AU7652591A - Method for the recombinant production of hiridius and hirudin-like polypeptides - Google Patents
Method for the recombinant production of hiridius and hirudin-like polypeptidesInfo
- Publication number
- AU7652591A AU7652591A AU76525/91A AU7652591A AU7652591A AU 7652591 A AU7652591 A AU 7652591A AU 76525/91 A AU76525/91 A AU 76525/91A AU 7652591 A AU7652591 A AU 7652591A AU 7652591 A AU7652591 A AU 7652591A
- Authority
- AU
- Australia
- Prior art keywords
- hirudin
- polypeptide
- gly
- glu
- asn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000000243 solution Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229960003766 thrombin (human) Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960000187 tissue plasminogen activator Drugs 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 108010087967 type I signal peptidase Proteins 0.000 description 1
- 241000701366 unidentified nuclear polyhedrosis viruses Species 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 108700001624 vesicular stomatitis virus G Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909010552A GB9010552D0 (en) | 1990-05-10 | 1990-05-10 | Method for the recombinant production of hirudins and novel hirudins |
| GB9010552 | 1990-05-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU7652591A true AU7652591A (en) | 1991-11-27 |
Family
ID=10675801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU76525/91A Abandoned AU7652591A (en) | 1990-05-10 | 1991-04-05 | Method for the recombinant production of hiridius and hirudin-like polypeptides |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0482144A1 (ja) |
| JP (1) | JPH05500615A (ja) |
| KR (1) | KR920703817A (ja) |
| CN (1) | CN1057294A (ja) |
| AU (1) | AU7652591A (ja) |
| CA (1) | CA2063575A1 (ja) |
| CS (1) | CS133191A3 (ja) |
| FI (1) | FI920058A0 (ja) |
| GB (1) | GB9010552D0 (ja) |
| HU (1) | HUT59961A (ja) |
| IE (1) | IE911578A1 (ja) |
| IL (1) | IL98074A0 (ja) |
| NO (1) | NO920116L (ja) |
| PT (1) | PT97604A (ja) |
| WO (1) | WO1991017250A1 (ja) |
| ZA (1) | ZA913503B (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992008736A1 (fr) * | 1990-11-08 | 1992-05-29 | Nippon Mining Company Limited | Mutant d'hirudine, sa production, anticoagulant, vecteur secretoire, microorganisme transforme par ledit vecteur et production d'un produit a partir dudit microorganisme |
| HU214698B (hu) * | 1992-04-09 | 1998-06-29 | Gyógyszerkutató Intézet Kft. | Eljárás rekombináns deszulfátó-hirudin HV-1 peptidek előállítására |
| US5972648A (en) * | 1993-09-28 | 1999-10-26 | Japan Energy Corporation | Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients |
| DE102005002978B4 (de) * | 2005-01-21 | 2013-04-25 | Merz Pharma Gmbh & Co. Kgaa | Rekombinante Expression von Proteinen in einer disulfidverbrückten, zweikettigen Form |
| ES2573522T3 (es) | 2011-01-25 | 2016-06-08 | Université Catholique de Louvain | Composiciones y métodos para el trasplante celular |
| US9775890B2 (en) | 2012-01-25 | 2017-10-03 | Université Catholique de Louvain | Factor Xa inhibitor used with liver-derived progenitor cells |
| CN108220369B (zh) * | 2017-12-04 | 2021-03-12 | 广东双骏生物科技有限公司 | 一种生产重组水蛭素的方法 |
| CN115572329B (zh) * | 2021-06-21 | 2024-02-06 | 王大勇 | 一组活性增强代谢较慢的菲牛蛭基因重组水蛭素及其制备方法 |
| CN115677850B (zh) * | 2021-07-24 | 2024-03-08 | 王大勇 | 具备较强抗凝血活性的医蛭基因突变水蛭素及其制备方法 |
| CN114736289B (zh) * | 2022-03-17 | 2023-07-18 | 华南理工大学 | 一种带有酪氨酸硫酸化修饰的水蛭素的化学合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3429430A1 (de) * | 1984-08-10 | 1986-02-20 | Hoechst Ag, 6230 Frankfurt | Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens |
| DE3445517C2 (de) * | 1984-12-13 | 1993-11-18 | Ciba Geigy | Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins |
| GB8817160D0 (en) * | 1988-07-19 | 1988-08-24 | Ciba Geigy Ag | Novel proteins |
-
1990
- 1990-05-10 GB GB909010552A patent/GB9010552D0/en active Pending
-
1991
- 1991-04-05 KR KR1019920700048A patent/KR920703817A/ko not_active Application Discontinuation
- 1991-04-05 AU AU76525/91A patent/AU7652591A/en not_active Abandoned
- 1991-04-05 HU HU9288A patent/HUT59961A/hu unknown
- 1991-04-05 WO PCT/EP1991/000643 patent/WO1991017250A1/en not_active Application Discontinuation
- 1991-04-05 CA CA002063575A patent/CA2063575A1/en not_active Abandoned
- 1991-04-05 JP JP3506842A patent/JPH05500615A/ja active Pending
- 1991-04-05 EP EP19910907785 patent/EP0482144A1/en not_active Withdrawn
- 1991-05-07 CS CS911331A patent/CS133191A3/cs unknown
- 1991-05-07 IL IL98074A patent/IL98074A0/xx unknown
- 1991-05-08 ZA ZA913503A patent/ZA913503B/xx unknown
- 1991-05-08 CN CN91103025A patent/CN1057294A/zh active Pending
- 1991-05-08 PT PT97604A patent/PT97604A/pt not_active Application Discontinuation
- 1991-05-09 IE IE157891A patent/IE911578A1/en unknown
-
1992
- 1992-01-07 FI FI920058A patent/FI920058A0/fi not_active Application Discontinuation
- 1992-01-09 NO NO92920116A patent/NO920116L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL98074A0 (en) | 1992-06-21 |
| ZA913503B (en) | 1992-02-26 |
| CS133191A3 (en) | 1992-01-15 |
| PT97604A (pt) | 1992-02-28 |
| IE911578A1 (en) | 1991-11-20 |
| GB9010552D0 (en) | 1990-07-04 |
| EP0482144A1 (en) | 1992-04-29 |
| NO920116D0 (no) | 1992-01-09 |
| HUT59961A (en) | 1992-07-28 |
| CA2063575A1 (en) | 1991-11-11 |
| CN1057294A (zh) | 1991-12-25 |
| HU9200088D0 (en) | 1992-06-29 |
| JPH05500615A (ja) | 1993-02-12 |
| WO1991017250A1 (en) | 1991-11-14 |
| FI920058A0 (fi) | 1992-01-07 |
| NO920116L (no) | 1992-03-10 |
| KR920703817A (ko) | 1992-12-18 |
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