AU749174B2 - Constitutive expression of non-infectious HIV-like particles - Google Patents

Constitutive expression of non-infectious HIV-like particles Download PDF

Info

Publication number
AU749174B2
AU749174B2 AU16577/99A AU1657799A AU749174B2 AU 749174 B2 AU749174 B2 AU 749174B2 AU 16577/99 A AU16577/99 A AU 16577/99A AU 1657799 A AU1657799 A AU 1657799A AU 749174 B2 AU749174 B2 AU 749174B2
Authority
AU
Australia
Prior art keywords
hiv
nucleic acid
acid molecule
expression
genome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU16577/99A
Other languages
English (en)
Other versions
AU1657799A (en
Inventor
Shi-Xian Cao
Benjamin Rovinski
Fei-Long Yao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Ltd
Original Assignee
Connaught Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25537545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU749174(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Connaught Laboratories Ltd filed Critical Connaught Laboratories Ltd
Publication of AU1657799A publication Critical patent/AU1657799A/en
Application granted granted Critical
Publication of AU749174B2 publication Critical patent/AU749174B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU16577/99A 1997-12-16 1998-12-14 Constitutive expression of non-infectious HIV-like particles Ceased AU749174B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/991773 1997-12-16
US08/991,773 US6121021A (en) 1997-12-16 1997-12-16 Constitutive expression of non-infectious HIV-like particles
PCT/CA1998/001164 WO1999031250A2 (en) 1997-12-16 1998-12-14 Constitutive expression of non-infectious hiv-like particles

Publications (2)

Publication Number Publication Date
AU1657799A AU1657799A (en) 1999-07-05
AU749174B2 true AU749174B2 (en) 2002-06-20

Family

ID=25537545

Family Applications (1)

Application Number Title Priority Date Filing Date
AU16577/99A Ceased AU749174B2 (en) 1997-12-16 1998-12-14 Constitutive expression of non-infectious HIV-like particles

Country Status (12)

Country Link
US (2) US6121021A (enExample)
EP (1) EP1038001B8 (enExample)
JP (1) JP2004509601A (enExample)
AT (1) ATE318909T1 (enExample)
AU (1) AU749174B2 (enExample)
BR (1) BR9813626A (enExample)
CA (1) CA2312943C (enExample)
DE (1) DE69833686T2 (enExample)
DK (1) DK1038001T3 (enExample)
ES (1) ES2262250T3 (enExample)
PT (1) PT1038001E (enExample)
WO (1) WO1999031250A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6080408A (en) * 1994-08-22 2000-06-27 Connaught Laboratories Limited Human immunodeficiency virus type 1 nucleic acids devoid of long terminal repeats capable of encoding for non-infectious, immunogenic, retrovirus-like particles
US7135191B2 (en) * 1997-09-04 2006-11-14 Zsolt Istvan Hertelendy Urogenital or anorectal transmucosal vaccine delivery system
US6121021A (en) * 1997-12-16 2000-09-19 Connaught Laboratories Limited Constitutive expression of non-infectious HIV-like particles
EP1083230A1 (en) * 1999-09-10 2001-03-14 Academisch Medisch Centrum Amsterdam Viral replicons and viruses dependent on inducing agents
US20040105871A1 (en) * 2000-03-02 2004-06-03 Robinson Harriet L. Compositions and methods for generating an immune response
US8623379B2 (en) * 2000-03-02 2014-01-07 Emory University Compositions and methods for generating an immune response
WO2001092470A2 (en) 2000-03-02 2001-12-06 Emory University Dna expression vectors and methods of use
EP1776961A1 (en) * 2000-04-27 2007-04-25 Sanofi Pasteur Limited Immunizing against HIV infection
EP1280551B1 (en) * 2000-04-27 2007-01-10 Sanofi Pasteur Limited Vaccines against hiv infection
US7122180B2 (en) * 2000-10-23 2006-10-17 Children's Medical Center Corporation DNA vectors containing mutated HIV proviruses
PT1372710E (pt) * 2001-03-08 2009-12-21 Us Gov Health & Human Serv Vam modificado que expressa os genes gag e pol do envelope de vih
US20060088909A1 (en) * 2002-05-17 2006-04-27 Compans Richard W Virus-like particles, methods of preparation, and immunogenic compositions
US9045727B2 (en) * 2002-05-17 2015-06-02 Emory University Virus-like particles, methods of preparation, and immunogenic compositions
EP2055316A1 (en) * 2003-09-09 2009-05-06 VIRxSYS Corporation Lentivirus vector-based approaches for generating an immune response to HIV in humans
US20090257983A1 (en) * 2008-04-11 2009-10-15 Scheiber Lane Bernard Medical treatment device for treating aids by utilizing modified human immunodeficiency virus virions to insert anti-viral medications into t-helper cells
US20110293693A1 (en) * 2010-05-31 2011-12-01 Scheiber Lane Bernard Quantum unit of inheritance vector therapy
US20110293694A1 (en) * 2010-05-31 2011-12-01 Scheiber Lane Bernard Quantum unit of inheritance vector therapy method
DK2694101T3 (en) 2011-04-06 2017-01-09 Biovaxim Ltd Pharmaceutical compositions for the prevention and / or treatment of HIV disease in humans

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996006177A2 (en) * 1994-08-22 1996-02-29 Connaught Laboratories Limited Retrovirus-like particles made non-infectious by a plurality of mutations
US5674984A (en) * 1990-04-03 1997-10-07 Genentech, Inc. Method for isolation of unclipped HIV envelope protein

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001230A (en) * 1988-02-18 1991-03-19 Schering Corporation T cell activation markers
GB8923123D0 (en) * 1989-10-13 1989-11-29 Connaught Lab A vaccine for human immunodeficiency virus
JPH05501201A (ja) * 1989-10-16 1993-03-11 ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ 非感染性ｈｉｖ―１粒子およびそれらの使用
WO1991007425A1 (en) * 1989-11-20 1991-05-30 Oncogen Limited Partnership Non-replicating recombinant-made retroviral particles used as antiviral agents and immunogens
AU678152B2 (en) * 1992-03-27 1997-05-22 Whitehead Institute For Biomedical Research Non-infectious HIV particles and uses therefor
AU700371B2 (en) * 1993-06-07 1999-01-07 Genentech Inc. Hiv envelope polypeptides
JPH08511007A (ja) * 1993-06-09 1996-11-19 コノート ラボラトリーズ リミテッド タンデム合成ｈｉｖ−１ペプチド
GB2325003B (en) * 1996-10-17 2000-05-10 Oxford Biomedica Ltd Rectroviral vectors
EP0973381B1 (en) * 1997-04-09 2010-03-03 AMDL, Inc. Animal model for evaluation of vaccines
US6121021A (en) * 1997-12-16 2000-09-19 Connaught Laboratories Limited Constitutive expression of non-infectious HIV-like particles

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674984A (en) * 1990-04-03 1997-10-07 Genentech, Inc. Method for isolation of unclipped HIV envelope protein
WO1996006177A2 (en) * 1994-08-22 1996-02-29 Connaught Laboratories Limited Retrovirus-like particles made non-infectious by a plurality of mutations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
IGARASHI T ET AL, J. OF GENERAL VIROLOGY, 1997, 78:985-989 *

Also Published As

Publication number Publication date
DK1038001T3 (da) 2006-07-10
AU1657799A (en) 1999-07-05
EP1038001B8 (en) 2006-09-13
EP1038001A2 (en) 2000-09-27
JP2004509601A (ja) 2004-04-02
ES2262250T3 (es) 2006-11-16
DE69833686T2 (de) 2006-11-30
ATE318909T1 (de) 2006-03-15
US6572863B1 (en) 2003-06-03
WO1999031250A3 (en) 1999-08-19
BR9813626A (pt) 2002-07-23
CA2312943C (en) 2009-02-24
EP1038001B1 (en) 2006-03-01
WO1999031250A2 (en) 1999-06-24
CA2312943A1 (en) 1999-06-24
DE69833686D1 (de) 2006-04-27
US6121021A (en) 2000-09-19
PT1038001E (pt) 2006-07-31

Similar Documents

Publication Publication Date Title
CA2312943C (en) Constitutive expression of non-infectious hiv-like particles
AU704309B2 (en) Antigenically-marked non-infectious retrovirus-like particles
US6451322B1 (en) Retrovirus like particles made non infectious by a plurality of mutations
US6544752B1 (en) Anigenically-marked non-infectious retrovirus-like particles
JP6165612B2 (ja) コンセンサス／先祖免疫原
US6518030B1 (en) Antigentically-marked non-infectious retrovirus-like particles
AU6967394A (en) Tandem synthetic hiv-1 peptides
AU7047894A (en) Hiv envelope polypeptides
JP2001516566A (ja) 遺伝子ワクチンのための弱毒化ｖｉｆＤＮＡ免疫化カセット
EP0762895A1 (en) Synthetic vaccine for protection against human immunodeficiency virus infection
Bolesta et al. Clustered epitopes within the Gag–Pol fusion protein DNA vaccine enhance immune responses and protection against challenge with recombinant vaccinia viruses expressing HIV-1 Gag and Pol antigens
CA2431881C (en) Polypeptide inducing hiv-neutralising antibodies
Letvin et al. Simian immunodeficiency virus-specific cytotoxic T lymphocytes in rhesus monkeys: characterization and vaccine induction
US7658927B2 (en) Materials and methods for immunizing against FIV infection
Wentworth et al. Epitopes recognized by HIV-SF2 nef-specific CD4+ T-cell clones generated from HIV-1-uninfected donors
AU2011203095A1 (en) Consensus/Ancestral Immunogens
AU2004200601A1 (en) Synthetic vaccine for protection against human immunodeficiency virus infection

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)