AU708658B2 - Methods and compounds for curing diseases caused by mutations - Google Patents
Methods and compounds for curing diseases caused by mutations Download PDFInfo
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- AU708658B2 AU708658B2 AU28225/97A AU2822597A AU708658B2 AU 708658 B2 AU708658 B2 AU 708658B2 AU 28225/97 A AU28225/97 A AU 28225/97A AU 2822597 A AU2822597 A AU 2822597A AU 708658 B2 AU708658 B2 AU 708658B2
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A61P7/06—Antianaemics
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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| PCT/US1997/007362 WO1997041141A1 (en) | 1996-05-01 | 1997-05-01 | Methods and compounds for curing diseases caused by mutations |
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| US5731181A (en) * | 1996-06-17 | 1998-03-24 | Thomas Jefferson University | Chimeric mutational vectors having non-natural nucleotides |
| US5888983A (en) * | 1996-05-01 | 1999-03-30 | Thomas Jefferson University | Method and oligonucleobase compounds for curing diseases caused by mutations |
| US20040266706A1 (en) * | 2002-11-05 | 2004-12-30 | Muthiah Manoharan | Cross-linked oligomeric compounds and their use in gene modulation |
| US6524613B1 (en) | 1997-04-30 | 2003-02-25 | Regents Of The University Of Minnesota | Hepatocellular chimeraplasty |
| JP2001512687A (ja) * | 1997-08-05 | 2001-08-28 | キメラジェン，インコーポレーテッド | 植物に局在性遺伝子変化を生じさせるための混合二本鎖オリゴヌクレオチドの使用 |
| US6010907A (en) * | 1998-05-12 | 2000-01-04 | Kimeragen, Inc. | Eukaryotic use of non-chimeric mutational vectors |
| US6004804A (en) | 1998-05-12 | 1999-12-21 | Kimeragen, Inc. | Non-chimeric mutational vectors |
| US6438561B1 (en) * | 1998-11-19 | 2002-08-20 | Navigation Technologies Corp. | Method and system for using real-time traffic broadcasts with navigation systems |
| US6917882B2 (en) * | 1999-01-19 | 2005-07-12 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
| US6368861B1 (en) | 1999-01-19 | 2002-04-09 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US20030054390A1 (en) * | 1999-01-19 | 2003-03-20 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US6961664B2 (en) | 1999-01-19 | 2005-11-01 | Maxygen | Methods of populating data structures for use in evolutionary simulations |
| US20070065838A1 (en) * | 1999-01-19 | 2007-03-22 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US7024312B1 (en) | 1999-01-19 | 2006-04-04 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
| AU3210100A (en) | 1999-01-19 | 2000-08-01 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
| EP1165132B1 (en) * | 1999-04-08 | 2011-10-19 | Intercell USA, Inc. | Dry formulation for transcutaneous immunization |
| WO2000071165A2 (en) * | 1999-05-21 | 2000-11-30 | The University Of Miami | Use of chimeric mutational vectors to change endogenous sequences in solid tissues |
| US6830902B1 (en) | 1999-07-02 | 2004-12-14 | Invitrogen Corporation | Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis |
| EP1196559B1 (en) * | 1999-07-02 | 2006-07-05 | Invitrogen Corporation | Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis |
| US6271360B1 (en) | 1999-08-27 | 2001-08-07 | Valigen (Us), Inc. | Single-stranded oligodeoxynucleotide mutational vectors |
| AR025996A1 (es) * | 1999-10-07 | 2002-12-26 | Valigen Us Inc | Plantas no transgenicas resistentes a los herbicidas. |
| US7430477B2 (en) * | 1999-10-12 | 2008-09-30 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
| US6656700B2 (en) | 2000-05-26 | 2003-12-02 | Amersham Plc | Isoforms of human pregnancy-associated protein-E |
| US6686188B2 (en) | 2000-05-26 | 2004-02-03 | Amersham Plc | Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle |
| US20030017593A1 (en) * | 2000-06-05 | 2003-01-23 | Gamper Howard B. | Binary hybrid mutational vectors |
| US6875907B2 (en) | 2000-09-13 | 2005-04-05 | Pioneer Hi-Bred International, Inc. | Antimicrobial peptides and methods of use |
| US20020123474A1 (en) * | 2000-10-04 | 2002-09-05 | Shannon Mark E. | Human GTP-Rho binding protein2 |
| WO2002079495A2 (en) * | 2001-03-27 | 2002-10-10 | University Of Delaware | Genomics applications for modified oligonucleotides |
| US20030045830A1 (en) * | 2001-04-17 | 2003-03-06 | De Bizemont Therese | Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis |
| US20040063922A1 (en) * | 2001-04-17 | 2004-04-01 | Conrad Charles A. | Methods and compositions for catalytic DNA exchange in a sequence specific manner |
| US20040078837A1 (en) * | 2001-08-02 | 2004-04-22 | Shannon Mark E. | Four human zinc-finger-containing proteins: MDZ3, MDZ4, MDZ7 and MDZ12 |
| WO2003013226A2 (en) * | 2001-08-09 | 2003-02-20 | Cibus Genetics | Non-transgenic herbicide resistant plants |
| EP1448766A2 (en) * | 2001-09-27 | 2004-08-25 | University Of Delaware | Coisogenic eukaryotic cell collections |
| US7468244B2 (en) * | 2001-09-27 | 2008-12-23 | University Of Delaware | Polymorphism detection and separation |
| AU2003220119A1 (en) * | 2002-03-07 | 2003-09-22 | University Of Delaware | Methods, compositions, and kits for enhancing oligonucleotide-mediated nucleic acid sequence alteration using compositions comprising a histone deacetylase inhibitor, lambda phage beta protein, or hydroxyurea |
| KR101201664B1 (ko) | 2002-08-05 | 2012-11-15 | 사일런스 테라퓨틱스 아게 | 신규한 형태의 간섭 ｒｎａ 분자 |
| AU2003282477A1 (en) * | 2002-10-07 | 2004-05-04 | Napro Bio Therapeutics, Inc. | Methods and compositions for reducing screening in oligonucleotide-directed nucleic acid sequence alteration |
| WO2004050907A2 (en) * | 2002-12-03 | 2004-06-17 | Aarhus Universitet | Method for determing predisposition to manifestation of immune system related diseases |
| WO2004098508A2 (en) * | 2003-04-30 | 2004-11-18 | Napro Biotherapeutics, Inc. | Methods for production of non-disease causing hemoglobin by ex vivo oligonucleotide gene editing of human stem/progenitor cells |
| US20070072815A1 (en) * | 2004-05-04 | 2007-03-29 | Kmiec Eric B | Methods and kits to increase the efficiency of oligonucleotide-directed nucleic acid sequence alteration |
| AU2004326206B2 (en) | 2004-12-28 | 2011-03-17 | Pioneer Hi-Bred International, Inc. | Improved grain quality through altered expression of seed proteins |
| ATE530656T1 (de) | 2005-02-23 | 2011-11-15 | Univ North Carolina State | Veränderung des alkaloidgehaltes in tabak durch modifikation spezifischer cytochrome p450 gene. |
| WO2006119775A2 (en) | 2005-05-11 | 2006-11-16 | Aarhus Universitet | Method for diagnosis and treatment, of a mental disease |
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| CN1880458B (zh) * | 2005-06-15 | 2010-04-28 | 中国医学科学院基础医学研究所 | 人β-珠蛋白基因簇的人源染色体打靶载体及其应用 |
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| BRPI0710455A2 (pt) | 2006-04-19 | 2011-08-16 | Pioneer Hi Bred Int | polipeptìdeo isolado, polinucleotìdeo isolado e métodos para aumentar o nìvel de um polipeptìdeo em uma planta, para modular o nìvel de um polipeptìdeo em uma planta e para modificar o crescimento de uma planta |
| EP2041047B1 (en) | 2006-06-28 | 2018-10-17 | Cibus Europe B.V. | Fatty acid blends and uses therefor |
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| CN101939431B (zh) | 2007-11-12 | 2015-01-28 | 北卡罗来纳州立大学 | 通过修饰特定细胞色素p450基因改变烟草生物碱含量 |
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| PL2234994T3 (pl) * | 2007-12-27 | 2018-02-28 | Cibus Europe B.V. | Mieszanki estrów butylowych kwasów tłuszczowych |
| KR20110023862A (ko) * | 2008-05-23 | 2011-03-08 | 시부스 오일즈, 엘엘씨 | 효모를 사용한 스쿠알렌 생산 |
| EA201691309A1 (ru) | 2008-09-26 | 2016-11-30 | Басф Агрокемикал Продактс Б.В. | Резистентные к гербицидам ahas-мутанты и способы применения |
| BRPI0920107A2 (pt) | 2008-10-30 | 2015-08-18 | Pioneer Hi Bred Int | Polinucleotídeo isolado, cassete de expressão recombinante, célula hospedeira, planta tansgênica, semente transgênica, método para modular gs em uma planta, método para reduzir atividade de polipeptídeo da enzima gs em uma célula de planta. |
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Family Cites Families (1)
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| WO1995015972A1 (en) * | 1993-12-09 | 1995-06-15 | Thomas Jefferson University | Compounds and methods for site-directed mutations in eukaryotic cells |
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- 1997-05-01 EP EP97922597A patent/EP0906328A4/en not_active Withdrawn
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| CN1223660A (zh) | 1999-07-21 |
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| US5760012A (en) | 1998-06-02 |
| KR20000064969A (ko) | 2000-11-06 |
| WO1997041141A1 (en) | 1997-11-06 |
| JP2000509282A (ja) | 2000-07-25 |
| AU2822597A (en) | 1997-11-19 |
| EP0906328A4 (en) | 2003-06-18 |
| CA2252762A1 (en) | 1997-11-06 |
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