CA2271843A1 - Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections - Google Patents
Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections Download PDFInfo
- Publication number
- CA2271843A1 CA2271843A1 CA002271843A CA2271843A CA2271843A1 CA 2271843 A1 CA2271843 A1 CA 2271843A1 CA 002271843 A CA002271843 A CA 002271843A CA 2271843 A CA2271843 A CA 2271843A CA 2271843 A1 CA2271843 A1 CA 2271843A1
- Authority
- CA
- Canada
- Prior art keywords
- lipid
- pharmaceutical formulation
- titer
- formulation
- millimolar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 208000011580 syndromic disease Diseases 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- ILLKMACMBHTSHP-UHFFFAOYSA-N tetradecaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ILLKMACMBHTSHP-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- PSVXZQVXSXSQRO-UHFFFAOYSA-N undecaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO PSVXZQVXSXSQRO-UHFFFAOYSA-N 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 229940044950 vaginal gel Drugs 0.000 description 1
- 239000000029 vaginal gel Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000012873 virucide Substances 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 201000000752 white piedra Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IS4386 | 1996-11-14 | ||
| IS4386 | 1996-11-14 | ||
| PCT/DK1997/000524 WO1998020872A1 (en) | 1996-11-14 | 1997-11-14 | Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2271843A1 true CA2271843A1 (en) | 1998-05-22 |
Family
ID=36699955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002271843A Abandoned CA2271843A1 (en) | 1996-11-14 | 1997-11-14 | Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6596763B1 (enExample) |
| EP (1) | EP0941087B1 (enExample) |
| JP (1) | JP2001504461A (enExample) |
| AP (1) | AP1209A (enExample) |
| AT (1) | ATE442844T1 (enExample) |
| AU (1) | AU729546B2 (enExample) |
| CA (1) | CA2271843A1 (enExample) |
| DE (1) | DE69739583D1 (enExample) |
| IS (1) | IS5051A (enExample) |
| WO (1) | WO1998020872A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19648545B4 (de) † | 1996-11-25 | 2009-05-07 | Ceramtec Ag | Monolithischer Vielschichtaktor mit Außenelektroden |
| WO1998058627A1 (en) * | 1997-06-20 | 1998-12-30 | Sabine Ebeling | A skin-protective composition |
| US6096332A (en) * | 1998-06-30 | 2000-08-01 | Mcneil-Ppc, Inc. | Adding pharmaceutically active compounds to substrates |
| RU2186563C2 (ru) * | 2000-02-25 | 2002-08-10 | Государственное унитарное предприятие Тихоокеанский научно-исследовательский рыбохозяйственный центр | Средство для лечения ожоговой раны |
| IL137559A (en) * | 2000-07-27 | 2006-12-31 | Amnon Sintov | A system for administering drugs through the skin |
| AU2002221412B2 (en) * | 2000-12-05 | 2006-04-13 | Alexander Macgregor | Hydrostatic delivery system for controlled delivery of agent |
| DE10156794B4 (de) * | 2001-11-19 | 2006-05-18 | Medigene Ag | Arzneimittel zur Behandlung von Warzen |
| ATE417611T1 (de) * | 2001-11-19 | 2009-01-15 | Medigene Ag | Arzneimittel zur behandlung von viralen haut- und tumorerkrankungen |
| US20050032896A1 (en) * | 2002-06-21 | 2005-02-10 | Liisa Neumann | Use of synthetic retinoic acid in form of 13-cis vitamin A for treatment of autism |
| WO2004082612A2 (en) * | 2003-03-14 | 2004-09-30 | Optime Therapeutics Inc. | Liposomal formulations and methods of use |
| ES2237298B1 (es) | 2003-07-16 | 2006-11-01 | Italfarmaco, S.A. | Formulaciones mucoadhesivas semisolidas. |
| GB0317999D0 (en) * | 2003-07-31 | 2003-09-03 | Univ Liege | Improvements in or relating to drug delivery systems |
| WO2005023023A1 (en) * | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Concentrated antimicrobial compositions and methods |
| US20050058673A1 (en) | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
| AR045865A1 (es) | 2003-10-09 | 2005-11-16 | Medigene Ag | El uso de un polifenol para el tratamiento de una lesion cancerosa o pre-cancerosa de la piel |
| US20050079235A1 (en) * | 2003-10-09 | 2005-04-14 | Eggert Stockfleth | Use of a polyphenol for the treatment of actinic keratosis |
| US20070276049A1 (en) * | 2003-11-11 | 2007-11-29 | Schlievert Patrick M | Regulation of Cell Membrane-Mediated Effects |
| US8796332B2 (en) * | 2004-08-03 | 2014-08-05 | Regents Of The University Of Minnesota | Compositions and methods for controlling infections |
| JP2008510804A (ja) * | 2004-08-23 | 2008-04-10 | オークランド ユニサービシズ リミテッド | 胃の治療法およびそのための組成物 |
| US8535709B2 (en) * | 2004-12-13 | 2013-09-17 | Southeastern Medical Technologies, Llc | Agents for controlling biological fluids and methods of use thereof |
| EP1833298B1 (en) * | 2004-12-17 | 2013-05-08 | Halldor Thormar | Stable concentrated anti-bacterial emulsions of monocaprin in water |
| EP3025704B1 (en) | 2005-03-10 | 2019-01-16 | 3M Innovative Properties Company | Methods of reducing microbial contamination |
| US20060229364A1 (en) * | 2005-03-10 | 2006-10-12 | 3M Innovative Properties Company | Antiviral compositions and methods of use |
| US9826770B2 (en) | 2005-03-10 | 2017-11-28 | 3M Innovative Properties Company | Antimicrobial compositions comprising esters of hydroxycarboxylic acids |
| WO2006099325A2 (en) | 2005-03-10 | 2006-09-21 | 3M Innovative Properties Company | Methods of treating ear infections |
| CA2598985A1 (en) * | 2005-03-10 | 2006-09-21 | 3M Innovative Properties Company | Antimicrobial pet wipes and methods |
| US20080075793A1 (en) * | 2006-09-21 | 2008-03-27 | Dunshee Wayne K | Antiviral compositions and methods of use |
| ES2561330T3 (es) * | 2007-10-17 | 2016-02-25 | Rudolf Wild Gmbh & Co. Kg | Composición que comprende extractos de toronjil |
| JP2009155257A (ja) * | 2007-12-26 | 2009-07-16 | Taiyo Corp | 抗菌剤及びそれを含有する口腔用組成物並びに飲食品 |
| ES2344673B1 (es) | 2008-08-07 | 2011-05-03 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral. |
| ES2344675B1 (es) | 2008-12-19 | 2011-04-28 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular. |
| DE102009008094A1 (de) | 2009-02-09 | 2010-08-19 | Barnikol-Keuten, Doris, Dr. | In situ Haft-Gelbildende Zubereitungen, insbesondere zur topischen Anwendung auf befeuchtete Haut/Schleimhaut |
| HUE028283T2 (en) | 2009-08-06 | 2016-12-28 | Anitox Corp | Water and feed preservative |
| AU2010314994B2 (en) | 2009-11-09 | 2016-10-06 | Spotlight Technology Partners Llc | Fragmented hydrogels |
| WO2011057131A1 (en) | 2009-11-09 | 2011-05-12 | Spotlight Technology Partners Llc | Polysaccharide based hydrogels |
| CN108077255A (zh) | 2010-08-27 | 2018-05-29 | 阿尼托克斯公司 | 处理动物饲料的方法、抗沙门氏菌组合物及其应用 |
| CN103119144B (zh) * | 2010-09-14 | 2014-08-27 | 日油株式会社 | 一种抗菌洗涤剂组合物 |
| JP5749915B2 (ja) * | 2010-11-02 | 2015-07-15 | 花王株式会社 | オートインデューサー−２阻害剤 |
| US20130261146A1 (en) * | 2010-12-09 | 2013-10-03 | The Research Foundation Of State University Of New York | Nitric oxide and its biomedical significance |
| EP2696677B1 (en) | 2011-04-13 | 2021-08-11 | BioSafe Technologies, Inc. | Insecticide, insect repellant and anti-irritation composition |
| WO2013059012A1 (en) | 2011-10-20 | 2013-04-25 | Anitox Corporation | Antimicrobial formulations with pelargonic acid |
| KR20140097253A (ko) | 2011-11-30 | 2014-08-06 | 아니톡스 코포레이션 | 알데히드, 유기산 및 유기산 에스테르의 항미생물성 혼합물 |
| US20190209510A1 (en) * | 2016-06-20 | 2019-07-11 | Capretto Ehf. | Synergistic effects, augmenting antimicrobal effects of lipids |
| CA3030408A1 (en) * | 2016-07-11 | 2018-01-18 | Hennepin Life Sciences, Llc | Compositions for sexually transmitted diseases |
| JP6754030B2 (ja) * | 2017-04-20 | 2020-09-09 | マイクロアルジェコーポレーション株式会社 | モノアシルグリセロール、抗菌剤、及びモノアシルグリセロールの製造方法 |
| CA3142831A1 (en) | 2019-06-14 | 2020-12-17 | Propella Therapeutics, Inc. | Topical acyclovir formulations and uses thereof |
| US11572342B2 (en) | 2020-09-18 | 2023-02-07 | Niche Biopharmaceuticals LLC | Antimicrobial and antiviral sulfur containing glycerol monoester derivatives |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4406884A (en) | 1981-06-23 | 1983-09-27 | The Procter & Gamble Company | Topical antimicrobial composition |
| US4520132A (en) * | 1982-09-27 | 1985-05-28 | Pennwalt Corporation | Use of undecylenic acid to treat herpes labialis |
| JPS5981329A (ja) * | 1982-09-30 | 1984-05-11 | ユニオン、カーバイド、コーポレーシヨン | 硬化し得るエポキシ樹脂含有成形組成物 |
| US5208257A (en) | 1986-04-21 | 1993-05-04 | Kabara Jon J | Topical antimicrobial pharmaceutical compositions and methods |
| US5434182A (en) * | 1987-12-31 | 1995-07-18 | Isaacs; Charles E. | Antibacterial fatty acid compositions |
| US5342625A (en) | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
| NZ250714A (en) | 1990-10-30 | 1996-05-28 | Mcneil Ppc Inc | Liquid composition comprising esters of higher fatty acids for use as a vaginal douche and to prevent toxic shock toxin production |
| IL104283A (en) | 1992-12-30 | 1996-12-05 | Agis Ind 1983 Ltd | Non-emulsion antiviral topical pharmaceutical composition comprising acyclovir an aqueous gel agent and an alkali oleate |
| IL110380A0 (en) | 1994-07-20 | 1994-10-21 | Agis Ind 1983 Ltd | Antiviral topical pharmaceutical compositions |
| IL163865A0 (en) | 1996-09-17 | 2005-12-18 | Avanir Pharmaceuticals | Compositions comprising a non-ionicsurfactant and n-docosanol |
-
1997
- 1997-11-14 AT AT97912073T patent/ATE442844T1/de not_active IP Right Cessation
- 1997-11-14 WO PCT/DK1997/000524 patent/WO1998020872A1/en not_active Ceased
- 1997-11-14 US US09/297,921 patent/US6596763B1/en not_active Expired - Fee Related
- 1997-11-14 CA CA002271843A patent/CA2271843A1/en not_active Abandoned
- 1997-11-14 AP APAP/P/1999/001551A patent/AP1209A/en active
- 1997-11-14 JP JP52206398A patent/JP2001504461A/ja not_active Ceased
- 1997-11-14 EP EP97912073A patent/EP0941087B1/en not_active Expired - Lifetime
- 1997-11-14 AU AU49411/97A patent/AU729546B2/en not_active Ceased
- 1997-11-14 DE DE69739583T patent/DE69739583D1/de not_active Expired - Lifetime
-
1999
- 1999-05-12 IS IS5051A patent/IS5051A/is unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0941087B1 (en) | 2009-09-16 |
| AU729546B2 (en) | 2001-02-01 |
| DE69739583D1 (de) | 2009-10-29 |
| AU4941197A (en) | 1998-06-03 |
| ATE442844T1 (de) | 2009-10-15 |
| WO1998020872A1 (en) | 1998-05-22 |
| US6596763B1 (en) | 2003-07-22 |
| EP0941087A1 (en) | 1999-09-15 |
| IS5051A (is) | 1999-05-12 |
| JP2001504461A (ja) | 2001-04-03 |
| AP1209A (en) | 2003-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |