AU725966B2 - Mass label linked hybridisation probes - Google Patents

Mass label linked hybridisation probes Download PDF

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Publication number
AU725966B2
AU725966B2 AU55700/98A AU5570098A AU725966B2 AU 725966 B2 AU725966 B2 AU 725966B2 AU 55700/98 A AU55700/98 A AU 55700/98A AU 5570098 A AU5570098 A AU 5570098A AU 725966 B2 AU725966 B2 AU 725966B2
Authority
AU
Australia
Prior art keywords
mass
probe
sequence
base sequence
hybridisation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU55700/98A
Other languages
English (en)
Other versions
AU5570098A (en
Inventor
Robert Alexander Walker Johnstone
Gunter Schmidt
Andrew Hugin Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xzillion GmbH and Co KG
Original Assignee
Brax Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9700746.2A external-priority patent/GB9700746D0/en
Priority claimed from GBGB9718255.4A external-priority patent/GB9718255D0/en
Priority claimed from GBGB9726953.4A external-priority patent/GB9726953D0/en
Application filed by Brax Group Ltd filed Critical Brax Group Ltd
Publication of AU5570098A publication Critical patent/AU5570098A/en
Application granted granted Critical
Publication of AU725966B2 publication Critical patent/AU725966B2/en
Assigned to XZILLION GMBH & CO. KG reassignment XZILLION GMBH & CO. KG Alteration of Name(s) in Register under S187 Assignors: BRAX GROUP LIMITED
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Discharge Heating (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Surgical Instruments (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU55700/98A 1997-01-15 1998-01-15 Mass label linked hybridisation probes Ceased AU725966B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB9700746.2A GB9700746D0 (en) 1996-10-04 1997-01-15 Hybridisation probes
GB9700746 1997-01-15
GB9718255 1997-08-28
GBGB9718255.4A GB9718255D0 (en) 1996-10-04 1997-08-28 Hybridisation probes
GB9726953 1997-12-19
GBGB9726953.4A GB9726953D0 (en) 1997-12-19 1997-12-19 Hybridisation probes
PCT/GB1998/000127 WO1998031830A1 (en) 1997-01-15 1998-01-15 Mass label linked hybridisation probes

Publications (2)

Publication Number Publication Date
AU5570098A AU5570098A (en) 1998-08-07
AU725966B2 true AU725966B2 (en) 2000-10-26

Family

ID=27268674

Family Applications (1)

Application Number Title Priority Date Filing Date
AU55700/98A Ceased AU725966B2 (en) 1997-01-15 1998-01-15 Mass label linked hybridisation probes

Country Status (10)

Country Link
EP (2) EP1400599B1 (enExample)
JP (3) JP3884087B2 (enExample)
CN (1) CN100434531C (enExample)
AT (2) ATE340869T1 (enExample)
AU (1) AU725966B2 (enExample)
CA (2) CA2441655A1 (enExample)
DE (2) DE69838519T2 (enExample)
IL (1) IL130885A (enExample)
NZ (1) NZ336769A (enExample)
WO (1) WO1998031830A1 (enExample)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9707980D0 (en) 1997-04-21 1997-06-11 Brax Genomics Ltd Characterising DNA
US6312904B1 (en) * 1997-07-11 2001-11-06 Xzillion Gmbh & Co. Kg Characterizing nucleic acid
EP0990047B1 (en) * 1997-07-22 2003-05-14 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acids by mass spectrometry
GB9718921D0 (en) 1997-09-05 1997-11-12 Brax Genomics Ltd Catalytically generated mass labels
EP1015632A1 (en) * 1997-09-15 2000-07-05 Brax Group Limited Characterising nucleic acid by mass spectrometry
DK1036202T3 (da) * 1997-12-05 2002-08-12 Max Planck Gesellschaft Fremgangsmåde til identifikation af nucleinsyrer ved matriksassisteret laserdesorptions/ionisationsmassespektrometri
GB9815164D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds for mass spectrometry
GB9815163D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds
GB9823646D0 (en) 1997-12-19 1998-12-23 Brax Genomics Ltd Compounds for mass spectrometry
GB9815166D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds for mass spectrometry
DE69913509T2 (de) * 1998-05-15 2004-09-23 Oxford Gene Technology Ip Ltd., Kidlington Bibliotheken von Oligomeren, die mit unterschiedlichen Markierungen (TAGS) markiert sind
US7399844B2 (en) 1998-07-09 2008-07-15 Agilent Technologies, Inc. Method and reagents for analyzing the nucleotide sequence of nucleic acids
US6270976B1 (en) 1998-09-15 2001-08-07 Brax Group Limited Characterizing nucleic acid by mass spectrometry
JP3668075B2 (ja) * 1999-10-12 2005-07-06 光夫 板倉 遺伝物質シーケンス決定用懸濁系、その懸濁系を用いた遺伝物質シーケンス決定方法およびその懸濁系を用いたSNPs高速スコアリング方法
US6509157B1 (en) * 1999-11-05 2003-01-21 Roche Molecular Systems, Inc 3 blocked nucleic acid amplification primers
DE19963536C2 (de) * 1999-12-20 2003-04-10 Epigenomics Ag Verfahren zur Analyse von Nukleinsäuresequenzen
JP2001204463A (ja) * 2000-01-27 2001-07-31 Toyo Kohan Co Ltd ヌクレオチド固定用担体
GB0006141D0 (en) 2000-03-14 2000-05-03 Brax Group Ltd Mass labels
CA2408291C (en) 2000-05-04 2014-07-15 Yale University High density protein arrays for screening of protein activity
WO2002014867A2 (en) * 2000-08-11 2002-02-21 Agilix Corporation Ultra-sensitive detection systems
DK1358458T3 (da) 2000-10-19 2012-06-18 Target Discovery Inc Massedefektmærkning til bestemmelse af oligomersekvenser
JPWO2002050307A1 (ja) * 2000-12-12 2004-04-22 中外製薬株式会社 質量分析を利用してdnaの多型を検出する方法
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
WO2004060278A2 (en) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Methods for rapid identification of pathogens in humans and animals
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
EP1425586B1 (en) 2001-09-14 2007-11-21 Electrophoretics Limited Mass labels
WO2003087839A1 (en) * 2002-04-04 2003-10-23 Xzillion Gmbh & Co. Kg Method for characterising analytes
JP2004037128A (ja) * 2002-06-28 2004-02-05 Canon Inc マトリクス援助レーザー脱着/イオン化飛行時間型質量分析法による基板上の物質の解析方法
SG190453A1 (en) 2002-10-29 2013-06-28 Target Discovery Inc Method for increasing ionization efficiency in mass spectroscopy
EP1588145B1 (en) 2003-01-30 2011-07-06 Life Technologies Corporation Methods, mixtures, kits and compositions pertaining to analyte determination
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US20120122102A1 (en) 2003-09-11 2012-05-17 Rangarajan Sampath Compositions for use in identification of bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
JP2005140755A (ja) * 2003-11-10 2005-06-02 Japan Science & Technology Agency 質量分析用プローブ及びそれを用いた質量分析方法
US8163895B2 (en) 2003-12-05 2012-04-24 Ibis Biosciences, Inc. Compositions for use in identification of orthopoxviruses
US20050148087A1 (en) 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
US7307169B2 (en) 2004-01-05 2007-12-11 Applera Corporation Isotopically enriched N-substituted piperazines and methods for the preparation thereof
US7355045B2 (en) 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
US7868547B2 (en) 2004-03-01 2011-01-11 Dh Technologies Development Pte. Ltd. Determination of analyte characteristics based upon binding properties
JP4810533B2 (ja) 2004-05-24 2011-11-09 アイビス バイオサイエンシズ インコーポレイティッド ディジタルスレショルド化による選択的イオン濾過作用を用いた質量分光測定法
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US20070048752A1 (en) 2004-07-12 2007-03-01 Applera Corporation Mass tags for quantitative analyses
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
US20060024722A1 (en) 2004-07-30 2006-02-02 Mark Fischer-Colbrie Samples for detection of oncofetal fibronectin and uses thereof
US20060183238A1 (en) 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
US20060205040A1 (en) 2005-03-03 2006-09-14 Rangarajan Sampath Compositions for use in identification of adventitious viruses
US8026084B2 (en) 2005-07-21 2011-09-27 Ibis Biosciences, Inc. Methods for rapid identification and quantitation of nucleic acid variants
GB0515323D0 (en) 2005-07-26 2005-08-31 Electrophoretics Ltd Mass labels
GB0518585D0 (en) * 2005-09-12 2005-10-19 Electrophoretics Ltd Mass labels
US8975404B2 (en) 2006-01-24 2015-03-10 Dh Technologies Development Pte. Ltd. Labeling reagents for analyte determination and methods and compounds used in making the same
US8088582B2 (en) 2006-04-06 2012-01-03 Ibis Biosciences, Inc. Compositions for the use in identification of fungi
EP2054540B1 (en) 2006-05-26 2014-11-26 DH Technologies Development Pte. Ltd. Tagging reagents and methods for hydroxylated compounds
US11098345B2 (en) 2006-06-05 2021-08-24 California Institute Of Technology Methods for detecting target analytes
US7906341B2 (en) 2006-06-30 2011-03-15 Dh Technologies Development Pte, Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
US8362242B2 (en) 2006-06-30 2013-01-29 Dh Technologies Development Pte. Ltd. Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
WO2008143627A2 (en) 2006-09-14 2008-11-27 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
JP5680304B2 (ja) 2007-02-23 2015-03-04 アイビス バイオサイエンシズ インコーポレイティッド 迅速な法医学的dna分析法
GB0704764D0 (en) 2007-03-12 2007-04-18 Electrophoretics Ltd Isobarically labelled reagents and methods of their use
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
CN101519698B (zh) * 2008-03-10 2013-05-22 周国华 一种利用序列标签定量测定核酸的方法
WO2017120148A1 (en) * 2016-01-04 2017-07-13 Quantumdx Group Limited Design, synthesis and use of synthetic nucleotides comprising charge mass tags
EP2347254A2 (en) 2008-09-16 2011-07-27 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
EP2349549B1 (en) 2008-09-16 2012-07-18 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, and system
EP2344893B1 (en) 2008-09-16 2014-10-15 Ibis Biosciences, Inc. Microplate handling systems and methods
EP2396803A4 (en) 2009-02-12 2016-10-26 Ibis Biosciences Inc IONIZATION PROBE ASSEMBLIES
WO2010104798A1 (en) 2009-03-08 2010-09-16 Ibis Biosciences, Inc. Bioagent detection methods
WO2010104981A2 (en) 2009-03-10 2010-09-16 University Of Maryland Biotechnology Institute Deuterium isobaric tag reagents for quantitative analysis
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
WO2011008972A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Systems for bioagent identification
US9416409B2 (en) 2009-07-31 2016-08-16 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
US9080209B2 (en) 2009-08-06 2015-07-14 Ibis Biosciences, Inc. Non-mass determined base compositions for nucleic acid detection
US9890408B2 (en) 2009-10-15 2018-02-13 Ibis Biosciences, Inc. Multiple displacement amplification
WO2011115840A2 (en) 2010-03-14 2011-09-22 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
DK2588144T3 (en) 2010-07-02 2018-07-23 Ventana Med Syst Inc Detection of targets using mass markers and mass spectrometry
US8492163B2 (en) 2011-01-31 2013-07-23 Dh Technologies Development Pte. Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
US9708647B2 (en) * 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US20170089915A1 (en) * 2015-09-30 2017-03-30 Agilent Technologies, Inc. Methods of analyte derivatization and enhanced soft ionization
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
EP3937780A4 (en) 2019-03-14 2022-12-07 InSilixa, Inc. METHODS AND SYSTEMS FOR TIMED FLUORESCENCE-BASED DETECTION
CN116490620A (zh) * 2020-11-06 2023-07-25 沃特世科技公司 可用于核酸分析的方法和组合物
WO2023282061A1 (ja) * 2021-07-08 2023-01-12 株式会社島津製作所 微生物の質量分析方法
CN116496335B (zh) * 2023-03-21 2024-03-08 中国药科大学 一种修饰核苷酸及其应用
CN118980740B (zh) * 2024-09-19 2025-01-24 常州越泰检测科技有限公司 一种磁粉检测用喷照一体装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004160A1 (en) * 1993-07-30 1995-02-09 Isis Innovation Limited Tag reagent and assay method
EP0735144A1 (en) * 1995-03-28 1996-10-02 Research Development Corporation Of Japan Method for molecular indexing categorising of expressed genes using restriction enzymes
WO1996032504A2 (en) * 1995-04-11 1996-10-17 Trustees Of Boston University Solid phase sequencing of biopolymers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE267877T1 (de) * 1993-01-07 2004-06-15 Sequenom Inc Dns - sequenzierung durch massenspektronomie
PT840804E (pt) * 1996-01-23 2000-10-31 Qiagen Genomics Inc Metodos e composicoes para a analise de moleculas de acidos nocleicos usando tecnicas de separacao por dimensoes
GB9618544D0 (en) * 1996-09-05 1996-10-16 Brax Genomics Ltd Characterising DNA

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004160A1 (en) * 1993-07-30 1995-02-09 Isis Innovation Limited Tag reagent and assay method
EP0735144A1 (en) * 1995-03-28 1996-10-02 Research Development Corporation Of Japan Method for molecular indexing categorising of expressed genes using restriction enzymes
WO1996032504A2 (en) * 1995-04-11 1996-10-17 Trustees Of Boston University Solid phase sequencing of biopolymers

Also Published As

Publication number Publication date
CA2277786A1 (en) 1998-07-23
JP2006208400A (ja) 2006-08-10
IL130885A0 (en) 2001-01-28
WO1998031830A1 (en) 1998-07-23
NZ336769A (en) 2001-01-26
DE69838519D1 (de) 2007-11-15
AU5570098A (en) 1998-08-07
ATE374836T1 (de) 2007-10-15
CN1250483A (zh) 2000-04-12
DE69838519T2 (de) 2008-07-03
EP1400599A1 (en) 2004-03-24
EP1400599B1 (en) 2007-10-03
EP0979305A1 (en) 2000-02-16
DE69836013T2 (de) 2007-05-24
CN100434531C (zh) 2008-11-19
IL130885A (en) 2005-05-17
JP3884087B2 (ja) 2007-02-21
ATE340869T1 (de) 2006-10-15
DE69836013D1 (de) 2006-11-09
JP2004357697A (ja) 2004-12-24
EP0979305B1 (en) 2006-09-27
JP2001508307A (ja) 2001-06-26
CA2441655A1 (en) 1998-07-23

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