EP1009404A4 - Procede de traitement de l'inflammation ou de maladies inflammatoires a l'aide d'inhibiteurs de poly-adp ribose polymerase - Google Patents
Procede de traitement de l'inflammation ou de maladies inflammatoires a l'aide d'inhibiteurs de poly-adp ribose polymeraseInfo
- Publication number
- EP1009404A4 EP1009404A4 EP98922359A EP98922359A EP1009404A4 EP 1009404 A4 EP1009404 A4 EP 1009404A4 EP 98922359 A EP98922359 A EP 98922359A EP 98922359 A EP98922359 A EP 98922359A EP 1009404 A4 EP1009404 A4 EP 1009404A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- inflammatory diseases
- treating inflammation
- padprt
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/855,616 US5908861A (en) | 1997-05-13 | 1997-05-13 | Methods for treating inflammation and inflammatory disease using pADPRT inhibitors |
US855616 | 1997-05-13 | ||
US56396 | 1998-04-06 | ||
US09/056,396 US6303629B1 (en) | 1997-05-13 | 1998-04-06 | Methods for treating inflammation, inflammatory diseases, arthritis and stroke using pADPRT inhibitors |
PCT/US1998/010033 WO1998051308A1 (fr) | 1997-05-13 | 1998-05-13 | Procede de traitement de l'inflammation ou de maladies inflammatoires a l'aide d'inhibiteurs de poly-adp ribose polymerase |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1009404A1 EP1009404A1 (fr) | 2000-06-21 |
EP1009404A4 true EP1009404A4 (fr) | 2009-07-01 |
Family
ID=26735288
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98922359A Ceased EP1009404A4 (fr) | 1997-05-13 | 1998-05-13 | Procede de traitement de l'inflammation ou de maladies inflammatoires a l'aide d'inhibiteurs de poly-adp ribose polymerase |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1009404A4 (fr) |
JP (1) | JP4362638B2 (fr) |
CN (1) | CN1198614C (fr) |
AU (2) | AU745790B2 (fr) |
BR (1) | BR9809115A (fr) |
CA (1) | CA2289119C (fr) |
IL (1) | IL132758A0 (fr) |
NZ (1) | NZ501650A (fr) |
WO (2) | WO1998051307A1 (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI20691B (sl) | 1999-01-11 | 2008-10-31 | Agouron Pharma | Triciklični inhibitorji poli(ADP-riboza) polimeraz |
ECSP003637A (es) | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
DE60218458T2 (de) | 2001-05-08 | 2007-11-15 | Kudos Pharmaceuticals Ltd. | Isochinolinon derivate als parp inhibitoren |
US7196085B2 (en) | 2002-04-30 | 2007-03-27 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
TW200536830A (en) | 2004-02-06 | 2005-11-16 | Chugai Pharmaceutical Co Ltd | 1-(2H)-isoquinolone derivative |
TWI389897B (zh) | 2005-02-22 | 2013-03-21 | Chugai Pharmaceutical Co Ltd | 1- (2H) -isoquinolinone derivatives |
KR20080031266A (ko) * | 2005-06-10 | 2008-04-08 | 바이파 사이언스 인코포레이티드 | Parp 조절제 및 암의 치료 |
GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
US7994222B2 (en) * | 2006-09-05 | 2011-08-09 | Bipar Sciences, Inc. | Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds |
EP2059802A4 (fr) * | 2006-09-05 | 2010-09-08 | Bipar Sciences Inc | Procedes de conception d'inhibiteurs de parp et leurs utilisations |
WO2008091555A2 (fr) | 2007-01-22 | 2008-07-31 | Gtx, Inc. | Agents se liant aux récepteurs nucléaires |
US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
CN101641339B (zh) | 2007-02-01 | 2013-07-17 | 雷斯韦洛吉克斯公司 | 用于预防和治疗心血管疾病的化合物 |
AU2008299721A1 (en) | 2007-09-14 | 2009-03-19 | Astrazeneca Ab | Phthalazinone derivatives |
UY31603A1 (es) | 2008-01-23 | 2009-08-31 | Derivados de ftalazinona | |
KR101629356B1 (ko) | 2008-06-26 | 2016-06-13 | 리스버로직스 코퍼레이션 | 퀴나졸리논 유도체의 제조방법 |
HUE030800T2 (en) | 2008-10-07 | 2017-05-29 | Astrazeneca Uk Ltd | Pharmaceutical Form No. 514 |
EP2377871A4 (fr) | 2008-11-28 | 2012-07-25 | Chugai Pharmaceutical Co Ltd | Dérivé de 1-(2h)-isoquinolone |
AU2010204106B2 (en) | 2009-01-08 | 2014-05-08 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
MX2021012876A (es) | 2009-03-18 | 2022-06-23 | Resverlogix Corp | Nuevos agentes anti-inflamatorios. |
ES2821018T3 (es) | 2009-04-22 | 2021-04-23 | Resverlogix Corp | Nuevos agentes antiinflamatorios |
PT2773354T (pt) | 2011-11-01 | 2019-07-17 | Resverlogix Corp | Formulações orais de libertação imediata para quinazolinonas substituídas |
WO2014080291A2 (fr) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Dérivés biaryle servant d'inhibiteurs de bromodomaines |
US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
AU2013365926B9 (en) | 2012-12-21 | 2019-01-17 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
US10111885B2 (en) | 2015-03-13 | 2018-10-30 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
WO2018237327A1 (fr) | 2017-06-22 | 2018-12-27 | Triact Therapeutics, Inc. | Procédés de traitement d'un glioblastome |
WO2019067991A1 (fr) | 2017-09-29 | 2019-04-04 | Triact Therapeutics, Inc. | Formulations d'iniparib et leurs utilisations |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992006687A1 (fr) * | 1990-10-19 | 1992-04-30 | The Regents Of The University Of California | Nouvelles 5-iodo-6-amino-1,2-benzopyrones ainsi que leurs analogues utilises comme agents cytostatiques et antiviraux |
WO1996031206A2 (fr) * | 1995-04-07 | 1996-10-10 | Warner-Lambert Company | Flavones et coumarines utilisees en tant qu'agents dans le traitement de l'atherosclerose |
US5583155A (en) * | 1989-09-26 | 1996-12-10 | Octamer, Inc. | 6-amino-1,2-benzopyrones useful for treatment of viral diseases |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5482975A (en) | 1991-10-22 | 1996-01-09 | Octamer, Inc. | Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents |
US5473074A (en) | 1991-10-22 | 1995-12-05 | Octamer, Incorporated | Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents-54 |
US5516941A (en) | 1991-10-22 | 1996-05-14 | Octamer, Inc. | Specific inactivators of "retroviral" (asymmetric) zinc fingers |
US5464871A (en) | 1993-05-12 | 1995-11-07 | Octamer, Inc. | Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents |
DE4436127A1 (de) | 1994-09-27 | 1996-03-28 | Deutsches Rheumaforschungszent | Verwendung von aromatischen Amiden und Säuren zur Behandlung von rheumatischen Erkrankungen |
US10766598B2 (en) | 2017-06-14 | 2020-09-08 | The Boeing Company | Wing-to-fuselage joints and aircraft including the same |
-
1998
- 1998-05-13 BR BR9809115-8A patent/BR9809115A/pt not_active Application Discontinuation
- 1998-05-13 AU AU74926/98A patent/AU745790B2/en not_active Ceased
- 1998-05-13 CN CNB988063891A patent/CN1198614C/zh not_active Expired - Fee Related
- 1998-05-13 IL IL13275898A patent/IL132758A0/xx unknown
- 1998-05-13 NZ NZ501650A patent/NZ501650A/en not_active IP Right Cessation
- 1998-05-13 AU AU74847/98A patent/AU7484798A/en not_active Abandoned
- 1998-05-13 WO PCT/US1998/009768 patent/WO1998051307A1/fr active Application Filing
- 1998-05-13 CA CA2289119A patent/CA2289119C/fr not_active Expired - Fee Related
- 1998-05-13 EP EP98922359A patent/EP1009404A4/fr not_active Ceased
- 1998-05-13 WO PCT/US1998/010033 patent/WO1998051308A1/fr not_active Application Discontinuation
- 1998-05-13 JP JP54960898A patent/JP4362638B2/ja not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5583155A (en) * | 1989-09-26 | 1996-12-10 | Octamer, Inc. | 6-amino-1,2-benzopyrones useful for treatment of viral diseases |
WO1992006687A1 (fr) * | 1990-10-19 | 1992-04-30 | The Regents Of The University Of California | Nouvelles 5-iodo-6-amino-1,2-benzopyrones ainsi que leurs analogues utilises comme agents cytostatiques et antiviraux |
WO1996031206A2 (fr) * | 1995-04-07 | 1996-10-10 | Warner-Lambert Company | Flavones et coumarines utilisees en tant qu'agents dans le traitement de l'atherosclerose |
Non-Patent Citations (12)
Title |
---|
BAUER P I ET AL: "REVERSION OF MALIGNANT PHENOTYPE BY 5-IODO-6-AMINO-1,2-BENZOPYRONE A NON-COVALENTLY BINDING LIGAND OF POLY(ADP-RIBOSE) POLYMERASE", BIOCHIMIE, MASSON, PARIS, FR, vol. 77, no. 5, 1 January 1995 (1995-01-01), pages 374 - 377, XP000573099, ISSN: 0300-9084 * |
KR\GER H ET AL: "SYNERGISTIC EFFECTS OF THALIDOMIDE AND POLY(ADP-RIBOSE) POLYMERASE INHIBITION ON TYPE II COLLAGEN-INDUCED ARTHRITIS IN MICE", INFLAMMATION, PLENUM PRESS, NEW YORK, NY, US, vol. 20, no. 2, 1 January 1996 (1996-01-01), pages 203 - 215, XP002954235, ISSN: 0360-3997 * |
KRÖGER H ET AL: "The influence of antagonists of poly(ADP-ribose)polymerase on the activity of antirheumatic drugs on the development of adjuvant arthritis in rats and on the induction of tyrosine aminotransferase in the liver of rats", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, SPRING ST., NY, vol. 398, 1 January 1996 (1996-01-01), pages 523 - 526, XP009116003, ISSN: 0065-2598 * |
MIESEL R KURPISZ M KR\GER H: "MODULATION OF INFLAMMATORY ARTHRITIS BY INHIBITION OF POLY(ADP RIBOSE) POLYMERASE", INFLAMMATION, PLENUM PRESS, NEW YORK, NY, US, vol. 19, no. 3, 1 January 1995 (1995-01-01), pages 379 - 387, XP002954234, ISSN: 0360-3997 * |
SCHRAUFSTATTER I U ET AL: "HYDROGEN PEROXIDE-INDUCED INJURY OF CELLS AND ITS PREVENTION BY INHIBITORS OF POLY-ADP-RIBOSE POLYMERASE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 83, no. 13, 1986, pages 4908 - 4912, XP002526047, ISSN: 0027-8424 * |
See also references of WO9851308A1 * |
SZABO C ET AL: "DNA STRAND BREAKAGE, ACTIVATION OF POLY(ADP-RIBOSE) SYNTHETASE, ANDCELLULAR ENERGY DEPLETION ARE INVOLVED IN THE CYTOTOXICITY IN MACROPHAGES AND SMOOTH MUSCLE CELLS EXPOSED TO PEROXYNITRITE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, vol. 93, 1 March 1996 (1996-03-01), pages 1753 - 1758, XP000960495, ISSN: 0027-8424 * |
SZABO CSABA ET AL: "Regulation of components of the inflammatory response by 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase and pleiotropic modifier of cellular signal pathways", INTERNATIONAL JOURNAL OF ONCOLOGY, DEMETRIOS A. SPANDIDOS ED. & PUB, GR, vol. 10, no. 6, 20 May 1997 (1997-05-20), pages 1093 - 1101, XP009116048, ISSN: 1019-6439 * |
SZABO CSABA ET AL: "Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite", CIRCULATION RESEARCH, vol. 78, no. 6, 1996, pages 1051 - 1063, XP002526068, ISSN: 0009-7330 * |
THIEMERMANN C ET AL: "Inhibition of the Activity of Poly(ADP Ribose) Synthetase Reduces Ischemia-Reperfusion Injury in the Heart and Skeletal Muscle", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, vol. 94, no. 2, 21 January 1997 (1997-01-21), pages 679 - 683, XP002080575, ISSN: 0027-8424 * |
ZINGARELLI B ET AL: "Protective effects of nicotinamide against nitric oxide-mediated delayed vascular failure in endotoxic shock: potential involvement of polyADP ribosyl synthetase", SHOCK (PHILADELPHIA): INJURY, INFLAMMATION, AND SEPSIS: LABORATORY AND CLINICAL APPROACHES, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 5, no. 4, 1 April 1996 (1996-04-01), pages 258 - 264, XP009116150, ISSN: 1073-2322 * |
ZINGARELLI BASILIA ET AL: "Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide", JOURNAL OF IMMUNOLOGY, vol. 156, no. 1, 1996, pages 350 - 358, XP002526046, ISSN: 0022-1767 * |
Also Published As
Publication number | Publication date |
---|---|
CA2289119A1 (fr) | 1998-11-19 |
WO1998051308A1 (fr) | 1998-11-19 |
JP4362638B2 (ja) | 2009-11-11 |
JP2002502367A (ja) | 2002-01-22 |
AU745790B2 (en) | 2002-03-28 |
BR9809115A (pt) | 2002-01-02 |
EP1009404A1 (fr) | 2000-06-21 |
IL132758A0 (en) | 2001-03-19 |
CN1261278A (zh) | 2000-07-26 |
AU7484798A (en) | 1998-12-08 |
CN1198614C (zh) | 2005-04-27 |
WO1998051307A1 (fr) | 1998-11-19 |
NZ501650A (en) | 2001-11-30 |
AU7492698A (en) | 1998-12-08 |
CA2289119C (fr) | 2011-03-15 |
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Legal Events
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