EP0817619A4 - Neue poly-(lactid/glycolid)-mikrosphären mit verzögerter freisetzung ohne initialstoss - Google Patents

Neue poly-(lactid/glycolid)-mikrosphären mit verzögerter freisetzung ohne initialstoss

Info

Publication number
EP0817619A4
EP0817619A4 EP96944247A EP96944247A EP0817619A4 EP 0817619 A4 EP0817619 A4 EP 0817619A4 EP 96944247 A EP96944247 A EP 96944247A EP 96944247 A EP96944247 A EP 96944247A EP 0817619 A4 EP0817619 A4 EP 0817619A4
Authority
EP
European Patent Office
Prior art keywords
crospheres
glycolide
lactide
burst
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP96944247A
Other languages
English (en)
French (fr)
Other versions
EP0817619A1 (de
Inventor
Ramasubbu Jeyanthi
Hamont John F Van
Phil Friden
Robert H Reid
F Donald Roberts
Charles E Mcqueen
Jean A Setterstrom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Army
Original Assignee
US Department of Army
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25744089&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0817619(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by US Department of Army filed Critical US Department of Army
Publication of EP0817619A1 publication Critical patent/EP0817619A1/de
Publication of EP0817619A4 publication Critical patent/EP0817619A4/de
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
EP96944247A 1996-01-24 1996-11-18 Neue poly-(lactid/glycolid)-mikrosphären mit verzögerter freisetzung ohne initialstoss Ceased EP0817619A4 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US59097396A 1996-01-24 1996-01-24
US590973 1996-01-24
PCT/US1996/019440 WO1997026869A1 (en) 1996-01-24 1996-11-18 Novel 'burst-free' sustained release poly-(lactide/glycolide) microspheres
CNB961947683A CN100391445C (zh) 1996-01-24 1996-11-18 新型的“非突发的”持续释放聚(丙交酯/乙交酯)的微球

Publications (2)

Publication Number Publication Date
EP0817619A1 EP0817619A1 (de) 1998-01-14
EP0817619A4 true EP0817619A4 (de) 1999-02-03

Family

ID=25744089

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96944247A Ceased EP0817619A4 (de) 1996-01-24 1996-11-18 Neue poly-(lactid/glycolid)-mikrosphären mit verzögerter freisetzung ohne initialstoss

Country Status (8)

Country Link
EP (1) EP0817619A4 (de)
JP (1) JPH11509862A (de)
CN (1) CN100391445C (de)
AP (1) AP665A (de)
AU (1) AU722884B2 (de)
BR (1) BR9607752B1 (de)
NZ (1) NZ325561A (de)
WO (1) WO1997026869A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7033608B1 (en) * 1995-05-22 2006-04-25 The United States Of America As Represented By The Secretary Of The Army “Burst-free” sustained release poly-(lactide/glycolide) microspheres
MY118835A (en) 1997-04-18 2005-01-31 Ipsen Pharma Biotech Sustained release compositions and the process for their preparation
CN1075945C (zh) * 1998-02-26 2001-12-12 中国科学院化学研究所 一种高分子包囊胰岛素微粒体及其制备方法和用途
CN1073412C (zh) * 1998-03-19 2001-10-24 中国科学院化学研究所 一种高分子微包囊的制备方法
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
AU2002236495B2 (en) 2000-11-29 2006-05-11 Allergan, Inc. Intraocular implants for preventing transplant rejection in the eye
US20040137059A1 (en) * 2003-01-09 2004-07-15 Thierry Nivaggioli Biodegradable ocular implant
US20050048099A1 (en) 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
GB0517674D0 (en) * 2005-08-31 2005-10-05 Astrazeneca Ab Formulation
GB0517673D0 (en) * 2005-08-31 2005-10-05 Astrazeneca Ab Formulation
CN101007169B (zh) * 2006-01-23 2011-05-25 珠海市嘉族生物科技有限公司 一种鸡卵黄免疫球蛋白微胶囊及其制备方法和应用
KR100816065B1 (ko) 2006-11-27 2008-03-24 동국제약 주식회사 초기 방출억제 특성이 우수한 서방출성 마이크로캡슐의제조방법 및 이에 의해 제조되는 마이크로캡슐
US8889173B2 (en) * 2008-04-18 2014-11-18 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of pain and/or inflammation
US8956641B2 (en) * 2008-04-18 2015-02-17 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of inflammatory diseases
CN101612111B (zh) * 2008-06-24 2011-11-23 上海医药工业研究院 醋酸诺美孕酮或其类似物的缓释微球及其制备方法和用途
KR20100037389A (ko) * 2008-10-01 2010-04-09 연세대학교 산학협력단 다중 약물방출조절이 가능한 솔리드 마이크로구조체 및 이의 제조방법
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
CN102357080B (zh) * 2011-11-04 2014-07-16 无锡中科光远生物材料有限公司 一种酸性环境中可实现药物快速释放的智能型多功能空心微球及其制备方法
US10675376B2 (en) 2012-05-24 2020-06-09 Ethicon Llc Mechanically strong absorbable polymeric blend compositions of precisely controllable absorption rates, processing methods, and products therefrom
US9943484B2 (en) * 2013-06-20 2018-04-17 Pharmathen S.A. Preparation of polylactide-polyglycolide microparticles having a sigmoidal release profile
US20170022256A1 (en) * 2015-07-23 2017-01-26 General Biologicals Corporation Anti-fungal and anti-bacterial peptide and therapeutic method using same
US11167003B2 (en) 2017-03-26 2021-11-09 Mapi Pharma Ltd. Methods for suppressing or alleviating primary or secondary progressive multiple sclerosis (PPMS or SPMS) using sustained release glatiramer depot systems
CN113384536B (zh) * 2020-03-14 2024-04-02 鲁南制药集团股份有限公司 一种注射用双羟萘酸加兰他敏缓释微粒及其制备方法
CN115025290A (zh) * 2022-06-15 2022-09-09 浙江天妍生物科技有限公司 一种可降解微球及其生产工艺

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052510A2 (de) * 1980-11-18 1982-05-26 Syntex (U.S.A.) Inc. Mikroverkapslung wasserlöslicher Polypeptide
DE4005415A1 (de) * 1990-02-21 1991-08-22 Boehringer Ingelheim Kg Verfahren zur herstellung von polyestern auf der basis von hydroxycarbonsaeuren
EP0463194A1 (de) * 1990-06-23 1992-01-02 Boehringer Ingelheim Kg Verfahren zur Herstellung von Poly-(D,L-lactid) und seine Verwendung als Wirkstoffträger
DE4235312A1 (de) * 1991-10-23 1993-04-29 Boehringer Ingelheim Kg Halbfeste mischungen aus oligomeren und/oder polymeren auf der basis von milchsaeure, verfahren zu deren herstellung und deren verwendung als resorbierbare implantate
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
DE19513659A1 (de) * 1995-03-10 1996-09-12 Boehringer Mannheim Gmbh Polypeptid-enthaltende pharmazeutische Darreichungsformen in Form von Mikropartikeln und Verfahren zu deren Herstellung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622244A (en) * 1979-09-04 1986-11-11 The Washington University Process for preparation of microcapsules
US4623588A (en) * 1984-02-06 1986-11-18 Biotek, Inc. Controlled release composite core coated microparticles
DE69431358T2 (de) * 1993-10-22 2003-06-05 Genentech Inc Verfahren und zusammensetzungen zur mikrokapselung von adjuvantien
GB9412273D0 (en) * 1994-06-18 1994-08-10 Univ Nottingham Administration means

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052510A2 (de) * 1980-11-18 1982-05-26 Syntex (U.S.A.) Inc. Mikroverkapslung wasserlöslicher Polypeptide
DE4005415A1 (de) * 1990-02-21 1991-08-22 Boehringer Ingelheim Kg Verfahren zur herstellung von polyestern auf der basis von hydroxycarbonsaeuren
EP0463194A1 (de) * 1990-06-23 1992-01-02 Boehringer Ingelheim Kg Verfahren zur Herstellung von Poly-(D,L-lactid) und seine Verwendung als Wirkstoffträger
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
DE4235312A1 (de) * 1991-10-23 1993-04-29 Boehringer Ingelheim Kg Halbfeste mischungen aus oligomeren und/oder polymeren auf der basis von milchsaeure, verfahren zu deren herstellung und deren verwendung als resorbierbare implantate
DE19513659A1 (de) * 1995-03-10 1996-09-12 Boehringer Mannheim Gmbh Polypeptid-enthaltende pharmazeutische Darreichungsformen in Form von Mikropartikeln und Verfahren zu deren Herstellung

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
R. JEYANTHI ET AL.: "NOVEL BURST FREE PROGRAMMABLE BIODEGRADABLE MICROSPHERES FOR CONTROLLED RELEASE OF POLYPEPTIDES", PROC. INT. SYMP. CONTROL. RELEASE BIOACT. MATER. (1996), July 1996 (1996-07-01), KYOTO, pages 351 - 352, XP002086331 *
See also references of WO9726869A1 *

Also Published As

Publication number Publication date
WO1997026869A1 (en) 1997-07-31
AU1410497A (en) 1997-08-20
CN100391445C (zh) 2008-06-04
BR9607752B1 (pt) 2009-05-05
CN1188408A (zh) 1998-07-22
JPH11509862A (ja) 1999-08-31
EP0817619A1 (de) 1998-01-14
BR9607752A (pt) 1999-11-30
AU722884B2 (en) 2000-08-10
AP665A (en) 1998-08-19
NZ325561A (en) 1999-06-29
AP9701088A0 (en) 1997-10-31

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