AU725998B2 - Treating NIDDM with RXR agonists - Google Patents
Treating NIDDM with RXR agonists Download PDFInfo
- Publication number
- AU725998B2 AU725998B2 AU70742/96A AU7074296A AU725998B2 AU 725998 B2 AU725998 B2 AU 725998B2 AU 70742/96 A AU70742/96 A AU 70742/96A AU 7074296 A AU7074296 A AU 7074296A AU 725998 B2 AU725998 B2 AU 725998B2
- Authority
- AU
- Australia
- Prior art keywords
- agonist
- insulin
- rxr
- rxr agonist
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07C251/32—Oximes
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- C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
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- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
- C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
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- C07C65/36—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic containing rings other than six-membered aromatic rings
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- G01N33/5061—Muscle cells
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- Medicinal Chemistry (AREA)
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- Public Health (AREA)
- Veterinary Medicine (AREA)
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- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Urology & Nephrology (AREA)
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- Diabetes (AREA)
- Microbiology (AREA)
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- Obesity (AREA)
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Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US386995P | 1995-09-18 | 1995-09-18 | |
| US60/003869 | 1995-09-18 | ||
| US489795P | 1995-10-06 | 1995-10-06 | |
| US60/004897 | 1995-10-06 | ||
| US988496P | 1996-01-10 | 1996-01-10 | |
| US60/009884 | 1996-01-11 | ||
| US1831896P | 1996-05-24 | 1996-05-24 | |
| US60/018318 | 1996-05-24 | ||
| US2183996P | 1996-07-10 | 1996-07-10 | |
| US60/021839 | 1996-07-10 | ||
| PCT/US1996/014904 WO1997010819A1 (en) | 1995-09-18 | 1996-09-17 | Treating niddm with rxr agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU7074296A AU7074296A (en) | 1997-04-09 |
| AU725998B2 true AU725998B2 (en) | 2000-10-26 |
Family
ID=27533028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU70742/96A Ceased AU725998B2 (en) | 1995-09-18 | 1996-09-17 | Treating NIDDM with RXR agonists |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP0859608B1 (enExample) |
| JP (1) | JPH11511472A (enExample) |
| KR (1) | KR19990045756A (enExample) |
| AT (1) | ATE259227T1 (enExample) |
| AU (1) | AU725998B2 (enExample) |
| BR (1) | BR9610624A (enExample) |
| DE (1) | DE69631541T2 (enExample) |
| DK (1) | DK0859608T3 (enExample) |
| ES (1) | ES2216062T3 (enExample) |
| NO (1) | NO981192L (enExample) |
| PT (1) | PT859608E (enExample) |
| WO (1) | WO1997010819A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7115728B1 (en) | 1995-01-30 | 2006-10-03 | Ligand Pharmaceutical Incorporated | Human peroxisome proliferator activated receptor γ |
| WO1998005331A2 (en) * | 1996-08-02 | 1998-02-12 | Ligand Pharmaceuticals Incorporated | Prevention or treatment of type 2 diabetes or cardiovascular disease with ppar modulators |
| ATE399545T1 (de) * | 1996-11-08 | 2008-07-15 | Nippon Chemiphar Co | Mittel zur verringerung der eigeweidefette |
| JP4549443B2 (ja) * | 1996-12-11 | 2010-09-22 | ダナ−ファーバー キャンサー インスティテュート インク. | 腫瘍細胞の成長を阻害するための方法および製薬学的組成物 |
| US6586455B1 (en) * | 1996-12-31 | 2003-07-01 | The Salk Institute For Biological Studies | Treatment of liposarcomas using a combination of thiazolidinediones and retinoid X receptor selective agonists |
| GB9712866D0 (en) * | 1997-06-18 | 1997-08-20 | Smithkline Beecham Plc | Novel method of treatment |
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| US5219888A (en) * | 1992-03-31 | 1993-06-15 | American Cyanamid Company | Use of retinoids for the treatment of coronary artery disease |
| WO1997012853A1 (en) * | 1995-10-06 | 1997-04-10 | Ligand Pharmaceuticals Incorporated | Dimer-selective rxr modulators and methods for their use |
| FR2746101B1 (fr) * | 1996-03-14 | 1998-04-30 | Composes bicycliques-aromatiques |
-
1996
- 1996-09-17 PT PT96931613T patent/PT859608E/pt unknown
- 1996-09-17 JP JP9512842A patent/JPH11511472A/ja active Pending
- 1996-09-17 DK DK96931613T patent/DK0859608T3/da active
- 1996-09-17 BR BR9610624A patent/BR9610624A/pt not_active Application Discontinuation
- 1996-09-17 EP EP96931613A patent/EP0859608B1/en not_active Expired - Lifetime
- 1996-09-17 EP EP04002911A patent/EP1426048A3/en not_active Withdrawn
- 1996-09-17 AT AT96931613T patent/ATE259227T1/de active
- 1996-09-17 DE DE69631541T patent/DE69631541T2/de not_active Expired - Lifetime
- 1996-09-17 AU AU70742/96A patent/AU725998B2/en not_active Ceased
- 1996-09-17 WO PCT/US1996/014904 patent/WO1997010819A1/en not_active Ceased
- 1996-09-17 ES ES96931613T patent/ES2216062T3/es not_active Expired - Lifetime
- 1996-09-17 KR KR1019980702000A patent/KR19990045756A/ko not_active Ceased
-
1998
- 1998-03-17 NO NO981192A patent/NO981192L/no unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0552624A1 (en) * | 1992-01-22 | 1993-07-28 | F. Hoffmann-La Roche Ag | Pharmaceutical compositions containing 9-cis retinoic acid, salts and esters thereof |
| WO1993021146A1 (en) * | 1992-04-22 | 1993-10-28 | Ligand Pharmaceuticals Incorporated | Compounds having selectivity for retinoid x receptors |
| AU2723295A (en) * | 1994-08-02 | 1996-02-29 | C.I.R.D. Galderma | Method and compositions for stimulating the differentiation of preadipocytic cells and associated therapeutic treatments |
Also Published As
| Publication number | Publication date |
|---|---|
| PT859608E (pt) | 2004-06-30 |
| NO981192D0 (no) | 1998-03-17 |
| JPH11511472A (ja) | 1999-10-05 |
| AU7074296A (en) | 1997-04-09 |
| ATE259227T1 (de) | 2004-02-15 |
| MX9802104A (es) | 1998-10-31 |
| ES2216062T3 (es) | 2004-10-16 |
| WO1997010819A1 (en) | 1997-03-27 |
| BR9610624A (pt) | 1999-03-16 |
| EP0859608A1 (en) | 1998-08-26 |
| DE69631541T2 (de) | 2004-12-23 |
| NO981192L (no) | 1998-05-18 |
| DK0859608T3 (da) | 2004-06-14 |
| DE69631541D1 (de) | 2004-03-18 |
| EP0859608B1 (en) | 2004-02-11 |
| EP1426048A3 (en) | 2004-06-16 |
| KR19990045756A (ko) | 1999-06-25 |
| EP1426048A2 (en) | 2004-06-09 |
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