AU667662B2 - Parathyroid hormone analogues modified at positions 3, 6 or 9 - Google Patents
Parathyroid hormone analogues modified at positions 3, 6 or 9Info
- Publication number
- AU667662B2 AU667662B2 AU82990/91A AU8299091A AU667662B2 AU 667662 B2 AU667662 B2 AU 667662B2 AU 82990/91 A AU82990/91 A AU 82990/91A AU 8299091 A AU8299091 A AU 8299091A AU 667662 B2 AU667662 B2 AU 667662B2
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- Ceased
Links
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- BJBUEDPLEOHJGE-IMJSIDKUSA-N trans-3-hydroxy-L-proline Chemical compound O[C@H]1CC[NH2+][C@@H]1C([O-])=O BJBUEDPLEOHJGE-IMJSIDKUSA-N 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55376090A | 1990-07-13 | 1990-07-13 | |
| US553760 | 1990-07-13 | ||
| PCT/US1991/004971 WO1992000753A1 (en) | 1990-07-13 | 1991-07-15 | PARATHYROID HORMONE ANALOGUES MODIFIED AT POSITIONS 3, 6 or 9 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU8299091A AU8299091A (en) | 1992-02-04 |
| AU667662B2 true AU667662B2 (en) | 1996-04-04 |
Family
ID=24210645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU82990/91A Ceased AU667662B2 (en) | 1990-07-13 | 1991-07-15 | Parathyroid hormone analogues modified at positions 3, 6 or 9 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0539491A1 (show.php) |
| JP (1) | JPH05509098A (show.php) |
| AU (1) | AU667662B2 (show.php) |
| CA (1) | CA2087190A1 (show.php) |
| WO (1) | WO1992000753A1 (show.php) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5434246A (en) * | 1992-03-19 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Parathyroid hormone derivatives |
| US5814603A (en) * | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| US5977070A (en) * | 1992-07-14 | 1999-11-02 | Piazza; Christin Teresa | Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis |
| US6235288B1 (en) | 1992-08-26 | 2001-05-22 | The Scripps Research Institute | Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus |
| JP3754072B2 (ja) * | 1994-03-22 | 2006-03-08 | リサーチ・コーポレーション・テクノロジーズ・インコーポレーテッド | 摂食抑制ペプチド |
| CO4410206A1 (es) * | 1994-07-28 | 1997-01-09 | Sandoz Ag | DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN |
| US6117455A (en) | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
| CA2178894A1 (en) * | 1995-06-15 | 1996-12-16 | Tsunehiko Fukuda | Parathyroid hormone derivatives and their use |
| EP0878201B1 (en) * | 1996-02-01 | 2002-06-19 | Chugai Seiyaku Kabushiki Kaisha | Medicaments for the treatment or prevention of thrombocytopenia |
| CN1095681C (zh) * | 1996-06-20 | 2002-12-11 | 久光制药株式会社 | 一种用于离子电渗疗法的装置结构 |
| TW505654B (en) * | 1996-07-30 | 2002-10-11 | Hoffmann La Roche | Synthesis of analogs of PTH and PTHrP |
| CN1817906B (zh) * | 1996-09-26 | 2011-08-10 | 中外制药株式会社 | 抗人副甲状腺激素相关蛋白的抗体 |
| TR199900666T2 (xx) | 1996-09-26 | 1999-06-21 | Chugai Seiyaku Kabushiki Kaisha | �nsan paratormonu ile ilgili peptidlere kar�� antikor. |
| EP1004313B1 (en) * | 1997-05-15 | 2007-05-02 | Chugai Seiyaku Kabushiki Kaisha | Cachexia remedy |
| KR20010083069A (ko) * | 1998-06-26 | 2001-08-31 | 나가야마 오사무 | 고칼슘혈증치료제 |
| TWI255718B (en) | 1999-07-02 | 2006-06-01 | Chugai Pharmaceutical Co Ltd | Ameliorative agent for low vasopressin concentration |
| CA2373885A1 (en) * | 1999-07-02 | 2001-01-11 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for diseases caused by pth or pthrp |
| WO2001002012A1 (fr) * | 1999-07-06 | 2001-01-11 | Chugai Seiyaku Kabushiki Kaisha | Remedes contre l'hypercalcemie chimio-resistante |
| US20030049211A1 (en) * | 2000-01-25 | 2003-03-13 | Atsuhiko Kato | Remedies and preventives for dental diseases |
| CA2401357A1 (en) * | 2000-02-28 | 2001-09-07 | Chugai Seiyaku Kabushiki Kaisha | Tissue degradation inhibitor agent |
| US8029793B2 (en) | 2000-04-28 | 2011-10-04 | Chugai Seiyaku Kabushiki Kaisha | Methods for inhibiting cell proliferation |
| CA2472472A1 (en) | 2002-01-10 | 2003-07-24 | Osteotrophin Llc | Treatment of bone disorders with skeletal anabolic drugs |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3886132A (en) * | 1972-12-21 | 1975-05-27 | Us Health | Human parathyroid hormone |
| US4508828A (en) * | 1983-03-21 | 1985-04-02 | Immuno Nuclear Corporation | Bioassay of parathyroid hormone |
| US4968669A (en) * | 1988-05-09 | 1990-11-06 | Merck & Co., Inc. | Parathyroid hormone antagonists |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4771124A (en) * | 1987-05-26 | 1988-09-13 | Merck & Co., Inc. | Parathyroid hormone antagonists with simplified synthetic methodology |
-
1991
- 1991-07-15 EP EP91913697A patent/EP0539491A1/en not_active Withdrawn
- 1991-07-15 WO PCT/US1991/004971 patent/WO1992000753A1/en not_active Ceased
- 1991-07-15 JP JP3513078A patent/JPH05509098A/ja active Pending
- 1991-07-15 CA CA002087190A patent/CA2087190A1/en not_active Abandoned
- 1991-07-15 AU AU82990/91A patent/AU667662B2/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3886132A (en) * | 1972-12-21 | 1975-05-27 | Us Health | Human parathyroid hormone |
| US4508828A (en) * | 1983-03-21 | 1985-04-02 | Immuno Nuclear Corporation | Bioassay of parathyroid hormone |
| US4968669A (en) * | 1988-05-09 | 1990-11-06 | Merck & Co., Inc. | Parathyroid hormone antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| AU8299091A (en) | 1992-02-04 |
| WO1992000753A1 (en) | 1992-01-23 |
| CA2087190A1 (en) | 1992-01-14 |
| JPH05509098A (ja) | 1993-12-16 |
| EP0539491A1 (en) | 1993-05-05 |
| EP0539491A4 (show.php) | 1994-03-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |