AU7652591A - Method for the recombinant production of hiridius and hirudin-like polypeptides - Google Patents

Method for the recombinant production of hiridius and hirudin-like polypeptides

Info

Publication number
AU7652591A
AU7652591A AU76525/91A AU7652591A AU7652591A AU 7652591 A AU7652591 A AU 7652591A AU 76525/91 A AU76525/91 A AU 76525/91A AU 7652591 A AU7652591 A AU 7652591A AU 7652591 A AU7652591 A AU 7652591A
Authority
AU
Australia
Prior art keywords
hirudin
polypeptide
gly
glu
asn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU76525/91A
Other languages
English (en)
Inventor
Luca Benatti
Paolo Carminati
Philippe De Taxis Du Poet
Jacqueline Lansen
Guy Mazue
Romeo Roncucci
Paolo Sarmientos
Emanuela Scacheri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Publication of AU7652591A publication Critical patent/AU7652591A/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/815Protease inhibitors from leeches, e.g. hirudin, eglin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU76525/91A 1990-05-10 1991-04-05 Method for the recombinant production of hiridius and hirudin-like polypeptides Abandoned AU7652591A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909010552A GB9010552D0 (en) 1990-05-10 1990-05-10 Method for the recombinant production of hirudins and novel hirudins
GB9010552 1990-05-10

Publications (1)

Publication Number Publication Date
AU7652591A true AU7652591A (en) 1991-11-27

Family

ID=10675801

Family Applications (1)

Application Number Title Priority Date Filing Date
AU76525/91A Abandoned AU7652591A (en) 1990-05-10 1991-04-05 Method for the recombinant production of hiridius and hirudin-like polypeptides

Country Status (16)

Country Link
EP (1) EP0482144A1 (ja)
JP (1) JPH05500615A (ja)
KR (1) KR920703817A (ja)
CN (1) CN1057294A (ja)
AU (1) AU7652591A (ja)
CA (1) CA2063575A1 (ja)
CS (1) CS133191A3 (ja)
FI (1) FI920058A0 (ja)
GB (1) GB9010552D0 (ja)
HU (1) HUT59961A (ja)
IE (1) IE911578A1 (ja)
IL (1) IL98074A0 (ja)
NO (1) NO920116L (ja)
PT (1) PT97604A (ja)
WO (1) WO1991017250A1 (ja)
ZA (1) ZA913503B (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008736A1 (fr) * 1990-11-08 1992-05-29 Nippon Mining Company Limited Mutant d'hirudine, sa production, anticoagulant, vecteur secretoire, microorganisme transforme par ledit vecteur et production d'un produit a partir dudit microorganisme
HU214698B (hu) * 1992-04-09 1998-06-29 Gyógyszerkutató Intézet Kft. Eljárás rekombináns deszulfátó-hirudin HV-1 peptidek előállítására
US5972648A (en) * 1993-09-28 1999-10-26 Japan Energy Corporation Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients
DE102005002978B4 (de) * 2005-01-21 2013-04-25 Merz Pharma Gmbh & Co. Kgaa Rekombinante Expression von Proteinen in einer disulfidverbrückten, zweikettigen Form
ES2573522T3 (es) 2011-01-25 2016-06-08 Université Catholique de Louvain Composiciones y métodos para el trasplante celular
US9775890B2 (en) 2012-01-25 2017-10-03 Université Catholique de Louvain Factor Xa inhibitor used with liver-derived progenitor cells
CN108220369B (zh) * 2017-12-04 2021-03-12 广东双骏生物科技有限公司 一种生产重组水蛭素的方法
CN115572329B (zh) * 2021-06-21 2024-02-06 王大勇 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法
CN115677850B (zh) * 2021-07-24 2024-03-08 王大勇 具备较强抗凝血活性的医蛭基因突变水蛭素及其制备方法
CN114736289B (zh) * 2022-03-17 2023-07-18 华南理工大学 一种带有酪氨酸硫酸化修饰的水蛭素的化学合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3429430A1 (de) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445517C2 (de) * 1984-12-13 1993-11-18 Ciba Geigy Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
GB8817160D0 (en) * 1988-07-19 1988-08-24 Ciba Geigy Ag Novel proteins

Also Published As

Publication number Publication date
IL98074A0 (en) 1992-06-21
ZA913503B (en) 1992-02-26
CS133191A3 (en) 1992-01-15
PT97604A (pt) 1992-02-28
IE911578A1 (en) 1991-11-20
GB9010552D0 (en) 1990-07-04
EP0482144A1 (en) 1992-04-29
NO920116D0 (no) 1992-01-09
HUT59961A (en) 1992-07-28
CA2063575A1 (en) 1991-11-11
CN1057294A (zh) 1991-12-25
HU9200088D0 (en) 1992-06-29
JPH05500615A (ja) 1993-02-12
WO1991017250A1 (en) 1991-11-14
FI920058A0 (fi) 1992-01-07
NO920116L (no) 1992-03-10
KR920703817A (ko) 1992-12-18

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