AU729546B2 - Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections - Google Patents

Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections Download PDF

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Publication number
AU729546B2
AU729546B2 AU49411/97A AU4941197A AU729546B2 AU 729546 B2 AU729546 B2 AU 729546B2 AU 49411/97 A AU49411/97 A AU 49411/97A AU 4941197 A AU4941197 A AU 4941197A AU 729546 B2 AU729546 B2 AU 729546B2
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AU
Australia
Prior art keywords
lipid
formulation
titre
concentration
incubated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU49411/97A
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English (en)
Other versions
AU4941197A (en
Inventor
Thordis Kristmundsdottir
Halldor Thormar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LipoMedica ehf
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LipoMedica ehf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LipoMedica ehf filed Critical LipoMedica ehf
Publication of AU4941197A publication Critical patent/AU4941197A/en
Assigned to LIPOMEDICA EHF. reassignment LIPOMEDICA EHF. Alteration of Name(s) of Applicant(s) under S113 Assignors: KRISTMUNDSDOTTIR, THORDIS, THORMAR, HALLDOR
Application granted granted Critical
Publication of AU729546B2 publication Critical patent/AU729546B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/08Ethers or acetals acyclic, e.g. paraformaldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU49411/97A 1996-11-14 1997-11-14 Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections Ceased AU729546B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IS4386 1996-11-14
IS4386 1996-11-14
PCT/DK1997/000524 WO1998020872A1 (en) 1996-11-14 1997-11-14 Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections

Publications (2)

Publication Number Publication Date
AU4941197A AU4941197A (en) 1998-06-03
AU729546B2 true AU729546B2 (en) 2001-02-01

Family

ID=36699955

Family Applications (1)

Application Number Title Priority Date Filing Date
AU49411/97A Ceased AU729546B2 (en) 1996-11-14 1997-11-14 Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections

Country Status (10)

Country Link
US (1) US6596763B1 (enExample)
EP (1) EP0941087B1 (enExample)
JP (1) JP2001504461A (enExample)
AP (1) AP1209A (enExample)
AT (1) ATE442844T1 (enExample)
AU (1) AU729546B2 (enExample)
CA (1) CA2271843A1 (enExample)
DE (1) DE69739583D1 (enExample)
IS (1) IS5051A (enExample)
WO (1) WO1998020872A1 (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19648545B4 (de) 1996-11-25 2009-05-07 Ceramtec Ag Monolithischer Vielschichtaktor mit Außenelektroden
IL133608A0 (en) * 1997-06-20 2001-04-30 Eggers Sabine A protective composition for inhibiting bacterial, viral and fungal growth on the skin and use thereof
US6096332A (en) * 1998-06-30 2000-08-01 Mcneil-Ppc, Inc. Adding pharmaceutically active compounds to substrates
RU2186563C2 (ru) * 2000-02-25 2002-08-10 Государственное унитарное предприятие Тихоокеанский научно-исследовательский рыбохозяйственный центр Средство для лечения ожоговой раны
IL137559A (en) * 2000-07-27 2006-12-31 Amnon Sintov A system for administering drugs through the skin
AU2002221412B2 (en) * 2000-12-05 2006-04-13 Alexander Macgregor Hydrostatic delivery system for controlled delivery of agent
DE10156794B4 (de) * 2001-11-19 2006-05-18 Medigene Ag Arzneimittel zur Behandlung von Warzen
US7858662B2 (en) * 2001-11-19 2010-12-28 Medigene Ag Medicament for the treatment of viral skin and tumour diseases
US20050032896A1 (en) * 2002-06-21 2005-02-10 Liisa Neumann Use of synthetic retinoic acid in form of 13-cis vitamin A for treatment of autism
WO2004082612A2 (en) * 2003-03-14 2004-09-30 Optime Therapeutics Inc. Liposomal formulations and methods of use
ES2237298B1 (es) 2003-07-16 2006-11-01 Italfarmaco, S.A. Formulaciones mucoadhesivas semisolidas.
GB0317999D0 (en) * 2003-07-31 2003-09-03 Univ Liege Improvements in or relating to drug delivery systems
US20050058673A1 (en) 2003-09-09 2005-03-17 3M Innovative Properties Company Antimicrobial compositions and methods
US20050084471A1 (en) * 2003-09-09 2005-04-21 3M Innovative Properties Company Concentrated antimicrobial compositions and methods
BRPI0415215B8 (pt) 2003-10-09 2021-05-25 Medigene Ag uso de polifenol na preparação de medicamento
US20050079235A1 (en) * 2003-10-09 2005-04-14 Eggert Stockfleth Use of a polyphenol for the treatment of actinic keratosis
JP5602335B2 (ja) * 2003-11-11 2014-10-08 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 細胞膜媒介性作用の調節
US8796332B2 (en) 2004-08-03 2014-08-05 Regents Of The University Of Minnesota Compositions and methods for controlling infections
US20080214618A1 (en) * 2004-08-23 2008-09-04 Auckland Uniservices Limited Gastric Therapies Amd Compositions Therefor
US8535709B2 (en) * 2004-12-13 2013-09-17 Southeastern Medical Technologies, Llc Agents for controlling biological fluids and methods of use thereof
WO2006064520A1 (en) * 2004-12-17 2006-06-22 Halldor Thormar Stable concentrated anti-bacterial emulsions of monocaprin in water
JP5642929B2 (ja) 2005-03-10 2014-12-17 スリーエム イノベイティブ プロパティズ カンパニー 微小生体汚染の低減方法
WO2006099232A2 (en) * 2005-03-10 2006-09-21 3M Innovative Properties Company Antimicrobial pet wipes
MX2007010908A (es) 2005-03-10 2007-12-05 3M Innovative Properties Co Composiciones antimicrobianas que comprenden esteres de acidos hidroxicarboxilicos.
US20060229364A1 (en) * 2005-03-10 2006-10-12 3M Innovative Properties Company Antiviral compositions and methods of use
JP2008533048A (ja) 2005-03-10 2008-08-21 スリーエム イノベイティブ プロパティズ カンパニー 耳の感染症の治療方法
US20080075793A1 (en) * 2006-09-21 2008-03-27 Dunshee Wayne K Antiviral compositions and methods of use
EP2060192B9 (en) * 2007-10-17 2016-05-04 Rudolf Wild GmbH & Co. KG Composition comprising lemon balm extracts
JP2009155257A (ja) * 2007-12-26 2009-07-16 Taiyo Corp 抗菌剤及びそれを含有する口腔用組成物並びに飲食品
ES2344673B1 (es) 2008-08-07 2011-05-03 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral.
ES2344675B1 (es) 2008-12-19 2011-04-28 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular.
DE102009008094A1 (de) 2009-02-09 2010-08-19 Barnikol-Keuten, Doris, Dr. In situ Haft-Gelbildende Zubereitungen, insbesondere zur topischen Anwendung auf befeuchtete Haut/Schleimhaut
US10785975B2 (en) 2009-08-06 2020-09-29 Anitox Corporation Water and feed antimicrobial preservative
JP2013509963A (ja) 2009-11-09 2013-03-21 スポットライト テクノロジー パートナーズ エルエルシー 断片化ヒドロゲル
WO2011057131A1 (en) 2009-11-09 2011-05-12 Spotlight Technology Partners Llc Polysaccharide based hydrogels
CA2771980C (en) 2010-08-27 2014-05-13 Anitox Corporation Antimicrobial formulation
JP5910912B2 (ja) * 2010-09-14 2016-04-27 日油株式会社 除菌洗浄剤組成物
JP5749915B2 (ja) * 2010-11-02 2015-07-15 花王株式会社 オートインデューサー−2阻害剤
US20130261146A1 (en) * 2010-12-09 2013-10-03 The Research Foundation Of State University Of New York Nitric oxide and its biomedical significance
EP2696677B1 (en) 2011-04-13 2021-08-11 BioSafe Technologies, Inc. Insecticide, insect repellant and anti-irritation composition
RU2014115606A (ru) 2011-10-20 2015-11-27 Анитокс Корпорейшн Антимикробные композиции, содержащие пеларгоновую кислоту
WO2013081777A1 (en) 2011-11-30 2013-06-06 Anitox Corporation Antimicrobial mixture of aldehydes, organic acids and organic acid esters
EP3471541B1 (en) * 2016-06-20 2021-05-05 Capretto EHF. Synergistic effects, augmenting antimicrobial effects of lipids
AU2017296016A1 (en) * 2016-07-11 2019-01-24 Hennepin Life Sciences, Llc Compositions for sexually transmitted diseases
JP6754030B2 (ja) * 2017-04-20 2020-09-09 マイクロアルジェコーポレーション株式会社 モノアシルグリセロール、抗菌剤、及びモノアシルグリセロールの製造方法
US11246872B2 (en) 2019-06-14 2022-02-15 Propella Therapeutics, Inc. Topical acyclovir formulations and uses thereof
US11572342B2 (en) 2020-09-18 2023-02-07 Niche Biopharmaceuticals LLC Antimicrobial and antiviral sulfur containing glycerol monoester derivatives

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4406884A (en) * 1981-06-23 1983-09-27 The Procter & Gamble Company Topical antimicrobial composition
US4520132A (en) 1982-09-27 1985-05-28 Pennwalt Corporation Use of undecylenic acid to treat herpes labialis
MX168518B (es) * 1982-09-30 1993-05-27 Union Carbide Corp Composiciones de modelo que contienen resina epoxida curable
US5208257A (en) 1986-04-21 1993-05-04 Kabara Jon J Topical antimicrobial pharmaceutical compositions and methods
US5434182A (en) * 1987-12-31 1995-07-18 Isaacs; Charles E. Antibacterial fatty acid compositions
US5342625A (en) 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
NZ250714A (en) * 1990-10-30 1996-05-28 Mcneil Ppc Inc Liquid composition comprising esters of higher fatty acids for use as a vaginal douche and to prevent toxic shock toxin production
IL104283A (en) 1992-12-30 1996-12-05 Agis Ind 1983 Ltd Non-emulsion antiviral topical pharmaceutical composition comprising acyclovir an aqueous gel agent and an alkali oleate
IL110380A0 (en) 1994-07-20 1994-10-21 Agis Ind 1983 Ltd Antiviral topical pharmaceutical compositions
PL189618B1 (pl) 1996-09-17 2005-08-31 Avanir Pharmaceuticals Kompozycje przeciwwirusowe i przeciwzapalne oraz zastosowanie tych kompozycji

Also Published As

Publication number Publication date
CA2271843A1 (en) 1998-05-22
JP2001504461A (ja) 2001-04-03
IS5051A (is) 1999-05-12
US6596763B1 (en) 2003-07-22
AU4941197A (en) 1998-06-03
AP1209A (en) 2003-09-30
EP0941087A1 (en) 1999-09-15
EP0941087B1 (en) 2009-09-16
WO1998020872A1 (en) 1998-05-22
DE69739583D1 (de) 2009-10-29
ATE442844T1 (de) 2009-10-15

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: LIPOMEDICA EHF.

Free format text: THE FORMER OWNER WAS: HALLDOR THORMAR, THORDIS KRISTMUNDSDOTTIR

FGA Letters patent sealed or granted (standard patent)