AU723955B2 - Compositions containing hydroxy acids or retinoids - Google Patents
Compositions containing hydroxy acids or retinoids Download PDFInfo
- Publication number
- AU723955B2 AU723955B2 AU53865/98A AU5386598A AU723955B2 AU 723955 B2 AU723955 B2 AU 723955B2 AU 53865/98 A AU53865/98 A AU 53865/98A AU 5386598 A AU5386598 A AU 5386598A AU 723955 B2 AU723955 B2 AU 723955B2
- Authority
- AU
- Australia
- Prior art keywords
- composition
- acid
- irritation
- retinol
- seed extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000203 mixture Substances 0.000 title claims description 116
- 150000001261 hydroxy acids Chemical class 0.000 title claims description 33
- 241001180933 Trichodesma <angiosperm> Species 0.000 claims description 48
- 239000000284 extract Substances 0.000 claims description 46
- 230000007794 irritation Effects 0.000 claims description 45
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 43
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 34
- 239000004615 ingredient Substances 0.000 claims description 31
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 27
- 229960003471 retinol Drugs 0.000 claims description 18
- 235000020944 retinol Nutrition 0.000 claims description 18
- 239000011607 retinol Substances 0.000 claims description 18
- 239000002537 cosmetic Substances 0.000 claims description 16
- 230000008901 benefit Effects 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 10
- 230000000699 topical effect Effects 0.000 claims description 9
- 150000004492 retinoid derivatives Chemical class 0.000 claims description 7
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims description 6
- 229930002330 retinoic acid Natural products 0.000 claims description 6
- 235000014655 lactic acid Nutrition 0.000 claims description 5
- 239000004310 lactic acid Substances 0.000 claims description 5
- 229960001727 tretinoin Drugs 0.000 claims description 4
- WWDMJSSVVPXVSV-YCNIQYBTSA-N retinyl ester Chemical compound CC1CCCC(C)(C)C1\C=C\C(\C)=C\C=C\C(\C)=C\C(O)=O WWDMJSSVVPXVSV-YCNIQYBTSA-N 0.000 claims description 3
- 229930002945 all-trans-retinaldehyde Natural products 0.000 claims description 2
- 230000002207 retinal effect Effects 0.000 claims description 2
- NCYCYZXNIZJOKI-OVSJKPMPSA-N retinal group Chemical group C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 claims description 2
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 claims description 2
- 125000002523 retinol group Chemical group 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 43
- 210000003491 skin Anatomy 0.000 description 26
- 238000011282 treatment Methods 0.000 description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
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- 231100000321 erythema Toxicity 0.000 description 16
- 235000020664 gamma-linolenic acid Nutrition 0.000 description 16
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 description 15
- 239000000463 material Substances 0.000 description 15
- 241001072256 Boraginaceae Species 0.000 description 14
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 description 14
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- 235000007689 Borago officinalis Nutrition 0.000 description 13
- 230000004044 response Effects 0.000 description 11
- OPGOLNDOMSBSCW-CLNHMMGSSA-N Fursultiamine hydrochloride Chemical compound Cl.C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N OPGOLNDOMSBSCW-CLNHMMGSSA-N 0.000 description 10
- 206010040880 Skin irritation Diseases 0.000 description 10
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 10
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- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 description 10
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 201000004624 Dermatitis Diseases 0.000 description 7
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 7
- 239000004205 dimethyl polysiloxane Substances 0.000 description 7
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- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 6
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- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 5
- ILCOCZBHMDEIAI-UHFFFAOYSA-N 2-(2-octadecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCO ILCOCZBHMDEIAI-UHFFFAOYSA-N 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 244000269722 Thea sinensis Species 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 239000010473 blackcurrant seed oil Substances 0.000 description 5
- 239000010474 borage seed oil Substances 0.000 description 5
- 229960000541 cetyl alcohol Drugs 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 235000009569 green tea Nutrition 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 5
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 5
- 229960002216 methylparaben Drugs 0.000 description 5
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 5
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 5
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- 150000008442 polyphenolic compounds Chemical class 0.000 description 5
- 235000013824 polyphenols Nutrition 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- -1 retinyl butyrate Chemical compound 0.000 description 5
- 229940098760 steareth-2 Drugs 0.000 description 5
- 229930003799 tocopherol Natural products 0.000 description 5
- 239000011732 tocopherol Substances 0.000 description 5
- 239000003981 vehicle Substances 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 4
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 4
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- XWCYDHJOKKGVHC-UHFFFAOYSA-N Vitamin A2 Chemical compound OCC=C(C)C=CC=C(C)C=CC1=C(C)C=CCC1(C)C XWCYDHJOKKGVHC-UHFFFAOYSA-N 0.000 description 4
- 208000010668 atopic eczema Diseases 0.000 description 4
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- 239000006071 cream Substances 0.000 description 4
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- 238000011156 evaluation Methods 0.000 description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 4
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 4
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 4
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- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- 235000010384 tocopherol Nutrition 0.000 description 4
- 229960001295 tocopherol Drugs 0.000 description 4
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 3
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 3
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 3
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- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 3
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- 229920001277 pectin Polymers 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- IUGYQRQAERSCNH-UHFFFAOYSA-M pivalate Chemical compound CC(C)(C)C([O-])=O IUGYQRQAERSCNH-UHFFFAOYSA-M 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229940104257 polyglyceryl-6-dioleate Drugs 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000001521 potassium lactate Substances 0.000 description 1
- 235000011085 potassium lactate Nutrition 0.000 description 1
- PHZLMBHDXVLRIX-UHFFFAOYSA-M potassium lactate Chemical compound [K+].CC(O)C([O-])=O PHZLMBHDXVLRIX-UHFFFAOYSA-M 0.000 description 1
- 229960001304 potassium lactate Drugs 0.000 description 1
- 229940096055 prax Drugs 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- BFZNCPXNOGIELB-UHFFFAOYSA-N propan-2-yl 10-[5,6-dihexyl-2-(8-oxo-8-propan-2-yloxyoctyl)cyclohex-3-en-1-yl]dec-9-enoate Chemical compound CCCCCCC1C=CC(CCCCCCCC(=O)OC(C)C)C(C=CCCCCCCCC(=O)OC(C)C)C1CCCCCC BFZNCPXNOGIELB-UHFFFAOYSA-N 0.000 description 1
- MILWSGRFEGYSGM-UHFFFAOYSA-N propane-1,2-diol;propane-1,2,3-triol Chemical compound CC(O)CO.OCC(O)CO MILWSGRFEGYSGM-UHFFFAOYSA-N 0.000 description 1
- 229940096792 quaternium-15 Drugs 0.000 description 1
- UKHVLWKBNNSRRR-TYYBGVCCSA-M quaternium-15 Chemical compound [Cl-].C1N(C2)CN3CN2C[N+]1(C/C=C/Cl)C3 UKHVLWKBNNSRRR-TYYBGVCCSA-M 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
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- 230000000717 retained effect Effects 0.000 description 1
- 239000011604 retinal Substances 0.000 description 1
- 229940071220 retinyl linoleate Drugs 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Chemical group 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000035909 sensory irritation Effects 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- 229940083037 simethicone Drugs 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- 229910021647 smectite Inorganic materials 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- ODFAPIRLUPAQCQ-UHFFFAOYSA-M sodium stearoyl lactylate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O ODFAPIRLUPAQCQ-UHFFFAOYSA-M 0.000 description 1
- 229940080352 sodium stearoyl lactylate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 230000008833 sun damage Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 125000002640 tocopherol group Chemical class 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- 230000036572 transepidermal water loss Effects 0.000 description 1
- VLMWBWYAHNRUGC-UHFFFAOYSA-N tridecyl 2-hydroxybenzoate Chemical compound CCCCCCCCCCCCCOC(=O)C1=CC=CC=C1O VLMWBWYAHNRUGC-UHFFFAOYSA-N 0.000 description 1
- 229940072029 trilaureth-4 phosphate Drugs 0.000 description 1
- GVPDNFYOFKBFEN-UHFFFAOYSA-N trimethyl(octadecoxy)silane Chemical compound CCCCCCCCCCCCCCCCCCO[Si](C)(C)C GVPDNFYOFKBFEN-UHFFFAOYSA-N 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- DTOSIQBPPRVQHS-UHFFFAOYSA-N α-Linolenic acid Chemical compound CCC=CCC=CCC=CCCCCCCCC(O)=O DTOSIQBPPRVQHS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3800897P | 1997-02-14 | 1997-02-14 | |
| US60/038008 | 1997-02-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU5386598A AU5386598A (en) | 1998-08-20 |
| AU723955B2 true AU723955B2 (en) | 2000-09-07 |
Family
ID=21897577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU53865/98A Ceased AU723955B2 (en) | 1997-02-14 | 1998-02-10 | Compositions containing hydroxy acids or retinoids |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5855893A (enEXAMPLES) |
| EP (1) | EP0858799B1 (enEXAMPLES) |
| JP (1) | JP3502252B2 (enEXAMPLES) |
| KR (1) | KR100315062B1 (enEXAMPLES) |
| CN (1) | CN1196237B (enEXAMPLES) |
| AR (1) | AR011673A1 (enEXAMPLES) |
| AU (1) | AU723955B2 (enEXAMPLES) |
| BR (1) | BR9803281A (enEXAMPLES) |
| CA (1) | CA2229271C (enEXAMPLES) |
| DE (1) | DE69813922T2 (enEXAMPLES) |
| ES (1) | ES2198646T3 (enEXAMPLES) |
| ID (1) | ID20481A (enEXAMPLES) |
| IN (1) | IN189605B (enEXAMPLES) |
| NZ (1) | NZ329701A (enEXAMPLES) |
| TW (1) | TW568789B (enEXAMPLES) |
| ZA (1) | ZA981130B (enEXAMPLES) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6340485B1 (en) * | 1996-06-03 | 2002-01-22 | Croda International Plc | Compositions and uses thereof |
| WO1999040887A1 (fr) * | 1998-02-10 | 1999-08-19 | Shiseido Company, Ltd. | Composition emulsionnees de type aqueux |
| JP3634139B2 (ja) * | 1998-02-10 | 2005-03-30 | 株式会社資生堂 | 水中油型乳化組成物 |
| IT1299264B1 (it) * | 1998-05-15 | 2000-02-29 | Codex V S R L | Composizioni farmaceutiche topiche utili per il trattamento di patologie cutanee su base infiammatoria, immunitaria o proliferativa |
| DE19839402A1 (de) * | 1998-08-29 | 2000-03-02 | Beiersdorf Ag | Retinoide enthaltende Hautpflegemittel |
| US6342255B1 (en) * | 1998-09-15 | 2002-01-29 | Codex V S.R.L. | Topical pharmaceutical compositions useful for the treatment of cutaneous of circulatory pathologies on inflammatory, immune, proliferative of degenerative basis |
| US7396526B1 (en) | 1998-11-12 | 2008-07-08 | Johnson & Johnson Consumer Companies, Inc. | Skin care composition |
| US6521237B2 (en) * | 1998-11-12 | 2003-02-18 | Johnson & Johnson Consumer Companies, Inc. | Skin care composition |
| US6114348A (en) * | 1999-03-10 | 2000-09-05 | Weber; Paul J. | Method of treating warts using tazarotene |
| GB9918028D0 (en) * | 1999-07-30 | 1999-09-29 | Unilever Plc | Skin care composition |
| KR100803817B1 (ko) * | 2000-03-06 | 2008-02-14 | 유니레버 엔.브이. | 미용 조성물 내의 자극방지 및 노화방지 증강제로서의에키나세아 추출물 |
| US6451330B1 (en) * | 2000-09-26 | 2002-09-17 | Unilever Home & Personal Care, Usa, Division Of Conopco, Inc. | High skin friction cosmetic creams with retinoids |
| JP3959025B2 (ja) * | 2000-12-01 | 2007-08-15 | メドトロニック・インコーポレーテッド | 平均肺動脈圧を決定する方法および装置 |
| DE10063660A1 (de) * | 2000-12-20 | 2002-07-04 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitungen in Form von O/W-Emulsionen mit einem Gehalt an Sterinen und/oder C¶1¶¶2¶-C¶4¶¶0¶-Fettsäuren |
| US6949247B2 (en) * | 2000-12-28 | 2005-09-27 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Stable skin care compositions containing a retinoid and a retinoid booster system |
| JP2002284705A (ja) | 2001-01-19 | 2002-10-03 | Shiseido Co Ltd | 刺激緩和剤 |
| JP2002293714A (ja) * | 2001-03-30 | 2002-10-09 | Fancl Corp | 皮膚化粧料 |
| DE10139580A1 (de) * | 2001-08-10 | 2003-02-20 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitungen in Form von O/W-Emulsionen mit einem Gehalt an Sterinen und/oder C12-C40-Fettsäuren |
| DE10139582A1 (de) * | 2001-08-10 | 2003-02-20 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitungen in Form von W/O/W-Emulsionen mit einem Gehalt an Sterinen und/oder C12-C40-Fettsäuren |
| JP2003104827A (ja) * | 2001-09-28 | 2003-04-09 | Kose Corp | 化粧料 |
| US6892094B2 (en) * | 2002-04-30 | 2005-05-10 | Medtronic, Inc. | Combined anti-tachycardia pacing (ATP) and high voltage therapy for treating ventricular arrhythmias |
| JP2004075549A (ja) * | 2002-08-12 | 2004-03-11 | Kanebo Ltd | 化粧料 |
| US7149577B2 (en) * | 2002-12-02 | 2006-12-12 | Medtronic, Inc. | Apparatus and method using ATP return cycle length for arrhythmia discrimination |
| US20050266051A1 (en) * | 2004-05-27 | 2005-12-01 | The Procter & Gamble Company | Pet food compositions and methods |
| JP4827433B2 (ja) * | 2005-04-21 | 2011-11-30 | 株式会社 資生堂 | 水中油型乳化皮膚化粧料 |
| US20090137534A1 (en) * | 2007-11-26 | 2009-05-28 | Chaudhuri Ratan K | Skin treatment compositions and methods |
| EP2164575A2 (en) * | 2007-06-01 | 2010-03-24 | Galderma Research & Development | Skin moisturizer and use thereof |
| JP4406035B1 (ja) * | 2008-07-09 | 2010-01-27 | 株式会社資生堂 | 水中油型乳化皮膚化粧料 |
| US8060617B2 (en) * | 2008-12-19 | 2011-11-15 | Cisco Technology, Inc. | Reserving network resources during scheduling of meeting event |
| FR2996135A1 (fr) | 2012-09-28 | 2014-04-04 | Inneov Lab | Composition orale pour renforcer la tolerance cutanee suite a une administration topique d'un compose retinoide. |
| US20150051296A1 (en) * | 2013-08-13 | 2015-02-19 | Access Business Group Internaional LLC | Use of fatty acid to reduce skin irritation associated with retinoid therapy |
| US9707216B2 (en) | 2015-07-13 | 2017-07-18 | Dr. Reddy's Laboratories, Ltd. | Topical retinoid compositions |
| EP3393481A1 (en) | 2015-12-23 | 2018-10-31 | Novartis Ag | Oil-in-water emulsions including retinoic acid |
| JP6944673B2 (ja) | 2017-03-30 | 2021-10-06 | 日光ケミカルズ株式会社 | 水中油型乳化化粧料 |
| US20210186845A1 (en) * | 2019-12-18 | 2021-06-24 | Barnet Products, LLC | Vitamin a and vitamin c combinations with enhanced stability |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3405151A (en) * | 1966-07-01 | 1968-10-08 | Upjohn Co | Chromatographic separation of gamma-linolenic acid esters |
| GB8420771D0 (en) * | 1984-08-15 | 1984-09-19 | Efamol Ltd | Treatment of skin disorders |
| WO1990007331A1 (en) * | 1988-12-23 | 1990-07-12 | Noel James Went | Anti-inflammatory liniment |
| GB8920228D0 (en) * | 1989-09-07 | 1989-10-18 | Efamol Holdings | Fatty acid therapy |
| EP0457950B1 (fr) * | 1990-05-23 | 1993-10-20 | Societe Des Produits Nestle S.A. | Utilisation de l'acide stéaridonique pour le traitement des maladies inflammatoires |
| DK0510165T3 (da) * | 1990-11-14 | 1995-04-10 | Oreal | Ikke-ioniske, amphiphile glycerolderivater, fremgangsmåde til fremstilling af disse, tilsvarende mellemprodukter, og midler indeholdende disse forbindelser |
| HK1003247A1 (en) * | 1992-03-20 | 1998-10-16 | Micro Motion Incorporated | Improved viscometer for sanitary applications |
| US5252604A (en) * | 1992-07-10 | 1993-10-12 | Hoffmann-La Roche Inc. | Compositions of retinoic acids and tocopherol for prevention of dermatitis |
| GB2271928A (en) * | 1992-10-27 | 1994-05-04 | Rose Mary Elizabeth Laing | Borage plant extracts |
| US5516793A (en) * | 1993-04-26 | 1996-05-14 | Avon Products, Inc. | Use of ascorbic acid to reduce irritation of topically applied active ingredients |
| ATE182783T1 (de) * | 1993-05-10 | 1999-08-15 | Nestle Sa | Ungesättigte fettsäure-triglyceride enthaltende lipidzusammensetzung für kosmetik |
| US5310556A (en) * | 1993-06-09 | 1994-05-10 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Cosmetic composition |
| US5401517A (en) | 1993-11-15 | 1995-03-28 | Elizabeth Arden Company, Division Of Conopco, Inc. | Cosmetic method for treatment of skin |
| US5411734A (en) | 1993-11-15 | 1995-05-02 | Elizabeth Arden Company, Division Of Conopco, Inc. | Non-irritating α-hydroxy carboxylic acid compositions |
| DE4410238A1 (de) | 1994-03-25 | 1995-09-28 | Beiersdorf Ag | Hautpflegemittel |
| FR2724319B1 (fr) * | 1994-09-08 | 1996-10-18 | Oreal | Utilisation d'un compose vegetal pour la fixation d'un parfum dans une composition cosmetique et/ou dermatologique |
| US5476661A (en) * | 1994-10-21 | 1995-12-19 | Elizabeth Arden Co., Division Of Conopco, Inc. | Compositions for topical application to skin, hair and nails |
| DE69526966T2 (de) | 1994-12-20 | 2002-09-19 | L'oreal, Clichy Cedex | Hautkräftigende kometische zusammensetzung |
| US5587149A (en) * | 1995-02-06 | 1996-12-24 | R.P. Scherer Corporation | Topical application emulsions |
| CA2271162C (en) * | 1996-06-03 | 2007-09-18 | Croda International Plc | Stearidonic acid compositions and uses thereof |
| US5690947A (en) * | 1996-08-30 | 1997-11-25 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Borage seed oil as an anti-irritant in compositions containing hydroxy acids or retinoids |
-
1997
- 1997-12-08 US US08/986,818 patent/US5855893A/en not_active Expired - Lifetime
-
1998
- 1998-02-04 ES ES98300793T patent/ES2198646T3/es not_active Expired - Lifetime
- 1998-02-04 DE DE69813922T patent/DE69813922T2/de not_active Expired - Lifetime
- 1998-02-04 EP EP98300793A patent/EP0858799B1/en not_active Expired - Lifetime
- 1998-02-04 NZ NZ329701A patent/NZ329701A/xx not_active IP Right Cessation
- 1998-02-09 IN IN69BO1998 patent/IN189605B/en unknown
- 1998-02-10 AU AU53865/98A patent/AU723955B2/en not_active Ceased
- 1998-02-10 CA CA002229271A patent/CA2229271C/en not_active Expired - Lifetime
- 1998-02-11 BR BR9803281-0A patent/BR9803281A/pt not_active Application Discontinuation
- 1998-02-11 ZA ZA9801130A patent/ZA981130B/xx unknown
- 1998-02-13 JP JP03123898A patent/JP3502252B2/ja not_active Expired - Lifetime
- 1998-02-13 KR KR1019980004328A patent/KR100315062B1/ko not_active Expired - Fee Related
- 1998-02-13 AR ARP980100650A patent/AR011673A1/es active IP Right Grant
- 1998-02-13 ID IDP980197A patent/ID20481A/id unknown
- 1998-02-14 CN CN981070396A patent/CN1196237B/zh not_active Expired - Lifetime
- 1998-03-21 TW TW087104253A patent/TW568789B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0858799B1 (en) | 2003-05-02 |
| TW568789B (en) | 2004-01-01 |
| JPH10226634A (ja) | 1998-08-25 |
| EP0858799A3 (en) | 1999-08-18 |
| ES2198646T3 (es) | 2004-02-01 |
| AR011673A1 (es) | 2000-08-30 |
| CA2229271A1 (en) | 1998-08-14 |
| EP0858799A2 (en) | 1998-08-19 |
| ID20481A (id) | 1998-12-24 |
| JP3502252B2 (ja) | 2004-03-02 |
| BR9803281A (pt) | 2000-01-18 |
| CN1196237A (zh) | 1998-10-21 |
| CA2229271C (en) | 2004-11-30 |
| KR19980071338A (ko) | 1998-10-26 |
| DE69813922T2 (de) | 2003-10-30 |
| NZ329701A (en) | 1999-08-30 |
| DE69813922D1 (de) | 2003-06-05 |
| CN1196237B (zh) | 2010-09-08 |
| US5855893A (en) | 1999-01-05 |
| KR100315062B1 (ko) | 2002-01-24 |
| IN189605B (enEXAMPLES) | 2003-03-29 |
| AU5386598A (en) | 1998-08-20 |
| ZA981130B (en) | 1999-08-11 |
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