AU735525C - Novel thyroid receptor ligands and method - Google Patents
Novel thyroid receptor ligands and methodInfo
- Publication number
- AU735525C AU735525C AU84405/98A AU8440598A AU735525C AU 735525 C AU735525 C AU 735525C AU 84405/98 A AU84405/98 A AU 84405/98A AU 8440598 A AU8440598 A AU 8440598A AU 735525 C AU735525 C AU 735525C
- Authority
- AU
- Australia
- Prior art keywords
- hydroxy
- isopropylphenoxy
- acid
- compound
- dibromo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 239000003446 ligand Substances 0.000 title claims abstract description 13
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- 108090000721 thyroid hormone receptors Proteins 0.000 title claims abstract description 13
- -1 alkenyl carboxylic acid Chemical class 0.000 claims abstract description 60
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- 229910052736 halogen Inorganic materials 0.000 claims abstract description 22
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 21
- 150000002148 esters Chemical class 0.000 claims abstract description 21
- 150000003839 salts Chemical class 0.000 claims abstract description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 14
- 208000003532 hypothyroidism Diseases 0.000 claims abstract description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 11
- 239000001257 hydrogen Substances 0.000 claims abstract description 11
- 230000002989 hypothyroidism Effects 0.000 claims abstract description 10
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- 201000010099 disease Diseases 0.000 claims abstract description 8
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- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 claims description 9
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- C07F9/40—Esters thereof
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9713739.2A GB9713739D0 (en) | 1997-06-27 | 1997-06-27 | Thyroid receptor ligands |
| GB9713739 | 1997-06-27 | ||
| PCT/EP1998/004039 WO1999000353A1 (en) | 1997-06-27 | 1998-06-26 | Novel thyroid receptor ligands and method |
Publications (3)
| Publication Number | Publication Date |
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| AU8440598A AU8440598A (en) | 1999-01-19 |
| AU735525B2 AU735525B2 (en) | 2001-07-12 |
| AU735525C true AU735525C (en) | 2002-02-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU84405/98A Ceased AU735525C (en) | 1997-06-27 | 1998-06-26 | Novel thyroid receptor ligands and method |
Country Status (13)
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| US (1) | US6465687B1 (https=) |
| EP (1) | EP1000008B1 (https=) |
| JP (1) | JP2002513422A (https=) |
| KR (1) | KR20010020472A (https=) |
| AT (1) | ATE243672T1 (https=) |
| AU (1) | AU735525C (https=) |
| CA (1) | CA2294098C (https=) |
| DE (1) | DE69815852T2 (https=) |
| DK (1) | DK1000008T3 (https=) |
| ES (1) | ES2197486T3 (https=) |
| GB (1) | GB9713739D0 (https=) |
| PT (1) | PT1000008E (https=) |
| WO (1) | WO1999000353A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1072998B (de) | 1957-08-21 | 1960-01-14 | Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brüning, Frankfurt/M | Verfahren zur Herstellung von substituierten Diphenyläthern |
| DE1078582B (de) | 1958-10-29 | 1960-03-31 | Hoechst Ag | Verfahren zur Herstellung substituierter Thyropropionsaeuren |
-
1997
- 1997-06-27 GB GBGB9713739.2A patent/GB9713739D0/en not_active Ceased
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1998
- 1998-06-26 KR KR1019997012084A patent/KR20010020472A/ko not_active Ceased
- 1998-06-26 CA CA002294098A patent/CA2294098C/en not_active Expired - Fee Related
- 1998-06-26 AU AU84405/98A patent/AU735525C/en not_active Ceased
- 1998-06-26 EP EP98935008A patent/EP1000008B1/en not_active Expired - Lifetime
- 1998-06-26 PT PT98935008T patent/PT1000008E/pt unknown
- 1998-06-26 DK DK98935008T patent/DK1000008T3/da active
- 1998-06-26 WO PCT/EP1998/004039 patent/WO1999000353A1/en not_active Ceased
- 1998-06-26 US US09/445,888 patent/US6465687B1/en not_active Expired - Fee Related
- 1998-06-26 DE DE69815852T patent/DE69815852T2/de not_active Expired - Fee Related
- 1998-06-26 ES ES98935008T patent/ES2197486T3/es not_active Expired - Lifetime
- 1998-06-26 JP JP50530199A patent/JP2002513422A/ja not_active Ceased
- 1998-06-26 AT AT98935008T patent/ATE243672T1/de not_active IP Right Cessation
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| Title |
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| JOURNAL OF MEDICINAL CHEMISTRY,VOL.6(5)SEPT 1963 PAGES560-3 * |
| JOURNAL OF ORGANCI CHEMISTRY,VOL.46(22),OCT1981 PAGES 4530-6 * |
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| CA2294098A1 (en) | 1999-01-07 |
| EP1000008A1 (en) | 2000-05-17 |
| US6465687B1 (en) | 2002-10-15 |
| AU735525B2 (en) | 2001-07-12 |
| DE69815852T2 (de) | 2004-05-19 |
| CA2294098C (en) | 2009-02-10 |
| JP2002513422A (ja) | 2002-05-08 |
| DE69815852D1 (de) | 2003-07-31 |
| EP1000008B1 (en) | 2003-06-25 |
| ES2197486T3 (es) | 2004-01-01 |
| AU8440598A (en) | 1999-01-19 |
| GB9713739D0 (en) | 1997-09-03 |
| ATE243672T1 (de) | 2003-07-15 |
| PT1000008E (pt) | 2003-10-31 |
| WO1999000353A1 (en) | 1999-01-07 |
| DK1000008T3 (da) | 2003-10-20 |
| KR20010020472A (ko) | 2001-03-15 |
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