AU752129B2 - Chimeric transcriptional activators and compositions and uses related thereto - Google Patents
Chimeric transcriptional activators and compositions and uses related thereto Download PDFInfo
- Publication number
- AU752129B2 AU752129B2 AU42402/97A AU4240297A AU752129B2 AU 752129 B2 AU752129 B2 AU 752129B2 AU 42402/97 A AU42402/97 A AU 42402/97A AU 4240297 A AU4240297 A AU 4240297A AU 752129 B2 AU752129 B2 AU 752129B2
- Authority
- AU
- Australia
- Prior art keywords
- nucleic acid
- gene
- domain
- chimeric
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
Landscapes
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1997/015219 WO1999010508A1 (en) | 1997-08-27 | 1997-08-27 | Chimeric transcriptional activators and compositions and uses related thereto |
Publications (2)
Publication Number | Publication Date |
---|---|
AU4240297A AU4240297A (en) | 1999-03-16 |
AU752129B2 true AU752129B2 (en) | 2002-09-05 |
Family
ID=22261527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU42402/97A Expired AU752129B2 (en) | 1997-08-27 | 1997-08-27 | Chimeric transcriptional activators and compositions and uses related thereto |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1003886A1 (de) |
JP (1) | JP2001514007A (de) |
AU (1) | AU752129B2 (de) |
CA (1) | CA2303482A1 (de) |
IL (1) | IL134643A0 (de) |
WO (1) | WO1999010508A1 (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2375490A1 (en) * | 1999-06-18 | 2000-12-28 | Ariad Gene Therapeutics, Inc. | Chimeric oca-b transcription factors |
CA2398010A1 (en) | 2000-01-24 | 2001-07-26 | The Trustees Of Columbia University In The City Of New York | An in vivo screen using chemical inducers of dimerization |
WO2001062780A1 (en) * | 2000-02-24 | 2001-08-30 | The Salk Institute For Biological Studies | Gene expression system based on chimeric receptors |
AU2000256183A1 (en) * | 2000-06-16 | 2002-01-02 | Ariad Gene Therapeutics, Inc. | Chimeric hsf transcription factors |
MXPA03007492A (es) * | 2001-02-20 | 2004-10-15 | Rheogene Holdings Inc | Receptores de retinoide x quimerico y su uso en un sistema de expresion de gen inducible basado en receptor de ecdisona novedoso. |
EP1435779A4 (de) | 2001-09-24 | 2005-06-01 | Sangamo Biosciences Inc | Modulation von stammzellen mittels zinkfingerproteinen |
US7083918B2 (en) | 2002-04-24 | 2006-08-01 | The Trustees Of Columbia University In The City Of New York | Bacterial small-molecule three-hybrid system |
AU2004274957B2 (en) | 2003-09-19 | 2009-02-05 | Sangamo Therapeutics, Inc. | Engineered zinc finger proteins for regulation of gene expression |
WO2006033859A2 (en) | 2004-09-16 | 2006-03-30 | Sangamo Biosciences, Inc. | Compositions and methods for protein production |
US9315825B2 (en) | 2010-03-29 | 2016-04-19 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
CA2793633A1 (en) | 2010-03-29 | 2011-10-13 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
EP2699688A1 (de) | 2011-04-20 | 2014-02-26 | The Trustees Of The University Of Pennsylvania | Dosierpläne und zusammensetzungen zur aav-vermittelten passiven immunisierung von luftbürtigen krankheitserregern |
WO2016200543A2 (en) | 2015-05-13 | 2016-12-15 | The Trustees Of The University Of Pennsylvania | Aav-mediated expression of anti-inluenza antibodies and methods of use thereof |
SG11201808426XA (en) | 2016-04-15 | 2018-10-30 | Univ Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
SG11201907611WA (en) | 2017-02-28 | 2019-09-27 | Univ Pennsylvania | Influenza vaccines based on aav vectors |
HRP20240257T1 (hr) | 2017-02-28 | 2024-05-24 | The Trustees Of The University Of Pennsylvania | Adeno-povezani virusni (aav) clade f vektor i njegova uporaba |
SG11202003479TA (en) | 2017-10-18 | 2020-05-28 | Regenxbio Inc | Fully-human post-translationally modified antibody therapeutics |
CA3079565A1 (en) | 2017-10-18 | 2019-04-25 | Regenxbio Inc. | Treatment of ocular diseases and metastatic colon cancer with human post-translationally modified vegf-trap |
CN113966236A (zh) | 2019-04-03 | 2022-01-21 | 再生生物股份有限公司 | 眼睛病状的基因疗法 |
TW202106708A (zh) | 2019-04-24 | 2021-02-16 | 美商銳進科斯生物股份有限公司 | 全人類轉譯後修飾之抗體治療劑 |
JP2022545967A (ja) | 2019-08-26 | 2022-11-01 | リジェネックスバイオ インコーポレイテッド | 完全ヒト翻訳後修飾抗VEGF Fabを用いる糖尿病性網膜症の処置 |
KR20220081365A (ko) | 2019-10-07 | 2022-06-15 | 리젠엑스바이오 인크. | 아데노-연관 바이러스 벡터 약제학적 조성물 및 방법 |
EP4214242A1 (de) | 2020-09-15 | 2023-07-26 | RegenxBio Inc. | Vektorisierte antikörper für antivirale therapie |
EP4213890A1 (de) | 2020-09-15 | 2023-07-26 | RegenxBio Inc. | Vektorisierte lanadlumab und verabreichung davon |
CA3197342A1 (en) | 2020-10-07 | 2022-04-14 | Regenxbio Inc. | Gene therapy for ocular manifestations of cln2 disease |
CN116528892A (zh) | 2020-10-28 | 2023-08-01 | 再生生物股份有限公司 | 用于眼部适应症的载体化抗TNF-α抗体 |
WO2022094157A1 (en) | 2020-10-28 | 2022-05-05 | Regenxbio Inc. | Vectorized anti-cgrp and anti-cgrpr antibodies and administration thereof |
WO2022094255A2 (en) | 2020-10-29 | 2022-05-05 | Regenxbio Inc. | Vectorized factor xii antibodies and administration thereof |
AU2021369833A1 (en) | 2020-10-29 | 2023-06-08 | Regenxbio Inc. | Vectorized tnf-alpha antagonists for ocular indications |
TW202237850A (zh) | 2020-12-01 | 2022-10-01 | 賓州大學委員會 | 具有組織特異性靶向基序的新穎構成物及含有其之組成物 |
CN112661820B (zh) * | 2020-12-31 | 2021-12-14 | 中国科学院天津工业生物技术研究所 | 天山根瘤菌转录调控蛋白MsiR突变蛋白及其在刀豆氨酸生物传感器中的应用 |
AR125406A1 (es) | 2021-04-23 | 2023-07-12 | Univ Pennsylvania | Nuevas composiciones con motivos selectivos para el cerebro y composiciones que las contienen |
TW202325845A (zh) | 2021-10-02 | 2023-07-01 | 賓州大學委員會 | 新穎aav衣殼及含其之組成物 |
WO2023147304A1 (en) | 2022-01-25 | 2023-08-03 | The Trustees Of The University Of Pennsylvania | Aav capsids for improved heart transduction and detargeting of liver |
WO2023201308A1 (en) | 2022-04-14 | 2023-10-19 | Regenxbio Inc. | Gene therapy for treating an ocular disease |
WO2023205610A2 (en) | 2022-04-18 | 2023-10-26 | Regenxbio Inc. | Hybrid aav capsids |
WO2023215806A2 (en) | 2022-05-03 | 2023-11-09 | Regenxbio Inc. | Vectorized anti-complement antibodies and complement agents and administration thereof |
WO2023215807A1 (en) | 2022-05-03 | 2023-11-09 | Regenxbio Inc. | VECTORIZED ANTI-TNF-α INHIBITORS FOR OCULAR INDICATIONS |
WO2024022474A1 (zh) * | 2022-07-29 | 2024-02-01 | 南京百斯杰生物工程有限公司 | 一种嵌合型转录激活因子及其应用 |
WO2024073669A1 (en) | 2022-09-30 | 2024-04-04 | Regenxbio Inc. | Treatment of ocular diseases with recombinant viral vectors encoding anti-vegf fab |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0882128A1 (de) * | 1996-02-23 | 1998-12-09 | Ariad Pharmaceuticals, Inc. | Auf zellen basierendes testverfahren |
WO1997044447A2 (en) * | 1996-05-03 | 1997-11-27 | President And Fellows Of Harvard College | Transcriptional activation system, activators, and uses therefor |
-
1997
- 1997-08-27 IL IL13464397A patent/IL134643A0/xx unknown
- 1997-08-27 WO PCT/US1997/015219 patent/WO1999010508A1/en not_active Application Discontinuation
- 1997-08-27 CA CA002303482A patent/CA2303482A1/en not_active Abandoned
- 1997-08-27 EP EP97940681A patent/EP1003886A1/de not_active Withdrawn
- 1997-08-27 JP JP2000507816A patent/JP2001514007A/ja not_active Withdrawn
- 1997-08-27 AU AU42402/97A patent/AU752129B2/en not_active Expired
Non-Patent Citations (2)
Title |
---|
EMAMI K.H & CAREY M. (1992) EMBO. J. 11(13): 5005-5012 * |
KODADEK T & JOHNSTON SA (1995) CHEMISTRY & BIOLOGY 2:187-194 * |
Also Published As
Publication number | Publication date |
---|---|
EP1003886A1 (de) | 2000-05-31 |
AU4240297A (en) | 1999-03-16 |
JP2001514007A (ja) | 2001-09-11 |
CA2303482A1 (en) | 1999-03-04 |
IL134643A0 (en) | 2001-04-30 |
WO1999010508A1 (en) | 1999-03-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FGA | Letters patent sealed or granted (standard patent) |