AU7171294A - Bis-imide polycyclic and heterocyclic chromophores useful as tumoricidals - Google Patents

Bis-imide polycyclic and heterocyclic chromophores useful as tumoricidals

Info

Publication number
AU7171294A
AU7171294A AU71712/94A AU7171294A AU7171294A AU 7171294 A AU7171294 A AU 7171294A AU 71712/94 A AU71712/94 A AU 71712/94A AU 7171294 A AU7171294 A AU 7171294A AU 7171294 A AU7171294 A AU 7171294A
Authority
AU
Australia
Prior art keywords
dicarboximido
azaphenanthrene
propylamino
nmr
mhz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU71712/94A
Other languages
English (en)
Inventor
Emeka Amaechi Akamike
Robert Joseph Cherney
Robert Frank Kaltenbach Iii
Michael James Orwat
Gregory James Pacofsky
Arthur David Patten
Steven Paul Seitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Publication of AU7171294A publication Critical patent/AU7171294A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/28—Pyronines ; Xanthon, thioxanthon, selenoxanthan, telluroxanthon dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B15/00—Acridine dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B5/00—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings
    • C09B5/002—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings the heterocyclic rings being condensed in peri position and in 1-2 or 2-3 position
    • C09B5/004—Dyes with an anthracene nucleus condensed with one or more heterocyclic rings with or without carbocyclic rings the heterocyclic rings being condensed in peri position and in 1-2 or 2-3 position only O-containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/08—Naphthalimide dyes; Phthalimide dyes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU71712/94A 1993-06-24 1994-06-15 Bis-imide polycyclic and heterocyclic chromophores useful as tumoricidals Abandoned AU7171294A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/080,862 US5416089A (en) 1993-06-24 1993-06-24 Polycyclic and heterocyclic chromophores for bis-imide tumoricidals
US080862 1993-06-24
PCT/US1994/006442 WO1995000490A1 (en) 1993-06-24 1994-06-15 Bis-imide polycyclic and heterocyclic chromophores useful as tumoricidals

Publications (1)

Publication Number Publication Date
AU7171294A true AU7171294A (en) 1995-01-17

Family

ID=22160120

Family Applications (1)

Application Number Title Priority Date Filing Date
AU71712/94A Abandoned AU7171294A (en) 1993-06-24 1994-06-15 Bis-imide polycyclic and heterocyclic chromophores useful as tumoricidals

Country Status (19)

Country Link
US (2) US5416089A (OSRAM)
EP (1) EP0705250A1 (OSRAM)
JP (1) JPH08511802A (OSRAM)
KR (1) KR960703113A (OSRAM)
CN (1) CN1125943A (OSRAM)
AU (1) AU7171294A (OSRAM)
BR (1) BR9407265A (OSRAM)
CA (1) CA2165765A1 (OSRAM)
CZ (1) CZ336795A3 (OSRAM)
FI (1) FI956231A0 (OSRAM)
HR (1) HRP940367A2 (OSRAM)
HU (1) HUT75121A (OSRAM)
IL (1) IL110033A0 (OSRAM)
NO (1) NO955257L (OSRAM)
PL (1) PL312272A1 (OSRAM)
SK (1) SK163095A3 (OSRAM)
TW (1) TW263506B (OSRAM)
WO (1) WO1995000490A1 (OSRAM)
ZA (1) ZA944370B (OSRAM)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703089A (en) * 1994-04-28 1997-12-30 Knoll Aktiengesellschaft Dihydrodibenzisoquinolinediones
US5641782A (en) * 1995-02-16 1997-06-24 The Dupont Merck Pharmaceutical Company 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides
FR2751655B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de bis-imides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1053237B1 (en) * 1998-02-04 2003-07-02 The Board Of Regents, The University Of Texas System Inhibition of human telomerase by a g-quadruplex-interaction compound
ES2191532B1 (es) * 2001-05-28 2005-02-16 Fundacion Universitaria San Pablo - Ceu Derivados de naftalimidas heterociclicas como agentes antiproliferativos.
US20040082788A1 (en) * 2002-07-08 2004-04-29 Chemgenex Therapeutics, Inc. Naphthalimide synthesis including amonafide synthesis and pharmaceutical preparations thereof
US20050192312A1 (en) * 2004-01-30 2005-09-01 Brown Dennis M. Naphthalimide dosing by N-acetyl transferase genotyping
CA2569279A1 (en) * 2004-06-04 2005-12-15 Chemgenex Pharmaceuticals, Inc. Methods of treating cellular proliferative disease using naphthalimide and parp-1 inhibitors
JP4993645B2 (ja) 2004-12-01 2012-08-08 ジェネンテック， インコーポレイテッド 抗体薬剤結合体および方法
US7947839B2 (en) * 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
KR20100074288A (ko) * 2007-10-22 2010-07-01 오키드 리서치 레버라토리즈 리미티드 히스톤 디아세틸라제 억제제
CN101638389B (zh) * 2008-03-03 2012-09-05 河南大学 一种含萘酰亚胺结构的多胺衍生物及其制备方法和应用
US9060776B2 (en) 2009-10-09 2015-06-23 Ethicon Endo-Surgery, Inc. Surgical generator for ultrasonic and electrosurgical devices
CN106167490B (zh) * 2016-08-10 2018-11-09 大连理工大学 一类含吲哚的咪唑并萘酰亚胺类衍生物及其合成和应用
CZ308568B6 (cs) 2018-12-03 2020-12-09 Univerzita Karlova Naftalimidofurany pro aplikace v molekulární biologii
JP6884920B2 (ja) * 2019-04-02 2021-06-09 旭化成株式会社 錠剤の保存安定性を向上させる方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3604827A1 (de) * 1986-02-15 1987-08-20 Bayer Ag Elektrophotographische toner
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
US5290931A (en) * 1990-02-21 1994-03-01 Hoechst Mitsubishi Kasei Co., Ltd. Water-insoluble naphthalic acid imide dyestuffs
US5086059A (en) * 1990-06-07 1992-02-04 Du Pont Merck Pharmaceutical Company Bis-naphthalimides as anticancer agents
US5206249A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
US5206250A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amide and thioamide linkers as anticancer agents

Also Published As

Publication number Publication date
US5585382A (en) 1996-12-17
BR9407265A (pt) 1996-10-01
PL312272A1 (en) 1996-04-15
ZA944370B (en) 1996-01-04
TW263506B (OSRAM) 1995-11-21
HU9503759D0 (en) 1996-02-28
EP0705250A1 (en) 1996-04-10
CA2165765A1 (en) 1995-01-05
CN1125943A (zh) 1996-07-03
IL110033A0 (en) 1994-10-07
KR960703113A (ko) 1996-06-19
FI956231L (fi) 1995-12-22
US5416089A (en) 1995-05-16
JPH08511802A (ja) 1996-12-10
HRP940367A2 (en) 1997-04-30
FI956231A7 (fi) 1995-12-22
FI956231A0 (fi) 1995-12-22
HUT75121A (en) 1997-04-28
SK163095A3 (en) 1996-09-04
WO1995000490A1 (en) 1995-01-05
NO955257D0 (no) 1995-12-22
CZ336795A3 (en) 1996-06-12
NO955257L (no) 1996-02-26

Similar Documents

Publication Publication Date Title
US5416089A (en) Polycyclic and heterocyclic chromophores for bis-imide tumoricidals
ES2223537T3 (es) Gamma-carbolinas condensadas con heterociclos sustituidas.
KR20160103986A (ko) N-벤질 트립탄트린 유도체, 및 이의 제조 방법 및 적용
EP0091241A2 (en) Condensed pyrrolinone derivatives, and their production
JPH08208652A (ja) ８ａ，９−ジヒドロ−１Ｈ−ジイミダゾ〔１，５−ａ：４′，５′−ｄ〕ピリジン誘導体
SK7032003A3 (en) Substituted pyrroloquinolines and pyridoquinolines as serotonin agonists and antagonists
US6737424B2 (en) Alpha-substituted pyridazino quinoline compounds
AU2003217373B2 (en) Novel tyloindicines and related processes, pharmaceutical compositions and methods
PT95646A (pt) Processo para a preparacao de derivados de isotiazolo-quinolina e de composicoes farmaceuticas que os contem
KR20180128456A (ko) 에스트로겐 수용체 하향 조절제로서의 치환된 인돌 화합물
CN114516832A (zh) 一种微管蛋白抑制剂及其制备方法与应用
DK172753B1 (da) N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat
CA2093108A1 (en) 9-fluoro-7-oxo-7h-pyrido[1,2,3-de][1,4]benzoxazine-6- carboxylic acids and esters
CA2220509C (en) Fused polycyclic heterocycle derivatives
CA2007529A1 (en) 3-phenyl-5, 6-dihydrobenz [c] acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents
FR2761071A1 (fr) Derives de quinolein-2(1h)-one et de dihydroquinolein-2(1h)- one, leur preparation et leur application en therapeutique
EP0538477B1 (en) Novel cyclic aminophenylacetic acid derivative, production thereof, and immune response modulator containing the same as active ingredient
US5641782A (en) 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides
US5952335A (en) Fused polycyclic heterocycle derivatives
CN110615766B (zh) 双取代的α、β不饱和酮及其制备方法和应用
KR20110030686A (ko) 트리시클릭 유도체, 이의 제조 방법 및 이를 함유하는 약학적 조성물
Veeraraghavan et al. Reissert compound studies. XXXIX. A novel approach to the berbine and 6‐azaberbine systems and related derivatives of ellipticine
SE446181B (sv) Substituerad kinazolin samt forfarande for dess framstellning
KR20040039404A (ko) 20(에스)-캄포테신의 약제학적으로 수용가능한 염
JPS5824587A (ja) オキソチエノベンゾオキセピンおよびその製法