BR9813626A - Expressão constitutiva de partìculas semelhantes ao hiv não infecciosas - Google Patents
Expressão constitutiva de partìculas semelhantes ao hiv não infecciosasInfo
- Publication number
- BR9813626A BR9813626A BR9813626-7A BR9813626A BR9813626A BR 9813626 A BR9813626 A BR 9813626A BR 9813626 A BR9813626 A BR 9813626A BR 9813626 A BR9813626 A BR 9813626A
- Authority
- BR
- Brazil
- Prior art keywords
- particles
- hiv
- constitutive expression
- modified
- genome
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- AIDS & HIV (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
"EXPRESSãO CONSTITUTIVA DE PARTìCULAS SEMELHANTES HIV NãO INFECCIOSAS". Partículas semelhantes ao HIV não infecciosas, não replicantes, imunogênicas são produzidas por expressão constitutiva estável duradoura em células de mamíferos pela eliminação de elementos.tóxicos às células de mamíferos. Um vetor de expressão contem uma molécula de ácido nucleico compreendendo um genoma de HIV modificado desprovido de repetições de terminação longa e de maneira que as seq³ências Tat e vpr são funcionalmente desabilitadas e um promotor constitutivo operacionalmente conectado ao genoma de HIV modificado para a expressão constitutiva do genoma modificado para produzir partículas semelhantes ao HIV.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/991,773 US6121021A (en) | 1997-12-16 | 1997-12-16 | Constitutive expression of non-infectious HIV-like particles |
PCT/CA1998/001164 WO1999031250A2 (en) | 1997-12-16 | 1998-12-14 | Constitutive expression of non-infectious hiv-like particles |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9813626A true BR9813626A (pt) | 2002-07-23 |
Family
ID=25537545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9813626-7A BR9813626A (pt) | 1997-12-16 | 1998-12-14 | Expressão constitutiva de partìculas semelhantes ao hiv não infecciosas |
Country Status (12)
Country | Link |
---|---|
US (2) | US6121021A (pt) |
EP (1) | EP1038001B8 (pt) |
JP (1) | JP2004509601A (pt) |
AT (1) | ATE318909T1 (pt) |
AU (1) | AU749174B2 (pt) |
BR (1) | BR9813626A (pt) |
CA (1) | CA2312943C (pt) |
DE (1) | DE69833686T2 (pt) |
DK (1) | DK1038001T3 (pt) |
ES (1) | ES2262250T3 (pt) |
PT (1) | PT1038001E (pt) |
WO (1) | WO1999031250A2 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6080408A (en) * | 1994-08-22 | 2000-06-27 | Connaught Laboratories Limited | Human immunodeficiency virus type 1 nucleic acids devoid of long terminal repeats capable of encoding for non-infectious, immunogenic, retrovirus-like particles |
US7135191B2 (en) * | 1997-09-04 | 2006-11-14 | Zsolt Istvan Hertelendy | Urogenital or anorectal transmucosal vaccine delivery system |
US6121021A (en) * | 1997-12-16 | 2000-09-19 | Connaught Laboratories Limited | Constitutive expression of non-infectious HIV-like particles |
EP1083230A1 (en) * | 1999-09-10 | 2001-03-14 | Academisch Medisch Centrum Amsterdam | Viral replicons and viruses dependent on inducing agents |
US8623379B2 (en) * | 2000-03-02 | 2014-01-07 | Emory University | Compositions and methods for generating an immune response |
US20040105871A1 (en) * | 2000-03-02 | 2004-06-03 | Robinson Harriet L. | Compositions and methods for generating an immune response |
EP2388015A1 (en) | 2000-03-02 | 2011-11-23 | Emory University | DNA expression vectors and methods of use |
EP1776961A1 (en) * | 2000-04-27 | 2007-04-25 | Sanofi Pasteur Limited | Immunizing against HIV infection |
ES2282251T3 (es) * | 2000-04-27 | 2007-10-16 | Sanofi Pasteur Limited | Vacunas contra la infeccion por vih. |
US7122180B2 (en) * | 2000-10-23 | 2006-10-17 | Children's Medical Center Corporation | DNA vectors containing mutated HIV proviruses |
DK1372710T3 (da) * | 2001-03-08 | 2010-01-18 | Us Gov Health & Human Serv | MVA der udtrykker modificeret HIV-kappe-, Gag- og Pol-gener |
US20060088909A1 (en) * | 2002-05-17 | 2006-04-27 | Compans Richard W | Virus-like particles, methods of preparation, and immunogenic compositions |
US9045727B2 (en) * | 2002-05-17 | 2015-06-02 | Emory University | Virus-like particles, methods of preparation, and immunogenic compositions |
JP2007505130A (ja) * | 2003-09-09 | 2007-03-08 | バイレクシス コーポレイション | ヒトにおいてhivに対する免疫応答を生成するための、レンチウイルスベクターベースのアプローチ |
US20090257983A1 (en) * | 2008-04-11 | 2009-10-15 | Scheiber Lane Bernard | Medical treatment device for treating aids by utilizing modified human immunodeficiency virus virions to insert anti-viral medications into t-helper cells |
US20110293694A1 (en) * | 2010-05-31 | 2011-12-01 | Scheiber Lane Bernard | Quantum unit of inheritance vector therapy method |
US20110293693A1 (en) * | 2010-05-31 | 2011-12-01 | Scheiber Lane Bernard | Quantum unit of inheritance vector therapy |
DK2694101T3 (en) | 2011-04-06 | 2017-01-09 | Biovaxim Ltd | Pharmaceutical compositions for the prevention and / or treatment of HIV disease in humans |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5001230A (en) * | 1988-02-18 | 1991-03-19 | Schering Corporation | T cell activation markers |
GB8923123D0 (en) * | 1989-10-13 | 1989-11-29 | Connaught Lab | A vaccine for human immunodeficiency virus |
JPH05501201A (ja) * | 1989-10-16 | 1993-03-11 | ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ | 非感染性hiv―1粒子およびそれらの使用 |
JPH05503629A (ja) * | 1989-11-20 | 1993-06-17 | オンコーゲン リミテッド パートナーシップ | 抗ウィルス剤及び免疫原として使用される、非複製組換え製レトロウィルス粒子 |
DE69111440T2 (de) * | 1990-04-03 | 1996-03-28 | Genentech Inc | Methoden und zusammensetzungen zur impfung gegen hiv. |
AU678152B2 (en) * | 1992-03-27 | 1997-05-22 | Whitehead Institute For Biomedical Research | Non-infectious HIV particles and uses therefor |
US5864027A (en) * | 1993-06-07 | 1999-01-26 | Genentech, Inc. | HIV envelope polypeptides |
CN1111540C (zh) * | 1993-06-09 | 2003-06-18 | 康诺特实验室有限公司 | 串联的合成hiv-1肽类 |
US6080408A (en) * | 1994-08-22 | 2000-06-27 | Connaught Laboratories Limited | Human immunodeficiency virus type 1 nucleic acids devoid of long terminal repeats capable of encoding for non-infectious, immunogenic, retrovirus-like particles |
DE69703974T2 (de) * | 1996-10-17 | 2001-07-19 | Oxford Biomedica (Uk) Ltd., Oxford | Retrovirale vektoren |
IL132164A0 (en) * | 1997-04-09 | 2001-03-19 | Chang Lung Ji | Animal model for evaluation of vaccines |
US6121021A (en) * | 1997-12-16 | 2000-09-19 | Connaught Laboratories Limited | Constitutive expression of non-infectious HIV-like particles |
-
1997
- 1997-12-16 US US08/991,773 patent/US6121021A/en not_active Expired - Lifetime
-
1998
- 1998-12-14 US US09/555,834 patent/US6572863B1/en not_active Expired - Fee Related
- 1998-12-14 JP JP2000539149A patent/JP2004509601A/ja active Pending
- 1998-12-14 PT PT98960976T patent/PT1038001E/pt unknown
- 1998-12-14 BR BR9813626-7A patent/BR9813626A/pt not_active Application Discontinuation
- 1998-12-14 ES ES98960976T patent/ES2262250T3/es not_active Expired - Lifetime
- 1998-12-14 AT AT98960976T patent/ATE318909T1/de active
- 1998-12-14 CA CA002312943A patent/CA2312943C/en not_active Expired - Fee Related
- 1998-12-14 AU AU16577/99A patent/AU749174B2/en not_active Ceased
- 1998-12-14 DK DK98960976T patent/DK1038001T3/da active
- 1998-12-14 DE DE69833686T patent/DE69833686T2/de not_active Expired - Lifetime
- 1998-12-14 WO PCT/CA1998/001164 patent/WO1999031250A2/en active IP Right Grant
- 1998-12-14 EP EP98960976A patent/EP1038001B8/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1038001B8 (en) | 2006-09-13 |
AU749174B2 (en) | 2002-06-20 |
DE69833686T2 (de) | 2006-11-30 |
US6572863B1 (en) | 2003-06-03 |
WO1999031250A3 (en) | 1999-08-19 |
CA2312943C (en) | 2009-02-24 |
DE69833686D1 (de) | 2006-04-27 |
EP1038001B1 (en) | 2006-03-01 |
CA2312943A1 (en) | 1999-06-24 |
ES2262250T3 (es) | 2006-11-16 |
PT1038001E (pt) | 2006-07-31 |
EP1038001A2 (en) | 2000-09-27 |
JP2004509601A (ja) | 2004-04-02 |
AU1657799A (en) | 1999-07-05 |
US6121021A (en) | 2000-09-19 |
ATE318909T1 (de) | 2006-03-15 |
DK1038001T3 (da) | 2006-07-10 |
WO1999031250A2 (en) | 1999-06-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9813626A (pt) | Expressão constitutiva de partìculas semelhantes ao hiv não infecciosas | |
PL332876A1 (en) | Lentoviral vectors | |
DE59813758D1 (de) | Herstellung von erythropoietin durch endogene genaktivierung mit viralen promotoren | |
AU5437886A (en) | Phenotypic modifications of host cells via RNA transformation vector | |
DK0452484T3 (da) | Fremstilling af proteiner ved homolog rekombination | |
CA2305013A1 (en) | Fusion proteins comprising hiv-1 tat and/or nef proteins | |
WO1999012950A3 (en) | Improvements in or relating to stability of plant starches | |
ATE349540T1 (de) | Expression der bazillus thuringiensis cry- proteine in pflanzen-plastiden | |
TR199801933A2 (xx) | Biyolojik olarak tolare edilebilen d���k molek�ler polietileniminler. | |
NO995475L (no) | Kjemiske forbindelser | |
AU1265097A (en) | Nucleic acid constructs for the cell cycle-regulated expression of genes, cells containing such constructs and their use for preparing drugs | |
IE840258L (en) | Expression of gene products. | |
CY1107431T1 (el) | Σωματιδια για γoνιδιακη θεραπεια | |
TR200001046T2 (tr) | Homolog rekombinasyonda pozitif-negatif seçimi. | |
DK0843731T3 (da) | Adenovirusvektorer til genterapi | |
AU2520595A (en) | Virosome-mediated intracellular delivery of therapeutic agents | |
DE3577994D1 (de) | Vergroessernde virale dna-segmente. | |
EP0336383A3 (en) | Novel recombinant human lymphotoxin | |
AU2190288A (en) | Vector for the expression of proteins of the HIV-2 virus, one of the casual agents of AIDS, cell culture infected or transformed by this vector, proteins obtained, vaccine and antibodies obtained | |
DK176387A (da) | Fremgangsmaade til frembringelse af et funktionelt polypeptid i en eukaryot vaertscelle ved anvendelse af en rekombinant dna udtrykkelsesvektor omfattende en bk virusforstaerker | |
WO2001083822A3 (en) | Use of representations of dna for genetic analysis | |
PT1032418E (pt) | Replicoes compactos do virus epstein-barr | |
EP1356063B8 (en) | Expression of multiple proteins in transgenic plants | |
Haynes et al. | Non-infectious HIV particles lacking long terminal repeats | |
DK0918739T3 (da) | Fremgangsmåde til fremstilling af 4,4,4-trichlorbutanol |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |