AU745790B2 - Methods for treating inflammation and inflammatory diseases using pADPRT inhibitors - Google Patents
Methods for treating inflammation and inflammatory diseases using pADPRT inhibitors Download PDFInfo
- Publication number
- AU745790B2 AU745790B2 AU74926/98A AU7492698A AU745790B2 AU 745790 B2 AU745790 B2 AU 745790B2 AU 74926/98 A AU74926/98 A AU 74926/98A AU 7492698 A AU7492698 A AU 7492698A AU 745790 B2 AU745790 B2 AU 745790B2
- Authority
- AU
- Australia
- Prior art keywords
- amino
- lps
- compound
- inh
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/855,616 US5908861A (en) | 1997-05-13 | 1997-05-13 | Methods for treating inflammation and inflammatory disease using pADPRT inhibitors |
US08/855616 | 1997-05-13 | ||
US09/056,396 US6303629B1 (en) | 1997-05-13 | 1998-04-06 | Methods for treating inflammation, inflammatory diseases, arthritis and stroke using pADPRT inhibitors |
US09/056396 | 1998-04-06 | ||
PCT/US1998/010033 WO1998051308A1 (fr) | 1997-05-13 | 1998-05-13 | Procede de traitement de l'inflammation ou de maladies inflammatoires a l'aide d'inhibiteurs de poly-adp ribose polymerase |
Publications (2)
Publication Number | Publication Date |
---|---|
AU7492698A AU7492698A (en) | 1998-12-08 |
AU745790B2 true AU745790B2 (en) | 2002-03-28 |
Family
ID=26735288
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU74847/98A Abandoned AU7484798A (en) | 1997-05-13 | 1998-05-13 | Methods for treating inflammation, inflammatory diseases, arthritis and strok e using padprt inhibitors |
AU74926/98A Ceased AU745790B2 (en) | 1997-05-13 | 1998-05-13 | Methods for treating inflammation and inflammatory diseases using pADPRT inhibitors |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU74847/98A Abandoned AU7484798A (en) | 1997-05-13 | 1998-05-13 | Methods for treating inflammation, inflammatory diseases, arthritis and strok e using padprt inhibitors |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1009404A4 (fr) |
JP (1) | JP4362638B2 (fr) |
CN (1) | CN1198614C (fr) |
AU (2) | AU7484798A (fr) |
BR (1) | BR9809115A (fr) |
CA (1) | CA2289119C (fr) |
IL (1) | IL132758A0 (fr) |
NZ (1) | NZ501650A (fr) |
WO (2) | WO1998051308A1 (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL210415B1 (pl) | 1999-01-11 | 2012-01-31 | Agouron Pharma | Pochodne indolu, środek farmaceutyczny i zastosowanie pochodnych indolu |
ECSP003637A (es) | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
JP2004528376A (ja) | 2001-05-08 | 2004-09-16 | クドス ファーマシューティカルズ リミテッド | Parp阻害薬としてのイソキノリノン誘導体 |
DE60335359D1 (de) | 2002-04-30 | 2011-01-27 | Kudos Pharm Ltd | Phthalazinonderivate |
US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
TW200536830A (en) | 2004-02-06 | 2005-11-16 | Chugai Pharmaceutical Co Ltd | 1-(2H)-isoquinolone derivative |
TWI389897B (zh) | 2005-02-22 | 2013-03-21 | Chugai Pharmaceutical Co Ltd | 1- (2H) -isoquinolinone derivatives |
US20070015814A1 (en) * | 2005-06-10 | 2007-01-18 | Ernest Kun | Parp Modulators and Treatment of Cancer |
GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
WO2008030887A2 (fr) * | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Procédés de conception d'inhibiteurs de parp et leurs utilisations |
US7994222B2 (en) * | 2006-09-05 | 2011-08-09 | Bipar Sciences, Inc. | Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds |
EA019833B1 (ru) | 2007-01-22 | 2014-06-30 | ДЖиТиЭкс, ИНК. | Вещества, связывающие ядерные рецепторы |
US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
PL2118074T3 (pl) | 2007-02-01 | 2014-06-30 | Resverlogix Corp | Związki chemiczne do celów profilaktyki i leczenia chorób układu sercowo-naczyniowego |
CN101809017A (zh) | 2007-09-14 | 2010-08-18 | 阿斯利康(瑞典)有限公司 | 酞嗪酮衍生物 |
AR070221A1 (es) | 2008-01-23 | 2010-03-25 | Astrazeneca Ab | Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas. |
ES2532402T3 (es) | 2008-06-26 | 2015-03-26 | Resverlogix Corporation | Métodos de preparación de derivados de quinazolinona |
EP2346495B2 (fr) | 2008-10-07 | 2023-05-24 | Kudos Pharmaceuticals Limited | Formulation pharmaceutique 514 |
EP2377871A4 (fr) | 2008-11-28 | 2012-07-25 | Chugai Pharmaceutical Co Ltd | Dérivé de 1-(2h)-isoquinolone |
ES2542835T3 (es) | 2009-01-08 | 2015-08-12 | Resverlogix Corporation | Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares |
EP2408454A2 (fr) | 2009-03-18 | 2012-01-25 | Resverlogix Corp. | Nouveaux agents anti-inflammatoires |
JP5813626B2 (ja) | 2009-04-22 | 2015-11-17 | レスバーロジックス コーポレイション | 新規抗炎症剤 |
KR102011641B1 (ko) | 2011-11-01 | 2019-08-19 | 리스버로직스 코퍼레이션 | 치환된 퀴나졸리논을 위한 경구 즉시 방출 제형 |
WO2014080290A2 (fr) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Amines cycliques servant d'inhibiteurs de bromodomaines |
US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
MX2015007921A (es) | 2012-12-21 | 2016-03-03 | Zenith Epigenetics Corp | Compuestos heterociclicos novedosos como inhibidores de bromodominio. |
JO3789B1 (ar) | 2015-03-13 | 2021-01-31 | Resverlogix Corp | التراكيب والوسائل العلاجية المعتمدة لمعالجة الامراض المتعلقة بالمتممة |
WO2018237327A1 (fr) | 2017-06-22 | 2018-12-27 | Triact Therapeutics, Inc. | Procédés de traitement d'un glioblastome |
WO2019067991A1 (fr) | 2017-09-29 | 2019-04-04 | Triact Therapeutics, Inc. | Formulations d'iniparib et leurs utilisations |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991004663A1 (fr) | 1989-09-26 | 1991-04-18 | The Regents Of The University Of California | 6-amino-1,2-benzopyrones utiles dans le traitement de maladies virales |
US5484951A (en) * | 1990-10-19 | 1996-01-16 | Octamer, Incorporated | 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents |
US5464871A (en) | 1993-05-12 | 1995-11-07 | Octamer, Inc. | Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents |
US5516941A (en) | 1991-10-22 | 1996-05-14 | Octamer, Inc. | Specific inactivators of "retroviral" (asymmetric) zinc fingers |
US5482975A (en) | 1991-10-22 | 1996-01-09 | Octamer, Inc. | Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents |
US5473074A (en) | 1991-10-22 | 1995-12-05 | Octamer, Incorporated | Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents-54 |
DE4436127A1 (de) | 1994-09-27 | 1996-03-28 | Deutsches Rheumaforschungszent | Verwendung von aromatischen Amiden und Säuren zur Behandlung von rheumatischen Erkrankungen |
WO1996031206A2 (fr) * | 1995-04-07 | 1996-10-10 | Warner-Lambert Company | Flavones et coumarines utilisees en tant qu'agents dans le traitement de l'atherosclerose |
US10766598B2 (en) | 2017-06-14 | 2020-09-08 | The Boeing Company | Wing-to-fuselage joints and aircraft including the same |
-
1998
- 1998-05-13 BR BR9809115-8A patent/BR9809115A/pt not_active Application Discontinuation
- 1998-05-13 AU AU74847/98A patent/AU7484798A/en not_active Abandoned
- 1998-05-13 CA CA2289119A patent/CA2289119C/fr not_active Expired - Fee Related
- 1998-05-13 WO PCT/US1998/010033 patent/WO1998051308A1/fr not_active Application Discontinuation
- 1998-05-13 JP JP54960898A patent/JP4362638B2/ja not_active Expired - Fee Related
- 1998-05-13 WO PCT/US1998/009768 patent/WO1998051307A1/fr active Application Filing
- 1998-05-13 EP EP98922359A patent/EP1009404A4/fr not_active Ceased
- 1998-05-13 CN CNB988063891A patent/CN1198614C/zh not_active Expired - Fee Related
- 1998-05-13 NZ NZ501650A patent/NZ501650A/en not_active IP Right Cessation
- 1998-05-13 AU AU74926/98A patent/AU745790B2/en not_active Ceased
- 1998-05-13 IL IL13275898A patent/IL132758A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
IL132758A0 (en) | 2001-03-19 |
NZ501650A (en) | 2001-11-30 |
CN1261278A (zh) | 2000-07-26 |
CA2289119A1 (fr) | 1998-11-19 |
AU7484798A (en) | 1998-12-08 |
BR9809115A (pt) | 2002-01-02 |
JP2002502367A (ja) | 2002-01-22 |
EP1009404A1 (fr) | 2000-06-21 |
EP1009404A4 (fr) | 2009-07-01 |
WO1998051308A1 (fr) | 1998-11-19 |
WO1998051307A1 (fr) | 1998-11-19 |
CN1198614C (zh) | 2005-04-27 |
AU7492698A (en) | 1998-12-08 |
CA2289119C (fr) | 2011-03-15 |
JP4362638B2 (ja) | 2009-11-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU745790B2 (en) | Methods for treating inflammation and inflammatory diseases using pADPRT inhibitors | |
US5908861A (en) | Methods for treating inflammation and inflammatory disease using pADPRT inhibitors | |
Jasiecka et al. | Pharmacological characteristics of metamizole | |
Kang et al. | Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages | |
Chan et al. | Adenosine A2A receptors play a role in the pathogenesis of hepatic cirrhosis | |
Colell et al. | Ganglioside GD3 enhances apoptosis by suppressing the nuclear factor‐κB‐dependent survival pathway | |
Rawls et al. | Effects of opioids, cannabinoids, and vanilloids on body temperature | |
Lee et al. | Inhibitory effects of a spinasterol glycoside on lipopolysaccharide-induced production of nitric oxide and proinflammatory cytokines via down-regulating MAP kinase pathways and NF-κB activation in RAW264. 7 macrophage cells | |
Zingarelli et al. | Activator protein‐1 signalling pathway and apoptosis are modulated by poly (ADP‐ribose) polymerase‐1 in experimental colitis | |
BRPI0616344A2 (pt) | mÉtodo para o tratamento de dependÊncia quÍmica e comportamental | |
AU2002255805A1 (en) | Method of using pyruvate and/or its derivatives for the treatment of cytokine-mediated inflammatory conditions | |
Guo et al. | Fumigaclavine C ameliorates dextran sulfate sodium-induced murine experimental colitis via NLRP3 inflammasome inhibition | |
Jiang et al. | CTRP1 prevents sepsis-induced cardiomyopathy via Sirt1-dependent pathways | |
KR100701539B1 (ko) | 멜라가트란의 신규 용도 | |
Busserolles et al. | Protection against 2, 4, 6-trinitrobenzenesulphonic acid-induced colonic inflammation in mice by the marine products bolinaquinone and petrosaspongiolide M | |
Toth et al. | Tumorigenic effect of 4-methylphenylhydrazine hydrochloride in Swiss mice | |
ES2274814T3 (es) | Uso de compuestos carboxy tales como cloruro de 2(4-acetofenil) -2cloro-n-metil-etilamonio como agentes antiinflamatorios. | |
Rowe et al. | The effect of fluoxetine on warfarin metabolism in the rat and man | |
Roth et al. | Dose-dependent attenuation of lipopolysaccharide-fever by inhibitors of inducible nitric oxide-synthase in guinea pigs | |
Eski et al. | Thalidomide decreases the plasma levels of IL-1 and TNF following burn injury: Is it a new drug for modulation of systemic inflammatory response | |
Alexandre-Moreira et al. | LASSBio-468: a new achiral thalidomide analogue which modulates TNF-α and NO production and inhibits endotoxic shock and arthritis in an animal model | |
Abekawa et al. | Effect of low doses of L-NAME on methamphetamine-induced dopaminergic depletion in the rat striatum | |
EP1758566A2 (fr) | Utilisation d'agonistes des recepteurs cb2 dans le traitement de la maladie d'huntington | |
MXPA99010417A (en) | METHODS FOR TREATING INFLAMMATION AND INFLAMMATORY DISEASES USING pADPRT INHIBITORS | |
US3036955A (en) | Analgesic 5-lower alkyl-2-amino thiazoles |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FGA | Letters patent sealed or granted (standard patent) |