AU715785B2 - 1-(pyrazol-3-ylethyl)-4-(indol-3-yl) piperdines as compositions affecting the central nervous system - Google Patents

1-(pyrazol-3-ylethyl)-4-(indol-3-yl) piperdines as compositions affecting the central nervous system Download PDF

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Publication number
AU715785B2
AU715785B2 AU14432/97A AU1443297A AU715785B2 AU 715785 B2 AU715785 B2 AU 715785B2 AU 14432/97 A AU14432/97 A AU 14432/97A AU 1443297 A AU1443297 A AU 1443297A AU 715785 B2 AU715785 B2 AU 715785B2
Authority
AU
Australia
Prior art keywords
ethyl
methyl
pyrazolyl
formula
piperidyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU14432/97A
Other languages
English (en)
Other versions
AU1443297A (en
Inventor
Gerd Bartoszyk
Henning Bottcher
Hartmut Greiner
Jurgen Harting
Joachim Marz
Christoph Seyfried
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU1443297A publication Critical patent/AU1443297A/en
Application granted granted Critical
Publication of AU715785B2 publication Critical patent/AU715785B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
AU14432/97A 1996-01-25 1997-01-17 1-(pyrazol-3-ylethyl)-4-(indol-3-yl) piperdines as compositions affecting the central nervous system Ceased AU715785B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19602505 1996-01-25
DE19602505A DE19602505A1 (de) 1996-01-25 1996-01-25 1-(Pyrazol-4-Indol-3-yl)-Piperidine
PCT/EP1997/000187 WO1997027186A1 (de) 1996-01-25 1997-01-17 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidine als das zentralnervensystem beeinflussende mittel

Publications (2)

Publication Number Publication Date
AU1443297A AU1443297A (en) 1997-08-20
AU715785B2 true AU715785B2 (en) 2000-02-10

Family

ID=7783568

Family Applications (1)

Application Number Title Priority Date Filing Date
AU14432/97A Ceased AU715785B2 (en) 1996-01-25 1997-01-17 1-(pyrazol-3-ylethyl)-4-(indol-3-yl) piperdines as compositions affecting the central nervous system

Country Status (16)

Country Link
EP (1) EP0879234A1 (pt)
JP (1) JP2000503972A (pt)
KR (1) KR19990081970A (pt)
CN (1) CN1209807A (pt)
AR (1) AR005549A1 (pt)
AU (1) AU715785B2 (pt)
BR (1) BR9707467A (pt)
CA (1) CA2244136A1 (pt)
CZ (1) CZ231898A3 (pt)
DE (1) DE19602505A1 (pt)
HU (1) HUP9900980A2 (pt)
NO (1) NO983439L (pt)
PL (1) PL328228A1 (pt)
SK (1) SK99298A3 (pt)
WO (1) WO1997027186A1 (pt)
ZA (1) ZA97572B (pt)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179823B1 (en) 1999-11-10 2007-02-20 Takeda Pharmaceutical Company Limited 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity
US7507729B2 (en) 2005-10-11 2009-03-24 Hoffmann-La Roche Inc. Substituted imidazo-[1,5-a][1,2,4]triazolo[1,5-d][1,4] benzodiazepine derivatives

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2219385T3 (es) * 1999-09-09 2004-12-01 H. Lundbeck A/S Indoles sustituidos con 5-aminoalquilo y 5-aminocarbonilo.
JP5140225B2 (ja) 2000-08-14 2013-02-06 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 置換ピラゾール
US7332494B2 (en) 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
US20050026927A1 (en) * 2001-11-14 2005-02-03 Henning Boettcher Pyrazole derivatives as psychopharmaceuticals
WO2007050381A2 (en) * 2005-10-24 2007-05-03 Janssen Pharmaceutica, N.V. 3-piperidin-4-yl-indole orl-1 receptor modulators
TWI548630B (zh) * 2011-04-06 2016-09-11 Ｌｇ生命科學有限公司 １－（３－氰基－１－異丙基－吲哚－５－基）吡唑－４－羧酸結晶型及其製造方法
KR20220060488A (ko) * 2020-11-04 2022-05-11 주식회사 엘지화학 1-(3-시아노-1-아이소프로필-인돌-5-일)피라졸-4-카르복실산의 결정성 입자의 제조방법 및 이를 포함하는 약학적 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0708102A1 (en) * 1994-10-05 1996-04-24 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060816C3 (de) * 1970-12-10 1980-09-04 Merck Patent Gmbh, 6100 Darmstadt 4-Phenylpiperidinderivate Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen enthaltend diese Verbindungen
DE2258033A1 (de) * 1972-11-27 1974-05-30 Merck Patent Gmbh Verfahren zur herstellung von pyrazolderivaten
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5045550A (en) * 1990-09-20 1991-09-03 Warner-Lambert Co. Substituted tetrahydropyridines as central nervous system agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0708102A1 (en) * 1994-10-05 1996-04-24 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179823B1 (en) 1999-11-10 2007-02-20 Takeda Pharmaceutical Company Limited 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity
US7507729B2 (en) 2005-10-11 2009-03-24 Hoffmann-La Roche Inc. Substituted imidazo-[1,5-a][1,2,4]triazolo[1,5-d][1,4] benzodiazepine derivatives

Also Published As

Publication number Publication date
WO1997027186A1 (de) 1997-07-31
CA2244136A1 (en) 1997-07-31
KR19990081970A (ko) 1999-11-15
PL328228A1 (en) 1999-01-18
AU1443297A (en) 1997-08-20
ZA97572B (en) 1997-08-04
AR005549A1 (es) 1999-06-23
HUP9900980A2 (hu) 1999-07-28
NO983439D0 (no) 1998-07-24
DE19602505A1 (de) 1997-07-31
JP2000503972A (ja) 2000-04-04
EP0879234A1 (de) 1998-11-25
SK99298A3 (en) 1999-01-11
BR9707467A (pt) 1999-07-20
CN1209807A (zh) 1999-03-03
CZ231898A3 (cs) 1998-10-14
NO983439L (no) 1998-09-25

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired