AU697167B2 - Chimeric proteins which block complement activation - Google Patents
Chimeric proteins which block complement activationInfo
- Publication number
- AU697167B2 AU697167B2 AU80719/94A AU8071994A AU697167B2 AU 697167 B2 AU697167 B2 AU 697167B2 AU 80719/94 A AU80719/94 A AU 80719/94A AU 8071994 A AU8071994 A AU 8071994A AU 697167 B2 AU697167 B2 AU 697167B2
- Authority
- AU
- Australia
- Prior art keywords
- protein
- mcp
- chimeric protein
- cab
- daf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 238000013223 sprague-dawley female rat Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12659693A | 1993-09-24 | 1993-09-24 | |
| US08/126596 | 1993-09-24 | ||
| US08/310,416 US5679546A (en) | 1993-09-24 | 1994-09-22 | Chimeric proteins which block complement activation |
| US08/310416 | 1994-09-22 | ||
| PCT/US1994/010786 WO1995008570A1 (en) | 1993-09-24 | 1994-09-23 | Chimeric proteins which block complement activation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU8071994A AU8071994A (en) | 1995-04-10 |
| AU697167B2 true AU697167B2 (en) | 1998-10-01 |
Family
ID=26824842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU80719/94A Ceased AU697167B2 (en) | 1993-09-24 | 1994-09-23 | Chimeric proteins which block complement activation |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5679546A (https=) |
| EP (1) | EP0723555B1 (https=) |
| JP (2) | JP3860605B2 (https=) |
| CN (1) | CN1057097C (https=) |
| AT (1) | ATE380875T1 (https=) |
| AU (1) | AU697167B2 (https=) |
| CA (1) | CA2172610A1 (https=) |
| DE (1) | DE69435049D1 (https=) |
| WO (1) | WO1995008570A1 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6482404B1 (en) | 1989-10-12 | 2002-11-19 | David James White | Transplantation of tissue comprising a DNA sequence encoding a homologous complement restriction factor |
| US5866402A (en) * | 1995-05-05 | 1999-02-02 | Chiron Corporation | Chimeric MCP and DAF proteins with cell surface localizing domain |
| FR2736916B1 (fr) * | 1995-07-21 | 1997-09-19 | Univ Paris Curie | Proteines hetero-multimeriques recombinantes du type alpha-beta c4bp |
| CA2298475A1 (en) * | 1997-10-31 | 1999-05-14 | Walter Reed Army Institute Of Research | Method of inhibiting side effects of pharmaceutical compositions containing amphiphilic vehicles or drug carrier molecules |
| US6956107B2 (en) * | 1998-02-20 | 2005-10-18 | Tanox, Inc. | Inhibitors of complement activation |
| US7112327B2 (en) * | 1998-02-20 | 2006-09-26 | Tanox, Inc. | Inhibition of complement activation |
| JP4437192B2 (ja) * | 1998-02-20 | 2010-03-24 | タノックス インコーポレイテッド | 補体活性化阻害剤 |
| US6297024B1 (en) | 1998-10-15 | 2001-10-02 | Cell Activation, Inc. | Methods for assessing complement activation |
| US6235494B1 (en) | 1999-02-08 | 2001-05-22 | The Scripps Research Institute | Substrates for assessing mannan-binding protein-associated serine protease activity and methods using the substrates |
| US6316253B1 (en) | 1999-11-01 | 2001-11-13 | Chiron Corporation | Expression vectors, transfection systems, and method of use thereof |
| EP2896631A1 (en) | 2000-10-10 | 2015-07-22 | Genentech, Inc. | Inhibition of complement C5 activation for the treatment and prevention of delayed xenograft or acute vascular rejection |
| US6820011B2 (en) * | 2001-04-11 | 2004-11-16 | The Regents Of The University Of Colorado | Three-dimensional structure of complement receptor type 2 and uses thereof |
| BR0209319A (pt) * | 2001-06-08 | 2004-07-20 | Novartis Ag | Tratamento ou profilaxia de rejeição de enxerto de célula produtora de insulina |
| EP1539811A4 (en) * | 2002-09-16 | 2006-05-24 | Elusys Therapeutics Inc | PREPARATION OF BISPEQIFIC MOLECULES WITH POLYETHYLENE GLYCOL LINKER |
| AU2003298650B2 (en) * | 2002-11-15 | 2010-03-11 | Musc Foundation For Research Development | Complement receptor 2 targeted complement modulators |
| WO2005069726A2 (en) | 2004-01-21 | 2005-08-04 | Case Western Reserve University | Hybrid and chimeric polypeptides that regulate activation of complement |
| BRPI0506629A (pt) * | 2004-02-10 | 2007-05-02 | Univ Colorado | inibição do fator b, a via alternativa do sistema complemento e métodos relacionados |
| JP4914344B2 (ja) * | 2004-03-31 | 2012-04-11 | ザ・フェインスタイン・インスティチュート・フォー・メディカル・リサーチ | 虚血／再灌流障害治療用のアドレノメデュリン及びアドレノメデュリン結合タンパク質 |
| US8703693B2 (en) * | 2004-03-31 | 2014-04-22 | The Feinstein Institute For Medical Research | Adrenomedullin and adrenomedullin binding protein for ischemia/reperfusion treatment |
| WO2006128006A1 (en) * | 2005-05-26 | 2006-11-30 | The Regents Of The University Of Colorado | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
| SG10201804008UA (en) * | 2005-11-04 | 2018-06-28 | Genentech Inc | Use of complement pathway inhibitors to treat ocular diseases |
| US7759304B2 (en) * | 2006-06-21 | 2010-07-20 | Regents Of The University Of Colorado | Targeting complement factor H for treatment of diseases |
| TW201716437A (zh) * | 2006-11-02 | 2017-05-16 | 建南德克公司 | 人類化之抗-因子ｄ抗體及其用途 |
| JP5332064B2 (ja) * | 2007-03-01 | 2013-11-06 | ウェルスタット イムノセラピューティクス， エルエルシー | 炎症により特徴付けられる疾患の治療 |
| CN101668773B (zh) | 2007-03-14 | 2016-08-31 | 亚力史制药公司 | 人工程化抗b因子抗体 |
| CR20170001A (es) | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
| WO2009151634A1 (en) * | 2008-06-12 | 2009-12-17 | The Board Of Trustees Of The Leland Stanford Junior University | Complement inhibitory agents as therapeutics in posttraumatic and degenerative arthritis |
| WO2011003098A1 (en) | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| CA2795311A1 (en) | 2009-11-05 | 2011-05-12 | Taligen Therapeutics, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis |
| CN102234332B (zh) * | 2010-04-26 | 2014-12-17 | 浙江海正药业股份有限公司 | 一种重组人血白蛋白及其融合蛋白的分离纯化工艺 |
| BR112012029067A2 (pt) | 2010-05-14 | 2019-09-24 | Univ Colorado Regents | grupos-alvo de receptor do complemento 2 (cr2) melhorados. |
| SG186397A1 (en) | 2010-06-22 | 2013-01-30 | Univ Colorado Regents | Antibodies to the c3d fragment of complement component 3 |
| AU2011295715B9 (en) | 2010-09-03 | 2017-02-23 | Abbvie Stemcentrx Llc | Novel modulators and methods of use |
| EP3524258B1 (en) | 2011-06-22 | 2025-10-01 | Apellis Pharmaceuticals, Inc. | Methods of treating chronic disorders with complement inhibitors |
| US9243070B2 (en) | 2012-04-03 | 2016-01-26 | Novelmed Therapeutics, Inc. | Humanized and chimeric anti-factor Bb antibodies and uses thereof |
| US9803005B2 (en) | 2012-05-24 | 2017-10-31 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| JP2015535212A (ja) | 2012-08-17 | 2015-12-10 | ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・コロラド、ア・ボデイー・コーポレイト | 補体活性化を検出するための組成物および方法 |
| SG11201601044XA (en) | 2013-08-12 | 2016-03-30 | Genentech Inc | Compositions and method for treating complement-associated conditions |
| CN110724691A (zh) | 2014-02-27 | 2020-01-24 | 阿勒根公司 | 补体因子Bb抗体 |
| AU2015253042A1 (en) | 2014-05-01 | 2016-10-20 | Genentech, Inc. | Anti-factor D antibody variants and uses thereof |
| EP3633371A1 (en) | 2014-12-18 | 2020-04-08 | F. Hoffmann-La Roche AG | Assay and method for determining cdc eliciting antibodies |
| CN108291216B (zh) | 2015-09-24 | 2022-09-16 | 宾夕法尼亚州大学信托人 | 用于治疗补体介导的疾病的组合物和方法 |
| US10407510B2 (en) | 2015-10-30 | 2019-09-10 | Genentech, Inc. | Anti-factor D antibodies and conjugates |
| EP3368090A1 (en) | 2015-10-30 | 2018-09-05 | H. Hoffnabb-La Roche Ag | Anti-factor d antibody variant conjugates and uses thereof |
| KR20180091097A (ko) * | 2015-12-23 | 2018-08-14 | 그리노파티온 바이오테크 게엠베하 | 보체 활성화를 억제하기 위한 폴리펩티드 |
| CA3029106A1 (en) | 2016-06-28 | 2018-01-04 | Universitat Ulm | Complement inhibitors and uses thereof |
| GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
| US20220195012A1 (en) * | 2019-04-13 | 2022-06-23 | National Centre For Cell Science | Daf-mcp chimeric proteins, process to manufacture the same and use of the chimeric protein for treating pathological conditions involving the complement system |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5212071A (en) * | 1988-04-01 | 1993-05-18 | The Johns Hopkins University | Nucleic acids encoding a human C3b/C4b receptor (CR1) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4774180A (en) * | 1986-02-26 | 1988-09-27 | Massachusetts Institute Of Technology | Construction and application of polyproteins |
| US5264357A (en) * | 1985-05-24 | 1993-11-23 | Genentech, Inc. | Nucleic acids vectors and cells for the synthesis of membrane anchor fusion polypeptides |
| IL82390A0 (en) * | 1986-05-02 | 1987-10-30 | Genentech Inc | Nucleic acid and methods for the synthesis of novel daf compositions |
| DE69007975T2 (de) * | 1989-08-22 | 1994-07-21 | Immunex Corp | Fusionsprotein bestehend aus gm-csf und il-3. |
| CA2049964A1 (en) * | 1990-01-26 | 1991-07-27 | Biogen, Inc. | C4 binding protein fusion proteins |
| EP1413587A2 (en) * | 1991-05-03 | 2004-04-28 | Washington University | Modified complement system regulator |
| US5252216A (en) * | 1992-03-24 | 1993-10-12 | Smithkline Beecham Corporation | Protein purification |
| US5627264A (en) * | 1994-03-03 | 1997-05-06 | Alexion Pharmaceuticals, Inc. | Chimeric complement inhibitor proteins |
-
1994
- 1994-09-22 US US08/310,416 patent/US5679546A/en not_active Expired - Lifetime
- 1994-09-23 CA CA002172610A patent/CA2172610A1/en not_active Abandoned
- 1994-09-23 AT AT94931763T patent/ATE380875T1/de not_active IP Right Cessation
- 1994-09-23 DE DE69435049T patent/DE69435049D1/de not_active Expired - Lifetime
- 1994-09-23 CN CN94194284A patent/CN1057097C/zh not_active Expired - Fee Related
- 1994-09-23 AU AU80719/94A patent/AU697167B2/en not_active Ceased
- 1994-09-23 WO PCT/US1994/010786 patent/WO1995008570A1/en not_active Ceased
- 1994-09-23 JP JP50995795A patent/JP3860605B2/ja not_active Expired - Fee Related
- 1994-09-23 EP EP94931763A patent/EP0723555B1/en not_active Expired - Lifetime
-
1997
- 1997-07-03 US US08/888,171 patent/US5851528A/en not_active Expired - Lifetime
-
2004
- 2004-09-28 JP JP2004282827A patent/JP2005041882A/ja not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5212071A (en) * | 1988-04-01 | 1993-05-18 | The Johns Hopkins University | Nucleic acids encoding a human C3b/C4b receptor (CR1) |
Non-Patent Citations (2)
| Title |
|---|
| J. BIOCHEM, VOL. 111, NO 5, 1992, PP 573-578 * |
| NUCLEIC ACIDS RESEARCH, VOL 12, 1984, PP 6797-6811 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0723555B1 (en) | 2007-12-12 |
| JP3860605B2 (ja) | 2006-12-20 |
| JP2005041882A (ja) | 2005-02-17 |
| WO1995008570A1 (en) | 1995-03-30 |
| EP0723555A4 (en) | 1999-04-28 |
| DE69435049D1 (de) | 2008-01-24 |
| CA2172610A1 (en) | 1995-03-30 |
| CN1057097C (zh) | 2000-10-04 |
| EP0723555A1 (en) | 1996-07-31 |
| ATE380875T1 (de) | 2007-12-15 |
| US5851528A (en) | 1998-12-22 |
| AU8071994A (en) | 1995-04-10 |
| CN1138863A (zh) | 1996-12-25 |
| JPH09502985A (ja) | 1997-03-25 |
| US5679546A (en) | 1997-10-21 |
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