1h-imidazol-4-yl)pentanamide and uses thereof
US11884634B2 (en) 2019-08-09 2024-01-30 Pfizer Inc. Compositions of solid forms of (S)-2-(((S)-6,8-difluoro-1,2,3,4- tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide
MX2024002590A (es) 2021-09-01 2024-03-22 Springworks Therapeutics Inc Sintesis de nirogacestat.
US11504354B1 (en) 2021-09-08 2022-11-22 SpringWorks Therapeutics Inc.. Chlorinated tetralin compounds and pharmaceutical compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK282166B6 (sk) * 1992-12-11 2001-11-06 Merck & Co., Inc. Spiropiperidínové deriváty, spôsob ich výroby a farmaceutický prostriedok s ich obsahom
IL107836A (en) * 1992-12-11 1998-01-04 Merck & Co Inc Spiro piperidines and homologues, their preparation and pharmaceutical preparations containing them
US5721250A (en) * 1993-12-23 1998-02-24 Merck & Co. Inc. Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
JP2001502319A (ja) * 1996-10-15 2001-02-20 藤沢薬品工業株式会社 成長ホルモンの放出を促進するベンズオキセピン誘導体
ZA987383B (en) * 1997-08-19 2000-02-17 Lilly Co Eli Treatment of congestive heart failure with growth hormone secretagogues.
ZA987385B (en) * 1997-08-19 2000-04-18 Lilly Co Eli Growth hormone secretagogues.

Also Published As

Publication number Publication date
CO5160260A1 (es) 2002-05-30
CN1347420A (zh) 2002-05-01
CA2362303A1 (en) 2000-08-24
WO2000049037A1 (en) 2000-08-24
EP1153034A1 (en) 2001-11-14
AU3496800A (en) 2000-09-04
PE20001468A1 (es) 2000-12-20
BR0008321A (pt) 2002-01-29
IL144350A0 (en) 2002-05-23
ATE375996T1 (de) 2007-11-15
AR023369A1 (es) 2002-09-04
JP2002539089A (ja) 2002-11-19
DE60036785D1 (de) 2007-11-29
EP1153034B1 (en) 2007-10-17
CN1179972C (zh) 2004-12-15

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)