AU737115B2 - Transdermal therapeutic system (TTS) for delivering active ingredient through the skin to a body and method for application to the skin - Google Patents
Transdermal therapeutic system (TTS) for delivering active ingredient through the skin to a body and method for application to the skin Download PDFInfo
- Publication number
- AU737115B2 AU737115B2 AU94344/98A AU9434498A AU737115B2 AU 737115 B2 AU737115 B2 AU 737115B2 AU 94344/98 A AU94344/98 A AU 94344/98A AU 9434498 A AU9434498 A AU 9434498A AU 737115 B2 AU737115 B2 AU 737115B2
- Authority
- AU
- Australia
- Prior art keywords
- layer
- skin
- active ingredient
- active
- matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000004480 active ingredient Substances 0.000 title claims description 45
- 230000001225 therapeutic effect Effects 0.000 title claims description 9
- 238000000034 method Methods 0.000 title claims description 8
- 239000010410 layer Substances 0.000 claims description 87
- 230000004888 barrier function Effects 0.000 claims description 45
- 239000011159 matrix material Substances 0.000 claims description 35
- 239000000853 adhesive Substances 0.000 claims description 18
- 239000011241 protective layer Substances 0.000 claims description 11
- 239000012790 adhesive layer Substances 0.000 claims description 8
- 230000001070 adhesive effect Effects 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 description 7
- 230000004907 flux Effects 0.000 description 6
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 5
- 238000009792 diffusion process Methods 0.000 description 4
- 239000011505 plaster Substances 0.000 description 4
- 238000005520 cutting process Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 239000012907 medicinal substance Substances 0.000 description 2
- 125000005395 methacrylic acid group Chemical group 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- TYCHBDHDMFEQMC-UHFFFAOYSA-N 3-(dimethylamino)-2-methylprop-2-enoic acid Chemical compound CN(C)C=C(C)C(O)=O TYCHBDHDMFEQMC-UHFFFAOYSA-N 0.000 description 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Natural products CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920002614 Polyether block amide Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 229920001800 Shellac Polymers 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920006243 acrylic copolymer Polymers 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229920006147 copolyamide elastomer Polymers 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229920003146 methacrylic ester copolymer Polymers 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19733981A DE19733981A1 (de) | 1997-08-06 | 1997-08-06 | Transdermales Therapeutisches System (TTS) zur Abgabe von Wirkstoff durch die Haut an einen Organismus und Verfahren zur Applikation auf der Haut |
| DE19733981 | 1997-08-06 | ||
| PCT/EP1998/004824 WO1999007349A2 (de) | 1997-08-06 | 1998-08-01 | Transdermales therapeutisches system (tts) zur abgabe von wirkstoff durch die haut an einen organismus und verfahren zur applikation auf der haut |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU9434498A AU9434498A (en) | 1999-03-01 |
| AU737115B2 true AU737115B2 (en) | 2001-08-09 |
Family
ID=7838128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU94344/98A Ceased AU737115B2 (en) | 1997-08-06 | 1998-08-01 | Transdermal therapeutic system (TTS) for delivering active ingredient through the skin to a body and method for application to the skin |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0986374A2 (tr) |
| JP (1) | JP2002517379A (tr) |
| KR (1) | KR20010022629A (tr) |
| AU (1) | AU737115B2 (tr) |
| CA (1) | CA2298442A1 (tr) |
| DE (1) | DE19733981A1 (tr) |
| HU (1) | HUP0003347A3 (tr) |
| ID (1) | ID24195A (tr) |
| IL (1) | IL134007A0 (tr) |
| NO (1) | NO20000376L (tr) |
| NZ (1) | NZ502405A (tr) |
| PL (1) | PL338793A1 (tr) |
| SK (1) | SK1482000A3 (tr) |
| TR (1) | TR200000249T2 (tr) |
| WO (1) | WO1999007349A2 (tr) |
| ZA (1) | ZA987006B (tr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10027258C1 (de) * | 2000-05-31 | 2001-10-31 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit okklusiver wirkstoffhaltiger Schicht und nicht-okklusiver Rückschicht |
| DE10056014A1 (de) * | 2000-11-11 | 2002-05-16 | Beiersdorf Ag | Mehrschichtige Trägerkonstruktion für wirkstofhaltige Pflastersyteme |
| CN1589128A (zh) | 2001-11-23 | 2005-03-02 | 科洛普拉斯特公司 | 伤口敷料 |
| DE102004020463A1 (de) * | 2004-04-26 | 2005-11-10 | Grünenthal GmbH | Wirkstoffabgabesystem aus einem wirkstoffhaltigen Pflaster und mindestens einem Wirkstoffabgaberegulierungsmittel |
| DE202005014347U1 (de) * | 2005-09-09 | 2007-01-18 | Grünenthal GmbH | Applikationssystem für ein wirkstoffhaltiges Pflaster und Wirkstoffabgaberegulierungsmittel |
| HU0900117D0 (en) | 2009-02-26 | 2009-04-28 | Genetic Immunity Kutatasi | Topical or transdermal delivery kit |
| DE102017125281A1 (de) | 2017-10-27 | 2019-05-02 | Dermatools Biotech Gmbh | Vorrichtung zur Bereitstellung einer Haut- oder Wundauflage |
| DE102018216244A1 (de) | 2018-09-24 | 2020-03-26 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit Barriereschicht |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0353972B1 (en) * | 1988-08-01 | 1994-01-19 | The Kendall Company | A novel discontinuous adhesive surface |
| EP0593807A1 (en) * | 1992-10-22 | 1994-04-27 | LTS Lohmann Therapie-Systeme GmbH & Co. KG | Patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature and a process for preparation |
| WO1997006784A1 (en) * | 1995-08-15 | 1997-02-27 | Universite Libre De Bruxelles | Liposomes preparation method and plant |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3908431A1 (de) * | 1989-03-15 | 1990-09-27 | Lohmann Therapie Syst Lts | Transdermales system mit gestufter wirkstoffabgabe und verwendung fuer die lokale oder systemische wirkstoffverabreichung |
| DE19503336C2 (de) * | 1995-02-02 | 1998-07-30 | Lohmann Therapie Syst Lts | Arzneiform zur Abgabe von Wirkstoffen an Wunden, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US5840327A (en) * | 1995-08-21 | 1998-11-24 | Alza Corporation | Transdermal drug delivery device having enhanced adhesion |
-
1997
- 1997-08-06 DE DE19733981A patent/DE19733981A1/de not_active Withdrawn
-
1998
- 1998-08-01 SK SK148-2000A patent/SK1482000A3/sk unknown
- 1998-08-01 IL IL13400798A patent/IL134007A0/xx unknown
- 1998-08-01 CA CA002298442A patent/CA2298442A1/en not_active Abandoned
- 1998-08-01 TR TR2000/00249T patent/TR200000249T2/tr unknown
- 1998-08-01 AU AU94344/98A patent/AU737115B2/en not_active Ceased
- 1998-08-01 HU HU0003347A patent/HUP0003347A3/hu unknown
- 1998-08-01 NZ NZ502405A patent/NZ502405A/xx unknown
- 1998-08-01 EP EP98947418A patent/EP0986374A2/de not_active Withdrawn
- 1998-08-01 PL PL98338793A patent/PL338793A1/xx unknown
- 1998-08-01 WO PCT/EP1998/004824 patent/WO1999007349A2/de not_active Ceased
- 1998-08-01 JP JP2000506942A patent/JP2002517379A/ja active Pending
- 1998-08-01 ID IDW20000165A patent/ID24195A/id unknown
- 1998-08-01 KR KR1020007001223A patent/KR20010022629A/ko not_active Withdrawn
- 1998-08-05 ZA ZA987006A patent/ZA987006B/xx unknown
-
2000
- 2000-01-25 NO NO20000376A patent/NO20000376L/no not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0353972B1 (en) * | 1988-08-01 | 1994-01-19 | The Kendall Company | A novel discontinuous adhesive surface |
| EP0593807A1 (en) * | 1992-10-22 | 1994-04-27 | LTS Lohmann Therapie-Systeme GmbH & Co. KG | Patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature and a process for preparation |
| WO1997006784A1 (en) * | 1995-08-15 | 1997-02-27 | Universite Libre De Bruxelles | Liposomes preparation method and plant |
Also Published As
| Publication number | Publication date |
|---|---|
| IL134007A0 (en) | 2001-04-30 |
| ZA987006B (en) | 1999-02-08 |
| EP0986374A2 (de) | 2000-03-22 |
| TR200000249T2 (tr) | 2000-08-21 |
| JP2002517379A (ja) | 2002-06-18 |
| SK1482000A3 (en) | 2000-07-11 |
| NO20000376D0 (no) | 2000-01-25 |
| KR20010022629A (ko) | 2001-03-26 |
| ID24195A (id) | 2000-07-13 |
| CA2298442A1 (en) | 1999-02-18 |
| HUP0003347A2 (hu) | 2001-02-28 |
| AU9434498A (en) | 1999-03-01 |
| NO20000376L (no) | 2000-01-25 |
| HUP0003347A3 (en) | 2001-04-28 |
| DE19733981A1 (de) | 1999-02-11 |
| NZ502405A (en) | 2001-01-26 |
| WO1999007349A3 (de) | 1999-08-05 |
| PL338793A1 (en) | 2000-11-20 |
| WO1999007349A2 (de) | 1999-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |