AU695166B2 - Compositions and formulations for producing analgesia and for inhibiting progression of neuropathic pain disorders - Google Patents

Compositions and formulations for producing analgesia and for inhibiting progression of neuropathic pain disorders Download PDF

Info

Publication number
AU695166B2
AU695166B2 AU64002/96A AU6400296A AU695166B2 AU 695166 B2 AU695166 B2 AU 695166B2 AU 64002/96 A AU64002/96 A AU 64002/96A AU 6400296 A AU6400296 A AU 6400296A AU 695166 B2 AU695166 B2 AU 695166B2
Authority
AU
Australia
Prior art keywords
snx
omega
conopeptide
mviia
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU64002/96A
Other languages
English (en)
Other versions
AU6400296A (en
Inventor
Peter Isadore Adriaenssens
Gary Arthur Amstutz
Stephen Scott Bowersox
Theresa Gadbois
Kishor Chandra Gohil
Ramasharma Kristipati
Robert R. Luther
Mark Raymond Pettus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Azur Pharma International Ltd
Original Assignee
Neurex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/496,847 external-priority patent/US5795864A/en
Priority claimed from US08/613,400 external-priority patent/US6054429A/en
Application filed by Neurex Corp filed Critical Neurex Corp
Publication of AU6400296A publication Critical patent/AU6400296A/en
Application granted granted Critical
Publication of AU695166B2 publication Critical patent/AU695166B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Control Of El Displays (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
AU64002/96A 1995-06-27 1996-06-26 Compositions and formulations for producing analgesia and for inhibiting progression of neuropathic pain disorders Ceased AU695166B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US496847 1995-06-27
US08/496,847 US5795864A (en) 1995-06-27 1995-06-27 Stable omega conopetide formulations
US613400 1996-03-08
US08/613,400 US6054429A (en) 1996-03-08 1996-03-08 Epidural method of producing analgesia
PCT/US1996/011041 WO1997001351A1 (en) 1995-06-27 1996-06-26 Compositions and formulations for producing analgesia and for inhibiting progression of neuropathic pain disorders

Publications (2)

Publication Number Publication Date
AU6400296A AU6400296A (en) 1997-01-30
AU695166B2 true AU695166B2 (en) 1998-08-06

Family

ID=27052304

Family Applications (1)

Application Number Title Priority Date Filing Date
AU64002/96A Ceased AU695166B2 (en) 1995-06-27 1996-06-26 Compositions and formulations for producing analgesia and for inhibiting progression of neuropathic pain disorders

Country Status (13)

Country Link
EP (2) EP1336409B1 (https=)
JP (1) JP2838073B2 (https=)
AT (2) ATE359086T1 (https=)
AU (1) AU695166B2 (https=)
CA (1) CA2224795C (https=)
DE (3) DE69627153T2 (https=)
DK (2) DK0835126T3 (https=)
ES (2) ES2283671T3 (https=)
FR (1) FR05C0027I2 (https=)
LU (1) LU91181I2 (https=)
NL (1) NL300201I2 (https=)
PT (2) PT1336409E (https=)
WO (1) WO1997001351A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5931809A (en) 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
JP2002509080A (ja) * 1998-02-20 2002-03-26 シンジェンタ リミテッド グラモストラ・スパチュラタの毒から得られる鎮痛性ペプチドおよびその使用
AUPP627498A0 (en) 1998-10-02 1998-10-22 University Of Queensland, The Novel peptides - i
EP2412719A1 (en) 2002-12-02 2012-02-01 Xenome Ltd Chi-conotoxin peptides
WO2004050690A1 (en) 2002-12-02 2004-06-17 Xenome Ltd NOVEL χ-CONOTOXIN PEPTIDES (-I)
SG168407A1 (en) 2003-01-28 2011-02-28 Ironwood Pharmaceuticals Inc Methods and compositions for the treatment of gastrointestinal disorders
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7268109B2 (en) 2003-10-02 2007-09-11 Elan Pharmaceuticals, Inc. Method for reducing pain
GB0410215D0 (en) * 2004-05-07 2004-06-09 Lescroart Pol Nerve damage
US8188048B2 (en) 2006-06-23 2012-05-29 Xenome Limited Combination therapy
US8673856B2 (en) * 2006-11-04 2014-03-18 Anygen Co., Ltd. Omega conotoxins
EP2527360B1 (en) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2009135258A1 (en) * 2008-05-06 2009-11-12 Cnsbio Pty Ltd Methods and compositions for the management of pain using omega-conotoxins
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
CA2994066A1 (en) 2008-12-03 2010-06-10 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase c agonists and methods of use
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
SI2384318T1 (en) 2008-12-31 2018-03-30 Ardelyx, Inc. MEASURES AND PROCEDURES FOR THE INHIBITION OF ANTIPORT INHIBITED BY NHE IN THE TREATMENT OF DISEASES RELATED TO STRENGTH OF FLAMMABILITY OR TRADEMARITY WITH SOLO, AND THE EMISSION OF GASTROINTESTINAL TREATMENT
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
MX366293B (es) 2012-08-21 2019-07-04 Ardelyx Inc Compuestos y metodos para inhibir al antipuerto mediado por nhe en el tratamiento de trastornos asociados con la retencion de fluidos o la sobrecarga de sal y trastornos del tracto gastrointestinal.
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
LT2983667T (lt) 2013-04-12 2019-07-10 Ardelyx, Inc. Nhe3 rišantys junginiai ir fosfato pernešimo slopinimo būdai
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
CA3049678A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3926287A1 (de) * 1989-08-09 1991-02-21 Bernhard Clasbrummel Medizinische anwendung von omega-conotoxin gvia oder omega-conotoxin gvia-analoga zur sympathikolyse
US5051403A (en) * 1989-11-22 1991-09-24 Neurex Corporation Method of treating ischemia-related neuronal damage
WO1993010145A1 (en) * 1991-11-12 1993-05-27 Neurex Corporation Compositions for delayed treatment of ischemia-related neuronal damage
SG50624A1 (en) * 1991-12-30 1998-07-20 Neurex Corp Methods of producing analgesia and enhancing opiate analgesia
JPH06247879A (ja) * 1993-02-17 1994-09-06 Bristol Myers Squibb Co デオキシチミジンヌクレオシドを含有する注射用製剤の安定化方法およびその方法によって得られる安定化注射用製剤

Also Published As

Publication number Publication date
DE122005000043I2 (de) 2006-08-03
DK0835126T3 (da) 2003-07-14
JPH09104634A (ja) 1997-04-22
JP2838073B2 (ja) 1998-12-16
ES2194998T3 (es) 2003-12-01
AU6400296A (en) 1997-01-30
EP1336409B1 (en) 2007-04-11
LU91181I2 (fr) 2005-09-06
ATE235914T1 (de) 2003-04-15
ATE359086T1 (de) 2007-05-15
NL300201I1 (nl) 2005-09-01
EP1336409A1 (en) 2003-08-20
DE122005000043I1 (de) 2006-06-29
EP0835126A1 (en) 1998-04-15
DE69637021D1 (de) 2007-05-24
DE69637021T2 (de) 2008-01-10
PT835126E (pt) 2003-07-31
DE69627153T2 (de) 2003-12-04
FR05C0027I1 (https=) 2005-08-12
FR05C0027I2 (https=) 2006-12-29
WO1997001351A1 (en) 1997-01-16
HK1058146A1 (en) 2004-05-07
DK1336409T3 (da) 2007-08-13
PT1336409E (pt) 2007-06-29
CA2224795A1 (en) 1997-01-16
CA2224795C (en) 2001-04-03
ES2283671T3 (es) 2007-11-01
NL300201I2 (nl) 2006-02-01
EP0835126B1 (en) 2003-04-02
DE69627153D1 (de) 2003-05-08

Similar Documents

Publication Publication Date Title
AU695166B2 (en) Compositions and formulations for producing analgesia and for inhibiting progression of neuropathic pain disorders
US5891849A (en) Methods and formulations for preventing progression of neuropathic pain
US6054429A (en) Epidural method of producing analgesia
EP0625162B1 (en) Methods of producing analgesia and enhancing opiate analgesia
AU648052B2 (en) Compositions for treating ischemia-related neuronal damage
US5189020A (en) Method of reducing neuronal damage using omega conotoxin peptides
US6136786A (en) Method for enhancing analgesia
CN102202677A (zh) 治疗疼痛的活性剂和方法
US20040138204A1 (en) Compositions and methods for pain reduction
JPH10511077A (ja) N末端基で切断されたダイノルフィン類似体を用いた鎮痛方法
US5559095A (en) Delayed treatment method of reducing ischemia-related neuronal damage
WO1993010145A1 (en) Compositions for delayed treatment of ischemia-related neuronal damage
ES2524564T3 (es) Identificación de nuevas toxinas antagonistas de canales de calcio de tipo T de aplicación analgésica
HK1058146B (en) Compositions and formulations for producing analgesia and for inhibiting progression of neuropathic pain disorders
CN121471320A (zh) 一种靶向trpv1的多肽及其应用
WO2023068949A1 (en) Peptide and its uses
Perry Kinins as neuropeptides
HK1013832B (en) Methods of producing analgesia and enhancing opiate analgesia
HK1006810B (en) Compositions comprising omega conotoxin peptide derivatives and their use for treating ischemia-related neuronal damage