HU9601347D0 - Pyrone derivaties as protease inhibitors and antiviral agents - Google Patents

Pyrone derivaties as protease inhibitors and antiviral agents

Info

Publication number
HU9601347D0
HU9601347D0 HU9601347A HU9601347A HU9601347D0 HU 9601347 D0 HU9601347 D0 HU 9601347D0 HU 9601347 A HU9601347 A HU 9601347A HU 9601347 A HU9601347 A HU 9601347A HU 9601347 D0 HU9601347 D0 HU 9601347D0
Authority
HU
Hungary
Prior art keywords
derivaties
pyrone
protease inhibitors
antiviral agents
antiviral
Prior art date
Application number
HU9601347A
Other languages
Hungarian (hu)
Other versions
HUT74888A (en
Inventor
John Michael Domagala
Edmund Lee Ellsworth
Elizabeth Lunney
Daniel Fred Ortwine
Kimberly Suzanne Para
Josyula Venkata Nagendr Prasad
Tomi Sawyer
Bradley Dean Tait
Original Assignee
Parke Davis & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/319,768 external-priority patent/US5808062A/en
Application filed by Parke Davis & Co filed Critical Parke Davis & Co
Publication of HU9601347D0 publication Critical patent/HU9601347D0/en
Publication of HUT74888A publication Critical patent/HUT74888A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HU9601347A 1993-11-19 1994-10-26 Pyrone derivaties as protease inhibitors and antiviral agents HUT74888A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15502893A 1993-11-19 1993-11-19
US08/319,768 US5808062A (en) 1993-11-19 1994-10-12 Pyrone derivatives as protease inhibitors and antiviral agents

Publications (2)

Publication Number Publication Date
HU9601347D0 true HU9601347D0 (en) 1996-07-29
HUT74888A HUT74888A (en) 1997-02-28

Family

ID=26851948

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9601347A HUT74888A (en) 1993-11-19 1994-10-26 Pyrone derivaties as protease inhibitors and antiviral agents

Country Status (16)

Country Link
EP (1) EP0729466A1 (en)
JP (1) JPH09505295A (en)
AU (1) AU682417B2 (en)
BG (1) BG62770B1 (en)
CA (1) CA2174124A1 (en)
CZ (1) CZ134396A3 (en)
EE (1) EE9600044A (en)
FI (1) FI962019A (en)
HR (1) HRP940938A2 (en)
HU (1) HUT74888A (en)
IL (1) IL111671A0 (en)
NO (1) NO962015D0 (en)
PL (1) PL314484A1 (en)
RU (1) RU2153497C2 (en)
SK (1) SK63996A3 (en)
WO (1) WO1995014014A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW587079B (en) * 1998-09-25 2004-05-11 Almirall Prodesfarma Ag 2-phenylpyran-4-one derivatives
ES2154561B1 (en) * 1998-09-25 2001-12-01 Almirall Prodesfarma Sa DERIVATIVES OF 2-FENILPIRAN-4-ONA.
ES2168895A1 (en) * 1999-03-26 2002-06-16 Almirall Prodesfarma Sa 2-Phenylpyran-4-one derivatives as cyclooxygenase-2 (COX-2) inhibitors useful e.g. for treating pain, fever or inflammation, preventing colorectal cancer or neurodegenerative diseases
PE20011333A1 (en) 2000-03-16 2002-01-16 Almirall Prodesfarma Ag DERIVATIVES OF 2-FENYLPYRAN-4-ONA AS INHIBITORS OF CYCLOOXYGENASE 2
CN109311821B (en) * 2016-06-14 2022-10-14 百时美施贵宝公司 6-hydroxy-5- (phenyl/heteroarylsulfonyl) pyrimidin-4 (1H) -ones as APJ agonists
US10889565B2 (en) * 2016-06-14 2021-01-12 Bristol-Myers Squibb Company 4-hydroxy-3-sulfonylpyridin-2(1H)-ones as APJ receptor agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3724M (en) * 1963-12-04 1965-12-06 Marcel Perrault Medicinal product based on anisoyl-3 hydroxy-4 p. methoxy-phenyl-6α-pyrone.
US3818046A (en) * 1972-12-18 1974-06-18 Dow Chemical Co Sulfur-containing hydroxy pyrones and alkali metal salts thereof
DE4308451A1 (en) * 1992-09-10 1994-04-14 Bayer Ag 3-aryl-pyrone derivatives
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
JP3372338B2 (en) * 1994-02-14 2003-02-04 オリンパス光学工業株式会社 Distance measuring device

Also Published As

Publication number Publication date
FI962019A0 (en) 1996-05-13
PL314484A1 (en) 1996-09-16
EP0729466A1 (en) 1996-09-04
RU2153497C2 (en) 2000-07-27
BG62770B1 (en) 2000-07-31
SK63996A3 (en) 1996-11-06
EE9600044A (en) 1996-10-15
NO962015L (en) 1996-05-15
WO1995014014A3 (en) 1995-06-15
WO1995014014A2 (en) 1995-05-26
HUT74888A (en) 1997-02-28
HRP940938A2 (en) 1997-06-30
JPH09505295A (en) 1997-05-27
AU682417B2 (en) 1997-10-02
CZ134396A3 (en) 1996-08-14
AU8127694A (en) 1995-06-06
BG100564A (en) 1996-12-31
CA2174124A1 (en) 1995-05-26
NO962015D0 (en) 1996-05-15
IL111671A0 (en) 1995-01-24
FI962019A (en) 1996-05-20

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Legal Events

Date Code Title Description
DFC4 Cancellation of temporary protection due to refusal