CA2312943C - Constitutive expression of non-infectious hiv-like particles - Google Patents
Constitutive expression of non-infectious hiv-like particles Download PDFInfo
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- CA2312943C CA2312943C CA002312943A CA2312943A CA2312943C CA 2312943 C CA2312943 C CA 2312943C CA 002312943 A CA002312943 A CA 002312943A CA 2312943 A CA2312943 A CA 2312943A CA 2312943 C CA2312943 C CA 2312943C
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- hiv
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- 239000000725 suspension Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 108700004027 tat Genes Proteins 0.000 description 1
- 101150098170 tat gene Proteins 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 229940125575 vaccine candidate Drugs 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
- 108700026215 vpr Genes Proteins 0.000 description 1
- 101150024249 vpr gene Proteins 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- AIDS & HIV (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/991,773 | 1997-12-16 | ||
| US08/991,773 US6121021A (en) | 1997-12-16 | 1997-12-16 | Constitutive expression of non-infectious HIV-like particles |
| PCT/CA1998/001164 WO1999031250A2 (en) | 1997-12-16 | 1998-12-14 | Constitutive expression of non-infectious hiv-like particles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2312943A1 CA2312943A1 (en) | 1999-06-24 |
| CA2312943C true CA2312943C (en) | 2009-02-24 |
Family
ID=25537545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002312943A Expired - Fee Related CA2312943C (en) | 1997-12-16 | 1998-12-14 | Constitutive expression of non-infectious hiv-like particles |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6121021A (enExample) |
| EP (1) | EP1038001B8 (enExample) |
| JP (1) | JP2004509601A (enExample) |
| AT (1) | ATE318909T1 (enExample) |
| AU (1) | AU749174B2 (enExample) |
| BR (1) | BR9813626A (enExample) |
| CA (1) | CA2312943C (enExample) |
| DE (1) | DE69833686T2 (enExample) |
| DK (1) | DK1038001T3 (enExample) |
| ES (1) | ES2262250T3 (enExample) |
| PT (1) | PT1038001E (enExample) |
| WO (1) | WO1999031250A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6080408A (en) * | 1994-08-22 | 2000-06-27 | Connaught Laboratories Limited | Human immunodeficiency virus type 1 nucleic acids devoid of long terminal repeats capable of encoding for non-infectious, immunogenic, retrovirus-like particles |
| US7135191B2 (en) * | 1997-09-04 | 2006-11-14 | Zsolt Istvan Hertelendy | Urogenital or anorectal transmucosal vaccine delivery system |
| US6121021A (en) * | 1997-12-16 | 2000-09-19 | Connaught Laboratories Limited | Constitutive expression of non-infectious HIV-like particles |
| EP1083230A1 (en) * | 1999-09-10 | 2001-03-14 | Academisch Medisch Centrum Amsterdam | Viral replicons and viruses dependent on inducing agents |
| US8623379B2 (en) * | 2000-03-02 | 2014-01-07 | Emory University | Compositions and methods for generating an immune response |
| US20040105871A1 (en) * | 2000-03-02 | 2004-06-03 | Robinson Harriet L. | Compositions and methods for generating an immune response |
| US20020106798A1 (en) | 2000-03-02 | 2002-08-08 | Robinson Harriet L. | DNA expression vectors and methods of use |
| EP1776961A1 (en) * | 2000-04-27 | 2007-04-25 | Sanofi Pasteur Limited | Immunizing against HIV infection |
| US20040013684A1 (en) * | 2000-04-27 | 2004-01-22 | Benjamin Rovinski | Immunizing against hiv infection |
| US7122180B2 (en) * | 2000-10-23 | 2006-10-17 | Children's Medical Center Corporation | DNA vectors containing mutated HIV proviruses |
| CN100446812C (zh) * | 2001-03-08 | 2008-12-31 | 美国国有健康与人类服务部 | 表达修饰的hiv包膜、gag和pol基因的mva |
| US20060088909A1 (en) * | 2002-05-17 | 2006-04-27 | Compans Richard W | Virus-like particles, methods of preparation, and immunogenic compositions |
| US9045727B2 (en) * | 2002-05-17 | 2015-06-02 | Emory University | Virus-like particles, methods of preparation, and immunogenic compositions |
| AU2004270275B2 (en) * | 2003-09-09 | 2010-02-18 | Virxsys Corporation | Lentivirus vector-based approaches for generating an immune response to HIV humans |
| US20090257983A1 (en) * | 2008-04-11 | 2009-10-15 | Scheiber Lane Bernard | Medical treatment device for treating aids by utilizing modified human immunodeficiency virus virions to insert anti-viral medications into t-helper cells |
| US20110293694A1 (en) * | 2010-05-31 | 2011-12-01 | Scheiber Lane Bernard | Quantum unit of inheritance vector therapy method |
| US20110293693A1 (en) * | 2010-05-31 | 2011-12-01 | Scheiber Lane Bernard | Quantum unit of inheritance vector therapy |
| ES2606511T3 (es) | 2011-04-06 | 2017-03-24 | Biovaxim Limited | Composiciones farmacéuticas para prevenir y/o tratar una enfermedad por VIH en seres humanos |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5001230A (en) * | 1988-02-18 | 1991-03-19 | Schering Corporation | T cell activation markers |
| GB8923123D0 (en) * | 1989-10-13 | 1989-11-29 | Connaught Lab | A vaccine for human immunodeficiency virus |
| CA2067778A1 (en) * | 1989-10-16 | 1991-04-17 | The Whitehead Institute For Biomedical Research | Non-infectious hiv-1 particles and uses therefor |
| HUT60506A (en) * | 1989-11-20 | 1992-09-28 | Oncogen | Process for producing non-replicable, recombinant retrovirus particles and antiviral and immunogenic preparations |
| AU647108B2 (en) * | 1990-04-03 | 1994-03-17 | Genentech Inc. | Methods and compositions for vaccination against HIV |
| JPH08500005A (ja) * | 1992-03-27 | 1996-01-09 | ホワイトヘッド インスティチュート フォー バイオメディカル リサーチ | 非感染性ｈｉｖ粒子およびその用途 |
| WO1994028929A1 (en) * | 1993-06-07 | 1994-12-22 | Genentech, Inc. | Hiv envelope polypeptides |
| AU693098B2 (en) * | 1993-06-09 | 1998-06-25 | Connaught Laboratories Limited | Tandem synthetic HIV-1 peptides |
| US6080408A (en) * | 1994-08-22 | 2000-06-27 | Connaught Laboratories Limited | Human immunodeficiency virus type 1 nucleic acids devoid of long terminal repeats capable of encoding for non-infectious, immunogenic, retrovirus-like particles |
| PT904392E (pt) * | 1996-10-17 | 2001-06-29 | Oxford Biomedica Ltd | Vectores retrovirais |
| IL132164A0 (en) * | 1997-04-09 | 2001-03-19 | Chang Lung Ji | Animal model for evaluation of vaccines |
| US6121021A (en) * | 1997-12-16 | 2000-09-19 | Connaught Laboratories Limited | Constitutive expression of non-infectious HIV-like particles |
-
1997
- 1997-12-16 US US08/991,773 patent/US6121021A/en not_active Expired - Lifetime
-
1998
- 1998-12-14 ES ES98960976T patent/ES2262250T3/es not_active Expired - Lifetime
- 1998-12-14 JP JP2000539149A patent/JP2004509601A/ja active Pending
- 1998-12-14 BR BR9813626-7A patent/BR9813626A/pt not_active Application Discontinuation
- 1998-12-14 US US09/555,834 patent/US6572863B1/en not_active Expired - Fee Related
- 1998-12-14 AT AT98960976T patent/ATE318909T1/de active
- 1998-12-14 CA CA002312943A patent/CA2312943C/en not_active Expired - Fee Related
- 1998-12-14 DE DE69833686T patent/DE69833686T2/de not_active Expired - Lifetime
- 1998-12-14 EP EP98960976A patent/EP1038001B8/en not_active Expired - Lifetime
- 1998-12-14 AU AU16577/99A patent/AU749174B2/en not_active Ceased
- 1998-12-14 WO PCT/CA1998/001164 patent/WO1999031250A2/en not_active Ceased
- 1998-12-14 PT PT98960976T patent/PT1038001E/pt unknown
- 1998-12-14 DK DK98960976T patent/DK1038001T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| BR9813626A (pt) | 2002-07-23 |
| EP1038001A2 (en) | 2000-09-27 |
| DK1038001T3 (da) | 2006-07-10 |
| DE69833686D1 (de) | 2006-04-27 |
| US6572863B1 (en) | 2003-06-03 |
| WO1999031250A3 (en) | 1999-08-19 |
| JP2004509601A (ja) | 2004-04-02 |
| WO1999031250A2 (en) | 1999-06-24 |
| PT1038001E (pt) | 2006-07-31 |
| US6121021A (en) | 2000-09-19 |
| ES2262250T3 (es) | 2006-11-16 |
| AU1657799A (en) | 1999-07-05 |
| EP1038001B1 (en) | 2006-03-01 |
| CA2312943A1 (en) | 1999-06-24 |
| DE69833686T2 (de) | 2006-11-30 |
| AU749174B2 (en) | 2002-06-20 |
| ATE318909T1 (de) | 2006-03-15 |
| EP1038001B8 (en) | 2006-09-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20141215 |