AU739002B2 - Aerosol medication delivery apparatus and system - Google Patents
Aerosol medication delivery apparatus and system Download PDFInfo
- Publication number
- AU739002B2 AU739002B2 AU93644/98A AU9364498A AU739002B2 AU 739002 B2 AU739002 B2 AU 739002B2 AU 93644/98 A AU93644/98 A AU 93644/98A AU 9364498 A AU9364498 A AU 9364498A AU 739002 B2 AU739002 B2 AU 739002B2
- Authority
- AU
- Australia
- Prior art keywords
- chamber housing
- medication
- mouthpiece
- containment baffle
- central axis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940079593 drug Drugs 0.000 title claims description 133
- 239000003814 drug Substances 0.000 title claims description 133
- 239000000443 aerosol Substances 0.000 title claims description 92
- 239000003380 propellant Substances 0.000 claims description 26
- 229940071648 metered dose inhaler Drugs 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 238000011144 upstream manufacturing Methods 0.000 claims description 9
- 238000007599 discharging Methods 0.000 claims description 4
- 239000002245 particle Substances 0.000 description 47
- 239000000203 mixture Substances 0.000 description 11
- 238000009472 formulation Methods 0.000 description 9
- 239000000725 suspension Substances 0.000 description 9
- 230000008901 benefit Effects 0.000 description 8
- 229960000676 flunisolide Drugs 0.000 description 8
- 210000004072 lung Anatomy 0.000 description 8
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 8
- 230000008878 coupling Effects 0.000 description 6
- 238000010168 coupling process Methods 0.000 description 6
- 238000005859 coupling reaction Methods 0.000 description 6
- 238000000151 deposition Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 230000008021 deposition Effects 0.000 description 5
- 230000003434 inspiratory effect Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 230000002411 adverse Effects 0.000 description 3
- 239000003570 air Substances 0.000 description 3
- 239000003246 corticosteroid Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000003300 oropharynx Anatomy 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 229960001334 corticosteroids Drugs 0.000 description 2
- 239000013536 elastomeric material Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 206010001382 Adrenal suppression Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 206010050346 Oropharyngeal candidiasis Diseases 0.000 description 1
- 102000004067 Osteocalcin Human genes 0.000 description 1
- 108090000573 Osteocalcin Proteins 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 238000002664 inhalation therapy Methods 0.000 description 1
- 229940125369 inhaled corticosteroids Drugs 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229940124624 oral corticosteroid Drugs 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/003—Particle size control by passing the aerosol trough sieves or filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/938,686 US6345617B1 (en) | 1997-09-26 | 1997-09-26 | Aerosol medication delivery apparatus and system |
| US08/938686 | 1997-09-26 | ||
| PCT/IB1998/001681 WO1999016490A1 (en) | 1997-09-26 | 1998-09-16 | Aerosol medication delivery apparatus and system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU9364498A AU9364498A (en) | 1999-04-23 |
| AU739002B2 true AU739002B2 (en) | 2001-10-04 |
Family
ID=25471799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU93644/98A Expired AU739002B2 (en) | 1997-09-26 | 1998-09-16 | Aerosol medication delivery apparatus and system |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6345617B1 (enExample) |
| EP (1) | EP1019127B1 (enExample) |
| JP (2) | JP2001518323A (enExample) |
| AR (1) | AR013968A1 (enExample) |
| AU (1) | AU739002B2 (enExample) |
| CA (3) | CA2304498C (enExample) |
| DE (1) | DE69819541T2 (enExample) |
| WO (1) | WO1999016490A1 (enExample) |
| ZA (1) | ZA988203B (enExample) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5823179A (en) * | 1996-02-13 | 1998-10-20 | 1263152 Ontario Inc. | Nebulizer apparatus and method |
| US6345617B1 (en) | 1997-09-26 | 2002-02-12 | 1263152 Ontario Inc. | Aerosol medication delivery apparatus and system |
| US6293279B1 (en) | 1997-09-26 | 2001-09-25 | Trudell Medical International | Aerosol medication delivery apparatus and system |
| SE9704185D0 (sv) * | 1997-11-14 | 1997-11-14 | Astra Pharma Prod | Inhalation device |
| US20060213505A1 (en) * | 1997-11-14 | 2006-09-28 | Astrazeneca Ab | Inhalation device |
| US7967011B2 (en) * | 1997-11-14 | 2011-06-28 | Astrazeneca Ab | Inhalation device |
| US6397837B1 (en) * | 1999-07-22 | 2002-06-04 | Martin W. Ferris | Inhaler assistive device |
| GB2360219A (en) | 2000-03-18 | 2001-09-19 | Astrazeneca Uk Ltd | Inhaler |
| US6557549B2 (en) | 2000-04-11 | 2003-05-06 | Trudell Medical International | Aerosol delivery apparatus with positive expiratory pressure capacity |
| US6501052B2 (en) * | 2000-12-22 | 2002-12-31 | Chrysalis Technologies Incorporated | Aerosol generator having multiple heating zones and methods of use thereof |
| US6698422B2 (en) * | 2001-03-12 | 2004-03-02 | Birdsong Medical Devices, Inc. | Canister inhaler having a spacer and easy to operate lever mechanism and a flexible, elastic mouthpiece |
| AU2002238801A1 (en) | 2001-03-20 | 2002-10-03 | Trudell Medical International | Nebulizer apparatus and method |
| AU2002322314B2 (en) * | 2001-06-26 | 2006-08-17 | Norton Healthcare, Ltd. | An improved aerosol actuator |
| US8440791B2 (en) * | 2001-09-06 | 2013-05-14 | Mgp Biotechnologies, Llc | Thimerosal removal device |
| US7767872B2 (en) * | 2001-09-06 | 2010-08-03 | Mpg Biotechnologies, Llc | Thimerosal removal device |
| US20030205226A1 (en) * | 2002-05-02 | 2003-11-06 | Pre Holding, Inc. | Aerosol medication inhalation system |
| AU2003225071A1 (en) * | 2002-05-03 | 2003-11-17 | Trudell Medical International | Aerosol medication delivery apparatus with narrow orifice |
| US6904908B2 (en) | 2002-05-21 | 2005-06-14 | Trudell Medical International | Visual indicator for an aerosol medication delivery apparatus and system |
| US7360537B2 (en) * | 2003-04-16 | 2008-04-22 | Trudell Medical International | Antistatic medication delivery apparatus |
| US8235036B2 (en) * | 2005-09-09 | 2012-08-07 | Vedat Obuz | Portable universal inhaler system |
| US20070074718A1 (en) * | 2005-10-04 | 2007-04-05 | Sp Medical Llc | Metered dose inhaler having spacing device |
| EP2043717A1 (en) * | 2006-07-14 | 2009-04-08 | Astra Zeneca AB | Inhalation system and delivery device for the administration of a drug in the form of dry powder |
| CA2661152A1 (en) | 2006-08-21 | 2008-02-28 | Trudell Medical International | Respiratory muscle endurance training device and method for the use thereof |
| US8978654B2 (en) * | 2007-12-08 | 2015-03-17 | Dimitrios Efthimiou | Personal air filter with amplifier and vibrator |
| CA2716511C (en) | 2008-02-21 | 2015-06-02 | Trudell Medical International | Respiratory muscle endurance training device and method for the use thereof |
| US8251876B2 (en) * | 2008-04-22 | 2012-08-28 | Hill-Rom Services, Inc. | Breathing exercise apparatus |
| US8539951B1 (en) | 2008-05-27 | 2013-09-24 | Trudell Medical International | Oscillating positive respiratory pressure device |
| US8327849B2 (en) | 2008-10-28 | 2012-12-11 | Trudell Medical International | Oscillating positive expiratory pressure device |
| US9149589B2 (en) | 2009-02-23 | 2015-10-06 | Trudell Medical International | Method and device for performing orientation dependent oscillating positive expiratory pressure therapy |
| US8485179B1 (en) | 2009-02-23 | 2013-07-16 | Trudell Medical International | Oscillating positive expiratory pressure device |
| EP2618876B1 (en) * | 2010-09-21 | 2018-11-14 | Koninklijke Philips N.V. | Valved holding chamber including valve retention system |
| CN103282071B (zh) | 2010-11-30 | 2016-06-01 | 梯瓦制药工业有限公司 | 吸入器和用于吸入器的外壳帽盖 |
| TR201815841T4 (tr) | 2011-06-06 | 2018-11-21 | Trudell Medical Int | Salınımlı pozitif ekspiratuar basınç aygıtı. |
| US8695589B2 (en) | 2011-12-06 | 2014-04-15 | Anthony J. Mullane | Inhaler assist device |
| US9180271B2 (en) | 2012-03-05 | 2015-11-10 | Hill-Rom Services Pte. Ltd. | Respiratory therapy device having standard and oscillatory PEP with nebulizer |
| US9364622B2 (en) | 2012-04-20 | 2016-06-14 | Fsc Laboratories, Inc. | Inhalation devices and systems and methods including the same |
| US9517315B2 (en) | 2012-11-30 | 2016-12-13 | Trudell Medical International | Oscillating positive expiratory pressure device |
| CA151549S (en) | 2013-02-14 | 2014-06-04 | Clement Clarke Int Ltd | Spacer for an asthma inhaler |
| USD735316S1 (en) | 2013-03-11 | 2015-07-28 | Fsc Laboratories, Inc. | Inhalation spacer |
| CA2915949C (en) | 2013-07-12 | 2020-01-28 | Trudell Medical International | Huff cough simulation device |
| US10207065B2 (en) | 2013-07-12 | 2019-02-19 | John H. Silva | Mouthpiece for inhalers |
| US9849257B2 (en) | 2013-08-22 | 2017-12-26 | Trudell Medical International | Oscillating positive respiratory pressure device |
| WO2015053361A1 (ja) * | 2013-10-11 | 2015-04-16 | 株式会社リーチハイアー | 経口粉末の吸入補助器具 |
| US10363383B2 (en) | 2014-02-07 | 2019-07-30 | Trudell Medical International | Pressure indicator for an oscillating positive expiratory pressure device |
| GB201408561D0 (en) * | 2014-05-14 | 2014-06-25 | The Technology Partnership Plc | Aerosolisation engine for liquid drug delivery |
| USD748242S1 (en) * | 2014-07-11 | 2016-01-26 | H. Stuart Campbell | Inhaler mouthpiece |
| US10004872B1 (en) | 2015-03-06 | 2018-06-26 | D R Burton Healthcare, Llc | Positive expiratory pressure device having an oscillating valve |
| CN205924624U (zh) * | 2015-05-12 | 2017-02-08 | 深圳瑞之谷医疗科技有限公司 | 药杯组件及医用雾化器 |
| CA2994792C (en) | 2015-07-30 | 2023-06-06 | Trudell Medical International | Combined respiratory muscle training and oscillating positive expiratory pressure device |
| USD780906S1 (en) | 2015-09-02 | 2017-03-07 | Trudell Medical International | Respiratory treatment device |
| USD778429S1 (en) | 2015-09-02 | 2017-02-07 | Trudell Medical International | Respiratory treatment device |
| EP3383465B1 (en) | 2015-12-04 | 2021-02-03 | Trudell Medical International | Huff cough simulation device |
| ES2883624T3 (es) | 2016-05-19 | 2021-12-09 | Trudell Medical Int | Cámara de retención con válvula inteligente |
| US10537693B2 (en) | 2016-05-30 | 2020-01-21 | Medical Developments International Limited | Collapsible disposable spacer for metered dose inhalers |
| EP3481476B1 (en) | 2016-07-08 | 2021-09-08 | Trudell Medical International | Smart oscillating positive expiratory pressure device |
| US10786638B2 (en) | 2016-07-08 | 2020-09-29 | Trudell Medical International | Nebulizer apparatus and method |
| JP7182287B2 (ja) * | 2016-12-06 | 2022-12-02 | ヒース レインボー, | 吸入器ハウジング |
| DE202017007545U1 (de) | 2016-12-09 | 2022-09-01 | Trudell Medical International | Intelligenter Vernebler |
| ES3022838T3 (en) | 2017-05-03 | 2025-05-29 | Trudell Medical Int Inc | Combined oscillating positive expiratory pressure therapy and huff cough simulation device |
| DE102017219364B4 (de) | 2017-10-27 | 2022-07-07 | Weiss Klimatechnik Gmbh | Klimagerät und Verfahren zur Desinfektion eines Klimageräts |
| EP3735287B1 (en) | 2018-01-04 | 2025-03-05 | Trudell Medical International Inc. | Smart oscillating positive expiratory pressure device |
| US10953278B2 (en) | 2018-02-02 | 2021-03-23 | Trudell Medical International | Oscillating positive expiratory pressure device |
| US11577033B2 (en) | 2018-06-05 | 2023-02-14 | Medline Industries, Lp | Valved spacer for inhalation device |
| CA3119536A1 (en) | 2018-11-14 | 2020-05-22 | Loop Laboratories, LLC | Inhalant dispensing system and apparatus |
| AU2020283486A1 (en) * | 2019-05-24 | 2022-01-27 | Blue Ocean Group, LLC | Compact spacer for metered dose inhaler |
| GB201909172D0 (en) * | 2019-06-26 | 2019-08-07 | Royal College Of Art | Inhaler |
| EP4494680A1 (en) | 2019-07-24 | 2025-01-22 | Trudell Medical International Inc. | Portable holding chamber |
| EP4021542B1 (en) | 2019-08-27 | 2025-07-16 | Trudell Medical International Inc. | Respiratory therapy device comprising a visual feedback array |
| USD1010101S1 (en) | 2020-09-18 | 2024-01-02 | Trudell Medical International | Holding chamber |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5012804A (en) * | 1989-03-06 | 1991-05-07 | Trudell Medical | Medication inhaler with adult mask |
| GB2299512A (en) * | 1995-04-06 | 1996-10-09 | Ian James Sharp | Inhaler |
| AU7735998A (en) * | 1996-12-18 | 1998-07-15 | Innovata Biomed Limited | Powder inhaler |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2670739A (en) | 1951-07-02 | 1954-03-02 | Charles M Mcneill | Inhaler |
| GB975754A (en) | 1961-05-15 | 1964-11-18 | Pfizer Ltd | Medicament administering apparatus |
| FR1322998A (fr) * | 1962-02-23 | 1963-04-05 | Perfectionnements aux dispositifs de production d'aérosols | |
| GB1017032A (en) | 1963-12-12 | 1966-01-12 | Aerosmoke Ltd | Aerosol compositions |
| DE1972590U (de) | 1964-06-15 | 1967-11-16 | Asmund S Laerdal | Ventil fuer wiederbelebungsapparate. |
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| CA2378713C (en) | 1995-06-21 | 2003-08-12 | Asta Medica Aktiengesellschaft | Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments |
| GB9513218D0 (en) | 1995-06-29 | 1995-09-06 | Fisons Plc | Inhalation device and method |
| AUPN417395A0 (en) | 1995-07-14 | 1995-08-10 | Techbase Pty. Ltd. | An improved spacer |
| US5617844A (en) | 1995-09-21 | 1997-04-08 | King; Russell W. | Aerosol medication delivery system |
| US5738087A (en) | 1995-09-21 | 1998-04-14 | King; Russell W. | Aerosol medication delivery system |
| GB2310607A (en) | 1996-02-29 | 1997-09-03 | Norton Healthcare Ltd | Spacer device for inhalers |
| FR2751553B1 (fr) | 1996-07-23 | 1999-06-11 | Pedrali Franck | Procede pour l'amelioration de la diffusion d'un produit bronchodilatateur en spray et appareils le mettant en oeuvre |
| US5765553A (en) | 1996-11-27 | 1998-06-16 | Diemolding Corporation | Aerosol medication delivery facemask adapter |
| US6345617B1 (en) | 1997-09-26 | 2002-02-12 | 1263152 Ontario Inc. | Aerosol medication delivery apparatus and system |
| US6039042A (en) | 1998-02-23 | 2000-03-21 | Thayer Medical Corporation | Portable chamber for metered dose inhaler dispensers |
| US6026807A (en) | 1998-02-27 | 2000-02-22 | Diemolding Corporation | Metered dose inhaler cloud chamber |
-
1997
- 1997-09-26 US US08/938,686 patent/US6345617B1/en not_active Expired - Lifetime
-
1998
- 1998-09-08 ZA ZA9808203A patent/ZA988203B/xx unknown
- 1998-09-16 CA CA002304498A patent/CA2304498C/en not_active Expired - Lifetime
- 1998-09-16 DE DE69819541T patent/DE69819541T2/de not_active Expired - Lifetime
- 1998-09-16 EP EP98946684A patent/EP1019127B1/en not_active Expired - Lifetime
- 1998-09-16 CA CA2790025A patent/CA2790025A1/en not_active Abandoned
- 1998-09-16 CA CA2689736A patent/CA2689736C/en not_active Expired - Lifetime
- 1998-09-16 WO PCT/IB1998/001681 patent/WO1999016490A1/en not_active Ceased
- 1998-09-16 AU AU93644/98A patent/AU739002B2/en not_active Expired
- 1998-09-16 JP JP2000513619A patent/JP2001518323A/ja active Pending
- 1998-09-25 AR ARP980104800A patent/AR013968A1/es unknown
-
2009
- 2009-10-09 JP JP2009235307A patent/JP5137929B2/ja not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5012804A (en) * | 1989-03-06 | 1991-05-07 | Trudell Medical | Medication inhaler with adult mask |
| GB2299512A (en) * | 1995-04-06 | 1996-10-09 | Ian James Sharp | Inhaler |
| AU7735998A (en) * | 1996-12-18 | 1998-07-15 | Innovata Biomed Limited | Powder inhaler |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA988203B (en) | 2000-03-22 |
| EP1019127A1 (en) | 2000-07-19 |
| DE69819541D1 (de) | 2003-12-11 |
| CA2304498A1 (en) | 1999-04-08 |
| CA2689736C (en) | 2012-12-18 |
| EP1019127B1 (en) | 2003-11-05 |
| AU9364498A (en) | 1999-04-23 |
| WO1999016490A1 (en) | 1999-04-08 |
| CA2689736A1 (en) | 1999-04-08 |
| CA2304498C (en) | 2010-01-05 |
| JP5137929B2 (ja) | 2013-02-06 |
| JP2010046500A (ja) | 2010-03-04 |
| US6345617B1 (en) | 2002-02-12 |
| AR013968A1 (es) | 2001-01-31 |
| DE69819541T2 (de) | 2004-04-15 |
| CA2790025A1 (en) | 1999-04-08 |
| JP2001518323A (ja) | 2001-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |