AU729546B2 - Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections - Google Patents

Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections Download PDF

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Publication number
AU729546B2
AU729546B2 AU49411/97A AU4941197A AU729546B2 AU 729546 B2 AU729546 B2 AU 729546B2 AU 49411/97 A AU49411/97 A AU 49411/97A AU 4941197 A AU4941197 A AU 4941197A AU 729546 B2 AU729546 B2 AU 729546B2
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AU
Australia
Prior art keywords
lipid
formulation
titre
concentration
incubated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU49411/97A
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English (en)
Other versions
AU4941197A (en
Inventor
Thordis Kristmundsdottir
Halldor Thormar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LipoMedica ehf
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LipoMedica ehf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LipoMedica ehf filed Critical LipoMedica ehf
Publication of AU4941197A publication Critical patent/AU4941197A/en
Assigned to LIPOMEDICA EHF. reassignment LIPOMEDICA EHF. Alteration of Name(s) of Applicant(s) under S113 Assignors: KRISTMUNDSDOTTIR, THORDIS, THORMAR, HALLDOR
Application granted granted Critical
Publication of AU729546B2 publication Critical patent/AU729546B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU49411/97A 1996-11-14 1997-11-14 Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections Ceased AU729546B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IS4386 1996-11-14
IS4386 1996-11-14
PCT/DK1997/000524 WO1998020872A1 (en) 1996-11-14 1997-11-14 Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections

Publications (2)

Publication Number Publication Date
AU4941197A AU4941197A (en) 1998-06-03
AU729546B2 true AU729546B2 (en) 2001-02-01

Family

ID=36699955

Family Applications (1)

Application Number Title Priority Date Filing Date
AU49411/97A Ceased AU729546B2 (en) 1996-11-14 1997-11-14 Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections

Country Status (10)

Country Link
US (1) US6596763B1 (https=)
EP (1) EP0941087B1 (https=)
JP (1) JP2001504461A (https=)
AP (1) AP1209A (https=)
AT (1) ATE442844T1 (https=)
AU (1) AU729546B2 (https=)
CA (1) CA2271843A1 (https=)
DE (1) DE69739583D1 (https=)
IS (1) IS5051A (https=)
WO (1) WO1998020872A1 (https=)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19648545B4 (de) † 1996-11-25 2009-05-07 Ceramtec Ag Monolithischer Vielschichtaktor mit Außenelektroden
IL133608A0 (en) * 1997-06-20 2001-04-30 Eggers Sabine A protective composition for inhibiting bacterial, viral and fungal growth on the skin and use thereof
US6096332A (en) * 1998-06-30 2000-08-01 Mcneil-Ppc, Inc. Adding pharmaceutically active compounds to substrates
RU2186563C2 (ru) * 2000-02-25 2002-08-10 Государственное унитарное предприятие Тихоокеанский научно-исследовательский рыбохозяйственный центр Средство для лечения ожоговой раны
IL137559A (en) * 2000-07-27 2006-12-31 Amnon Sintov A system for administering drugs through the skin
WO2002045695A2 (en) * 2000-12-05 2002-06-13 Alexander Macgregor Hydrostatic delivery system for controlled delivery of agent
DE10156794B4 (de) * 2001-11-19 2006-05-18 Medigene Ag Arzneimittel zur Behandlung von Warzen
MXPA04004532A (es) * 2001-11-19 2004-08-11 Medigene Ag Medicamento para el tratamiento de enfermedades tumorales y virales de la piel.
US20050032896A1 (en) * 2002-06-21 2005-02-10 Liisa Neumann Use of synthetic retinoic acid in form of 13-cis vitamin A for treatment of autism
US20050095281A1 (en) * 2003-03-14 2005-05-05 Optime Therapeutics, Inc. Liposomal formulations and methods of use
ES2237298B1 (es) 2003-07-16 2006-11-01 Italfarmaco, S.A. Formulaciones mucoadhesivas semisolidas.
GB0317999D0 (en) * 2003-07-31 2003-09-03 Univ Liege Improvements in or relating to drug delivery systems
US20050058673A1 (en) 2003-09-09 2005-03-17 3M Innovative Properties Company Antimicrobial compositions and methods
CA2538119C (en) * 2003-09-09 2013-05-14 3M Innovative Properties Company Concentrated antimicrobial compositions and methods
US7910138B2 (en) 2003-10-09 2011-03-22 Medigene Ag Use of a polyphenol for the treatment of a cancerous or precancerous lesion of the skin
US20050079235A1 (en) * 2003-10-09 2005-04-14 Eggert Stockfleth Use of a polyphenol for the treatment of actinic keratosis
US20050215634A1 (en) * 2003-11-11 2005-09-29 Schlievert Patrick M Regulation of cell membrane-mediated effects
US8796332B2 (en) * 2004-08-03 2014-08-05 Regents Of The University Of Minnesota Compositions and methods for controlling infections
CA2578404A1 (en) * 2004-08-23 2006-03-02 Auckland Uniservices Limited Gastric therapies and compositions therefor
US8535709B2 (en) * 2004-12-13 2013-09-17 Southeastern Medical Technologies, Llc Agents for controlling biological fluids and methods of use thereof
ES2411054T3 (es) * 2004-12-17 2013-07-04 Halldor Thormar Emulsiones antibacterianas concentradas estables de monocaprina en agua
MX2007010904A (es) * 2005-03-10 2007-12-05 3M Innovative Properties Co Panuelo para mascota antimicrobiano.
WO2006099325A2 (en) 2005-03-10 2006-09-21 3M Innovative Properties Company Methods of treating ear infections
US20060229364A1 (en) * 2005-03-10 2006-10-12 3M Innovative Properties Company Antiviral compositions and methods of use
BRPI0608691A2 (pt) 2005-03-10 2010-12-07 3M Innovative Properties Company composição antimicrobiana, e, métodos para matar ou inativar microorganismos em tecido da mucosa de um mamìfero, para tratar uma lesão ou ferimento infectado, para descolonização de microorganismos, para proporcionar eficácia antimicrobiana residual sobre uma superfìcie e para tratar uma condição
BRPI0608690B8 (pt) 2005-03-10 2021-05-25 3M Innovative Properties Co uso de uma composição antimicrobiana
US20080075793A1 (en) * 2006-09-21 2008-03-27 Dunshee Wayne K Antiviral compositions and methods of use
EP2060192B9 (en) * 2007-10-17 2016-05-04 Rudolf Wild GmbH & Co. KG Composition comprising lemon balm extracts
JP2009155257A (ja) * 2007-12-26 2009-07-16 Taiyo Corp 抗菌剤及びそれを含有する口腔用組成物並びに飲食品
ES2344673B1 (es) 2008-08-07 2011-05-03 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral.
ES2344675B1 (es) 2008-12-19 2011-04-28 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular.
DE102009008094A1 (de) 2009-02-09 2010-08-19 Barnikol-Keuten, Doris, Dr. In situ Haft-Gelbildende Zubereitungen, insbesondere zur topischen Anwendung auf befeuchtete Haut/Schleimhaut
UA104899C2 (uk) 2009-08-06 2014-03-25 Анітокс Корпорейшн Консервант для води та корму
CN106913902A (zh) 2009-11-09 2017-07-04 聚光灯技术合伙有限责任公司 多糖基水凝胶
CN102695501A (zh) 2009-11-09 2012-09-26 聚光灯技术合伙有限责任公司 碎裂水凝胶
US12075777B2 (en) 2010-08-27 2024-09-03 Anitox Corporation Antimicrobial formulation
CN103119144B (zh) * 2010-09-14 2014-08-27 日油株式会社 一种抗菌洗涤剂组合物
JP5749915B2 (ja) * 2010-11-02 2015-07-15 花王株式会社 オートインデューサー−２阻害剤
WO2012078155A1 (en) * 2010-12-09 2012-06-14 The Research Foundation Of State University Of New York Nitric oxide and its biomedical significance
US9055745B2 (en) 2011-04-13 2015-06-16 Natureza, Inc. Compositions for internal and external insecticides, ovicides, repellents and wound healing
PT2768539T (pt) 2011-10-20 2017-03-13 Anitox Corp Formulações antimicrobianas com ácido pelargónico
KR20140097253A (ko) 2011-11-30 2014-08-06 아니톡스 코포레이션 알데히드, 유기산 및 유기산 에스테르의 항미생물성 혼합물
DK3471541T3 (da) * 2016-06-20 2021-08-09 Capretto Ehf Synergistiske virkninger, der forøger de antimikrobielle virkninger af lipider
CA3030408A1 (en) * 2016-07-11 2018-01-18 Hennepin Life Sciences, Llc Compositions for sexually transmitted diseases
JP6754030B2 (ja) * 2017-04-20 2020-09-09 マイクロアルジェコーポレーション株式会社 モノアシルグリセロール、抗菌剤、及びモノアシルグリセロールの製造方法
CN114302707A (zh) 2019-06-14 2022-04-08 普洛拉治疗公司 局部阿昔洛韦制剂及其用途
US11572342B2 (en) 2020-09-18 2023-02-07 Niche Biopharmaceuticals LLC Antimicrobial and antiviral sulfur containing glycerol monoester derivatives

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4406884A (en) 1981-06-23 1983-09-27 The Procter & Gamble Company Topical antimicrobial composition
US4520132A (en) 1982-09-27 1985-05-28 Pennwalt Corporation Use of undecylenic acid to treat herpes labialis
MX168518B (es) * 1982-09-30 1993-05-27 Union Carbide Corp Composiciones de modelo que contienen resina epoxida curable
US5208257A (en) 1986-04-21 1993-05-04 Kabara Jon J Topical antimicrobial pharmaceutical compositions and methods
US5434182A (en) * 1987-12-31 1995-07-18 Isaacs; Charles E. Antibacterial fatty acid compositions
US5342625A (en) 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
NZ250714A (en) * 1990-10-30 1996-05-28 Mcneil Ppc Inc Liquid composition comprising esters of higher fatty acids for use as a vaginal douche and to prevent toxic shock toxin production
IL104283A (en) 1992-12-30 1996-12-05 Agis Ind 1983 Ltd Non-emulsion antiviral topical pharmaceutical composition comprising acyclovir an aqueous gel agent and an alkali oleate
IL110380A0 (en) 1994-07-20 1994-10-21 Agis Ind 1983 Ltd Antiviral topical pharmaceutical compositions
CA2273960C (en) 1996-09-17 2003-12-30 Avanir Pharmaceuticals Viral inhibition by long-chain alcohols, alkanes, fatty acids and amides

Also Published As

Publication number Publication date
EP0941087A1 (en) 1999-09-15
US6596763B1 (en) 2003-07-22
IS5051A (is) 1999-05-12
DE69739583D1 (de) 2009-10-29
ATE442844T1 (de) 2009-10-15
CA2271843A1 (en) 1998-05-22
EP0941087B1 (en) 2009-09-16
JP2001504461A (ja) 2001-04-03
WO1998020872A1 (en) 1998-05-22
AP1209A (en) 2003-09-30
AU4941197A (en) 1998-06-03

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PC1 Assignment before grant (sect. 113)

Owner name: LIPOMEDICA EHF.

Free format text: THE FORMER OWNER WAS: HALLDOR THORMAR, THORDIS KRISTMUNDSDOTTIR

FGA Letters patent sealed or granted (standard patent)