AU722884B2 - Novel "burst-free" sustained release poly-(lactide/glycolide) microspheres - Google Patents
Novel "burst-free" sustained release poly-(lactide/glycolide) microspheres Download PDFInfo
- Publication number
- AU722884B2 AU722884B2 AU14104/97A AU1410497A AU722884B2 AU 722884 B2 AU722884 B2 AU 722884B2 AU 14104/97 A AU14104/97 A AU 14104/97A AU 1410497 A AU1410497 A AU 1410497A AU 722884 B2 AU722884 B2 AU 722884B2
- Authority
- AU
- Australia
- Prior art keywords
- microcapsules
- release
- uncapped
- emulsion
- capped
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59097396A | 1996-01-24 | 1996-01-24 | |
US08/590973 | 1996-01-24 | ||
PCT/US1996/019440 WO1997026869A1 (en) | 1996-01-24 | 1996-11-18 | Novel 'burst-free' sustained release poly-(lactide/glycolide) microspheres |
CNB961947683A CN100391445C (zh) | 1996-01-24 | 1996-11-18 | 新型的“非突发的”持续释放聚(丙交酯/乙交酯)的微球 |
Publications (2)
Publication Number | Publication Date |
---|---|
AU1410497A AU1410497A (en) | 1997-08-20 |
AU722884B2 true AU722884B2 (en) | 2000-08-10 |
Family
ID=25744089
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU14104/97A Ceased AU722884B2 (en) | 1996-01-24 | 1996-11-18 | Novel "burst-free" sustained release poly-(lactide/glycolide) microspheres |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0817619A4 (de) |
JP (1) | JPH11509862A (de) |
CN (1) | CN100391445C (de) |
AP (1) | AP665A (de) |
AU (1) | AU722884B2 (de) |
BR (1) | BR9607752B1 (de) |
NZ (1) | NZ325561A (de) |
WO (1) | WO1997026869A1 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7033608B1 (en) * | 1995-05-22 | 2006-04-25 | The United States Of America As Represented By The Secretary Of The Army | “Burst-free” sustained release poly-(lactide/glycolide) microspheres |
TW577759B (en) | 1997-04-18 | 2004-03-01 | Ipsen Pharma Biotech | Sustained release compositions in the form of microcapsules or implants and the process for their preparation |
CN1075945C (zh) * | 1998-02-26 | 2001-12-12 | 中国科学院化学研究所 | 一种高分子包囊胰岛素微粒体及其制备方法和用途 |
CN1073412C (zh) * | 1998-03-19 | 2001-10-24 | 中国科学院化学研究所 | 一种高分子微包囊的制备方法 |
US7217770B2 (en) * | 2000-05-17 | 2007-05-15 | Samyang Corporation | Stable polymeric micelle-type drug composition and method for the preparation thereof |
US6726918B1 (en) | 2000-07-05 | 2004-04-27 | Oculex Pharmaceuticals, Inc. | Methods for treating inflammation-mediated conditions of the eye |
DE60114229T2 (de) | 2000-11-29 | 2006-07-06 | Allergan, Inc., Irvine | Verhinderung von transplantatabstossung im auge |
US20040137059A1 (en) * | 2003-01-09 | 2004-07-15 | Thierry Nivaggioli | Biodegradable ocular implant |
US20050048099A1 (en) | 2003-01-09 | 2005-03-03 | Allergan, Inc. | Ocular implant made by a double extrusion process |
US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
GB0517674D0 (en) * | 2005-08-31 | 2005-10-05 | Astrazeneca Ab | Formulation |
GB0517673D0 (en) * | 2005-08-31 | 2005-10-05 | Astrazeneca Ab | Formulation |
CN101007169B (zh) * | 2006-01-23 | 2011-05-25 | 珠海市嘉族生物科技有限公司 | 一种鸡卵黄免疫球蛋白微胶囊及其制备方法和应用 |
KR100816065B1 (ko) | 2006-11-27 | 2008-03-24 | 동국제약 주식회사 | 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐 |
US8956641B2 (en) * | 2008-04-18 | 2015-02-17 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for treatment of inflammatory diseases |
US8889173B2 (en) * | 2008-04-18 | 2014-11-18 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for treatment of pain and/or inflammation |
CN101612111B (zh) * | 2008-06-24 | 2011-11-23 | 上海医药工业研究院 | 醋酸诺美孕酮或其类似物的缓释微球及其制备方法和用途 |
KR20100037389A (ko) * | 2008-10-01 | 2010-04-09 | 연세대학교 산학협력단 | 다중 약물방출조절이 가능한 솔리드 마이크로구조체 및 이의 제조방법 |
USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
CN102357080B (zh) * | 2011-11-04 | 2014-07-16 | 无锡中科光远生物材料有限公司 | 一种酸性环境中可实现药物快速释放的智能型多功能空心微球及其制备方法 |
US10675376B2 (en) * | 2012-05-24 | 2020-06-09 | Ethicon Llc | Mechanically strong absorbable polymeric blend compositions of precisely controllable absorption rates, processing methods, and products therefrom |
HUE036141T2 (hu) * | 2013-06-20 | 2018-06-28 | Pharmathen Sa | Szigmoid kibocsátási profillal bíró polilaktid-poliglikolid mikrorészecskék elõállítása |
US20170022256A1 (en) * | 2015-07-23 | 2017-01-26 | General Biologicals Corporation | Anti-fungal and anti-bacterial peptide and therapeutic method using same |
CN110382052A (zh) | 2017-03-26 | 2019-10-25 | Mapi医药公司 | 用于治疗进展型形式的多发性硬化症的格拉替雷储库系统 |
CN113384536B (zh) * | 2020-03-14 | 2024-04-02 | 鲁南制药集团股份有限公司 | 一种注射用双羟萘酸加兰他敏缓释微粒及其制备方法 |
CN115025290A (zh) * | 2022-06-15 | 2022-09-09 | 浙江天妍生物科技有限公司 | 一种可降解微球及其生产工艺 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4622244A (en) * | 1979-09-04 | 1986-11-11 | The Washington University | Process for preparation of microcapsules |
PH19942A (en) * | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
US4623588A (en) * | 1984-02-06 | 1986-11-18 | Biotek, Inc. | Controlled release composite core coated microparticles |
DE4005415C2 (de) * | 1990-02-21 | 1996-04-11 | Boehringer Ingelheim Kg | Verfahren zum Herstellen von Polyestern auf der Basis von Hydroxycarbonsäuren |
EP0463194A1 (de) * | 1990-06-23 | 1992-01-02 | Boehringer Ingelheim Kg | Verfahren zur Herstellung von Poly-(D,L-lactid) und seine Verwendung als Wirkstoffträger |
US5410016A (en) * | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
DE4235312A1 (de) * | 1991-10-23 | 1993-04-29 | Boehringer Ingelheim Kg | Halbfeste mischungen aus oligomeren und/oder polymeren auf der basis von milchsaeure, verfahren zu deren herstellung und deren verwendung als resorbierbare implantate |
DK0724431T3 (da) * | 1993-10-22 | 2003-01-06 | Genentech Inc | Fremgangsmåder og sammensætninger til mikroindkapsling af adjuvanser |
GB9412273D0 (en) * | 1994-06-18 | 1994-08-10 | Univ Nottingham | Administration means |
DE19513659A1 (de) * | 1995-03-10 | 1996-09-12 | Boehringer Mannheim Gmbh | Polypeptid-enthaltende pharmazeutische Darreichungsformen in Form von Mikropartikeln und Verfahren zu deren Herstellung |
-
1996
- 1996-11-18 EP EP96944247A patent/EP0817619A4/de not_active Ceased
- 1996-11-18 NZ NZ325561A patent/NZ325561A/xx not_active IP Right Cessation
- 1996-11-18 AU AU14104/97A patent/AU722884B2/en not_active Ceased
- 1996-11-18 JP JP9526833A patent/JPH11509862A/ja active Pending
- 1996-11-18 AP APAP/P/1997/001088A patent/AP665A/en active
- 1996-11-18 CN CNB961947683A patent/CN100391445C/zh not_active Expired - Fee Related
- 1996-11-18 WO PCT/US1996/019440 patent/WO1997026869A1/en not_active Application Discontinuation
- 1996-11-18 BR BRPI9607752-2A patent/BR9607752B1/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BR9607752B1 (pt) | 2009-05-05 |
CN1188408A (zh) | 1998-07-22 |
AP665A (en) | 1998-08-19 |
AP9701088A0 (en) | 1997-10-31 |
CN100391445C (zh) | 2008-06-04 |
BR9607752A (pt) | 1999-11-30 |
WO1997026869A1 (en) | 1997-07-31 |
JPH11509862A (ja) | 1999-08-31 |
AU1410497A (en) | 1997-08-20 |
EP0817619A1 (de) | 1998-01-14 |
EP0817619A4 (de) | 1999-02-03 |
NZ325561A (en) | 1999-06-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FGA | Letters patent sealed or granted (standard patent) |