AU682417B2 - Pyrone derivatives as protease inhibitors and antiviral agents - Google Patents

Pyrone derivatives as protease inhibitors and antiviral agents

Info

Publication number
AU682417B2
AU682417B2 AU81276/94A AU8127694A AU682417B2 AU 682417 B2 AU682417 B2 AU 682417B2 AU 81276/94 A AU81276/94 A AU 81276/94A AU 8127694 A AU8127694 A AU 8127694A AU 682417 B2 AU682417 B2 AU 682417B2
Authority
AU
Australia
Prior art keywords
pyran
hydroxy
thio
phenyl
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU81276/94A
Other languages
English (en)
Other versions
AU8127694A (en
Inventor
John Michael Domagala
Edmund Lee Ellsworth
Elizabeth Lunney
Daniel Fred Ortwine
Kimberly Suzanne Para
Josyula Venkata Nagendra Vara Prasad
Tomi Sawyer
Bradley Dean Tait
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/319,768 external-priority patent/US5808062A/en
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of AU8127694A publication Critical patent/AU8127694A/en
Application granted granted Critical
Publication of AU682417B2 publication Critical patent/AU682417B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU81276/94A 1993-11-19 1994-10-26 Pyrone derivatives as protease inhibitors and antiviral agents Ceased AU682417B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15502893A 1993-11-19 1993-11-19
US155028 1993-11-19
US319768 1994-10-12
US08/319,768 US5808062A (en) 1993-11-19 1994-10-12 Pyrone derivatives as protease inhibitors and antiviral agents
PCT/US1994/012367 WO1995014014A2 (en) 1993-11-19 1994-10-26 Pyrone derivatives as protease inhibitors and antiviral agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU40974/97A Division AU695088B2 (en) 1993-11-19 1997-10-13 Intermediates useful for preparing pyrone derivatives

Publications (2)

Publication Number Publication Date
AU8127694A AU8127694A (en) 1995-06-06
AU682417B2 true AU682417B2 (en) 1997-10-02

Family

ID=26851948

Family Applications (1)

Application Number Title Priority Date Filing Date
AU81276/94A Ceased AU682417B2 (en) 1993-11-19 1994-10-26 Pyrone derivatives as protease inhibitors and antiviral agents

Country Status (16)

Country Link
EP (1) EP0729466A1 (fi)
JP (1) JPH09505295A (fi)
AU (1) AU682417B2 (fi)
BG (1) BG62770B1 (fi)
CA (1) CA2174124A1 (fi)
CZ (1) CZ134396A3 (fi)
EE (1) EE9600044A (fi)
FI (1) FI962019A (fi)
HR (1) HRP940938A2 (fi)
HU (1) HUT74888A (fi)
IL (1) IL111671A0 (fi)
NO (1) NO962015D0 (fi)
PL (1) PL314484A1 (fi)
RU (1) RU2153497C2 (fi)
SK (1) SK63996A3 (fi)
WO (1) WO1995014014A2 (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2168895A1 (es) * 1999-03-26 2002-06-16 Almirall Prodesfarma Sa Derivados de 2-fenilpiran-4-ona.
ES2154561B1 (es) * 1998-09-25 2001-12-01 Almirall Prodesfarma Sa Derivados de 2-fenilpiran-4-ona.
TW587079B (en) * 1998-09-25 2004-05-11 Almirall Prodesfarma Ag 2-phenylpyran-4-one derivatives
PE20011333A1 (es) 2000-03-16 2002-01-16 Almirall Prodesfarma Ag Derivados de 2-fenilpiran-4-ona como inhibidores de ciclooxigenasa 2
ES2844184T3 (es) * 2016-06-14 2021-07-21 Bristol Myers Squibb Co 4-hidroxi-3-sulfonilpiridin-2(1H)-onas como agonistas del receptor de APJ
KR102384668B1 (ko) * 2016-06-14 2022-04-07 브리스톨-마이어스 스큅 컴퍼니 Apj 효능제로서의 6-히드록시-5-(페닐/헤테로아릴술포닐)피리미딘-4(1h)-온

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0588137A1 (de) * 1992-09-10 1994-03-23 Bayer Ag 3-Aryl-pyron-Derivate
WO1994011361A1 (en) * 1992-11-13 1994-05-26 The Upjohn Company Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hiv and other retroviruses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3724M (fr) * 1963-12-04 1965-12-06 Marcel Perrault Médicament a base d'anisoyl-3 hydroxy-4 p. méthoxy-phényl-6α-pyrone.
US3818046A (en) * 1972-12-18 1974-06-18 Dow Chemical Co Sulfur-containing hydroxy pyrones and alkali metal salts thereof
JP3372338B2 (ja) * 1994-02-14 2003-02-04 オリンパス光学工業株式会社 測距装置

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0588137A1 (de) * 1992-09-10 1994-03-23 Bayer Ag 3-Aryl-pyron-Derivate
WO1994011361A1 (en) * 1992-11-13 1994-05-26 The Upjohn Company Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hiv and other retroviruses

Also Published As

Publication number Publication date
FI962019A (fi) 1996-05-20
EP0729466A1 (en) 1996-09-04
WO1995014014A2 (en) 1995-05-26
FI962019A0 (fi) 1996-05-13
JPH09505295A (ja) 1997-05-27
CA2174124A1 (en) 1995-05-26
PL314484A1 (en) 1996-09-16
BG62770B1 (bg) 2000-07-31
HRP940938A2 (en) 1997-06-30
RU2153497C2 (ru) 2000-07-27
NO962015L (no) 1996-05-15
SK63996A3 (en) 1996-11-06
HUT74888A (en) 1997-02-28
EE9600044A (et) 1996-10-15
WO1995014014A3 (en) 1995-06-15
NO962015D0 (no) 1996-05-15
AU8127694A (en) 1995-06-06
BG100564A (bg) 1996-12-31
IL111671A0 (en) 1995-01-24
HU9601347D0 (en) 1996-07-29
CZ134396A3 (en) 1996-08-14

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired